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Epidemiological observations of invasive group B Streptococcus infections in six major hospitals in Peninsular Malaysia

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Asian Pacific Journal of Tropical Medicine 2024年第9期17卷 384-391页

作者： AbdulRahman Muthanna Mohd Nasir Mohd Desa Nurul Asyikin Abdul Rahman Nurul Diana Dzaraly Nurul Hana Zainal Baharin Nur Afiza Aziz Chua Hui Shan Zalina Ismail Lailatul Akmar Mat Nor Marlindawati Mohd Ali Nur Hanani Ahmad Mohammad Noor Amal Azmai syafinaz amin-nordin Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia School of Biology Faculty of Applied SciencesUniversiti Teknologi MARANegeri Sembilan72000 Kuala PilahMalaysia Department of Oral Biology&Biomedical Sciences Faculty of DentistryMAHSA University42610 JenjaromSelangorMalaysia School of Bioscience Faculty of Pharmacy and Biomedical SciencesMAHSA University42610 JenjaromSelangorMalaysia Department of Pathology Sultanah Aminah Hospital80100 Johor BahruJohorMalaysia Department of Pathology Melaka General Hospital75400 MelakaMalaysia Department of Medical Microbiology and Immunology Faculty of MedicineUniversiti Kebangsaan Malaysia56000 CherasKuala LumpurMalaysia Department of Pathology Sultan Idris Shah Serdang Hospital43000 KajangSelangorMalaysia Department of Pathology Tuanku Ja'afar Hospital70300 SerembanNegeri SembilanMalaysia Department of Pathology Sungai Buloh Hospital47000 Sungai BulohSelangorMalaysia Department of Biology Faculty of ScienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Aquatic Animal Health and Therapeutics Laboratory Institute of BioscienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Sultan Abdul Aziz Shah HospitalUniversiti Putra MalaysiaPersiaran MARDI-UPM43400SelangorMalaysia

Objective:To address the lack of research on invasive group B Streptococcus(GBS)infections in Malaysia and Southeast Asia through a comprehensive analysis of GBS isolates obtained from ***:Medical records from patients with GBS infection isolated from the sterile site,such as blood and cerebrospinal fluid from 14 July 2019 to 15 December 2020,were reviewed from six major hospitals in Peninsular *** criteria were invasive GBS,sterile sites and non-repeated GBS isolated from the same patients in the same *** isolates were re-identified for GBS and ***:A total of 118 patients were eligible,with a majority of non-pregnant adults(76.3%).Over half of the patients(62.7%)had underlying medical conditions,with diabetes as the most common disease,followed by respiratory disease,renal disease,cardiovascular disease and skin and soft tissue *** most common manifestations were sepsis,followed by soft tissue abscess,diabetic foot ulcer,wet gangrene and *** overall mortality was 7.6%.The most common serotype was serotype桋.Conclusions:Invasive GBS infection among non-pregnant adults showed a rising trend,particularly among diabetic *** study underscores the importance of reducing risk factors and highlights the necessity of developing GBS vaccination as a preventive strategy for both infants and adults.

关键词： Streptococcus agalactiae Group B Streptococcus Invasive GBS infections Malaysia

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Vaccine development for leptospirosis:A systematic review

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Asian Pacific Journal of Tropical Medicine 2023年第12期16卷 533-545页

作者： Yocyny Surendran Mahalingam Nandikha syafinaz amin-nordin Sandeep Kumar Dhanda Mohamad Ridhuan Mohd Ali Narcisse MS Joseph Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400Malaysia Department of Biomedical Science Faculty of MedicineQuest International University30250Malaysia Department of Oncology St Jude Children’s Research Hospital Memphis38105USA Institute for Medical Research Ministry of HealthMalaysia

Objective:To assess the efficacy of various types of vaccines developed for ***:A comprehensive search was conducted in three databases:PubMed,Scopus,and Cochrane *** authors(YS and MN)selected the articles based on manual *** study eligibility criteria are all Leptospira species regardless of any cluster(pathogenic,intermediate and non-pathogenic).This study recorded articles with positive and negative results and showed a comparison among various membrane proteins as vaccine *** studies on the effectiveness of outer membrane protein as vaccine candidates were also *** articles obtained in the databases were imported into the WPS spreadsheet,and duplicate documents were removed ***:A total of 24 studies were included in the review,which evaluated various types of leptospirosis *** vaccines were developed and tested;however,the heterogeneity of Leptospira species pose a *** an effective approach,an epitope based vaccine shows quite a promising ***,sufficient validation,testing and clinical trials are ***:Developing an effective vaccine for leptospirosis remains a global health *** significant progress has been made in recent years,there is a need for further research to optimize vaccine development and to ensure that vaccines are accessible and effective for high-risk populations.

关键词： Leptospira Vaccine candidate Outer membrane protein

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Disease burden,antimicrobial resistance and molecular characterization of invasive group B Streptococcus among non-pregnant adults in Malaysia:A protocol study

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Asian Pacific Journal of Tropical Medicine 2023年第11期16卷 498-505页

作者： Abdulrahman Muthanna Nurul Hana Zainal Baharin Mohd Nasir Mohd Desa Nurul Diana Dzaraly Mohammad Noor Amal Azmai syafinaz amin-nordin Department of Biomedical Sciences Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Biology Faculty of ScienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Aquatic Animal Health and Therapeutics Laboratory Institute of BioscienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangorMalaysia Department of Medical Microbiology Sultan Abdul Aziz Shah HospitalUniversiti Putra MalaysiaPersiaran MARDI-UPM43400SelangorMalaysia Laboratory of Vaccine and Biomolecules Institute of BioscienceUniversiti Putra Malaysia43400 SerdangSelangorMalaysia

and pili genes are also ***:This multicentre,prospective,observational study is conducted in seven major tertiary hospitals in Malaysia among non-pregnant ***,a retrospective study is conducted in the selected hospitals with similar *** isolates are subjected to phenotyping,serotyping by multiplex PCR,antimicrobial susceptibility testing and PCR-detection of GBS virulence and pilus *** housekeeping genes are amplified and sequenced for multi-locus sequence ***:Findings from the study may contribute to the management of clinical practice to diagnose and prevent GBS related diseases in a timely *** use of antibiotics is encouraged by monitoring antimicrobial resistance.

