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Enhancing Mild Cognitive Impairment Detection through Efficient Magnetic Resonance Image Analysis

Computers, Materials & Continua 2024年第8期80卷 2081-2098页

作者： Atif Mehmood Zhonglong Zheng Rizwan Khan Ahmad Al Smadi Farah shahid shahid Iqbal Mutasem K.Alsmadi Yazeed Yasin Ghadi syed aziz shah Mostafa M.Ibrahim Department of Computer Science and Technology Zhejiang Normal UniversityJinhua321002China Zhejiang Institute of Photoelectronics&Zhejiang Institute for Advanced Light Source Zhejiang Normal UniversityJinhua321004China Department of Data Science and Artificial Intelligence Zarqa UniversityZarqa13100Jordan School of Chemical and Environmental Engineering College of ChemistryChemical Engineering andMaterials ScienceSoochow UniversitySuzhou215123China Department of Management Information Systems College of Applied Studies and Community ServiceImam Abdulrahman Bin Faisal UniversityDammam32244Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi999041United Arab Emirates Department of Electrical Engineering Faculty of EngineeringMinia UniversityMinia61519Egypt Healthcare Technology and Innovation Theme Faculty Research Centre for Intelligent HealthcareCoventry UniversityCoventryCV48BWUK

Neuroimaging has emerged over the last few decades as a crucial tool in diagnosing Alzheimer’s disease(AD).Mild cognitive impairment(MCI)is a condition that falls between the spectrum of normal cognitive function and ***,previous studies have mainly used handcrafted features to classify MCI,AD,and normal control(NC)*** paper focuses on using gray matter(GM)scans obtained through magnetic resonance imaging(MRI)for the diagnosis of individuals with MCI,AD,and *** improve classification performance,we developed two transfer learning strategies with data augmentation(i.e.,shear range,rotation,zoom range,channel shift).The first approach is a deep Siamese network(DSN),and the second approach involves using a cross-domain strategy with customized *** performed experiments on the Alzheimer’s Disease Neuroimaging Initiative(ADNI)dataset to evaluate the performance of our proposed *** experimental results demonstrate superior performance in classifying the three binary classification tasks:NC ***,NC ***,and MCI ***,we achieved a classification accuracy of 97.68%,94.25%,and 92.18%for the three cases,*** study proposes two transfer learning strategies with data augmentation to accurately diagnose MCI,AD,and normal control individuals using GM *** findings provide promising results for future research and clinical applications in the early detection and diagnosis of AD.

关键词： Alzheimer’s disease mild cognitive impairment normal control transfer learning classification augmentation

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Machine learning empowered COVID-19 patient monitoring using non-contact sensing:An extensive review

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Journal of Pharmaceutical Analysis 2022年第2期12卷 193-204页

作者： Umer Saeed syed Yaseen shah Jawad Ahmad Muhammad Ali Imran Qammer H.Abbasi syed aziz shah Research Centre for Intelligent Healthcare Coventry UniversityCoventryCV15FBUK School of Computing Engineering and Built EnvironmentGlasgow Caledonian UniversityGlasgowG40BAUK School of Computing Edinburgh Napier UniversityEdinburghEH114BNUK James Watt School of Engineering University of GlasgowGlasgowG128QQUK

The severe acute respiratory syndrome coronavirus 2(SARS-CoV-2),which caused the coronavirus disease 2019(COVID-19)pandemic,has affected more than 400 million people *** the recent rise of new Delta and Omicron variants,the efficacy of the vaccines has become an important *** goal of various studies has been to limit the spread of the virus by utilizing wireless sensing technologies to prevent human-to-human interactions,particularly for healthcare *** this paper,we discuss the current literature on invasive/contact and non-invasive/noncontact technologies(including Wi-Fi,radar,and software-defined radio)that have been effectively used to detect,diagnose,and monitor human activities and COVID-19 related symptoms,such as irregular *** addition,we focused on cutting-edge machine learning algorithms(such as generative adversarial networks,random forest,multilayer perceptron,support vector machine,extremely randomized trees,and k-nearest neighbors)and their essential role in intelligent healthcare ***,this study highlights the limitations related to non-invasive techniques and prospective research directions.

