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Expression quantitative trait analyses to identify causal genetic variants for type 2 diabetes susceptibility

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World Journal of Diabetes 2014年第2期5卷 97-114页

作者： swapan kumar das Neeraj kumar Section on Endocrinology and Metabolism Department of Internal Medicine Wake Forest School of Medicine

Type 2 diabetes(T2D) is a common metabolic disorder which is caused by multiple genetic perturbations affecting different biological pathways. Identifying genetic factors modulating the susceptibility of this complex heterogeneous metabolic phenotype in different ethnic and racial groups remains challenging. Despite recent success, the functional role of the T2D susceptibility variants implicated by genome-wide association studies(GWAS) remains largely unknown. Genetic dissection of transcript abundance or expression quantitative trait(eQTL) analysis unravels the genomic architecture of regulatory variants. Availability of eQTL information from tissues relevant for glucose homeostasis in humans opens a new avenue to prioritize GWASimplicated variants that may be involved in triggering a causal chain of events leading to T2D. In this article, we review the progress made in the field of eQTL research and knowledge gained from those studies in understanding transcription regulatory mechanisms in human subjects. We highlight several novel approaches that can integrate eQTL analysis with multiple layers of biological information to identify ethnic-specific causal variants and gene-environment interactions relevant to T2D pathogenesis. Finally, we discuss how the eQTL analysis mediated search for "missing heritability" may lead us to novel biological and molecular mechanisms involved in susceptibility to T2D.

关键词： Type 2 diabetes Single nucleotide polymorphisms Expression quantitative trait locus Expression regulatory SNPs Gene-environment interaction Genome-wide association study

Influence of scattering of SH-waves in dynamic interaction of shear wall with soil layers

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Earthquake Engineering and Engineering Vibration 2020年第3期19卷 583-595页

作者： Shashi kumar swapan kumar Chakraborty Department of Mathematics Sarala Birla UniversityRanchi 835103India Department of Applied Mathematics Cambridge Institute of TechnologyRanchi 835103India Department of Mathematics Birla Institute of TechnologyMesraRanchi 835215India

The dynamic soil-structure interaction of a shear wall embedded in elastic isotropic and homogeneous soil layers underlain by bedrock,subjected to SH waves,is modeled in the present *** soil layers consist of irregular interfaces and it has been shown that the scattering due to the roughness of the layers has significant effect on the displacement of both the foundation and the shear *** demonstrate the phenomena indirect boundary element method(IBEM)has been used on the basis of its validation in previous problems of similar *** system response is compared with the analytical solution of the same type of model for vertically propagating incident SH *** is observed that for the low frequency of wave,displacement is abruptly high,and as a result the combination of shear wall and foundation perceives *** thickness of the soil layer,mass of the shear wall,stiffness of the bedrock and the soil layers all affects the system frequency and displacement.

关键词： soil dynamic interaction

Tree assemblages and diversity patterns in Tropical Juri Forest,Bangladesh

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Journal of Forestry Research 2015年第1期26卷 159-169页

作者： swapan kumar Sarker Muhammad Nur-Un-Nabi Md.Mohasinul Haque Mahmuda Sharmin Sanjay Saha Sonet Sourav das Niamjit das Department of Forestry and Environmental Science Shahjalal University of Science & Technology

Juri is a biodiversity-rich primary forest in Bangladesh, which remains ecologically unexplored. We identified tree species and examined the richness, alpha（a）diversity and floristic similarity patterns within the identified communities. Vegetation and environmental data were sampled in 120（0.04 ha） study plots. Tree communities were delimited by two-way indicator species analysis（TWINSPAN）. In total, 78 tree species of 35 families and58 genera were identified. TWINSPAN identified six tree communities： A—Tricalysia singularis; B—Kydia calycina-Castanopsis tribuloides; C—Polyalthia simiarum-Duabanga grandiflora; D—Ficus roxburghii; E—Artocarpus lacucha; F—Artocarpus lacucha. Mean richness, Shannon and Gini-Simpson indices were highest for the Polyalthia simiarum-Duabanga grandiflora community, while Ficus roxburghii showed lowest diversity. Significant differences（p = 0.05） in three diversity indices were recorded between Polyalthia simiarum-Duabanga grandiflora and Ficus roxburghii. Tree compositional similarity was greatest between Kydia calycina-Castanopsis tribuloides and Polyalthia simiarum-Duabanga grandiflora（0.712）.

