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A novel herbal combination ameliorates ovarian dysfunction and regulates altered biochemical parameters in rats with letrozole-induced polycystic ovary syndrome

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Asian pacific Journal of Reproduction 2023年第1期12卷 23-34页

作者： Sunita Shailajan Sasikumar Menon swati singh Yugandhara Patil Herbal Research Lab(Department of Botany) Ramnarain Ruia Autonomous CollegeMatungaMumbai-400019India Therapeutic Drug Monitoring Laboratory Sion(East)Mumbai-400022India

Objective:To investigate the potential activity of novel herbal combination and novel herbal formulation(syrup)in female Sprague Dawley rats with letrozole-induced polycystic ovary syndrome(PCOS).Methods:Forty-two rats were randomly divided into seven groups with six rats in each *** 1 received 0.5%carboxy methylcellulose orally for 37 days and served as the normal control *** 2 was orally administered with letrozole of 1 mg/kg for 21 days and served as the PCOS induction group without *** 3 to 7 were administered with letrozole of 1 mg/kg for 21 days orally to induce PCOS,and then respectively received clomiphene citrate at 1 mg/kg,100 and 200 mg/kg of novel herbal combination,200 mg/kg of novel herbal formulation(syrup),and 400 mg/kg of marketed formulation of Pushyanuga churna,once daily for 15 *** of the novel herbal combination and its syrup formulation were evaluated on the hormonal profile,the levels of antioxidants,the lipid profile and on the ovarian morphology,using letrozole-induced PCOS model in ***:Letrozole caused alterations in hormonal levels and lipid levels similar to PCOS and ovarian histology showed presence of ovarian cysts confirming the induction of PCOS in *** treatment with the novel herbal combination and its syrup formulation in PCOS-induced rats,the altered hormonal and lipid profiles showed significant recovery to normal *** histology confirmed the restoration of folliculogenesis in the PCOS-induced *** treatment with the syrup formulation of novel herbal combination was found to be more effective than novel herbal combination and showed better recovery in various parameters *** results of the study,however,suggested that treatment with novel herbal combination and its syrup formulation provided minimal protection against oxidative stress caused due to the induction of ***:The integrated approach for management of PCOS is to counterbalance the limita

关键词： Polycystic ovarian syndrome Polyherbal combination Letrozole Pushyanuga churna Clomiphene citrate Histopathology Biochemical Herbal

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Deep Learning Based Automated Detection of Diseases from Apple Leaf Images

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Computers, Materials & Continua 2022年第4期71卷 1849-1866页

作者： swati singh Isha Gupta Sheifali Gupta Deepika Koundal Sultan Aljahdali Shubham Mahajan Amit Kant Pandit Department of Electronics and Communication Engineering University Institute of TechnologyHimachal Pradesh UniversityShimla171005India Chitkara University Institute of Engineering and Technology Chitkara UniversityPunjabIndia Department of Systemics School of Computer ScienceUniversity of Petroleum and Energy StudiesDehradunIndia Department of Computer Science College of Computers and Information TechnologyTaif UniversityP.O.Box 11099Taif 21944Saudi Arabia School of Electronics&Communication Shri Mata Vaishno Devi UniversityKatra185320India

In Agriculture Sciences, detection of diseases is one of the mostchallenging tasks. The mis-interpretations of plant diseases often lead towrong pesticide selection, resulting in damage of crops. Hence, the automaticrecognition of the diseases at earlier stages is important as well as economicalfor better quality and quantity of fruits. Computer aided detection (CAD)has proven as a supportive tool for disease detection and classification, thusallowing the identification of diseases and reducing the rate of degradationof fruit quality. In this research work, a model based on convolutional neuralnetwork with 19 convolutional layers has been proposed for effective andaccurate classification of Marsonina Coronaria and Apple Scab diseases fromapple leaves. For this, a database of 50,000 images has been acquired bycollecting images of leaves from apple farms of Himachal Pradesh (H.P)and Uttarakhand (India). An augmentation technique has been performedon the dataset to increase the number of images for increasing the *** performance analysis of the proposed model has been compared with thenew two Convolutional Neural Network (CNN) models having 8 and 9 layersrespectively. The proposed model has also been compared with the standardmachine learning classifiers like support vector machine, k-Nearest Neighbour, Random Forest and Logistic Regression models. From experimentalresults, it has been observed that the proposed model has outperformed theother CNN based models and machine learning models with an accuracy of99.2%.