关键词： Artificial intelligence Non-invasive healthcare Machine learning Non-contact sensing COVID-19

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A Novel Parallel Computing Confidentiality Scheme Based on Hindmarsh-Rose Model

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Computers, Materials & Continua 2023年第8期76卷 1325-1341页

作者： Jawad Ahmad Mimonah Al Qathrady Mohammed SAlshehri Yazeed Yasin Ghadi Mujeeb Ur Rehman syed aziz shah School of Computing Engineering and the Built EnvironmentEdinburgh Napier UniversityEdinburghEH105DTUK Department of Information Systems College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Computer Science College of Computer Science and Information SystemsNajran UniversityNajran61441Saudi Arabia Department of Computer Science Al Ain UniversityAbu Dhabi112612United Arab Emirates School of Science Technology and HealthYork St John UniversityYorkYO317EXUK Research Centre for Intelligent Healthcare Coventry UniversityCoventryCV15FBUK

Due to the inherent insecure nature of the Internet,it is crucial to ensure the secure transmission of image data over this ***,given the limitations of computers,it becomes evenmore important to employ efficient and fast image encryption *** 1D chaotic maps offer a practical approach to real-time image encryption,their limited flexibility and increased vulnerability restrict their practical *** this research,we have utilized a 3DHindmarsh-Rosemodel to construct a secure *** randomness of the chaotic map is assessed through standard *** proposed system enhances security by incorporating an increased number of system parameters and a wide range of chaotic parameters,as well as ensuring a uniformdistribution of chaotic signals across the entire value ***,a fast image encryption technique utilizing the new chaotic system is *** novelty of the approach is confirmed through time complexity *** further strengthen the resistance against cryptanalysis attacks and differential attacks,the SHA-256 algorithm is employed for secure key *** results through a number of parameters demonstrate the strong cryptographic performance of the proposed image encryption approach,highlighting its exceptional suitability for secure ***,the security of the proposed scheme has been compared with stateof-the-art image encryption schemes,and all comparison metrics indicate the superior performance of the proposed scheme.

关键词： Hindmarsh-rose model image encryption SHA-256 parallel computing

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Conservation laws,Lie symmetries,self adjointness,and soliton solutions for the Selkov–Schnakenberg system

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Communications in Theoretical Physics 2024年第2期76卷 29-44页

作者： Kashif Ali Aly R Seadawy syed T R Rizvi Noor aziz Department of Mathematics COMSATS University IslamabadLahore CampusPakistan Mathematics Department Faculty of ScienceTaibah UniversityAl-Madinah Al-Munawarah41411Saudi Arabia

In this article,we explore the famous Selkov–Schnakenberg(SS)system of coupled nonlinear partial differential equations(PDEs)for Lie symmetry analysis,self-adjointness,and conservation ***,miscellaneous soliton solutions like dark,bright,periodic,rational,Jacobian elliptic function,Weierstrass elliptic function,and hyperbolic solutions of the SS system will be achieved by a well-known technique called sub-ordinary differential *** these results are displayed graphically by 3D,2D,and contour plots.

关键词： Selkov-Schnakenberg system Lie symmetry analysis conservation laws adjointness integrability

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Comparison of resistive index and shear-wave elastography in the evaluation of chronic kidney allograft dysfunction

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World Journal of Transplantation 2024年第1期14卷 154-163页

作者： Ameet Kumar Jesrani syed M Faiq Rahma Rashid Tariq Ali Kalwar Rehan Mohsin Tahir aziz Nida Amin Khan Muhammed Mubarak Department of Radiology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Pathology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Transplantation Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan Department of Urology Sindh Institute of Urology and TransplantationKarachi 74200SindhPakistan

BACKGROUND Detection of early chronic changes in the kidney allograft is important for timely intervention and long-term *** and novel ultrasound-based investigations are being increasingly used for this purpose with variable *** To compare the diagnostic performance of resistive index(RI)and shear wave elastography(SWE)in the diagnosis of chronic fibrosing changes of kidney allograft with histopathological *** This is a cross-sectional and comparative study.A total of 154 kidney transplant recipients were included in this study,which was conducted at the Departments of Transplantation and Radiology,Sindh Institute of Urology and Transplantation,Karachi,Pakistan,from August 2022 to February *** consecutive patients with increased serum creatinine levels and reduced glomerular filtration rate(GFR)after three months of transplantation were enrolled in this *** and RI were performed and the findings of these were evaluated against the kidney allograft biopsy results to determine their diagnostic *** The mean age of all patients was 35.32±11.08 *** these,126(81.8%)were males and 28(18.2%)were *** mean serum creatinine in all patients was 2.86±1.68 mg/dL and the mean estimated GFR was 35.38±17.27 mL/min/1.73 *** allograft biopsy results showed chronic changes in 55(37.66%)*** sensitivity,specificity,positive predictive value(PPV),and negative predictive value(NPV)of SWE for the detection of chronic allograft damage were 93.10%,96.87%%,94.73%,and 95.87%,respectively,and the diagnostic accuracy was 95.45%.For RI,the sensitivity,specificity,PPV,and NPV were 76.92%,83.33%,70.17%,and 87.62%,respectively,and the diagnostic accuracy was 81.16%.CONCLUSION The results from this study show that SWE is more sensitive and specific as compared to RI in the evaluation of chronic allograft *** can be of great help during the routine follow-up of kidney transplant recipients for screening a

