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Hepatitis C Associated B-cell Non-Hodgkin Lymphoma:Clinical Features and the Role of Antiviral Therapy

Journal of Clinical and Translational Hepatology 2015年第2期3卷 134-139页

作者： syed tasleem Gagan K Sood Department of Surgery St.Luke's Center for Liver Disease Baylor College of Medicine Houston Texas USA Department of Surgery St.Luke's Center for Liver Disease Baylor College of Medicine Houston Texas USA Department of Gastroenterology and Hepatology Baylor College of Medicine Houston Texas USA

The link between chronic hepatitis C virus (HCV) infection and a subset of B-cell non-Hodgkin lymphomas (B-NHL) is strongly supported by epidemiological *** demonstrating complete regression of lymphoma after antiviral treatments suggests possible chronic antigenic stimulation for the origin of B-NHL and provides evidence for a virus-mediated lymphomagenesis.B-NHL is a heterogeneous group of lymphomas with varied clinical presentation and may be indolent or *** optimal management of HCV related B-NHL is not *** treatment may be sufficient for low-grade lymphomas,but chemotherapy is necessary in patients with high grade *** (IFN)-based antiviral treatment regimens for HCV infection are limited by poor tolerance and suboptimal antiviral *** approved novel direct acting antiviral (DAA) drugs are highly effective and *** has opened a new era for the treatment of HCV related B-NHL alone or in conjunction with *** of HCV associated B-NHL should be performed in an interdisciplinary approach in close consultation with hematologist and *** this review,we summarize data regarding clinical features and epidemiology of B-NHL and discuss novel therapeutic approaches,including DAAs,that may prove to be effective in the treatment of HCV associated lymphomas.

关键词： Hepatitis C Non-Hodgkin lymphoma Mixed cryoglobulinemia Rituximab

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Detection of onset of agglomeration in a bubbling fluidized bed biomass combustor using reactive Eulerian computational fluid dynamics

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Particuology 2024年第7期90卷 504-515页

作者： Abdullah tasleem Atta Ullah Fei Li Qun Yi William Nimmo syed Sheraz Daood Department of Chemical Engineering Pakistan Institute of Engineering and Applied Sciences(PIEAS)Lehtrar RoadP.O.Nilore45650IslamabadPakistan Institute of Process Engineering Chinese Academy of SciencesBeijing100190China School of Chemical Engineering and Pharmacy Wuhan Institute of TechnologyWuhan430205China Energy Engineering Group Energy 2050Department of Mechanical EngineeringUniversity of SheffieldSheffieldS37RDUnited Kingdom Institute of Energy and Environmental Engineering Faculty of ElectricalEnergy&Environmental EngineeringUniversity of the PunjabQuaid-e-Azam CampusLahorePakistan Energy Engineering Research and Development Centre Faculty of ElectricalEnergy&Environmental EngineeringUniversity of the PunjabQuaid-e-Azam CampusLahorePakistan

The choice of a type of combustion technology to be used for heat or power generation depends on economic,technical,operational and fuel availability *** benefits associated with the evolving market driven by the fluidised bed combustion(FBC)technology cannot be overlooked especially when gauged at 65 GWth of worldwide installed capacity alongside added benefits of handling fuel variation,low pollutant emissions and high combustion *** or biomass waste will continue to have a vital role to play in the future FBC technology-based power *** often contains high levels of inorganic species that can form sticky agglomerates posing a significant risk to boiler operation resulting in unscheduled *** added complexity of the behaviour of the fuel and bed material mix highlights the requirement for simulation models to identify agglomeration to help improve the overall performance and reliability of FBC *** resolve this problem,this research devised a simulation strategy for the detection of agglomeration using the Eulerian–Eulerian *** developed modelling strategy is validated with the experimental data available in literature for two-dimensional simplified geometry of a pilot-scale fluidised bed *** model results were found promising and robust to predict bed defluidisation times and other parameters consistent with the experimental data.

关键词： Fluidized bed combustion Eulerian Models Biomass Agglomeration Defluidisation

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Association of genetic variants with diabetic nephropathy

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World Journal of Diabetes 2014年第6期5卷 809-816页

作者： Saliha Rizvi syed tasleem Raza Farzana Mahdi Department of Biochemistry Era’s Lucknow Medical College and Hospital

Diabetic nephropathy accounts for the most serious microvascular complication of diabetes mellitus. It is suggested that the prevalence of diabetic nephropathy will continue to increase in future posing a major challenge to the healthcare system resulting in increased morbidity and mortality. It occurs as a result of interaction between both genetic and environmental factors in individuals with both type 1 and type 2 diabetes. Genetic susceptibility has been proposed as an important factor for the development and progression of diabetic nephropathy, and various research efforts are being executed worldwide to identify the susceptibility gene for diabetic nephropathy. Numerous single nucleotide polymorphisms have been found in various genes giving rise to various gene variants which have been found to play a major role in genetic susceptibility to diabetic nephropathy. The risk of developing diabetic nephropathy is increased several times by inheriting risk alleles at susceptibility loci of various genes like ACE, IL, TNF-α, COL4A1, e NOS, SOD2, APOE, GLUT, etc. The identification of these genetic variants at a biomarker level could thus, allow the detection of those individuals at high risk for diabetic nephropathy which could thus help in the treatment, diagnosis and early prevention of the disease. The present review discusses about the various gene variants found till date to be associated with diabetic nephropathy.

关键词： Diabetes mellitus Diabetic nephropathy Genetic polymorphism Gene variants Nephropathy

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Trajectory of cause of death among brought dead neonates in tertiary care public facilities of Pakistan: A multicenter study

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World Journal of Pediatrics 2017年第1期13卷 57-62页

作者： Muhammad Ayaz Mustufa Munir Ahmed Sheikh Ijaz-ul-Haque Taseer syed Jamal Raza Muhammad Sohail Arshad tasleem Akhter Ghazala Mohyuddin Arain Sultana Habibuilah Sohail Safdar Rukhsana Firdous Muhammad Adnan PMRC Specialized Research Center on Child Health National Institute of Child HealthKarachiPakistan PMRC Research Center Liaquat University of Health and Medical SciencesJamshoroHyderabadPakistan PMRC Research Center Nishtar MedicaI CollegeMultan.Pakistan PMRC Research Center Khyber Medical CollegePeshawarPakistan PMRC Research Center Punjab Medical CollegeFaisalabad.Pakistan PMRC Research Center Dow University of Health Sciences.Karachi.Pakistan PMRC Research Center Bolan Medical CollegeOuettaPakistan PMRc Research Center FJMCLahore.Pakistan.

Background:Considering the fact that Pakistan is amongst the countries with very high neonatal mortality rates,we conducted a research study to determine the possible causes and characteris廿cs of neonates presenting dead to the emergency department of tertiary public health care facilities of Pakistan using verbal ***:A descriptive case series study was conducted in emergency department/pediatrics ward/neonatal ward/nursery unit of ten tertiary care public health facilities,situated in seven malor cities of Pakistan from November,2011 to June。*** verbal autopsy proforma was used to collect information regarding cause of death,family narratives and other associated risks accountable for pathway to mortality.

关键词： autopsy child health services early childhood emergency department use neonatal mortality

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