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Decoding molecular mechanisms:brain aging and Alzheimer's disease

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Neural Regeneration Research 2025年第8期20卷 2279-2299页

作者： Mahnoor Hayat Rafay Ali syed Hammad Qaiser Mohammad Uzair Khalid Al-Regaiey Roaa Khallaf Lubna Abdullah Mohammed Albassam Imdad Kaleem Xueyi Wang Ran Wang Mehwish SBhatti Shahid Bashir Atta-ur-Rahman School of Applied Biosciences(ASAB) National University of Sciences and Technology(NUST)IslamabadPakistan Department of Biotechnology Quaid-i-Azam UniversityIslamabadPakistan Department of Biological Sciences Faculty of Basic&Applied SciencesInternational Islamic University Islamabad(IIUI)IslamabadPakistan Department of Bioengineering King Fahd University of Petroleum and MineralsDhahranSaudi Arabia Department of Physiology College of MedicineKing Saud UniversityRiyadhSaudi Arabia Department of Neurology Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Mental Health Neuroscience CenterKing Fahad Specialist HospitalDammamSaudi Arabia Department of Biosciences Commission on Science and Technology for Sustainable Development in the South(COMSATS University)IslamabadPakistan Department of Psychiatry The First Hospital of Hebei Medical UniversityShijiazhuangHebei ProvinceChina Mental Health Institute of Hebei Medical University ShijiazhuangHebei ProvinceChina Department of Neurobiology and Behavior University of CaliforniaIrvineCAUSA Neuroscience Center King Fahad Specialist Hospital DammamDammamSaudi Arabia

The complex morphological,anatomical,physiological,and chemical mechanisms within the aging brain have been the hot topic of research for *** aging process alters the brain structure that affects functions and cognitions,but the worsening of such processes contributes to the pathogenesis of neurodegenerative disorders,such as Alzheimer's *** these observable,mild morphological shifts,significant functional modifications in neurotransmission and neuronal activity critically influence the aging *** these changes is important for maintaining cognitive health,especially given the increasing prevalence of age-related conditions that affect *** review aims to explore the age-induced changes in brain plasticity and molecular processes,differentiating normal aging from the pathogenesis of Alzheimer's disease,thereby providing insights into predicting the risk of dementia,particularly Alzheimer's disease.

关键词： Alzheimer’s disease brain aging cognitive health dementia molecular mechanisms neuronal activity neuroplasticity neurotransmission

Cardiac amyloidosis: state-of-the-art review

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Journal of Geriatric Cardiology 2023年第5期20卷 361-375页

作者： syed Bukhari Department of Medicine Temple University HospitalPhiladelphiaPAUSA

Cardiac amyloidosis(CA)is caused by deposition of amyloid fibrils in the myocardium and has two main sub-types,transthyretin cardiac amyloidosis(ATTR)and immunoglobulin light chain cardiac amyloidosis(AL).ATTR is further dif-ferentiated into wild-type(wtATTR)and hereditary(hATTR),depending on the absence or presence of mutation in the trans-thyretin *** increased recognition of disease with the improvement in diagnostic armamentarium and serendipitous ad-vancements in the therapeutic landscape have changed the status of CA from being a rare and untreatable disease to being a not-so-rare and treatable *** ATTR and AL have certain clinical aspects that can provide early clues for the *** electrocardiography followed by echocardiography and subsequently cardiac magnetic resonance can raise suspicion for CA,the definitive diagnosis of ATTR is non-invasively established by bone scintigraphy while that of AL always needs histological *** of CA can be gauged by serum biomarker-based staging of both ATTR and *** therapies work by silen-cing or stabilizing TTR or by degrading amyloid fibrils,while AL is managed with anti-plasma cell therapies and autologous stem cell transplant.

关键词： amyloid Cardiac diagnosis

Survey and technological analysis of laser and its defense applications

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Defence Technology（防务技术） 2021年第2期17卷 583-592页

作者： syed Affan Ahmed Mujahid Mohsin syed Muhammad Zubair Ali Department of Avionics Engineering-College of Aeronautical Engineering(CAE) National University of Sciences and Technology(NUST)RisalpurKPKPakistan