关键词： Shear wave Sonoelastography Resistive index Chronic allograft changes Biopsy Histopathology

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National guidelines for the diagnosis and treatment of hilar cholangiocarcinoma

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World Journal of Gastroenterology 2024年第9期30卷 1018-1042页

作者： Faisal Saud Dar Zaigham Abbas Irfan Ahmed Muhammad Atique Usman Iqbal Aujla Muhammad Azeemuddin Zeba aziz Abu Bakar Hafeez Bhatti Tariq Ali Bangash Amna Subhan Butt Osama Tariq Butt Abdul Wahab Dogar Javed Iqbal Farooqi Faisal Hanif Jahanzaib Haider Siraj Haider syed Mujahid Hassan Adnan Abdul Jabbar Aman Nawaz Khan Muhammad Shoaib Khan Muhammad Yasir Khan Amer Latif Nasir Hassan Luck Ahmad Karim Malik Kamran Rashid Sohail Rashid Mohammad Salih Abdullah Saeed Amjad Salamat Ghias-un-Nabi Tayyab Aasim Yusuf Haseeb Haider Zia Ammara Naveed Department of Hepatopancreatic Biliary Surgery&Liver Transplant Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Hepatogastroenterology and Liver Transplantation Dr.Ziauddin University HospitalKarachi 75600SindhPakistan University of Aberdeen Aberdeen B243FXUnited Kingdom Department of Pathology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Gastroenterology&Hepatology Pakistan Kidney and Liver Institute&Research CentreLahore 54000Pakistan Department of Radiology Aga Khan UniversityKarachi 74800Pakistan Department of Oncology Hameed Latif HospitalLahore 54000Pakistan Division of Hepatopancreatic Biliary Surgery&Liver Transplantation Shifa International HospitalIslamabad 44000Pakistan Department of Hepatopancreatic Biliary Surgery&Liver Transplant Shaikh Zayed Hospital and Post Graduate Medical InstituteLahore 54000Pakistan Department of Medicine Aga Khan University HospitalKarachi 74800Pakistan Department of Liver Transplant Pir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Medicine&Gastroenterology Lifecare Hospital and Research CentrePeshawar 25000Khyber PakhtunkhwaPakistan Department of Hepatopancreatobiliary&Liver Transplant Bahria International HospitalLahore 54000Pakistan Department of Surgery Hepatopancreatobiliary&Liver TransplantDow University of Health SciencesKarachi 74800Pakistan Department of Gastroenterology Hepatology&NutritionPir Abdul Qadir Shah Jeelani Institute of Medical SciencesGambat 66020Pakistan Department of Oncology Dr.Ziauddin HospitalKarachi 74800Pakistan Department of Radiology Rehman Medical InstitutePeshawar 25000Pakistan Army Liver Transplant Unit Pak Emirates Military HospitalRawalpindi 46000Pakistan Department of Gastroenterology Sindh Institute of Urology and TransplantationKarachi 75500Pakistan Rashid Nursing Home and Cancer Clinic Rashid Nursing Home and Cancer ClinicRawalpindi 46000Pakistan Department of Gastroentero

A consensus meeting of national experts from all major national hepatobiliary centres in the country was held on May 26,2023,at the Pakistan Kidney and Liver Institute&Research Centre(PKLI&RC)after initial consultations with the *** Pakistan Society for the Study of Liver Diseases(PSSLD)and PKLI&RC jointly organised this *** effort was based on a comprehensive literature review to establish national practice guidelines for hilar cholangiocarcinoma(hCCA).The consensus was that hCCA is a complex disease and requires a multidisciplinary team approach to best manage these *** coordinated effort can minimise delays and give patients a chance for curative treatment and effective *** diagnostic and staging workup includes high-quality computed tomography,magnetic resonance imaging,and magnetic resonance *** cytology or biopsy utilizing endoscopic retrograde cholangiopancreatography is a mainstay for ***,histopathologic confirmation is not always required before *** ultrasound with fine needle aspiration of regional lymph nodes and positron emission tomography scan are valuable adjuncts for *** only curative treatment is the surgical resection of the biliary tree based on the Bismuth-Corlette *** patients with unresectable hCCA can be considered for liver *** chemotherapy should be offered to patients with a high risk of *** use of preoperative biliary drainage and the need for portal vein embolisation should be based on local multidisciplinary *** with acute cholangitis can be drained with endoscopic or percutaneous biliary *** chemotherapy with cisplatin and gemcitabine has shown improved survival in patients with irresectable and recurrent hCCA.