关键词： Deep learning convolutional neural network apple leaves apple scab support vector machine

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Merkel Cell Carcinoma of Eyelid: A Rare Clinical Presentation and Diagnostic Challenge

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Open Journal of Ophthalmology 2013年第1期3卷 16-18页

作者： Manpreet singh swati singh Usha singh Zoramthara Zadeng Department of ophthalmology Advanced Eye Center Post Graduate Institute of Medical Education and Research Chandigarh India.

The purpose of this paper is to report a case of rare localised (limited to eyelid) malignant eyelid tumor in a 70 year old Indian male. Histopathology confirmed it to be a Merkel cell carcinoma. Surgical excision and eyelid reconstruction was done successfully. No local or systemic recurrence has been noted at a follow up of 2 years. The well defined nature of a highly malignant tumor, its localised presentation and management is being described in following report.

关键词： Merkel Cell Carcinoma Eyelid Clinical Features Management

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Polaritonic heat engines-a single atom and a single photon

Polaritonic heat engines-a single atom and a single photon

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第十七届全国量子光学学术会议

作者：宋乔 swati singh Keye Zhangy Weiping Zhang Pierre Meystre 华东师范大学 B2 Institute Department of Physics and College of Optical SciencesUniversity of Arizona Quantum Institute for Light and Atoms School of Physics and Material ScienceEast China Normal University Department of Physics and Astronomy Shanghai Jiao Tong University

＜正＞Hybrid quantum systems can often be described in terms of *** are quasiparticles formed of superpositions of their constituents with relative weights depending on some control parameter in their *** many cases,these constituents are coupled to reservoirs at different *** suggests a general approach to the realization of

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Genetic Variability and Elite Line Selection for High Essential Oil and Nepetalactone Content in Catmint (<i>Nepeta cataria</i>L.)

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American Journal of Plant Sciences 2021年第7期12卷 1135-1154页

作者： Abhilasha Srivastava Soni Gupta swati singh Ram Swaroop Verma Ramesh Kumar Srivastava Anil Kumar Gupta Raj Kishori Lal Academy of Scientific and Innovative Research (AcSIR) Ghaziabad India Division of Plant Breeding and Genetic Resource Conservation CSIR—Central Institute of Medicinal and Aromatic Plants P.O. CIMAP Lucknow India Phytochemistry Division CSIR—Central Institute of Medicinal and Aromatic Plants P.O. CIMAP Lucknow India Technology and Business Development Division CSIR—Central Institute of Medicinal and Aromatic Plants P.O. CIMAP Lucknow India

Nepeta cataria L., commonly known as catmint or catnip, belongs to the family “Lamiaceae” and is indigenous to Europe and Asia. The essential oil of this species is known for the richness and diversity of nepetalactones (NPL) which are used as mosquito/insect repellents in perfumery and cosmetic industries. Reports on Indian catmint germplasm are very meager and warrants exploration of its commercial potential as a natural, non-toxic source of insect repellents. With this objective, commercial open-pollinated seeds of catmint collected from its native, temperate habitat in Himalayas were introduced in the tropical plains. Subsequent to adaptation to a new zone we were able to isolate nineteen individual plants based on plant growth. Hydrodistillation of the fresh herb yielded essential oil in the range of 0.01% to 0.2%. Gas Chromatography (GC) and GC-Mass Spectrometry (GC-MS) analyses of the oil revealed the dominance of monoterpene hydrocarbon, namely, 4aα,7α,7aα NPL (1) isomer (84%). The other two isomers of nepetalactone, 4aα,7α,7aβ NPL (2) and 4aα,7β,7aα NPL (3) were also present, although in very less amounts (1.0% and 1.6%, respectively). Sesquiterpenes identified were α-humulene (traces), (

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Detection of Behavioral Patterns Employing a Hybrid Approach of Computational Techniques

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Computers, Materials & Continua 2022年第7期72卷 2015-2031页

作者： Rohit Raja Chetan Swarup Abhishek Kumar Kamred Udham singh Teekam singh Dinesh Gupta Neeraj Varshney swati Jain Department of Information Technology Guru Ghasidas VishwavidyalayaBilaspur495009India Department of Basic Science College of Science&Theoretical StudiesSaudi Electronic University13316Saudi Arabia Department of Computer Science&IT JAIN(Deemed to be University)Bangalore560069India Computer Science and Information Science Cheng Kung University621301Taiwan School of Computer Science University of Petroleum and Energy StudiesDehradun248007India Department of CSE I K Gujral Punjab Technical UniversityJalandhar144603India Department of Computer Engineering and Applications GLA UniversityMathura281406India Department of Computer Science Government J Yoganandam Chhattisgarh CollegeRaipur492001India

