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水稻临界氮浓度稀释模型及氮素营养诊断研究（摘要）

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中国稻米 2013年第4期19卷 149-149页

作者：刘小军 syed Tahir Ata-Ul-Karim 陆震洲曹卫星朱艳南京农业大学国家信息农业工程技术中心江苏省信息农业高技术研究重点实验室南京210095

开展水稻临界氮浓度稀释模型及营养诊断研究，可为明确水稻生长过程中氮素状况的变化规律，实现作物氮素状况的科学诊断和追肥调控，进而提高氮素利用效率、改善作物产量和品质提供理论依据和技术指导。本研究于2009—2011年在江苏省仪... 详细信息

开展水稻临界氮浓度稀释模型及营养诊断研究，可为明确水稻生长过程中氮素状况的变化规律，实现作物氮素状况的科学诊断和追肥调控，进而提高氮素利用效率、改善作物产量和品质提供理论依据和技术指导。本研究于2009—2011年在江苏省仪征市开展了3年的水稻小区试验，

关键词：氮素营养诊断临界氮浓度水稻模型稀释摘要氮素利用效率氮素状况

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眼睑斑痣性迷芽瘤1例

世界核心医学期刊文摘（皮肤病学分册） 2005年第1期1卷 43-43页

作者： Szyfelbein K. Kozakewicz H.P.W. syed N.A. Zembowicz A. 张宪旗 Dermatopathology Unit Massachusetts General Hospital 820 Warren Bldg. 55 F ruit Street Boston MA 02114 United States Dr.

Phakomatous choristoma is a rare congenital hamartoma of lens *** prese nts in newborns or young infants as a subcutaneous mass in the medial lower eyel *** present a case of phakomatous choristoma recently identified among old co nsultation files at Childrens Hospital in *** case illustrates unique histological features of this entity which has to be included in differential di agnosis of skin lesions of the inferonasal eyelid.

关键词：斑痣迷芽瘤错构瘤皮下肿块儿童医院鉴别诊断文章报道特异性

应用国立眼科研究所的25项目视觉功能问卷调查视网膜中央静脉阻塞患者与视觉相关的生活质量

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美国医学会眼科杂志（中文版） 2004年第2期16卷 128-128页

作者： VincentA.Deramo TerryA.Cox ArjumandB.syed PaulP.Lee SharonFekrat 李爱军

Immunohistochemical Expression of Biomarkers and Human Papilloma Virus Infection in Esophageal Squamous Cell Carcinoma Patients of Pakistan-HPV and Biomarkers in ESCC

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国际感染病学（电子版） 2019年第1期8卷 1-7页

作者： S.M.Adnan Ali Yumna Mirza M.Ozair Awan K.M.Inam Pal Zubair Ahmad Office of Academia and Research in Surgery Department of SurgeryAga Khan University Hospital Medical College Aga Khan University Hospital Section of General Surgery Department of SurgeryAga Khan University Hospital Section of Histopathology Department of Pathology and Laboratory MedicinesAga Khan University Hospital

Objective To determine HPV infection status and expression of p16, cyclooxygenase-2(COX-2), Cyclin D1 and epidermal growth factor receptor(EGFR) in ESCC patients of Pakistan. Methods 51 ESCC patients treated at Aga Khan University Hospital(AKUH) were included. HPV infection status was confirmed via PCR while the expression of the four biomarkers was determined using immunohistochemistry. The correlation of all markers with patient clinicopathological features as well as each other was analyzed. Results HPV infection status and p16 overexpression was found to be negative in all the patients while COX-2, Cyclin D1 and EGFR were overexpressed in 56.9%, 62.7% and 49.0% of the patients respectively. COX-2 showed a significant correlation with tumor invasion while EGFR was shown to be significantly correlated with histological grading and COX-2 expression. Conclusion COX-2 and EGFR can be used as prognostic markers. HPV does not seem to be a causative agent for ESCC in Pakistan.

