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Gastric precancerous lesions are associated with gene variants in Helicobacter pylori -susceptible ethnic Malays

World Journal of Gastroenterology 2013年第23期19卷 3615-3622页

作者： Sathiya Maran Yeong Yeh Lee Shuhua Xu Nur-Shafawati Rajab Norhazrini Hasan syed hassan syed abdul aziz Noorizan abdul Majid Bin Alwi Zilfalil Human Genome Center School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Medicine School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Max Planck Independent Research Group on Population Genomics Chinese Academy of Sciences and Max Planck Society Partner Institute for Computational Biology Shanghai Institutes for Biological Sciences Chinese Academy of Sciences200031 Shanghai China Department of Immunology School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Surgery School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia Department of Paediatrics School of Medical Sciences Universiti Sains Malaysia16150 Kubang Kerian Malaysia

AIM: To identify genes associated with gastric pre-cancerous lesions in Helicobacter pylori (H. pylori )susceptible ethnic Malays. METHODS: Twenty-three Malay subjects with H. pylori infection and gastric precancerous lesions identified during endoscopy were included as "cases". Thirtyseven Malay subjects who were H. pylori negative and had no precancerous lesions were included as "controls". Venous blood was collected for genotyping with Affymetrix 50K Xba1 kit. Genotypes with call rates 0.5 was considered as significant markers. RESULTS: Of the 23 H. pylori -positive subjects recruited, one sample was excluded from further analysis due to a low genotyping call rate. Of the 22 H. pylori positive samples, atrophic gastritis only was present in 50.0%, complete intestinal metaplasia was present in 18.25%, both incomplete intestinal metaplasia and dysplasia was present in 22.7%, and dysplasia only was present in 9.1%. SNPs rs9315542 (UFM1 gene), rs6878265 (THBS4 gene), rs1042194 (CYP2C19 gene) and rs10505799 (MGST1 gene) were significantly associated with atrophic gastritis, complete intestinal metaplasia, incomplete metaplasia with foci of dysplasia and dysplasia, respectively. Allele frequencies in "cases" vs "controls" for rs9315542, rs6878265, rs1042194 and rs10505799 were 0.4 vs 0.06, 0.6 vs 0.01, 0.6 vs 0.01 and 0.5 vs 0.02, respectively. CONCLUSION: Genetic variants possibly related to gastric precancerous lesions in ethnic Malays susceptible to H. pylori infection were identified for testing in subsequent trials.

关键词： Gastric precancerous lesions Gene polymorphisms Genome-wide association Helicobacter pylori Malays

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Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies tofightthe infection

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Bio-Design and Manufacturing 2021年第3期4卷 490-505页

作者： Zainularifeen abduljaleel Faisal A.Al-Allaf syed A.aziz Department of Medical Genetics Faculty of MedicineUmm Al-Qura UniversityP.O.Box715Mecca21955Kingdom of Saudi Arabia Science and Technology Unit UmmAl-Qura UniversityP.O.Box 715Mecca21955Kingdom of SaudiArabia The Regional Laboratory Molecular Diagnostics UnitDepartment of Molecular BiologyMinistry of Health(MOH)P.O.Box 6251MeccaKingdom of SaudiArabia Department of Pathology and Lab Medicine University of Ottawa451Smyth RoadOttawaONK1H8M5Canada

The World Health Organization has declared the rapidly spreading coronavirus to be a global *** FDA is yet to approve a vaccine for human novel ***,we developed a peptide-based vaccine and used high-throughput screening by molecular dynamics simulation to identify T-cell-and p-cell-recognized epitopes for producing specific antibod-ies against *** construct~12 P'antigenic epitope peptides to develop a more effective vaccine and identify specific *** epitope peptides selectively presented the best antigen presentation scores for both human pMHC class I and II alleles to develop a strong binding *** antigens identified of SARS-nCoV-2 different proteins by each attached specific~1-7 L linker adaptor were used to construct a broad single peripheral peptide *** is expected to be highly antigenic with a minimum allergic *** a result of these exciting outcomes,expressing a vaccine using the intimated peptide was highly promising and positive to be highly proposed as epitope-based peptide vaccine of specific antibody against SARS-nCoV-2 by initiating T cells and β-*** in vitro study for the proposed peptide-based vaccine *** *** clinical trials are required to check the efficacy of this vaccine.

