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Integrating Electronic Systems for Requesting Clinical Laboratory Test into Digital Clinical Records: Design and Implementation

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Health 2017年第4期9卷 622-639页

作者： Félix Gascón Luna Isidoro herrera Contreras Antonio Cruz Guerrero Francisco Bermudo Guitarte Department of Clinical Laboratory “Valle de los Pedroches” Hospital Córdoba Spain Department of Clinical Laboratory Hospital Complex Jaén Spain

Clinical laboratory tests are basic elements that support healthcare tasks such as disease detection, diagnosis and monitoring of response to treatments. Current laboratory information systems focus on the patient database, tests and results, with multiple modules available, connecting with the various analytical systems or work areas. However laboratory information systems functioned as “islands of information”, because their design was fundamentally inward-looking and disconnected from other healthcare computer applications. Actually, the Electronic Health Register (EHR) is considered by clinicians as a tool with great potential healthcare benefits. The EHR, in the sense of a unique and complete record of a patient’s healthcare and state of health, regardless of the healthcare level used, is a real attempt to eliminate these “islands of information” and need modules to act as “bridges” with the laboratory information systems. This type of module, which in generic terms may be referred to as a laboratory test request module, has become an essential feature of the EHR. These modules need to use a laboratory coding system as a common language for exchanging information, ensuring that tests and results are unequivocally identified. The development of the laboratory test request module requires the commitment of professionals and political authorities, being necessary time for their design and an adequate pilot phase. The laboratory professionals have to assume a leadership role in the whole process of design, development and implementation of these modules, integrating in the equipment of information technologies of healthcare providers. In our manuscript we review the elements that may prove electronic systems for requesting clinical laboratory test into digital clinical records and the key elements to move from theory to practice.

关键词： Electronic Health Records Laboratory Information Systems Test Request Module Medical Order Entry Systems Systems Integration Laboratory Test Codes Systematic Nomenclature

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Relevance of Protein Content within the Renal Scaffold for Kidney Bioengineering and Regeneration

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Journal of Biomedical Science and Engineering 2017年第11期10卷 509-526页

作者： Fatima Guerrero Andres Carmona Rosa Ortega Sagrario Canadillas Rodolfo Crespo Concha herrera Pedro Aljama Maimonides Institute of Biomedical Research of Cordoba CordobaSpain Anatomical Pathology Service Reina Sofia University HospitalCordobaSpain Cellular Therapy Unit Reina Sofia University HospitalCordobaSpain Department of Nephrology Nephrology ServiceReina Sofia University HospitalCordobaSpain University of Cordoba CordobaSpain Hematology Departament Reina Sofia University HospitalCordobaSpain RETICs Red Renal Instituto de Salud Carlos IIIMadridSpain

Chronic kidney disease is currently a major public health problem around the world. Although hemodialysis increases survival of patients with end-stage renal disease, kidney transplantation remains the only potentially curative treatment. However, transplantation as a therapeutic option is limited by availability of suitable donor organs. This situation highlights the urgent need to find new and potentially inexhaustible sources of transplantable organs. Perfusion decellularizarion of whole organs is a novel approach to organ engineering and regeneration. In the present research, we used a continuous perfusion decellularization protocol to eliminate cellular componet of kidney and evaluated residual scaffold components after decellularizarion process by proteomics analysis. Our proteomic data show that this protocol results in incomplete removal of cellular proteins. However, unlike other authors, we assume that proteins retained within decellularized kidney scaffold could be the basis for specific homing and celular differentation in the recellularization process.

关键词： Bioengineering Kidney Decellularization Scaffold Proteomic

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Visual Anosognosia (Anton-Babinski Syndrome): Report of Two Cases Associated with Ischemic Cerebrovascular Disease

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Journal of Behavioral and Brain Science 2012年第3期2卷 394-398页

作者： Juan JoseRomero Carvajal Augusto Alejandro Arias Cardenas German Zamora Pazmino Patricio Abad herrera Resident of Internal Medicine Department Hospital MetropolitanoUniversidadInternacional del EcuadorQuitoEcuador Department of Neuroradiology Hospital MetropolitanoQuitoEcuador Department of Neurology Hospital MetropolitanoQuitoEcuador

Visual anosognosia or Anton-Babinski syndrome is a rare neurological condition related to cortical blindness. The patients deny their blindness and affirm adamantly that they are capable of seeing. The clinical presentation includes confabulations and sometimes confusional states. In this article we report two patients with anosognosia related to ischemic stroke in two different sets of etiology and pathogenesis. We describe the major clinical manifestations of this syndrome and review the current medical literature. Two patients were identified, a 96-year-old male with visual anosognosia secondary to a right posterior cerebral artery thrombosis, and a 56-year-old female with the same syndrome but related to central nervous system angiitis in relation with multiple sclerosis and Hashimoto’s thyroiditis. Visual anosognosia or Anton-Babinski syndrome is a rare neurological condition, however the ischemic vascular cerebral disease is a frequent etiology. We believe that this is the first report of this syndrome in relation to angiitis with a clear autoimmune pathogenesis.

