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Association of Serum Ferritin Levels and Thyroid Hormones

Open Journal of Clinical Diagnostics 2023年第3期13卷 68-79页

作者： Hari Krishnan Krishnamurthy swarnkumar re.dy Vasanth Jayaraman Karthik Krishna Qi Song Karenah E. Rajasekaran Tianhao Wang Kang Bei John J. Rajasekaran Vibrant Sciences LLC. San Carlos USA Vibrant America LLC. San Carlos USA

Thyroid metabolism is orchestrated by the action of various minerals and trace elements including iron, iodine, selenium, and zinc. Iron deficiency, specifically deficiency in serum ferritin levels, is one of the common causes of thyroid dysfunction. Our objective was to evaluate the relationship between serum ferritin levels and circulating thyroid hormones. For this, a retrospective analysis was performed on 16,512 individuals who tested for serum levels of ferritin and thyroid profile at Vibrant America Clinical Laboratories. Subjects were stratified based on the serum levels of ferritin. Age (p −0.03232, p relation exhibited a considerable correlation between varying serum ferritin levels with all tested thyroid hormones. The study concludes that serum ferritin levels were associated with thyroid hormone synthesis and metabolism in individuals with optimal levels of circulating ferritin.

关键词： Ferritin Thyroxine Free Triiodothyronine Free Thyroxine Thyroid Stimulating Hormone

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relationship of High Sensitivity C-reactive Protein with Cardiovascular, Diabetic, and Hepatic Biomarkers

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International Journal of Clinical Medicine 2023年第9期14卷 389-401页

作者： Hari Krishnan Krishnamurthy swarnkumar re.dy Vasanth Jayaraman Karthik Krishna Qi Song Karenah E. Rajasekaran Tianhao Wang Kang Bei John J. Rajasekaran Vibrant Sciences LLC San Carlos CA USA Vibrant America LLC San Carlos CA USA

Biomarkers are early predictors of various disorders, circulating level of C-reactive protein is a sensitive biomarker of systemic inflammation and may also be associated with the development of diabetic, hepatic, and cardiovascular diseases. In the present study, we aimed to investigate the association between circulating levels of high sensitive C-reactive protein (hs-CRP) and various biomarkers for hepatic, diabetic, and cardiovascular health. The retrospective analysis included 438 individuals who were tested for these panels simultaneously at Vibrant America Clinical Laboratory. The study population included free-living individuals without any preexisting clinical conditions. Among the cardiovascular markers, a positive correlation and significant association was found between high levels of hs-CRP and serum levels of triglycerides (r = 0.0964, p −0.1423, p −0.1216, p re positively correlated with circulating hs-CRP. In the hepatic panel, AST, a transaminase that plays a vital role in amino acid metabolism, was found to have a strong positive correlation with hs-CRP (r = 0.2139, p results clearly show the association of hs-CRP with diabetic, hepatic, and cardiovascular risk factors indicating its central value as a key marker for several lifestyle-associated disorders.

关键词： High Sensitive C-reactive Protein Systemic Inflammation Cardiovascular Disorders Diabetes Triglycerides

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