关键词： COVID-19 SARS-nCoV-2 Peptide-based vaccine Cell-penetrating peptides Lipid membrane Vaccine efficacy

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Mechanical performance of cold mix asphalt containing cup lump rubber as a sustainable bio-modifier

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Journal of Traffic and Transportation Engineering(English Edition) 2024年第3期11卷 424-440页

作者： syed abdul Ghafar Muhammad Naqiuddin Mohd Warid Norhidayah abdul hassan Zulfiqar Ali Jattak Ashraf Abdalla Mohammed Radwan Faculty of Civil Engineering Universiti Teknologi MalaysiaSkudai 81310Malaysia Department of Civil Engineering Balochistan University of Information TechnologyEngineering&Management SciencesQuettaPakistan Department of Civil Engineering Balochistan University of Engineering and TechnologyKhuzdarPakistan Department of Civil Engineering Faculty of EngineeringUniversity of TripoliTripoliLibya

The road construction industry aims to contribute to the protection of already compromised *** mix asphalt(CMA)is a measure initiated by the road industry to protect the environment and preserve *** having additional benefits,CMA has attracted little attention due to its inferior ***'s performance is enhanced using a sustainable binder bio-modifier,natural cup lump rubber(CLR)is one of *** study evaluated the tensile properties,rutting,moisture susceptibility,and adhesion properties of CLR-modified CMA(CMA-CR).The tensile property was enhanced by 26%due to CLR ***-CR had excellent rutting resistance of less than 2 mm rut depth at 10,000 load cycles,showing 70%improvement compared with conventional *** susceptibility evaluation indicated that CMA-CR had tensile strength ratio(TSR)value of 104%,satisfying the minimum 80%requirement of AASHTO *** also retained more than 96%bitumen *** moisture damage resistance was improved by 12%and 10%in terms of TSR and stripping,*** durability results revealed that the CMA-CR mixture prevented higher mass loss,representing 14%improvement compared with conventional CMA.

关键词： Cup lump rubber Cup lump modified cold mix asphalt Moisture damage Tensile property Rutting Digital imaging

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Earthquake induced pounding between adjacent buildings considering soil-structure interaction

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Earthquake Engineering and Engineering Vibration 2012年第3期11卷 343-358页

作者： Sadegh Naserkhaki Farah N.A.abdul aziz hassan Pourmohammad Department of Civil Engineering Faculty of EngineeringUniversiti Putra Malaysia Department of Civil Engineering Faculty of EngineeringIslamic Azad University

Many closely located adjacent buildings have suffered from pounding during past earthquakes because they vibrated out of phase. Furthermore, buildings are usually constructed on soil; hence, there are interactions between the buildings and the underlying soil that should also be considered. This paper examines both the interaction between adjacent buildings due to pounding and the interaction between the buildings through the soil as they affect the buildings＇ seismic responses. The developed model consists of adjacent shear buildings resting on a discrete soil model and a linear visco- elastic contact force model that connects the buildings during pounding. The seismic responses of＇ adjacent buildings due to ground accelerations are obtained for two conditions： fixed-based （FB） and structure-soil-structure interaction （SSSI）. The results indicate that pounding worsens the buildings＇ condition because their seismic responses are amplified after pounding. Moreover, the underlying soil negatively impacts the buildings＇ seismic responses during pounding because the ratio of their seismic response under SSSI conditions with pounding to those without pounding is greater than that of the FB condition.

关键词： adjacent buildings underlying soil pounding seismic response fixed-based (FB) structure-soil-structureinteraction (SSSI)

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Intelligent approach of score-based artificial fish swarm algorithm(SAFSA)for Parkinson’s disease diagnosis

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International Journal of Intelligent Computing and Cybernetics 2022年第4期15卷 540-561页

作者： syed Haroon abdul Gafoor Padma Theagarajan Bharathiar University CoimbatoreIndia Department of Computer Applications Sona College of TechnologySalemIndia