As far as the present state is concerned in detecting the behavioral pattern of humans(subject)using morphological image processing,a considerable portion of the study has been conducted utilizing frontal vision data of human *** present research work had used a side vision of human-face data to develop a theoretical framework via a hybrid analytical model *** this example,hybridization includes an artificial neural network(ANN)with a genetic algorithm(GA).We researched the geometrical properties extracted from side-vision human-face *** additional study was conducted to determine the ideal number of geometrical characteristics to pick while *** close vicinity ofminimum distance measurements is done for these clusters,mapped for proper classification and decision process of behavioral *** identify the data acquired,support vector machines and artificial neural networks are utilized.A method known as an adaptiveunidirectional associative memory(AUTAM)was used to map one side of a human face to the other side of the same *** behavioral pattern has been detected based on two-class problem classification,and the decision process has been done using a genetic algorithm with best-fit *** developed algorithm in the present work has been tested by considering a dataset of 100 subjects and tested using standard databases like FERET,Multi-PIE,Yale Face database,RTR,CASIA,*** complexity measures have also been calculated under worst-case and best-case situations.

关键词： Adaptive-unidirectional-associative-memory technique artificial neural network genetic algorithm hybrid approach

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Stability assessment of emulsion of carotenoids extracted from carrot bio-waste in flaxseed oil and its application in food model system

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Food Bioscience 2022年第3期47卷 1016-1022页

作者： swati Tiwari Neelam Upadhyay Ashish Kumar singh Dairy Technology Division ICAR-National Dairy Research InstituteKarnal132001HaryanaIndia

The research was conducted on the stability assessment of emulsion of carotenoids extracted from carrot-pomace in omega-3 rich flaxseed oil,followed by converting this emulsion into freeze-dried powder,and its application as natural functional colorant in the preparation of flavored *** study indicated that emulsion was stable over a range of pH (5–9),temperature (forewarming to HTST pasteurization) and ionic strength (0.1–0.75 M NaCl) except at pH 4,sterilization temperature and 1.0 M NaCl based on zeta potential and particle size of emulsion analysed at these *** percent (out of 8,10 and 12%) of freeze-dried emulsion was selected for addition as a natural functional ingredient in flavored milk on the basis of organoleptic *** fat,protein,total solids,total carotenoid content and antioxidant value (in terms of ABTS and reducing power assay) of developed product were significantly higher (p < 0.05) than *** whiteness index of control was significantly higher (p < 0.05) than the developed product,while reverse was true for yellowness ***,both the products showed total color difference of *** research concludes that carotenoid-rich emulsion can be efficiently freeze-dried and used as a functional natural colorant in flavored milk for providing it better bio-functional attributes over control.

关键词： Carotenoids Carrot bio-waste Nano-emulsion Stability studies Flavored milk

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Dengue:epidemiology,prevention and pressing need for vaccine development

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Asian Pacific Journal of Tropical Medicine 2010年第12期3卷 997-1000页

作者： Kuldeep Kumar Pankaj Kumar singh Juhi Tomar swati Baijal UCL Centre for International Health and Development Institute of Child Health 30 Guilford StreetLondon WC1N 1EHUK Department of Medical Physics and Neurosurgery Royal Hallamshire hospitalSheffieldUK Medical Education Centre Northern General HospitalSheffieldUK Cambridge School SriniwaspuriNew DelhiIndia 110065

Dengue fever is a mosquito born viral infection,and the complicated form of dengue is dengue hemorrhagic fever(DHF).In the recent decades incidence and distribution of dengue has increased *** viruses belong to family flaviviridae with four serotypes and are transmitted mainly by mosquito Aedes *** almost two-fifth of world’s population (2.5 million) is at risk of dengue and no specific antiviral drug or vaccine is available against *** population growth in Africa and South East Asia has increased number of susceptible hosts in urban and semi urban *** 40%of world population resides in the high risk area for dengue *** to latest estimates by WHO,yearly 50 to 100 million infections occur globally,this includes around 500 000 DHF and 22 000 deaths,mostly among *** symptomatic treatment in the form of analgesic,antipyretics and body fluid management is provided to the *** strategies mainly focus on two approaches, firsdy on activities to control vector and secondly on activities to protect human from mosquito bite but there is always concerns regarding their sustainably and *** development of an effective dengue vaccine is feasible and production of an effective and affordable vaccine could be a viable option to save humans from this dreadful disease. Conceptually vaccine production is possible,but it has to be tetravalent,providing immunity against all *** candidate vaccines are in advance stage of their development:however international cooperation is needed to make these vaccines available on cheaper rates to the poor and vulnerable *** of this review is to discuss various aspects related to dengue,its epidemiology,available preventive methods,need for vaccine and challenges in its development.