关键词： Visual Anosognosia Cortical Blindness Anton-Babinski Syndrome Stroke MRI

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Thematic Trends in Complementary and Alternative Medicine Applied in Cancer-Related Symptoms

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Journal of Data and Information Science 2018年第2期3卷 1-19页

作者： Jose A.Moral-Munoz Manuel Arroyo-Morales Barbara F.Piper Antonio I.Cuesta-Vargas Lourdes Díaz-Rodríguez William C.S.Cho Enrique herrera-Viedma Manuel J.Cobo Dept. Nursing and Physiotherapy University of Cádiz Cádiz Spai Institute of Research and Innovation in Biomedical Sciences of the Province of Cádiz （INiBICA） University of Cádiz Cádiz Spain 3Dept. Physical Therapy University of Granada Granada Spain 4Dept. Nursing School of Health and Human Services National University San Diego CA US 5School Clinical Science Queensland University of Technology Brisbane QLD Australi 6Instituto Biosanitario （IBS） University of Granada Granada Spai 7Hospital Authority Hong Kong Chin 8Dept. Computer Science and Artificial Intelligence University of Granada Granada Spai 9Dept. of Computer Science and Engineering University of Cádiz Cádiz Spai

Purpose： The main goal of this study is to discover the scientific evolution of Cancer-Related Symptoms in Complementary and Alternative Medicine research area, analyzing the articles indexed in the Web of Science database from 1980 to ***/Methodology/Approach： A co-word science mapping analysis is performed under a longitudinal framework（1980 to 2013）. The documental corpus is divided into two subperiods,1980–2008 and 2009–2013. Thus, the performance and impact rates, and conceptual evolution of the research field are ***： According to the results, the co-word analysis allows us to identify 12 main thematic areas in this emerging research field： anxiety, survivors and palliative care,meditation, treatment, symptoms and cancer types, postmenopause, cancer pain, low back pain, herbal medicine, children, depression and insomnia, inflammation mediators, and lymphedema. The different research lines are identified according to the main thematic areas,centered fundamentally on anxiety and suffering prevention. The scientific community can use this information to identify where the interest is focused and make decisions in different *** limitation： Several limitations can be addressed： 1） some of the Complementary and Alternative Medicine therapies may not have been included; 2） only the documents indexed in Web of Science are analyzed; and 3） the thematic areas detected could change if another dataset was *** implications： The results obtained in the present study could be considered as an evidence-based framework in which future studies could be ***/value： Currently, there are no studies that show the thematic evolution of this research area.

关键词： Cancer-related symptoms Complementary and Alternative Medicine Bibliometrics Science mapping analysis Thematic evolution H-index

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Plant abiotic stress response and nutrient use efficiency

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Science China(Life Sciences) 2020年第5期63卷 635-674页

作者： Zhizhong Gong Liming Xiong Huazhong Shi Shuhua Yang Luis R.herrera-Estrella Guohua Xu Dai-Yin Chao Jingrui Li Peng-Yun Wang Feng Qin Jigang Li Yanglin Ding Yiting Shi Yu Wang Yongqing Yang Yan Guo Jian-Kang Zhu State Key Laboratory of Plant Physiology and Biochemistry College of Biological SciencesChina Agricultural UniversityBeijing 100193China Department of Biology Hong Kong Baptist UniversityKowlong TongHong KongChina Department of Chemistry and Biochemistry Texas Tech UniversityLubbockTX 79409USA Plant and Soil Science Department(IGCAST) Texas Tech UniversityLubbockTX 79409USA Unidad de Genómica Avanzada(Langebio) Centro de Investigación y de Estudios AvanzadosIrapuato 36610México College of Resources and Environmental Sciences Nanjing Agricultural UniversityNanjing 210095China National Key laboratory of Plant Molecular Genetics CAS Center for Excellence in Molecular Plant SciencesShanghai Institute of Plant Physiology and EcologyChinese Academy of SciencesShanghai 200032China School of Life Science Henan UniversityKaifeng 457000China Shanghai Center for Plant Stress Biology CAS Center for Excellence in Molecular Plant SciencesChinese Academy of SciencesShanghai 200032China

Abiotic stresses and soil nutrient limitations are major environmental conditions that reduce plant growth,productivity and *** have evolved mechanisms to perceive these environmental challenges,transmit the stress signals within cells as well as between cells and tissues,and make appropriate adjustments in their growth and development in order to survive and *** recent years,significant progress has been made on many fronts of the stress signaling research,particularly in understanding the downstream signaling events that culminate at the activation of stress-and nutrient limitation-responsive genes,cellular ion homeostasis,and growth ***,the revelation of the early events of stress signaling,particularly the identification of primary stress sensors,still lags *** this review,we summarize recent work on the genetic and molecular mechanisms of plant abiotic stress and nutrient limitation sensing and signaling and discuss new directions for future studies.