Purpose-Conventional diagnostic techniques,on the other hand,may be prone to subjectivity since they depend on assessment of motions that are often subtle to individual eyes and hence hard to classify,potentially resulting in ***,early nonmotor signs of Parkinson’s disease(PD)can be mild and may be due to variety of other *** a result,these signs are usually ignored,making early PD diagnosis *** learning approaches for PD classification and healthy controls or individuals with similar medical symptoms have been introduced to solve these problems and to enhance the diagnostic and assessment processes of PD(like,movement disorders or other Parkinsonian syndromes).Design/methodology/approach-Medical observations and evaluation of medical symptoms,including characterization of a wide range of motor indications,are commonly used to diagnose *** quantity of the data being processed has grown in the last five years;feature selection has become a prerequisite before any *** study introduces a feature selection method based on the score-based artificial fish swarm algorithm(SAFSA)to overcome this ***-This study adds to the accuracy of PD identification by reducing the amount of chosen vocal features while to use the most recent and largest publicly accessible *** subset selection in PD detection techniques starts by eliminating features that are not relevant or *** to a few objective functions,features subset chosen should provide the best *** limitations/implications-In many situations,this is an Nondeterministic Polynomial Time(NPHard)*** method enhances the PD detection rate by selecting the most essential features from the *** begin,the data set’s dimensionality is reduced using Singular Value Decomposition dimensionality ***,Biogeography-Based Optimization(BBO)for feature selection;the weight value is a vital parameter for find

关键词： Parkinson disease dysphonia features Feature subset selection Score-based artificial fish swarm algorithm(SAFSA) Singular value decomposition(SVD) Classification

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Machine learning empowered COVID-19 patient monitoring using non-contact sensing:An extensive review

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Journal of Pharmaceutical Analysis 2022年第2期12卷 193-204页

作者： Umer Saeed syed Yaseen Shah Jawad Ahmad Muhammad Ali Imran Qammer H.Abbasi syed aziz Shah Research Centre for Intelligent Healthcare Coventry UniversityCoventryCV15FBUK School of Computing Engineering and Built EnvironmentGlasgow Caledonian UniversityGlasgowG40BAUK School of Computing Edinburgh Napier UniversityEdinburghEH114BNUK James Watt School of Engineering University of GlasgowGlasgowG128QQUK

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which caused the coronavirus disease 2019(COVID-19)pandemic,has affected more than 400 million people *** the recent rise of new Delta and Omicron variants,the efficacy of the vaccines has become an important *** goal of various studies has been to limit the spread of the virus by utilizing wireless sensing technologies to prevent human-to-human interactions,particularly for healthcare *** this paper,we discuss the current literature on invasive/contact and non-invasive/noncontact technologies(including Wi-Fi,radar,and software-defined radio)that have been effectively used to detect,diagnose,and monitor human activities and COVID-19 related symptoms,such as irregular *** addition,we focused on cutting-edge machine learning algorithms(such as generative adversarial networks,random forest,multilayer perceptron,support vector machine,extremely randomized trees,and k-nearest neighbors)and their essential role in intelligent healthcare ***,this study highlights the limitations related to non-invasive techniques and prospective research directions.

关键词： Artificial intelligence Non-invasive healthcare Machine learning Non-contact sensing COVID-19

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Generalized Statistical Convergence and Statistical Core of Double Sequences

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Acta Mathematica Sinica,English Series 2010年第11期26卷 2131-2144页

作者： Mohammad MURSALEEN Celal ■AKAN syed abdul MOHIUDDINE Ekrem SAVA■ Department of Mathematics Aligarh Muslim University Faculty of Education Inn University Department of Mathematics Istanbul Ticaret University

In this paper we extend the notion of A-statistical convergence to the （λ,μ）statistical convergence for double sequences x =（xjk）. We also determine some matrix transformations and establish some core theorems r... 详细信息

关键词： Double sequence statistical convergence matrix transformation core

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Conservation laws,Lie symmetries,self adjointness,and soliton solutions for the Selkov–Schnakenberg system

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Communications in Theoretical Physics 2024年第2期76卷 29-44页

作者： Kashif Ali Aly R Seadawy syed T R Rizvi Noor aziz Department of Mathematics COMSATS University IslamabadLahore CampusPakistan Mathematics Department Faculty of ScienceTaibah UniversityAl-Madinah Al-Munawarah41411Saudi Arabia

In this article,we explore the famous Selkov–Schnakenberg(SS)system of coupled nonlinear partial differential equations(PDEs)for Lie symmetry analysis,self-adjointness,and conservation ***,miscellaneous soliton solutions like dark,bright,periodic,rational,Jacobian elliptic function,Weierstrass elliptic function,and hyperbolic solutions of the SS system will be achieved by a well-known technique called sub-ordinary differential *** these results are displayed graphically by 3D,2D,and contour plots.