关键词： Group B Streptococcus Incidence Serotype Antimicrobial resistance Virulence gene Multi-locus sequence typing

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An update on Gardneralla vaginalis associated bacterial vaginosis in Malaysia

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Asian Pacific Journal of Tropical Biomedicine 2017年第9期7卷 831-835页

作者： Nada Khairi Younus Renu Gopinath Ravindran Jegasothy syafinaz amin nordin Alex van Belkum Narcisse Mary Vasantha Kumari Neela Department of Medical Microbiology and Parasitology Faculty of Medicine and Health SciencesUniversiti Putra Malaysia43400 SerdangSelangor Darul EhsanMalaysia Obstetrics and Gynaecology MAHSA University CollegeMalaysia bioMerieux R&D MicrobiologyLa Balme les GrottesFrance

Objective: To update the status of Gardnerella vaginalis(G. vaginalis) as a causative agent of bacterial vaginosis(BV) in Malaysia and to define its epidemiology, metronidazole resistance and virulence ***: It is a single-centre(Gynaecology clinic at the Hospital Kuala Lumpur,Malaysia) prospective study with laboratory-based microbiological follow up and analyses. Vaginal swabs collected from the patients suspected for BV were subjected to clinical BV diagnosis, isolation and identification of G. vaginalis, metronidazole susceptibility testing, vaginolysin and sialidase gene PCR, Piot's biotyping and amplified ribosomal DNA restriction analysis ***: Among the 207 patients suspected for BV, G. vaginalis was isolated from 47 subjects. G. vaginalis coexisted with Trichomonas vaginalis and Candida albicans in 26 samples. Three G. vaginalis isolates were resistant to metronidazole. Biotyping revealed 1 and 7 as the common types. Amplified ribosomal DNA restriction analysis genotype II was found to be more common(n = 22; 46%) than I(n = 12; 25.53%) and III(n = 13;27.6%). All genotype I and III isolates carried the sialidase gene, while 91.6% and 84.6%contained the vaginolysin gene. Genotype I was significantly associated with postgynaecological surgical complications and abortions(P = 0.002).Conclusions: The existence of pathogenic G. vaginalis clones in Malaysia including drug resistant strains should not be taken lightly and needs to be monitored as these may bring more complications especially among women of child bearing age and pregnant women.

关键词： Gardnerella vaginalis Piot’s biotype ARDRA Vaginolysin Sialidase

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Effects of palbociclib on oral squamous cell carcinoma and the role of PIK3CA in conferring resistance

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Cancer Biology & Medicine 2019年第2期16卷 264-275页

作者： Nur syafinaz Zainal Bernard Kok Bang Lee Zheng Wei Wong Iuan Sheau Chin Pei San Yee Chai Phei Gan Kein Seong Mun Zainal Ariff Abdul Rahman J. Silvio Gutkind Vyomesh Patel Sok Ching Cheong Head and Neck Team Cancer Research Malaysia Selangor 47500 Malaysia Department of Oral & Maxillofacial Clinical Sciences Faculty of Dentistry University of Malaya Kuala Lumpur 50603 Malaysia Department of Pathology Faculty of Medicine University of Malaya Kuala Lumpur 50603 Malaysia Oral Cancer Research and Co-ordinating Centre (OCRCC) Faculty of Dentistry University of Malaya Kuala Lumpur 50603 Malaysia Department of Pharmacology University of California San Diego 92093-5004 CA USA

Objective: Lack of effective therapies remains a problem in the treatment of oral squamous cell carcinoma(OSCC), especially in patients with advanced tumors. OSCC development is driven by multiple aberrancies within the cell cycle pathway, including amplification of cyclin D1 and loss of p16. Hence, cell cycle inhibitors of the CDK4/6-cyclin D axis are appealing targets for OSCC treatment. Here, we determined the potency of palbociclib and identified genetic features that are associated with the response of palbociclib in ***: The effect of palbociclib was evaluated in a panel of well-characterized OSCC cell lines by cell proliferation assays and further confirmed by in vivo evaluation in xenograft models. PIK3CA-mutant isogenic cell lines were used to investigate the effect of PIK3CA mutation towards palbociclib ***: We demonstrated that 80% of OSCC cell lines are sensitive to palbociclib at sub-micromolar ***, palbociclib was effective in controlling tumor growth in mice. We identified that palbociclib-resistant cells harbored mutations in PIK3CA. Using isogenic cell lines, we showed that PIK3CA mutant cells are less responsive to palbociclib as compared to wild-type cells with concurrent upregulation of CDK2 and cyclin E1 protein levels. We further demonstrated that the combination of a PI3 K/mTOR inhibitor(PF-04691502) and palbociclib completely controlled tumor growth in ***: This study demonstrated the potency of palbociclib in OSCC models and provides a rationale for the inclusion of PIK3CA testing in the clinical evaluation of CDK4/6 inhibitors and suggests combination approaches for further clinical studies.

关键词： OSCC palbociclib CDK4/6 inhibitors PIK3CA

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