The laser technology has made remarkable progress over the past couple of *** is being widely employed in diverse domains,such as holography,space sciences,spectroscopy,medical sciences,micro and power electronics,industrial engineering,and most distinctively,as directed energy military *** to their active transmissions,laser systems are similar to microwave radars to some extent;however,unlike conventional radars,the laser operates at very high frequencies thus making it a potent enabler of narrow-beam and high energy aerial deployments,both in offensive and defensive *** modern avionics systems,laser target indicators and beam riders are the most common devices that are used to direct the Laser Guided Weapons(LGW)accurately to the ground ***,compact size and outstanding angular resolution of laser-based systems motivate their use for drones and unmanned aerial ***,the narrow-beam divergence of laser emissions offers a low probability of intercept,making it a suitable contender for secure transmissions and safety-critical ***,the developments in space sciences and laser technology have given synergistic potential outcomes to use laser systems in space *** paper comprehensively reviews laser applications and projects for strategic defense actions on the ground or in ***,a detailed analysis has been done on recent advancements of the laser technology for target indicators and *** also reviews the advancements in the field of laser communications for surveillance,its earlier state of the art,and ongoing scientific research and advancements in the domain of high energy directed laser weapons that have revolutionized the evolving military *** offering a comprehensive taxonomy,the paper also critically analyzes some of the recent contributions in the associated domains.

关键词： Laser systems Laser military applications Directed energy weapons Non-lethal weapons Laser military projects Survey Taxonomy

Slender reinforced concrete shear walls with high-strength concrete boundary elements

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Frontiers of Structural and Civil Engineering 2023年第1期17卷 138-151页

作者： Mohammad syed Pinar OKUMUS Department of Civil Structural and Environmental EngineeringUniversity at BuffaloBuffaloNY 14260USA

Reinforced concrete structural walls are commonly used for resisting lateral forces in buildings. Owing to the advancements in the field of concrete materials over the past few decades, concrete mixes of high compressive strength, commonly referred to as high-strength concrete (HSC), have been developed. In this study, the effects of strategic placement of HSC on the performance of slender walls were examined. The finite-element model of a conventional normal-strength concrete (NSC) prototype wall was validated using test data available in extant studies. HSC was incorporated in the boundary elements of the wall to compare its performance with that of the conventional wall at different axial loads. Potential reductions in the reinforcement area and size of the boundary elements were investigated. The HSC wall exhibited improved strength and stiffness, and thereby, allowed reduction in the longitudinal reinforcement area and size of the boundary elements for the same strength of the conventional wall. Cold joints resulting from dissimilar concrete pours in the web and boundary elements of the HSC wall were modeled and their impact on behavior of the wall was examined.

关键词： slender walls high-strength concrete rectangular and barbell-shaped walls cold joints

Robust stability analysis of Takagi-Sugeno uncertain stochastic fuzzy recurrent neural networks with mixed time-varying delays

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Chinese Physics B 2011年第8期20卷 1-15页

作者： M.syed Ali Department of Mathematics Thiruvalluvar UniversityVellore-632 106TamilnaduIndia

In this paper, the global stability of Takagi-Sugeno （TS） uncertain stochastic fuzzy recurrent neural networks with discrete and distributed time-varying delays （TSUSFRNNs） is considered. A novel LMI-based stability criterion is obtained by using Lyapunov functional theory to guarantee the asymptotic stability of TSUSFRNNs. The proposed stability conditions are demonstrated through numerical examples. Furthermore, the supplementary requirement that the time derivative of time-varying delays must be smaller than one is removed. Comparison results are demonstrated to show that the proposed method is more able to guarantee the widest stability region than the other methods available in the existing literature.

关键词： recurrent neural networks linear matrix inequality Lyapunov stability time-varyingdelays TS fuzzy model

Novel delay-dependent stability analysis of Takagi-Sugeno fuzzy uncertain neural networks with time varying delays

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Chinese Physics B 2012年第7期21卷 49-60页

作者： M. syed Ali Department of Mathematics Thiruvalluvar University

This paper presents the stability analysis for a class of neural networks with time varying delays that are represented by the Takagi^ugeno IT-S） model. The main results given here focus on the stability criteria using a new Lyapunov functional. New relaxed conditions and new linear matrix inequality-based designs are proposed that outperform the previous results found in the literature. Numerical examples are provided to show that the achieved conditions are less conservative than the existing ones in the literature.

关键词： neutral neural networks linear matrix inequality Lyapunov stability time varying delays

Stability analysis of Markovian jumping stochastic Cohen Grossberg neural networks with discrete and distributed time varying delays

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Chinese Physics B 2014年第6期23卷 131-137页

作者： M.syed Ali Department of Mathematics Thiruvalluvar University

In this paper, the global asymptotic stability problem of Markovian jumping stochastic Cohen-Grossberg neural networks with discrete and distributed time-varying delays （MJSCGNNs） is considered. A novel LMI-based stability criterion is obtained by constructing a new Lyapunov functional to guarantee the asymptotic stability of MJSCGNNs. Our results can be easily verified and they are also less restrictive than previously known criteria and can be applied to Cohen-Grossberg neural networks, recurrent neural networks, and cellular neural networks. Finally, the proposed stability conditions are demonstrated with numerical examples.

