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The role of autophagy in the treatment of osteoporosis by Chinese medicines(natural)

Traditional Medicine Research 2023年第10期8卷 30-46页

作者： Yu Zhou Xin Li Yang Chen Liqi Ng swastina nath varma Chao-Zong Liu Qing Gong Cheng-Liang Yin Foot and Ankle Surgery Chongqing Orthopedic Hospital of Traditional Chinese MedicineChongqing 400012China Institute of Orthopaedic and Musculoskeletal Science Royal National Orthopaedic HospitalLondon HA74LPUK Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130117China Department of Endocrinology Chongqing Hospital of Traditional Chinese MedicineChongqing 400011China Institute of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchun 130117China Faculty of Medicine Macao University of Science and TechnologyMacao 999078China

Osteoporosis is one of the common orthopaedic diseases,characterised by increased bone fragility due to reduced bone mass and microstructural degeneration,posing a great threat to patients’quality of life and *** recent years,Chinese medicine(natural)has had a unique advantage in the treatment of osteoporosis and has shown good *** is an inherent cellular survival mechanism for the removal and recycling of damaged proteins and organelles and plays an important role in maintaining the stability of the intracellular environment and organ ***,this article aims to provide a comprehensive review of these Chinese medicines(natural)for the treatment of osteoporosis through *** have been intensively studied and reported to have effects such as promoting osteogenesis and anti-bone *** Chinese medicines include plants such as Cistanche deserticola,Epimedium,Curculigo orchioides Gaertn,Achyranthes bidentata Blume,Leonurus japonicus Houtt,Ginseng,Chuanxiong Rhizome,Eucommia ulmoides,Morindae Officinalis Radix,Curcuma longa,Polygoni Cuspidati Rhizoma et Radix,Anemarrhena asphodeloides Bunge,Salvia miltiorrhiza Bge and Pueraria Lobata,thus providing evidence for the use of alternative herbal therapies for the effective treatment of osteoporosis.

关键词： osteoporosis traditional Chinese medicine autophagy herb review

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Myeloid sarcoma with ulnar nerve entrapment:A case report

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World Journal of Clinical Cases 2022年第28期10卷 10227-10235页

作者： Da-Peng Li Chao-Zong Liu Mortimer Jeremy Xin Li Jin-Chao Wang swastina nath varma Ting-Ting Gai Wei-Qi Tian Qi Zou Yan-Mian Wei Hao-Yu Wang Chang-Jiang Long Yu Zhou Yantai Hospital of Shandong Wendeng Osteopathic&Traumatology Hand and Foot MicrosurgeryYantai 264009Shandong ProvinceChina University College London Royal National Orthopaedic HospitalLondon HA74LPUnited Kingdom Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina Yantai Hospital of Shandong Wendeng Osteopathic&Traumatology Hand and Foot MicrosurgeryYantai 264009China Qinhai University Medical InstituteXining 810000Qinhai ProvinceChina College of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina

BACKGROUND Myeloid sarcoma(MS) is relatively rare,occurring mainly in the skin and lymph nodes,and MS invasion of the ulnar nerve is particularly *** main aim of this article is to present a case of MS invading the brachial plexus,causing ulnar nerve entrapment syndrome,and to further clinical understanding of the possibility of MS invasion of peripheral *** SUMMARY We present the case of a 46-year-old man with a 13-year history of well-treated acute nonlymphocytic leukaemia who was admitted to the hospital after presenting with numbness and pain in his left little *** initial diagnosis was considered a simple case of nerve entrapment disease,with magnetic resonance imaging showing slightly abnormal left brachial plexus nerve alignment with local thickening,entrapment,and high signal on compression lipid *** to the severity of the ulnar nerve compression,we surgically investigated and cleared the entrapment and nerve tissue hyperplasia;however,subsequent pathological biopsy results revealed evidence of *** patient had significant relief from his neurological symptoms,with no postoperative complications,and was referred to the haemato-oncology department for further consultation about the primary *** is the first report of safe treatment of ulnar nerve entrapment from *** is intended to inform hand surgeons that nerve entrapment may be associated with extramedullary MS,as a rare presenting feature of the *** MS invasion of the brachial plexus and surrounding tissues of the upper arm,resulting in ulnar nerve entrapment and degeneration with significant neurological pain and numbness in the little finger,is *** treatment significantly relieved the patient’s nerve entrapment symptoms and prevented further neurological *** case is reported to highlight the rare presenting features of MS.

