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Metabolic complications of psychotropic medications in psychiatric disorders:Emerging role of de novo lipogenesis and therapeutic consideration

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World Journal of Psychiatry 2024年第6期14卷 767-783页

作者： Mohammad M Khan Zaw ali Khan mohsin ali Khan Laboratory of Translational Neurology and Molecular Psychiatry Department of BiotechnologyEra’s Lucknow Medical College and Hospitaland Faculty of ScienceEra UniversityLucknow 226003India Era’s Lucknow Medical College and Hospital Era UniversityLucknow 226003India

Although significant advances have been made in understanding the pathophysiology of psychiatric disorders(PDs),therapeutic advances have not been very *** psychotropic medications can reduce classical symptoms in patients with PDs,their long-term use has been reported to induce or exaggerate various pre-existing metabolic abnormalities including diabetes,obesity and non-alcoholic fatty liver disease(NAFLD).The mechanism(s)underlying these metabolic abnormalities is not clear;however,lipid/fatty acid accumulation due to enhanced de novo lipogenesis(DNL)has been shown to reduce membrane fluidity,increase oxidative stress and inflammation leading to the development of the aforementioned metabolic ***,emerging evidence suggest that DNL dysregulation and fatty acid accumulation could be the major mechanisms associated with the development of obesity,diabetes and NAFLD after long-term treatment with psychotropic medications in patients with *** support of this,several adjunctive drugs comprising of anti-oxidants and antiinflammatory agents,that are used in treating PDs in combination with psychotropic medications,have been shown to reduce insulin resistance and development of *** conclusion,the above evidence suggests that DNL could be a potential pathological factor associated with various metabolic abnormalities,and a new avenue for translational research and therapeutic drug designing in PDs.

关键词： Psychotropic medications Metabolic complications De novo lipogenesis Obesity Diabetes Non-alcoholic fatty liver disease

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用于储能应用的可生物降解的聚合物基电介质复合材料的制备

用于储能应用的可生物降解的聚合物基电介质复合材料的制备

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作者： mohsin ali KADHIM KADHIM 北京化工大学

学位级别：硕士

由于具有宽容量范围、高工作电压、轻质、性能可靠等优点,聚合物基的电介质薄膜电容器等在现代电子学中具有重要作用。通常所研究的介电聚合物和填料都是不可生物降解的,这是产生电子废物污染的原因之一。为了解决这个问题,本研究选择... 详细信息

由于具有宽容量范围、高工作电压、轻质、性能可靠等优点,聚合物基的电介质薄膜电容器等在现代电子学中具有重要作用。通常所研究的介电聚合物和填料都是不可生物降解的,这是产生电子废物污染的原因之一。为了解决这个问题,本研究选择了可生物降解的聚酯PBAT作为基体,将其分别与两种自制的生物质衍生填料复合,制备了可生物降解的聚合物基电介质复合材料。论文主要分为以下几个主要内容:首先,以香蕉皮废弃物（BP-W）为原料,通过热解的方法,分别制备了N掺杂和非掺杂的生物质炭,N掺杂技术解决了非掺杂生物炭性能上的一些缺陷,通过透射电子显微镜（TEM）、X射线衍射（XRD）、能量色散X射线分析（EDX）、X射线光电子能谱（XPS）、傅里叶变换红外光谱（FTIR）和热重分析（TGA）等手段对产物进行了系统表征,结果证实了氮的成功掺杂。并将它们作为含碳导电有机填料分别与PBAT复合制备了复合电介质材料,掺杂N生物炭可以改善聚合物复合材料的介电性能和热稳定性,而不会牺牲力学性能和生物降解性。具体而言,含有10 wt.%N掺杂生物炭的PBAT纳米复合材料的介电常数为10.64,比纯PBAT（介电常数为5.85）增加了83%。此外,复合材料介电损耗在1000 Hz时保持在0.071以下。其次,通过对生物质废料牛骨头的热解,制备了羟基磷灰石（HAp）并将其作为陶瓷无机填料,对其进行了系统的表征。随后,利用溶液共混和热压技术制备了包含HAp和PBAT的可生物降解介电复合材料,并进行了系统的表征。结果表明了单相结晶HAp的成功制备,具有良好定义的晶界,所得到的可生物降解复合材料表现出显著的介电性能,包括高介电常数、低介电损耗和良好的低填料含量下的击穿强度。介电常数随着填料含量的增加而增加,而介电损耗保持低水平,击穿强度随着填料含量的增加而略有降低。能量储存密度的理论研究表明,PBAT/HAp-3%复合材料具有较高的能量储存密度(Ust=3.56 J/cm3),比纯PBAT(Ust=2.48J/cm3)高出43.55%。HAp/PBAT复合材料的力学性能和热稳定性均得到了不同程度的提升。此外,对两个体系的复合材料生物降解性能进行了分析,评估了介电复合材料的生物降解行为,包括在不同时间段内浸泡在谷胱甘肽溶液中以模拟酶降解。评估参数包括重量损失率、力学性能和外观检查等。对完全可生物降解的PBAT/绿色填料复合材料的生物降解性能进行了全面的评价。