关键词： Dengue Epidemiology Prevention Vaccine

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Conservation Strategy for African Medicinal Species: In Vitro Biotechnological Approach

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Phyton-International Journal of Experimental Botany 2020年第4期89卷 779-794页

作者： Priyanka Jha swati Chahal Devendra Kumar Pandey Joginder singh Ram Prasad Vijay Kumar Amity Institute of Biotechnology Amity UniversityKolkataWest Bengal700156India Plant Biotechnology Laboratory Division of Research and DevelopmentLovely Professional UniversityPhagwara144411PunjabIndia Department of Biotechnology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara144411PunjabIndia Department of Microbiology School of Bioengineering and BiosciencesLovely Professional UniversityPhagwara144411PunjabIndia Department of Botany School of Life SciencesMahatma Gandhi Central UniversityMotihariBihar845401India

The use of medicinal plants for different therapeutic values is well documented in African *** diverse biodiversity hotspots provide a wide range of endemic species,which ensures a potential medicinal *** feasible conservation approach and sustainable harvesting for the medicinal species remains a huge ***,conservation approach through different biotechnological tools such as micropropagation,somatic embryogenesis,synthetic seed production,hairy root culture,molecular markers based study and cryopreservation of endemic African medicinal species is much *** this review,an attempt has been made to provide different in vitro biotechnological approaches for the conservation of African medicinal *** present review will be helpful in further technology development and deciding the priorities at decision-making levels for in vitro conservation and sustainable use of African medicinal species.

关键词： Biotechnological approach conservation medicinal plant African traditional medicine(ATM) start codon targeted polymorphism(SCoT) somatic embryogenesis

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Feasibility and efficacy of delayed pharmacoinvasive therapy for STelevation myocardial infarction

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World Journal of Cardiology 2023年第1期15卷 23-32页

作者： Rishi Sethi Lalit Mohan Pravesh Vishwakarma Abhishek singh swati Sharma Monika Bhandari Ayush Shukla Akhil Sharma Gaurav Chaudhary Akshyaya Pradhan Sharad Chandra Varun Shankar Narain Sudhanshu Kumar Dwivedi Department of Cardiology King George's Medical UniversityLucknow 226003Uttar PradeshIndia

BACKGROUND ST-elevation myocardial infarction(STEMI)refers to a clinical syndrome that features symptoms of myocardial ischemia with consequent ST-elevation on electrocardiography and an associated rise in cardiac *** restoration of brisk flow in the coronary vasculature is critical in reducing mortality and *** patients with STEMI who could not receive primary percutaneous coronary intervention(PCI)on time,pharmacoinvasive strategy(thrombolysis followed by timely PCI within 3-24 h of its initiation)is an effective *** To analyze the role of delayed pharmacoinvasive strategy in the window period of 24-72 h after *** This was a physician-initiated,single-center prospective registry between January 2017 and July 2017 which enrolled 337 acute STEMI patients with partially occluded coronary *** received routine pharmacoinvasive therapy(PCI within 3-24 h of thrombolysis)in one group and delayed pharmacoinvasive therapy(PCI within 24-72 h of thrombolysis)in another *** primary endpoint was major adverse cardiac and cerebrovascular events(MACCE)within 30 d of the *** secondary endpoints included major bleeding as defined by Bleeding Academic Research Consortium classification,angina,and dyspnea within 30 *** The mean age in the two groups was comparable(55.1±10.1 years vs 54.2±10.5 years,P=0.426).Diabetes was present among 20.2%and 22.1%of patients in the routine and delayed groups,*** rate was 54.6%and 55.8%in the routine and delayed groups,*** was initiated within 6 h of onset of symptoms in both groups(P=0.125).The mean time from thrombolysis to PCI in the routine and delayed groups was 16.9±5.3 h and 44.1±14.7 h,*** significant difference was found for the occurrence of measured clinical outcomes in the two groups within 30 d(8.7%vs 12.9%,P=0.152).Univariate analysis of demographic characteristics and risk factors for patients who reporte

关键词： Coronary artery disease ST-elevation myocardial infarction Primary percutaneous coronary intervention Pharmacoinvasive strategy Thrombolysis Atherosclerosis

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