关键词： Hilar cholangiocarcinoma Bismuth-Corlette classification Memorial Sloan Kettering Cancer Centre Staging Preoperative biliary drainage Portal vein embolisation Surgical resection Hepatectomy

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Peptides-based vaccine against SARS-nCoV-2 antigenic fragmented synthetic epitopes recognized by T cell and β-cell initiation of specific antibodies tofightthe infection

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Bio-Design and Manufacturing 2021年第3期4卷 490-505页

作者： Zainularifeen Abduljaleel Faisal A.Al-Allaf syed A.aziz Department of Medical Genetics Faculty of MedicineUmm Al-Qura UniversityP.O.Box715Mecca21955Kingdom of Saudi Arabia Science and Technology Unit UmmAl-Qura UniversityP.O.Box 715Mecca21955Kingdom of SaudiArabia The Regional Laboratory Molecular Diagnostics UnitDepartment of Molecular BiologyMinistry of Health(MOH)P.O.Box 6251MeccaKingdom of SaudiArabia Department of Pathology and Lab Medicine University of Ottawa451Smyth RoadOttawaONK1H8M5Canada

The World Health Organization has declared the rapidly spreading coronavirus to be a global *** FDA is yet to approve a vaccine for human novel ***,we developed a peptide-based vaccine and used high-throughput screening by molecular dynamics simulation to identify T-cell-and p-cell-recognized epitopes for producing specific antibod-ies against *** construct~12 P'antigenic epitope peptides to develop a more effective vaccine and identify specific *** epitope peptides selectively presented the best antigen presentation scores for both human pMHC class I and II alleles to develop a strong binding *** antigens identified of SARS-nCoV-2 different proteins by each attached specific~1-7 L linker adaptor were used to construct a broad single peripheral peptide *** is expected to be highly antigenic with a minimum allergic *** a result of these exciting outcomes,expressing a vaccine using the intimated peptide was highly promising and positive to be highly proposed as epitope-based peptide vaccine of specific antibody against SARS-nCoV-2 by initiating T cells and β-*** in vitro study for the proposed peptide-based vaccine *** *** clinical trials are required to check the efficacy of this vaccine.

关键词： COVID-19 SARS-nCoV-2 Peptide-based vaccine Cell-penetrating peptides Lipid membrane Vaccine efficacy

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Metabolic investigations in patients with hepatitis B and C

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World Journal of Gastroenterology 2010年第5期16卷 603-607页

作者： Abdul aziz Mastoi Bikha Ram Devrajani syed Zulfiquar Ali shah Qasim Rohopoto Sikander Ali Memon Marya Baloch Ghulam Ali Qureshi Waqas Sami M.A.Kazi Institute of Chemistry University of SindJamshoro 75000Pakistan Department of Medicine Liaquat University of Medical and Health SciencesJamshoro 75000Pakistan Medical Research Centre Liaquat University of Medical and Health SciencesJamshoro 75000 Pakistan Department of Biochemistry University of Health SciencesLahore 54600Pakistan

AIM:To investigate the similarities and dissimilarities in patients with hepatitis B and hepatitis C,clinically and metabolically. METHODS:Fifty patients with hepatitis B virus and hepatitis C virus infection were included in this study, along with fifty healthy controls for comparison *** blood(10 mL)samples from patients and healthy subjects were collected and made to clot before serum was separated and immediately levels of the enzymes,alkaline phosphatase(ALK),creatinine phosphokinase(CPK),lactate dehydrogenase (LDH),serum glutamate oxaloacetate transaminase(sGOT)and serum glutamate pyruvate transaminase(sGPT)were determined by a kit *** total con-tent of each metal the serum samples were analyzed using atomic absorption *** of cholesterol,triglycerides,urea,creatinine and uric acid were determined using a kit method on Microlab 300. RESULTS:Serum magnesium and copper levels remained unchanged,whereas the concentration of zinc decreased and iron increased significantly in both groups of *** antioxidant activity was significantly decreased in both hepatitis B and *** the enzymes analyzed,ALK,s-GPT,LDH and s-GOT were all significantly increased in both patients with hepatitis B and C whereas CPK was significantly decreased in patients with hepatitis B and remained unchanged in patients with hepatitis C. CONCLUSION:The information accumulated by this study will help provide a better understanding of involved metabolic processes in order to design appropriate therapeutic approaches for treating these patients,so they can recover and lead normal lives.