关键词： Myeloid sarcoma Ulnar nerve entrapment syndrome Acute nonlymphocytic leukaemia Sarcoma Upper limb surgery Case report

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On the mechanical aspect of additive manufactured polyether-ether-ketone scaffold for repair of large bone defects

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Biomaterials Translational 2022年第2期3卷 142-151页

作者： Seyed Ataollah Naghavi Changning Sun Mahbubeh Hejazi Maryam Tamaddon Jibao Zheng Leilei Wang Chenrui Zhang swastina nath varma Dichen Li Mehran Moazen Ling Wang Chaozong Liu Institute of Orthopaedic&Musculoskeletal Science University College LondonRoyal National Orthopaedic HospitalLondonUK State Key Laboratory for Manufacturing Systems Engineering School of Mechanical EngineeringXi’an Jiaotong UniversityXi’anShaanxi ProvinceChina Department of Mechanical Engineering University College LondonLondonUK.

Polyether-ether-ketone(PEEK)is widely used in producing prosthesis and have gained great attention for repair of large bone defect in recent years with the development of additive *** is due to its excellent biocompatibility,good heat and chemical stability and similar mechanical properties which mimics natural *** this study,three replicates of rectilinear scaffolds were designed for compression,tension,three-point bending and torsion test with unit cell size of 0.8 mm,a pore size of 0.4 mm,strut thickness of 0.4 mm and nominal porosity of 50%.Stress-strain graphs were developed from experimental and finite element analysis *** Young’s modulus and yield strength of the scaffolds were measured from the slop of the stress-strain graph to be 395 and 19.50 MPa respectively for compression,427 and 6.96 MPa respectively for tension,257 and 25.30 MPa respectively for three-point bending and 231 and 12.83 MPa respectively for torsion *** finite element model was found to be in good agreement with the experimental *** fracture of the struct subjected to tensile strain was the main failure mode of the PEEK scaffold,which stems from the low crystallinity of additive manufacturing *** mechanical properties of porous PEEK are close to those of cancellous bone and thus are expected to be used in additive manufacturing PEEK bone implants in the future,but the lower yield strength poses a design challenge.

关键词： additive manufacturing bone scaffold finite element analysis mechanical behaviour lattice structure PEEK scaffold

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Giant schwannoma of thoracic vertebra: A case report

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World Journal of Clinical Cases 2021年第36期9卷 11448-11456页

作者： Yu Zhou Chao-Zong Liu Shan-Yong Zhang Hao-Yu Wang swastina nath varma Lan-Qing Cao Ting-Ting Hou Xin Li Bao-Jin Yao College of Traditional Chinese Medicine Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina Division of Surgery and Interventional Science University College LondonRoyal National Orthopaedic HospitalLondon Stanmore HA74LPUnited Kingdom Department of Spinal Surgery The Second Affiliated Hospital of Jilin UniversityChangchun 130000Jilin ProvinceChina Department of Pathology The Second Affiliated Hospital of Jilin UniversityChangchun 130041Jilin ProvinceChina Jilin Ginseng Academy Changchun University of Chinese MedicineChangchun 130000Jilin ProvinceChina

BACKGROUND It is relatively rare for schwannomas to invade bone,but it is very rare for a large mass to form concurrently in the paravertebral *** resection is the only effective *** of the extensive tumor involvement and the many important surrounding structures,the tumor needs to be fully *** of the tumors are completely removed by posterior combined open-heart surgery to relieve spinal cord compression,restore the stability of the spine and maximize the recovery of nerve and spinal cord *** main objective of this article is to present a schwannoma that had invaded the T5 and T6 vertebral bodies and formed a large paravertebral mass with simultaneous invasion of the spinal canal and compression of the spinal *** SUMMARY A 40-year-old female suffered from intermittent chest and back pain for 8 *** tomography and magnetic resonance imaging scans showed a paravertebral tumor of approximately 86 mm×109 mm×116 mm,where the adjacent T5 and T6 vertebral bodies were invaded by the tumor,the right intervertebral foramen was enlarged,and the tumor had invaded the spinal canal to compress the thoracic *** preoperative puncture biopsy diagnosed a benign *** resection of the tumor was achieved by a two-step *** the first step,the thoracic surgeon adopted a lateral approach to separate the thoracic tumor from the *** the second step,a spine surgeon performed a posterior midline approach to dissect the tumor from the vertebral junction through removal of the tumor from the posterior side and further resection of the entire T5 and T6 vertebral *** large bone defect was reconstructed with titanium mesh,and the posterior root arch was *** to the large amount of intraoperative bleeding,we performed tumor angioembolization before surgery to reduce and avoid large intraoperative *** postoperative diagnosis of benign schwannoma was confirmed by histochemical exam

关键词： Giant schwannoma Neurilemmoma Spinal tumor Surgery Case report

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