关键词： abiotic stress sensing nutrient use efficiency heavy metal Ca2+signaling ROS signal transduction phosphorylation transcription factor transporter

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Renewable Diesel Fuel from Processing of Vegetable Oil in Hydrotreatment Units: Theoretical Compliance with European Directive 2009/28/EC and Ongoing Projects in Spain

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Smart Grid and Renewable Energy 2010年第2期1卷 70-73页

作者： Daniel Garraín Israel herrera Carmen Lago Yolanda Lechón Rosa Sáez 不详

Oil hydrotreating units in refineries are aimed at reducing the sulfur content of fuels to accomplish standard par-ticular specifications. However, this process is currently one of the best available technologies to produce biofuels from vegetable oil in a refinery. Vegetable oils can be processed or co-processed in these units if several adaptations are performed, so some properties could be improved in comparison with conventional fuel such as density and cetane number. This study highlights the theoretical greenhouse gases (GHG) emissions (using a life cycle assessment–LCA-approach) of a hydrotreated vegetable oil (HVO) from bibliographical data. Results were compared with other biofuel production processes, such as those obtained by transesterification of vegetable oil (FAME, fatty acid methyl ester). It has also been included the comparison with conventional fossil diesel as a benchmark in order to assess the theoretical compliance with GHG savings proposed in European Directive 2009/28/EC. Finally, ongoing projects and future perspectives in Spain are mentioned.

关键词： Hydrotreated Vegetable Oil Fatty Acid Methyl Ester GHG Emissions Savings Directive 2009/28/EC Renewable Diesel Fuel

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Macronutrient Composition of Giant Water Bug （Lethocerus sp.） Edible Insect in Mexico and Thailand

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Journal of Agricultural Science and Technology(A) 2016年第5期6卷 349-354页

作者： Virginia Melo-Ruiz Consuelo Moreno-Bonett Karina Sanchez-herrera Rafael Diaz-Garcia Cesar Gazga-Urioste Department of Biologic Systems Metropolitan Autonomous University Mexico City 04960 Mexico Department of Health Care Metropolitan Autonomous University Mexico City 04960 exico

The health benefits of nutrients provided by edible insects are not properly studied, even though insect intake in LatinAmerican and Asia is a cultural tradition since ancient times. Insects from the giant water bug （Belostomidae family） are consumedboth in Mexico and Thailand, and are known as ＂Cucarachon de agua＂（Lethocerus americanus） and ＂Mangda＂（Lethocerus indicus）,respectively. Raw samples of these insects were collected on 2014 at Xochimilco channels from Mexico and from Warorot nightmarket in Chiang Mai, Thailand to further analyze nutrient composition of samples according to official methods of analysis （AOAC）techniques. The nutrient compositions were as following： proteins 60.12% and 53.11%; lipids 5.72% and 8.15%; minerals 5.46% and6.75%; fiber 10.95 % and 12.23%; soluble carbohydrates 17.75% and 19.74%, for insects obtained from Mexico and Thailand,respectively. Giant water bug shows differences in nutrient composition. It may be the consequence of differences in the environmentwhere they acquire the nutrients necessary for growth and reproduction. However, giant water bugs are available all year around andare a good source of proteins that could help people to obtain a cheaper source of this important macronutrient.

关键词： Giant water bug, edible insect, nutrition, health, nutraceutical.

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Polyurethane as substrate for fungal strains

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Advances in Bioscience and Biotechnology 2011年第2期2卷 52-58页

作者： Araceli Loredo-Trevino Gilberto Garcia Abraham Velasco-Tellez Raul Rodriguez-herrera Cristobal N.Aguilar Group of Bioprocesses.School of Chemistry.University of Coahuila.Saltillo Mexico Research and Development Division.Nemak SA GarciaN.L.Mexico Biotechnology Department.School of Chemistry.University of Coahuila.Saltillo Mexico

Polyurethane is a versatile plastic with several industrial applications in the modern life, but it is considered as a very recalcitrant material. Biodegradation of this plastic has been poorly explored, and most of the studies that have been published focus on bacterial enzymes. In this work, some fungi with the capacity of growing with polyurethane foam as nutrient source were isolated from sands contaminated with this plastic and from DIA/UAdeC collection, testing their ability to grow on polyurethane as sole carbon and nitrogen sources and their enzymatic activities were determined in specific media as well as their invasion capacity on polyurethane agar plates. 22 fungal strains demonstrated their capacity of growing on polyurethane. Among the enzymatic activities evaluate, the most common was the urease activity (95% of the strains).Protease, esterase and laccase activities were present in 86%, 50% and 36% respectively. The great ability of the isolated fungal strains to use polyurethane foam as nutrient opens an important opportunity to study at detail the biodegradation of this plastic, with clear implications in cell biology and environmental technology.