关键词： Hepatitis B virus Hepatitis C virus Antioxidant activity Metal content Enzyme activity

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Dynamical Analysis of Radiation and Heat Transfer on MHD Second Grade Fluid

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Computer Modeling in Engineering & Sciences 2021年第11期129卷 689-703页

作者： aziz-Ur-Rehman Muhammad Bilal Riaz syed Tauseef Saeed Shaowen Yao Department of Mathematics University of Management and TechnologyLahore54770Pakistan Institute for Groundwater Studies(IGS) University of the Free StateBloemfontein9301South Africa Department of Science&Humanities National University of Computer and Emerging SciencesLahore54000Pakistan School of Mathematics and Information Science Henan Polytechnic UniversityJiaozuo454000China

Convective flow is a self-sustained flow with the effect of the temperature *** density is non-uniform due to the variation of *** effect of the magnetic flux plays a major role in convective *** process of heat transfer is accompanied by a mass transfer process;for instance,condensation,evaporation,and chemical *** to the applications of the heat and mass transfer combined effects in a different field,the main aim of this paper is to do a comprehensive analysis of heat and mass transfer of MHD unsteady second-grade fluid in the presence of ramped boundary conditions near a porous *** dynamical analysis of heat transfer is based on classical differentiation with no memory *** non-dimensional form of the governing equations of the model is *** are solved by the classical integral(Laplace)transform technique/method with the convolution theorem and closed-form solutions are attained for temperature,concentration,and *** physical aspects of distinct parameters are discussed via graph to see the influence on the fluid concentration,velocity,and *** results suggest that the velocity profile decrease by increasing the Prandtl *** existence of a Prandtl number may reflect the control of the thickness of momentum and enlargement of thermal ***,to validate our results,some results are recovered from the literature.

关键词： Heat transfer magnetic effect ramped conditions porous medium Laplace transform thermal radiation

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Cartesian Product Based Transfer Learning Implementation for Brain Tumor Classification

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Computers, Materials & Continua 2022年第11期73卷 4369-4392页

作者： Irfan Ahmed Usmani Muhammad Tahir Qadri Razia Zia Asif aziz Farheen Saeed Electronic Engineering Department Sir Syed University of Engineering&TechnologyKarachi75300Pakistan Department of Computer Science Bahria University Karachi CampusKarachi75260Pakistan Christus Trinity Clinic TexasUSA

Knowledge-based transfer learning techniques have shown good performance for brain tumor classification,especially with small ***,to obtain an optimized model for targeted brain tumor classification,it is challenging to select a pre-trained deep learning(DL)model,optimal values of hyperparameters,and optimization algorithm(solver).This paper first presents a brief review of recent literature related to brain tumor ***,a robust framework for implementing the transfer learning technique is *** the proposed framework,a Cartesian product matrix is generated to determine the optimal values of the two important hyperparameters:batch size and learning *** extensive exercise consisting of 435 simulations for 11 state-of-the-art pre-trained DL models was performed using 16 paired hyperparameters from the Cartesian product matrix to input the model with the three most popular solvers(stochastic gradient descent with momentum(SGDM),adaptive moment estimation(ADAM),and root mean squared propagation(RMSProp)).The 16 pairs were formed using individual hyperparameter values taken from literature,which generally addressed only one hyperparameter for optimization,rather than making a grid for a particular *** proposed framework was assessed using a multi-class publicly available dataset consisting of glioma,meningioma,and pituitary *** assessment shows that ResNet18 outperforms all other models in terms of accuracy,precision,specificity,and recall(sensitivity).The results are also compared with existing state-of-the-art research work that used the same *** comparison was mainly based on performance metric“accuracy”with support of three other parameters“precision,”“recall,”and“specificity.”The comparison shows that the transfer learning technique,implemented through our proposed framework for brain tumor classification,outperformed all existing *** the best of our knowledge,the proposed framework is a

关键词： Deep transfer learning Cartesian product hyperparameter optimization magnetic resonance imaging(MRI) brain tumor classification

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