关键词：聚合物基复合材料介电性能生物降解生物炭生物来源羟基磷灰石

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Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

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World Journal of Transplantation 2024年第1期14卷 154-163页

作者： Ameet Kumar Jesrani syed M Faiq Rahma Rashid Tariq ali Kalwar Rehan mohsin Tahir Aziz Nida Amin Khan Muhammed Mubarak Department of Radiology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Pathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Transplantation Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Urology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

BACKGROUND Detection of early chronic changes in the kidney allograft is important for timely intervention and long-term *** and novel ultrasound-based investigations are being increasingly used for this purpose with variable *** To compare the diagnostic performance of resistive index(RI)and shear wave elastography(SWE)in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological *** This is a cross-sectional and comparative study.A total of 154 kidney transplant recipients were included in this study,which was conducted at the Departments of Transplantation and Radiology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from August 2022 to February *** consecutive patients with increased serum creatinine levels and reduced glomerular filtration rate(GFR)after three months of transplantation were enrolled in this *** and RI were performed and the findings of these were evaluated against the kidney allograft biopsy results to determine their diagnostic *** The mean age of all patients was 35.32±11.08 *** these,126(81.8%)were males and 28(18.2%)were *** mean serum creatinine in all patients was 2.86±1.68 mg/dL and the mean estimated GFR was 35.38±17.27 mL/min/1.73 *** allograft biopsy results showed chronic changes in 55(37.66%)*** sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of SWE for the detection of chronic allograft damage were 93.10%,96.87%%,94.73%,and 95.87%,respectively,and the diagnostic accuracy was 95.45%.For RI,the sensitivity,specificity,PPV,and NPV were 76.92%,83.33%,70.17%,and 87.62%,respectively,and the diagnostic accuracy was 81.16%.CONCLUSION The results from this study show that SWE is more sensitive and specific as compared to RI in the evaluation of chronic allograft *** can be of great help during the routine follow-up of kidney transplant recipients for screening a

关键词： Shear wave Sonoelastography Resistive index Chronic allograft changes Biopsy Histopathology

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Conservation laws,Lie symmetries,self adjointness,and soliton solutions for the Selkov–Schnakenberg system

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Communications in Theoretical Physics 2024年第2期76卷 29-44页

作者： Kashif ali Aly R Seadawy syed T R Rizvi Noor Aziz Department of Mathematics COMSATS University IslamabadLahore CampusPakistan Mathematics Department Faculty of ScienceTaibah UniversityAl-Madinah Al-Munawarah41411Saudi Arabia

In this article,we explore the famous Selkov–Schnakenberg(SS)system of coupled nonlinear partial differential equations(PDEs)for Lie symmetry analysis,self-adjointness,and conservation ***,miscellaneous soliton solutions like dark,bright,periodic,rational,Jacobian elliptic function,Weierstrass elliptic function,and hyperbolic solutions of the SS system will be achieved by a well-known technique called sub-ordinary differential *** these results are displayed graphically by 3D,2D,and contour plots.