关键词： Cohen-Grossberg neural networks global asymptotic stability linear matrix inequality Lyapunovfunctional time-varying delays

Body Mass Index and Body Fat Percentage in Assessment of Obesity Prevalence in Saudi Adults

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Biomedical and Environmental Sciences 2013年第2期26卷 94-99页

作者： syed Shahid HABIB Department of Physiology College of Medicine&King Khalid University HospitalKing Saud University

Objective To assess the obesity prevalence in body mass index （BMI） and body fat percentage Saudi adults according to the international standards of （BF%）. Methods Five hundred and thirty healthy Saudi adults aged 18-72 years （mean 36.91＋15.22 years） were enrolled in this study. Their body composition was assessed by bioelectrical impendence analysis with a commercially available body composition analyzer. Standard BMI and BF% values were used to define obesity. Results The prevalence of underweight, normal underweight, overweight and obesity in Saudi adults according to the BMI criteria （〈18.5 kg/mz, 18.5-24.4 kg/m2, 25-29.9 kg/m2, 30 k＆/m2 and above, respectively） was 2.5%, 30.2%, 33.6%, and 33.8%, respectively, whereas the obesity prevalence was 60% （n=31g） in Saudi adults according to the BF% criteria （25% for males and 30% for females）, which was significantly higher than that according to BMI criteria. However, it was 50.6% （n=268） when the BMI cutoff point was 27.5 kg/m2, proposed by WHO for the Asian population. Kappa analysis showed that the obesity prevalence defined by BMI and BF% was higher in females than in males （k=0.530 vs k=0.418, P〈O.O001）. The sensitivity and specificity of BMI （30 kg/m2 and 27.5 kg/m2） were 54.1% and 96.7% and 76.4% and 88.2%, respectively, for obesity. A lower BMI cutoff point （26.60 kg/m2） was proposed in this study, which gave the maximum sensitivity （84.3%） and specificity （85.4%）, with a moderate kappa agreement （k=0.686）. Moreover, the obesity prevalence at this cutoff point （56.4%） was significantly higher than that recommended by WHO. Conclusion The specificity of BMI for obesity is high and its sensitivity is low in both sexes. Its sensitivity can be increased by changing BMI cutoff to a lower value. The choice of BF% reference is of great influence for the assessment of obesity prevalence according to the BMI.

关键词： Body composition Obesity Body mass index Body fat percentage Kappa analysis

COMPARISON OF TWO METHODS TO INCREASE TIP CLEARANCE AND ITS EFFECT ON PERFORMANCE OF TURBOCHARGER CENTRIFUGAL COMPRESSOR STAGE

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Chinese Journal of Mechanical Engineering 2007年第4期20卷 60-65页

作者： syed Noman Danish School of Mechanical and Vehicular Engineering Beijing Institute of TechnologyBeijing 100081China

Tip clearance between the blade tip and casing of a centrifugal compressor can be varied through two methods： by changing the blade height （MI） or by changing the casing diameter （M2）. Numerical simulations are carried out to compare these two methods and their effect on the stage and impeller performance. The impeller and diffuser are connected through rotor stator boundary using frozen rotor approach. Overall stage performance and the flow configuration have been investigated for nine tip clearance levels from no gap to 1 mm. Impeller and diffuser performances are also presented separately. It has been found that the overall and impeller performance are comparatively better for MI below tip clearance of 0.5 mm whereas M2 is found advantageous above 0.5 mm of tip clearance. Both MI and M2 show performance degradation with the increase in tip clearance. Two models have been proposed for the stage total pressure ratio and efficiency, which are found to be in agreement with experimental results. The impeller efficiency and the pressure ratio are found to be maximum at tip clearance of 0.1 mm for both the cases however minimum diffuser effectiveness is also observed at the same clearance level. Diffuser effectiveness is found to be maximum at zero gap for both cases. As it is practically impossible to have zero gap for unshrouded impellers so it is concluded that the optimum thickness is 0.5 mm onwards for MI and 0.5 mm for M2 in terms of diffuser effectiveness. Mass averaged flow parameters, entropy, blade loading diagram and relative pressure fields are presented, showing the loss production within the impeller passage with tip clearance.

关键词： Centrifugal impeller Diffuser Stage Tip clearance Numerical simulation Entropy