关键词： COX-2 Cyclin D1 EGFR ESCC HPV

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巴基斯坦原发性耐多药结核病流行情况

国际结核病与肺部疾病杂志 2008年第2期3卷 73-77页

作者： A.Javaid R.Hasan A.Zafar A.Ghafoor A.J.Pathan A.Rab A.Sadiq C.M.Akram I.Burki K.Shah M.Ansari N.Rizvi S.U.Khan S.R.Awan Z.A.syed Z.H.lqbal Z.Shaheen N.ur Rehman 邢超 Department of Pulmonology Postgraduate Medical InstituteLady Reading Hospital Peshawar Department of Microbiology Agha Khan University HospitalKarachi TB Control Programme North West Frontier Province(NWFP)Peshawar Institute of Chest Diseases Kotri Department of Pulmonology Ayub Teaching HospitalAbbotabad Oiha Institute of Chest Diseases Karachi Gulab Devi Hospital Lahore Lyari General Hospital Karachi National TB Control Programme Islamabad Liaqat National Hospital Karachi Jinnah Postgraduate Medical Centre Karachi King Edwards Medical University Lahore Nishtar Medical College Multan Allama Iqbal Medical Lahore Wyeth(Pvt) Limited KarachiPakistan

背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(MDR-TB)问题已十分严重,急需在社区水平对耐多药... 详细信息

背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(MDR-TB)问题已十分严重,急需在社区水平对耐多药结核病的严重程度开展评估。本研究为针对巴基斯坦耐药结核病流行状况开展的横段面研究,所使用的痰标本来自于巴基斯坦全国742例未经治疗的新诊断的肺结核患者。目的:评估巴基斯坦原发性耐药的流行情况结果:在672例痰培养阳性患者中,有76例(11.3%)出现了对1种或多种抗结核药物耐药。36例(5.4%)患者对链霉素(10μg/ml)耐药; 51例(7.6%)患者对异烟肼(1μg/ml)耐药;15例(2.2%)患者对利福平(5μg/ml)耐药;12例(1.8%)患者对乙胺丁醇(10μg/ml)耐药;22例(3.3%)患者对吡嗪酰胺耐药。有46例(6.8%)患者痰标本中分离的结核菌株耐1种抗结核药物, 10例(1.5%)同时耐2种抗结核药物,12例(1.8%)同时耐3种抗结核药物,6例(0.9%)同时耐4种抗结核药物,2例(0.3%)同时耐全部5种抗结核一线药。原发性耐多药率为1.8%,(n= 12)(异烟肼1μg/ml,利福平5μg/ml)。结论:研究结果表明,巴基斯坦原发性耐多药率<2%,需要进一步实施有效的DOTS策略。

关键词：原发性耐药耐多药结核病巴基斯坦

Association of latitude and altitude with adverse outcomes in patients with COVID-19: The VIRUS registry

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World Journal of Critical Care Medicine 2022年第2期11卷 102-111页

作者： Aysun Tekin Shahraz Qamar Romil Singh Vikas Bansal Mayank Sharma Allison M LeMahieu Andrew C Hanson Phillip J Schulte Marija Bogojevic Neha Deo Simon Zec Diana J Valencia Morales Katherine A Belden Smith F Heavner Margit Kaufman Sreekanth Cheruku Valerie C Danesh Valerie M Banner-Goodspeed Catherine A St Hill Amy B Christie syed A Khan Lynn Retford Karen Boman Vishakha KKumar John C O'Horo Juan Pablo Domecq Allan J Walkey Ognjen Gajic Rahul Kashyap Salim Surani TheSociety of Critical Care Medicine(SCCM)Discovery Viral Infection and Respiratory Illness Universal Study(VIRUS):COVID-Registry Investigator Group Department of Anesthesiology Mayo ClinicRochesterMN 55905United States Post-baccalaureate Research Education Program Mayo Clinic College of Medicine and ScienceRochesterMN 55905United States Division of Pulmonary and Critical Care Medicine Department of Internal MedicineMayo ClinicRochesterMN 55905United States Division of Clinical Trials and Biostatistics Department of Quantitative Health SciencesMayo ClinicRochesterMN 55905United States Alix School of Medicine Mayo ClinicRochesterMN 55905United States Division of Infectious Diseases Thomas Jefferson University HospitalPhiladelphiaPA 19107United States Prisma Health GreenvilleSC 29605United States Englewood Health EnglewoodNJ 07631United States Divisions of Cardiothoracic Anesthesiology and Critical Care Medicine Department of Anesthesiology and Pain ManagementUT Southwestern Medical CenterDallasTX 75390United States Center for Applied Health Research Baylor Scott and White HealthDallasTX 75246United States Department of Anesthesiology Critical Care and Pain MedicineBeth Israel Deaconess Medical CenterBostonMA 02215United States Allina Health MinneapolisMN 55407United States Department of Critical Care Atrium Health NavicentMaconGA 31201United States Division of Critical Care Medicine Mayo Clinic Health SystemMankatoMN 56001United States Society of Critical Care Medicine Mount ProspectIL 60056United States Division of Infectious Diseases Mayo ClinicRochesterMN 55905United States Division of Nephrology and Hypertension Department of Internal MedicineMayo ClinicRochesterMN 55905United States Pulmonary Center Division of PulmonaryAllergyCritical Care and Sleep MedicineDepartment of MedicineEvans Center of Implementation and Improvement SciencesBoston University School of MedicineBostonMA 02118United States Department of Pulmonary and Critical Care Medicine Texas A&M UniversityBryanTX 77807United States 不详