关键词： Selkov-Schnakenberg system Lie symmetry analysis conservation laws adjointness integrability

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Climate Change Perceptions , Impacts and Adaptation Strategies of F arm Households in Potohar Region of Punjab, Pakistan

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Journal of Energy and Power Engineering 2023年第4期17卷 136-151页

作者： Sohaib Aqib syed mohsin ali kazmi Muhammad Amjad Ahmed ali Soomro Ghulam Farooque Khoso Department of Economics Faculty of Economics and Administrative ScienceNear East UniversityNicosia 99138North Cyprus Data Scientist Knowledge CorporationBusiness Center No 310Al Hilal Bank Buildingm AI Tawar AreaAl Qusais 2DubaiUAE Senior Scientific Officer-Global Climate-Change Impact Studies Centre Ministry of Climate ChangeIslamabad 44000Pakistan Depa rtment of Business Administration University of SindhJamshoroSindh 76060Pakistan Department of English Literature and Linguistics University of SindhJamshoroSindh 76060Pakistan

Climate change has become a global phenomenon and is adversely affecting agricultural development across the *** countries like Pakistan where 18.9%of the GDP(gross domestic product)came from the agriculture sector and also 42%of the labor force involved in *** are directly and indirectly affected by climate change due to an increase in the frequency and intensity of climatic extreme events such as floods,droughts and extreme weather *** this paper,we have focused on the impact of climate change on farm households and their adaptation strategies to cope up the climatic *** this purpose,we have selected farm households by using multistage stratified random sampling from four districts of the Potohar region ***,Rawalpindi,Jhelum and *** districts were selected by dividing the Potohar region into rain-fed *** have employed logistic regression to assess the determinants of adaptation to climate change and its *** have also calculated the marginal effect of each independent variable of the logistic regression to measure the immediate rate of change in the *** order to check the significance of our suggested model,we have used hypothesis testing.

关键词： Climate change multistage stratified random sampling impacts adaptation strategies logistic regression marginal effect Hypothesis testing

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Mechanical performance of cold mix asphalt containing cup lump rubber as a sustainable bio-modifier

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 424-440页

作者： syed Abdul Ghafar Muhammad Naqiuddin Mohd Warid Norhidayah Abdul Hassan Zulfiqar ali Jattak Ashraf Abdalla Mohammed Radwan Faculty of Civil Engineering Universiti Teknologi MalaysiaSkudai 81310Malaysia Department of Civil Engineering Balochistan University of Information TechnologyEngineering&Management SciencesQuettaPakistan Department of Civil Engineering Balochistan University of Engineering and TechnologyKhuzdarPakistan Department of Civil Engineering Faculty of EngineeringUniversity of TripoliTripoliLibya

The road construction industry aims to contribute to the protection of already compromised *** mix asphalt(CMA)is a measure initiated by the road industry to protect the environment and preserve *** having additional benefits,CMA has attracted little attention due to its inferior ***'s performance is enhanced using a sustainable binder bio-modifier,natural cup lump rubber(CLR)is one of *** study evaluated the tensile properties,rutting,moisture susceptibility,and adhesion properties of CLR-modified CMA(CMA-CR).The tensile property was enhanced by 26%due to CLR ***-CR had excellent rutting resistance of less than 2 mm rut depth at 10,000 load cycles,showing 70%improvement compared with conventional *** susceptibility evaluation indicated that CMA-CR had tensile strength ratio(TSR)value of 104%,satisfying the minimum 80%requirement of AASHTO *** also retained more than 96%bitumen *** moisture damage resistance was improved by 12%and 10%in terms of TSR and stripping,*** durability results revealed that the CMA-CR mixture prevented higher mass loss,representing 14%improvement compared with conventional CMA.

