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Utility of convalescent plasma for addressing the COVID-19 infection: brief review and case reports

Life Research 2022年第1期5卷 3-8页

作者： Fazli Azim Md Shahidul Islam Ashraful Hoque Muhammad Javed Aneela Hayat Kaniz Fatema Molla Amiruzzaman Md.Nasir Uddin Kajal Kumar Karmakar syed A.A.rizvi IHITC:Isolation Hospital&Infections Treatment Centre IslamabadPakistan Upazila Health Complex DaudkandiCumillaBangladesh Department of Blood Transfusion Sheikh Hasina National Institute of Burn&Plastic SurgeryDhakaBangladesh Medical A Unit Hayatabad Medical Complex HospitalMTIPeshawarPakistan Department of Pathology Bacha Khan Medical CollegeMardanPakistan Department of Biochemistry National Institute of Cardiovascular Diseases&HospitalDhakaBangladesh Department of Biochemistry National Institute of Laboratory Medicine and Referral CentreDhakaBangladesh. Department of Clinical Chemistry National Institute of Cardiovascular Diseases&HospitalDhakaBangladesh. Department of Cardiology National Institute of Cardiovascular Diseases&HospitalDhakaBangladesh Department of Pharmaceutical Sciences Hampton University School of PharmacyHamptonVirginiaUSA.

Novel coronavirus,SARS-CoV-2 is responsible for causing a pandemic that has affected individuals worldwide,over 192 million people and about 4.1 million people died so *** spread is ongoing and the numbers are still *** therapeutic approaches have been explored and developed during this *** with virus-specific antibodies in convalescent plasma(CP)has shown potential benefits for various pathogenic *** many instances,it is the only available and safe management option for the COVID-19 *** we describe two confirmed cases of COVID-19 from two different geographical areas that were managed with standard treatment modalities *** of the patients were presented with high-grade fever,dry cough,and sore *** reports showed increased values of D-dimer,serum ferritin,leukocyte count(LC),Lactate dehydrogenase(LDH),and C-reactive protein(CRP).Chest X-ray showed bilateral infiltration(multifocal and bilateral ground-glass opacities and consolidations with peripheral and basal predominance),consistent with the previous reports on COVID-19 *** patients received conservative treatment according to the hospital's *** convalescent plasma(from recovered patients)infusion was the last treatment given to both *** the convalescent plasma transfusion,both patients showed a reduction of viral load,an increase of anti-SARS-CoV-2 IgG and IgM antibodies,reduction in lung infiltration,with no adverse ***,further randomized controlled trials are needed to investigate the full scope of safety and efficacy(both short and long-term)of convalescent plasma therapy for COVID-19 and other related infections.

关键词： SARS-CoV-2 COVID-19 pandemic convalescent plasma therapy critical care neutralizing antibody titer acute respiratory distress syndrome

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巴基斯坦原发性耐多药结核病流行情况

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国际结核病与肺部疾病杂志 2008年第2期3卷 73-77页

作者： A.Javaid R.Hasan A.Zafar A.Ghafoor A.J.Pathan A.Rab A.Sadiq C.M.Akram I.Burki K.Shah M.Ansari N.rizvi S.U.Khan S.R.Awan Z.A.syed Z.H.lqbal Z.Shaheen N.ur Rehman 邢超 Department of Pulmonology Postgraduate Medical InstituteLady Reading Hospital Peshawar Department of Microbiology Agha Khan University HospitalKarachi TB Control Programme North West Frontier Province(NWFP)Peshawar Institute of Chest Diseases Kotri Department of Pulmonology Ayub Teaching HospitalAbbotabad Oiha Institute of Chest Diseases Karachi Gulab Devi Hospital Lahore Lyari General Hospital Karachi National TB Control Programme Islamabad Liaqat National Hospital Karachi Jinnah Postgraduate Medical Centre Karachi King Edwards Medical University Lahore Nishtar Medical College Multan Allama Iqbal Medical Lahore Wyeth(Pvt) Limited KarachiPakistan

背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(MDR-TB)问题已十分严重,急需在社区水平对耐多药... 详细信息

背景:巴基斯坦是世界第6位结核病高负担国家。据世界卫生组织(WHO)估计,巴基斯坦结核病发病率为181/10万,全国每年新增结核病患者28.6万例。来自于医院的资料表明:巴基斯坦耐多药结核病(MDR-TB)问题已十分严重,急需在社区水平对耐多药结核病的严重程度开展评估。本研究为针对巴基斯坦耐药结核病流行状况开展的横段面研究,所使用的痰标本来自于巴基斯坦全国742例未经治疗的新诊断的肺结核患者。目的:评估巴基斯坦原发性耐药的流行情况结果:在672例痰培养阳性患者中,有76例(11.3%)出现了对1种或多种抗结核药物耐药。36例(5.4%)患者对链霉素(10μg/ml)耐药; 51例(7.6%)患者对异烟肼(1μg/ml)耐药;15例(2.2%)患者对利福平(5μg/ml)耐药;12例(1.8%)患者对乙胺丁醇(10μg/ml)耐药;22例(3.3%)患者对吡嗪酰胺耐药。有46例(6.8%)患者痰标本中分离的结核菌株耐1种抗结核药物, 10例(1.5%)同时耐2种抗结核药物,12例(1.8%)同时耐3种抗结核药物,6例(0.9%)同时耐4种抗结核药物,2例(0.3%)同时耐全部5种抗结核一线药。原发性耐多药率为1.8%,(n= 12)(异烟肼1μg/ml,利福平5μg/ml)。结论:研究结果表明,巴基斯坦原发性耐多药率<2%,需要进一步实施有效的DOTS策略。

关键词：原发性耐药耐多药结核病巴基斯坦

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