关键词： Polyurethane Biodegradation Fungal Enzymes In-Plate Screening

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Protective Effect of Phenolic-Rich Extracts from Different Parts of <i>Opuntia joconostle</i>Fruit against Carbon Tetrachloride-Induced Oxidative Stress in Mice

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Journal of Biomaterials and Nanobiotechnology 2013年第3期4卷 35-42页

作者： Obed Osorio-Esquivel Alicia Ortiz-Moreno Julieta herrera-Martínez María Dolores Hernández-Navarro Departamento de Bioingenieria y Biotecnología Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional México City México Departamento de Farmacia Facultad de Química Universidad Autónoma del Estado de México Toluca México Departamento de Morfología Escuela Nacional de Ciencias Biológicas Instituto Politécnico Nacional México City México

Opuntia joconostle fruit is a rich source of biocompounds such as polyphenols including gallic, vanilic, 4-hidroxybenzoic, cafeic, and syringic acids, catechin, epicatechin, rutin, and vanillin, besides betalains. The objective of this research was to evaluate the effect of supplementation polyphenols-rich extracts from different parts of Opuntia joconostle against carbon tetrachloride-induced oxidative stress in a mouse model. The animals were treated orally with polyphenols-rich extracts at 50, 100 and 200 mg/kg BW for 30 consecutive days. On day 30th the mice received carbon tetrachloride (CCl4) as hepatoxic agent. Biochemical evaluations were carried out 24 h after induction of the oxidative stress. Data showed that methanolic extracts from different parts of Opuntia joconostle exerting protective effect against the CCl4-induced oxidative stress in mice. Histology examination revealed that the damage decreased in groups treated with polyphenols-rich extracts compared to the group that did not receive any treatment. Opuntia joconostle fruit contains many phenolic compounds, flavonoids and betalains. The protective effect of extracts may be related to the phenolic composition and also by a counteraction with other compounds, such as betalains and flavonoids that increase their antioxidant effect.

关键词： Opuntia joconostle Oxidative Stress Carbon Tetrachloride Phenolic Compounds

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Cysteine Supplementation to Parenteral Nutrition Improves Red Blood Cell Glutathione Concentrations of Critically Ill Preterm Neonates

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Food and Nutrition Sciences 2018年第5期9卷 619-631页

作者： Oscar R. herrera Michael C. Storm Emma M. Tillman Richard A. Helms Department of Clinical Pharmacy and Translational Science University of Tennessee Health Science Center Memphis USA State of Tennessee Center for Pediatric Experimental Therapeutics Memphis USA Department of Pediatrics University of Tennessee Health Science Center Memphis USA

Premature neonates have immature antioxidant enzyme systems rendering them more susceptible to oxidative injury. One key antioxidant is glutathione (GSH). The rate limiting amino acid (AA) in GSH production is thought to be cysteine. Critically ill premature neonates who are parenterally fed are often supplemented with additional cysteine, yet the need for cysteine and optimal dose is unknown. This was a prospective, un-blinded, three-group, randomized crossover study aimed to evaluate three doses of cysteine by analyzing red blood cell (RBC) GSH, plasma AA, weight, and nitrogen balance. Neonates were randomized to receive 72 hours of each of the following cysteine doses: 10 mg/g AA, 20 mg/g AA, and 40 mg/g AA. GSH, plasma AAs, weight, and nitrogen balance were evaluated at baseline (after 72 hours of 0 mg/g AA), day three, day six, and day nine. Sixteen patients completed all doses of cysteine, which resulted in significantly increased RBC GSH concentrations over baseline. Plasma concentrations of cystine, total and free cysteine/cystine, glycine and serine increased with cysteine dose. All cysteine doses were associated with adequate weight gain, and positive nitrogen balance. These results are contrary to more recent studies of cysteine effect on RBC GSH concentrations in preterm neonates and infants, but may reflect the severity of illness in our study subjects, where cysteine requirements may be increased.

关键词： Cysteine Protein Sulfur Amino Acid Pediatric Parenteral Nutrition Septic

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