关键词： Cup lump rubber Cup lump modified cold mix asphalt Moisture damage Tensile property Rutting Digital imaging

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Classification and Comprehension of Software Requirements Using Ensemble Learning

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Computers, Materials & Continua 2024年第8期80卷 2839-2855页

作者： Jalil Abbas Arshad Ahmad syed Muqsit Shaheed Rubia Fatima Sajid Shah Mohammad Elaffendi Gauhar ali School of Computer Science and Technology Anhui UniversityHefei230039China School of Computing Sciences Pak Austria FachhochschuleInstitute of Applied Sciences and TechnologyHaripur22620Pakistan Department of Computer Science and IT University of LahoreLahore55150Pakistan Department of Computer Science Emerson UniversityPunjabMultan60000Pakistan EIAS(Emerging Intelligent Autonomous Systems)Data Science Lab Prince Sultan UniversityRiyad12435Saudi Arabia

The software development process mostly depends on accurately identifying both essential and optional ***,user needs are typically expressed in free-form language,requiring significant time and human resources to translate these into clear functional and non-functional *** address this challenge,various machine learning(ML)methods have been explored to automate the understanding of these requirements,aiming to reduce time and human ***,existing techniques often struggle with complex instructions and large-scale *** our study,we introduce an innovative approach known as the Functional and Non-functional Requirements Classifier(FNRC).By combining the traditional random forest algorithm with the Accuracy Sliding Window(ASW)technique,we develop optimal sub-ensembles that surpass the initial classifier’s accuracy while using fewer *** results demonstrate that our FNRC methodology performs robustly across different datasets,achieving a balanced Precision of 75%on the PROMISE dataset and an impressive Recall of 85%on the CCHIT *** datasets consistently maintain an F-measure around 64%,highlighting FNRC’s ability to effectively balance precision and recall in diverse *** findings contribute to more accurate and efficient software development processes,increasing the probability of achieving successful project outcomes.

关键词： Ensemble learning machine learning non-functional requirements requirement engineering accuracy sliding window

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An Implementation of Multiscale Line Detection and Mathematical Morphology for Efficient and Precise Blood Vessel Segmentation in Fundus Images

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Computers, Materials & Continua 2024年第5期79卷 2565-2583页

作者： syed Ayaz ali Shah Aamir Shahzad Musaed Alhussein Chuan Meng Goh Khursheed Aurangzeb Tong Boon Tang Muhammad Awais Department of Electrical and Computer Engineering COMSATS University IslamabadAbbottabad CampusAbbottabad22060Pakistan Department of Computer Engineering College of Computer and Information SciencesKing Saud UniversityP.O.Box 51178Riyadh11543Saudi Arabia Faculty of Information and Communication Technology University Tunku Abdul RehmanKampar CampusKampar31900Malaysia Centre for Intelligent Signal and Imaging Research University Teknologi PETRONASBandar Seri IskandarPerak32610Malaysia School of Computing Sciences University of East AngliaNorwichNR47TJUK

Diagnosing various diseases such as glaucoma,age-related macular degeneration,cardiovascular conditions,and diabetic retinopathy involves segmenting retinal blood *** task is particularly challenging when dealing with color fundus images due to issues like non-uniformillumination,low contrast,and variations in vessel appearance,especially in the presence of different ***,the speed of the retinal vessel segmentation system is of utmost *** the surge of now available big data,the speed of the algorithm becomes increasingly important,carrying almost equivalent weightage to the accuracy of the *** address these challenges,we present a novel approach for retinal vessel segmentation,leveraging efficient and robust techniques based on multiscale line detection and mathematical *** algorithm’s performance is evaluated on two publicly available datasets,namely the Digital Retinal Images for Vessel Extraction dataset(DRIVE)and the Structure Analysis of Retina(STARE)*** experimental results demonstrate the effectiveness of our method,withmean accuracy values of 0.9467 forDRIVE and 0.9535 for STARE datasets,aswell as sensitivity values of 0.6952 forDRIVE and 0.6809 for STARE ***,our algorithmexhibits competitive performance with state-of-the-art ***,it operates at an average speed of 3.73 s per image for DRIVE and 3.75 s for STARE *** is worth noting that these results were achieved using Matlab scripts containing multiple *** suggests that the processing time can be further reduced by replacing loops with *** the proposed algorithm can be deployed in real time *** summary,our proposed system strikes a fine balance between swift computation and accuracy that is on par with the best available methods in the field.