BACKGROUND The coronavirus disease 2019(COVID-19)course may be affected by environmental *** studies previously suggested a link between climatological factors and COVID-19 fatality ***,individual-level impact of these factors has not been thoroughly evaluated *** To study the association of climatological factors related to patient location with unfavorable outcomes in *** In this observational analysis of the Society of Critical Care Medicine Discovery Viral Infection and Respiratory Illness Universal Study:COVID-19 Registry cohort,the latitudes and altitudes of hospitals were examined as a covariate for mortality within 28 d of admission and the length of hospital *** for baseline parameters and admission date,multivariable regression modeling was *** estimating equations were used to fit the *** Twenty-two thousand one hundred eight patients from over 20 countries were *** median age was 62(interquartile range:49-74)years,and 54%of the included patients were *** median age increased with increasing latitude as well as the frequency of ***,the percentage of comorbidities was lower in elevated *** within 28 d of hospital admission was found to be 25%.The median hospital-free days among all included patients was 20 *** the significant linear relationship between mortality and hospital-free days(adjusted odds ratio(aOR)=1.39(1.04,1.86),P=0.025 for mortality within 28 d of admission;aOR=-1.47(-2.60,-0.33),P=0.011 for hospital-free days),suggesting that adverse patient outcomes were more common in locations further away from the Equator;the results were no longer significant when adjusted for baseline differences(aOR=1.32(1.00,1.74),P=0.051 for 28-day mortality;aOR=-1.07(-2.13,-0.01),P=0.050 for hospital-free days).When we looked at the altitude’s effect,we discovered that it demonstrated a non-linear association with mortality wi

关键词： 28 d mortality Altitude COVID-19 Hospital-free days Latitude Outcomes

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《回眸》

山东工艺美术学院学报 2018年第6期 38-38页

作者：塞德·贾维尔·A卡济

射频消融术代替手术在治疗无法切除的老年乳腺癌病人的初步研究及长期结果

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国际医学放射学杂志 2012年第5期 491-491页

作者： J.Palussière C.Henriques L.Mauriac M.Asad-syed F.Valentin V.Brouste 袁磊 Department of Interventional Radiology Institut Bergonié229 cours de l'Argonne33076 BordeauxFrance

摘要目的评价超声(ultrasonography,US)引导下经皮射频(radiofrequency,RF)消融联合内分泌治疗在拒绝手术或身体状况较差而不能手术的老年乳腺癌病人的疗效及耐受度。材料与方法本研究经伦理委员会批准,并签署知情同意书。过去6个月接... 详细信息

摘要目的评价超声(ultrasonography,US)引导下经皮射频(radiofrequency,RF)消融联合内分泌治疗在拒绝手术或身体状况较差而不能手术的老年乳腺癌病人的疗效及耐受度。材料与方法本研究经伦理委员会批准,并签署知情同意书。过去6个月接受了内分泌治疗的大于70岁女性乳腺癌病人,在局麻下行US引导下的RF消融手术。纳入标准为肿瘤直径≤3cm且位于距离皮肤、乳头与胸壁至少1cm的部位。采用多极电极。内分泌治疗持续5年而未行乳腺照射治疗。

关键词：乳腺癌乳腺肿瘤内分泌治疗射频消融术病人手术老年

DPHL:A DIA Pan-human Protein Mass Spectrometry Library for Robust Biomarker Discovery

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Genomics, Proteomics & Bioinformatics 2020年第2期18卷 104-119页

