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Engineering microscale systems for fully autonomous intracellular neural interfaces

Microsystems & Nanoengineering 2020年第1期6卷 1276-1295页

作者： swathy sampath kumar Michael S.Baker Murat Okandan Jit Muthuswamy Biomedical Engineering School of Biological and Health Systems EngineeringArizona State UniversityTempeAZ 85287USA Mechanical Engineering Sandia National laboratoriesAlbuquerqueNMUSA mPower Technology Inc.AlbuquerqueNM 87102USA

Conventional electrodes and associated positioning systems for intracellular recording from single neurons in vitro and in vivo are large and bulky,which has largely limited their scalability.Further,acquiring successful intracellular recordings is very tedious,requiring a high degree of skill not readily achieved in a typical laboratory.We report here a robotic,MEMS-based intracellular recording system to overcome the above limitations associated with form factor,scalability,and highly skilled and tedious manual operations required for intracellular recordings.This system combines three distinct technologies:(1)novel microscale,glass–polysilicon penetrating electrode for intracellular recording;(2)electrothermal microactuators for precise microscale movement of each electrode;and(3)closed-loop control algorithm for autonomous positioning of electrode inside single neurons.Here we demonstrate the novel,fully integrated system of glass–polysilicon microelectrode,microscale actuators,and controller for autonomous intracellular recordings from single neurons in the abdominal ganglion of Aplysia californica(n=5 cells).Consistent resting potentials(60 mV)were recorded after each successful penetration attempt with the controller and microactuated glass–polysilicon microelectrodes.The success rate of penetration and quality of intracellular recordings achieved using electrothermal microactuators were comparable to that of conventional positioning systems.Preliminary data from in vivo experiments in anesthetized rats show successful intracellular recordings.The MEMS-based system offers significant advantages:(1)reduction in overall size for potential use in behaving animals,(2)scalable approach to potentially realize multi-channel recordings,and(3)a viable method to fully automate measurement of intracellular recordings.This system will be evaluated in vivo in future rodent studies.

关键词： recording electrode system

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