关键词： Selkov-Schnakenberg system Lie symmetry analysis conservation laws adjointness integrability

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Dynamical Analysis of Radiation and Heat Transfer on MHD Second Grade Fluid

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Computer Modeling in Engineering & Sciences 2021年第11期129卷 689-703页

作者： aziz-Ur-Rehman Muhammad Bilal Riaz syed Tauseef Saeed Shaowen Yao Department of Mathematics University of Management and TechnologyLahore54770Pakistan Institute for Groundwater Studies(IGS) University of the Free StateBloemfontein9301South Africa Department of Science&Humanities National University of Computer and Emerging SciencesLahore54000Pakistan School of Mathematics and Information Science Henan Polytechnic UniversityJiaozuo454000China

Convective flow is a self-sustained flow with the effect of the temperature *** density is non-uniform due to the variation of *** effect of the magnetic flux plays a major role in convective *** process of heat transfer is accompanied by a mass transfer process;for instance,condensation,evaporation,and chemical *** to the applications of the heat and mass transfer combined effects in a different field,the main aim of this paper is to do a comprehensive analysis of heat and mass transfer of MHD unsteady second-grade fluid in the presence of ramped boundary conditions near a porous *** dynamical analysis of heat transfer is based on classical differentiation with no memory *** non-dimensional form of the governing equations of the model is *** are solved by the classical integral(Laplace)transform technique/method with the convolution theorem and closed-form solutions are attained for temperature,concentration,and *** physical aspects of distinct parameters are discussed via graph to see the influence on the fluid concentration,velocity,and *** results suggest that the velocity profile decrease by increasing the Prandtl *** existence of a Prandtl number may reflect the control of the thickness of momentum and enlargement of thermal ***,to validate our results,some results are recovered from the literature.

关键词： Heat transfer magnetic effect ramped conditions porous medium Laplace transform thermal radiation

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Root-Of-Trust for Continuous Integration and Continuous Deployment Pipeline in Cloud Computing

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Computers, Materials & Continua 2022年第11期73卷 2223-2239页

作者： abdul Saboor Mohd Fadzil hassan Rehan Akbar Erwin Susanto syed Nasir Mehmood Shah Muhammad Aadil Siddiqui Saeed Ahmed Magsi High-Performance Cloud Computing Centre(HPC3) Department of Computer&Information SciencesUniversiti Teknologi PETRONASSeri IskandarPerakMalaysia Centre for Research in Data Science(CeRDaS) Department of Computer&Information SciencesUniversiti Teknologi PETRONASSeri IskandarPerakMalaysia School of Electrical Engineering Telkom UniversityBandungIndonesia KICSIT Institute of Space Technology(IST)IslamabadPakistan Department of Electrical and Electronics Engineering Universiti Teknologi PETRONASSeri IskandarPerakMalaysia

Cloud computing has gained significant use over the last decade due to its several benefits,including cost savings associated with setup,deployments,delivery,physical resource sharing across virtual machines,and availability of on-demand cloud ***,in addition to usual threats in almost every computing environment,cloud computing has also introduced a set of new threats as consumers share physical resources due to the physical co-location ***,since there are a growing number of attacks directed at cloud environments(including dictionary attacks,replay code attacks,denial of service attacks,rootkit attacks,code injection attacks,etc.),customers require additional assurances before adopting cloud ***,the continuous integration and continuous deployment of the code fragments have made cloud services more prone to security *** this study,the model based on the root of trust for continuous integration and continuous deployment is proposed,instead of only relying on a single signon authentication method that typically uses only id and *** underlying study opted hardware security module by utilizing the Trusted Platform Module(TPM),which is commonly available as a cryptoprocessor on the motherboards of the personal computers and data center *** preliminary proof of concept demonstrated that the TPM features can be utilized through RESTful services to establish the root of trust for continuous integration and continuous deployment pipeline and can additionally be integrated as a secure microservice feature in the cloud computing environment.

关键词： Root of Trust(RoT) Trusted Platform Module(TPM) cryptoprocessor microservices Hardware Security Modules(HSM) DevOps

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