作者： Tiansheng Zhu Yi Zhu Yue Xuan Huanhuan Gao Xue Cai Sander R.Piersma Thang V.Pham Tim Schelfhorst Richard R.G.D.Haas Irene V.Bijnsdorp Rui Sun Liang Yue Guan Ruan Qiushi Zhang Mo Hu Yue Zhou Winan J.Van Houdt Tessa Y.S.Le Large Jacqueline Cloos Anna Wojtuszkiewicz Danijela Koppers-Lalic Franziska Bottger Chantal Scheepbouwer Ruud H.Brakenhoff Geert J.L.H.van Leenders Jan N.M.Ijzermans John W.M.Martens Renske D.M.Steenbergen Nicole C.Grieken Sathiyamoorthy Selvarajan Sangeeta Mantoo Sze S.Lee Serene J.Y.Yeow syed M.F.Alkaff Nan Xiang Yaoting Sun Xiao Yi Shaozheng Dai Wei Liu Tian Lu Zhicheng Wu Xiao Liang Man Wang Yingkuan Shao Xi Zheng Kailun Xu Qin Yang Yifan Meng Cong Lu Jiang Zhu Jin'e Zheng Bo Wang Sai Lou Yibei Dai Chao Xu Chenhuan Yu Huazhong Ying Tony K.Lim Jianmin Wu Xiaofei Gao Zhongzhi Luan Xiaodong Teng Peng Wu Shi'ang Huang Zhihua Tao Narayanan G.Iyer Shuigeng Zhou Wenguang Shao Henry Lam Ding Ma Jiafu Ji Oi L.Kon Shu Zheng Ruedi Aebersold Connie R.Jimenez Tiannan Guo Zhejiang Provincial Laboratory of Life Sciences and Biomedicine Westlake UniversityHangzhou 310024China Key Laboratory of Structural Biology of Zhejiang Province School of Life SciencesWestlake UniversityHangzhou 310024China Institute of Basic Medical Sciences Westlake Institute for Advanced StudyHangzhou 310024China School of Computer Science Shanghai Key Laboratory of Intelligent Information ProcessingFudan UniversityShanghai 200433China Thermo Fisher Scientific(BREMEN)GmbH Bremen 28195Germany OncoProteomics Laboratory Department of Medical OncologyVU University Medical CenterVU UniversityAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamUrologyCancer Center AmsterdamAmsterdam 1011The Netherlands Thermo Fisher Scientific Shanghai 201206China The Netherlands Cancer Institute Surgical OncologyAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamSurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPediatric Oncology/HematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamHematologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamMedical OncologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamNeurosurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamPathologyCancer Center AmsterdamAmsterdam 1011The Netherlands Amsterdam UMC Vrije Universiteit AmsterdamOtolaryngology/Head and Neck SurgeryCancer Center AmsterdamAmsterdam 1011The Netherlands Erasmus MC University Medical Center PathologyRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center SurgeryRotterdam 1016LVThe Netherlands Erasmus MC University Medical Center Medical OncologyRotterdam 1016LVThe Netherlands Department of Anatomical Pathology Singapore General HospitalSingapore 169608Singapore Division of Medical Scie

To address the increasing need for detecting and validating protein biomarkers in clinical specimens,mass spectrometry(MS)-based targeted proteomic techniques,including the selected reaction monitoring(SRM),parallel reaction monitoring(PRM),and massively parallel dataindependent acquisition(DIA),have been *** optimal performance,they require the fragment ion spectra of targeted peptides as prior *** this report,we describe a MS pipeline and spectral resource to support targeted proteomics studies for human tissue *** build the spectral resource,we integrated common open-source MS computational tools to assemble a freely accessible computational workflow based on *** then applied the workflow to generate DPHL,a comprehensive DIA pan-human library,from 1096 data-dependent acquisition(DDA)MS raw files for 16 types of cancer *** extensive spectral resource was then applied to a proteomic study of 17 prostate cancer(PCa)***,PRM validation was applied to a larger study of 57 PCa patients and the differential expression of three proteins in prostate tumor was *** a second application,the DPHL spectral resource was applied to a study consisting of plasma samples from 19 diffuse large B cell lymphoma(DLBCL)patients and 18 healthy control *** expressed proteins between DLBCL patients and healthy control subjects were detected by DIA-MS and confirmed by *** data demonstrate that the DPHL supports DIA and PRM MS pipelines for robust protein biomarker *** is freely accessible at https://***/page/***?id=IPX0001400000.

关键词： Data-independent acquisition Parallel reaction monitoring Spectral library Prostate cancer Diffuse large B cell lymphoma