关键词： Line detector vessel detection localization mathematical morphology image processing

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新型PCV2衣壳融合蛋白在HEK293F细胞瞬时表达研究

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华东理工大学学报（自然科学版） 2024年第1期50卷 62-70页

作者：罗清平彭妍 ali mohsin 庄英萍郭美锦华东理工大学生物反应器工程国家重点实验室上海200237 上海国佳生化工程技术研究中心有限公司上海200237

猪圆环病毒2型(Porcine Circovirus type 2,PCV2)衣壳(Capsid)蛋白是制备抗猪圆环2型病毒亚单位疫苗的有效免疫抗原,能在大肠杆菌及杆状病毒/昆虫细胞表达系统中获得表达,然而在哺乳细胞中的表达研究仍然缺乏。瞬时表达条件考察结果显示... 详细信息

猪圆环病毒2型(Porcine Circovirus type 2,PCV2)衣壳(Capsid)蛋白是制备抗猪圆环2型病毒亚单位疫苗的有效免疫抗原,能在大肠杆菌及杆状病毒/昆虫细胞表达系统中获得表达,然而在哺乳细胞中的表达研究仍然缺乏。瞬时表达条件考察结果显示,采用宿主HEK293F细胞及PEI-40kDa转染试剂能获得35%病毒PCV2 Capsid基因细胞转染效率。转染试剂PEI(Polyethylenimine)与DNA比例差异会影响复合物形成大小及形态,复合物形成15~80 nm颗粒有利于转染效率的提高。实验以免疫逃逸型猪圆环病毒2b型NDSU41513病毒株,设计了新型PCV2 Capsid (△1-41aa)-Fc(pig) protein(PCFP)分子。在3 L反应器中成功实现了HEK293F细胞瞬时表达PCFP,表达水平达到3.8 mg/L。PCFP蛋白能够自主装形成约为41 nm类病毒颗粒,诱导小鼠机体内产生强烈的体液免疫反应,具有很高的应用潜力。

关键词：猪圆环病毒2型瞬时表达 HEK293F 类病毒颗粒疫苗

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Smart Breeding Platform:A web-based tool for high-throughput population genetics,phenomics,and genomic selection

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Molecular Plant 2024年第5期17卷 677-681页

作者： Huihui Li Xin Li Peng Zhang Yingwei Feng Junri Mi Shang Gao Lele Sheng mohsin ali Zikun Yang Liang Li Wei Fang Wensheng Wang Qian Qian Fei Gu Wenbin Zhou State Key Laboratory of Crop Gene Resources and Breeding Institute of Crop SciencesChinese Academy of Agricultural Sciences(CAAS)Beijing 100081China Nanfan Research Institute CAASSanyaHainan 572024China DAMO Academy Alibaba GroupHangzhou 310023China Hupan Lab Hangzhou 310023China Yazhouwan National Laboratory No.8 Huanjin RoadYazhou DistrictSanya CityHainan Province 572024China State Key Laboratory of Rice Biology China National Rice Research InstituteHangzhouZhejiang 310006China

Dear Editor,In the era of big data and artificial intelligence,"smart breeding"has become a broad conceptual framework encompassing the paradigm shift of crop breeding to relying on analysis of high-throughput population genetics and phenomics data to conduct genomic selection,allowing identification and optimal use of the genetic potential in crop species(Xiao et al.,2022;Xu et al.,2022;Wang et al.,2023).Most existing tools for analyzing high-throughput breeding data require extensive computational power,complex installation processes,and command-line expertise and are therefore challenging and inconvenient for the majority of researchers and breeders(Brandies and Hogg,2021).

关键词： breeding artificial breed

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