关键词： Two-way indicator species analysis(TWINSPAN) Richness index Shannon index Gini-Simpson index Tropical forest Conservation

Effect of molasses binder on the physical and mechanical properties

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International Journal of Minerals,Metallurgy and Materials 2019年第1期26卷 41-51页

作者： Anand Babu Kotta Anshuman Patra Mithilesh kumar swapan kumar Karak Department of Metallurgical and Materials Engineering National Institute of Technology

Molasses was used as an alternative binder to the bentonite binder. The change in moisture absorption by pellets prepared with different iron ores and different molasses contents were investigated. Iron ore properties exerted the major effect on pellet behavior and final pellet quality. The absorbed moisture content of pellets prepared without binder, bentonite-added pellets, and molasses-added pellets were in the range of 7.72%–9.95%, 9.62%–10.84%, and 6.14%-6.69%, respectively. The wet pellet compressive strength of molasses-added pellets(43–230 N/pellet) was superior to that of bentonite-added pellets(9.47–11.92 N/pellet). The compressive strength of dried molasses-modified pellets increased to 222–394 N/pellet, which is currently the highest value achieved for dried pellets.

关键词： iron ore molasses binder moisture absorption pellet strength physical and mechanical properties

Study of Improved Load Sharing Methodologies for Distributed Generation Units Connected in a Microgrid

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CSEE Journal of Power and Energy Systems 2017年第3期3卷 311-320页

作者： Rajashree Dhua Debashis Chatterjee swapan kumar Goswami Electrical Engineering Department Jadavpur UniversityKolkata 700032India

In this paper,an improved load sharing strategy is proposed for distributed generation units(DGs)connected in a *** frequency and voltage droop control result in unacceptable active and reactive power *** proposed method formulates a suitable algorithm for load sharing in the islanded *** feeder power loss and the line impedance voltage drops are minimized so as to regulate the voltage at the point of common coupling(PCC)at its nominal *** desired DG output voltages are calculated and a linear relationship is obtained between the shared active and reactive powers and the DG output voltages.A master DG controller sets the frequency which is followed by other DG *** reference powers for the DG units are adjusted so as to maintain the rated PCC *** proposed strategy is verified taking into account the DG ratings,unequal line impedance drops,feeder losses,change in system impedance and effect of DG local loads and formulates an improved power sharing strategy that also facilitates PCC voltage regulation under variable loading *** and experimental results are presented to verify the effectiveness of the proposed method.

关键词： DG local loads distributed generation(DG) line impedance drops microgrid point of common coupling(PCC)voltage regulation power sharing

Analysis of a fractional-order SIS epidemic model with saturated treatment

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International Journal of Modeling, Simulation, and Scientific Computing 2021年第1期12卷 185-212页

作者： Soovoojeet Jana Manotosh Mandal swapan kumar Nandi T.K.Kar Department of Mathematics Ramsaday College Amta-711401HowrahWest BengalIndia Department of Mathematics Tamralipta Mahavidyalaya Tamluk-721636West BengalIndia Department of Mathematics Nayabasat P.M.Sikshaniketan Paschim Medinipur-721253West BengalIndia Department of Mathematics Indian Institute of Engineering Science and Technology Shibpur Howrah-711103West BengalIndia

In this paper,we propose and analyze a fractional-order SIS epidemic model with the saturated treatment and disease *** existence and uniqueness,nonnegativity and finiteness of solutions for our suggested model have been *** equilibria of the model are found and their local and global stability analyses are also ***,the conditions for fractional backward and fractional Hopf bifurcation are also analyzed in both the commensurate and incommensurate fractional-order *** study how the control parameter and the order of the fractional derivative play role in local as well as global stability of equilibrium points and Hopf *** have demonstrated the analytical results of our proposed model system through several numerical simulations.

关键词： Caputo fractional differentiation SIS epidemic model global asymptotic stability treatment control fractional Hopf bifurcation fractional backward bifurcation

Analysis of a fuzzy epidemic model with saturated treatment and disease transmission

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International Journal of Biomathematics 2018年第1期11卷 23-40页

作者： swapan kumar Nandi Soovoojeet Jana Manotosh Manadal T. K. Kar Department of MathematicsNayabasat P. M. Sikshaniketan Paschim Medinipur 721253 West Bengal India Department of Mathematics Ramsaday College Amta 711501 West Bengal India Department of Mathematics Tamralipta MahavidyalayaTamluk 721636 West Bengal India Department of MathematicsIndian Institute of Engineering Science and Technology Shibpur Howrah 711103 West Bengal India

In this paper, we describe an SIS epidemic model where both the disease transmission rate and treatment function are considered in saturated forms. The dynamical behavior of the system is analyzed. The system is customized by considering the disease trans- mission rate and treatment control as fuzzy numbers and then fuzzy expected value of the infected individuals is determined. The fuzzy basic reproduction number is investi- gated and a threshold condition of pathogen is derived at which the system undergoes a backward bifurcation.

关键词： SIS epidemic model fuzzy expected value fuzzy basic reproduction number backward bifurcation.

Chemical, physical, thermal, textural and mineralogical studies of natural iron ores from Odisha and Chhattisgarh regions, India

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Journal of Central South University 2018年第12期25卷 2857-2870页

作者： Anand Babu KOTTA swapan kumar KARAK Mithilesh kumar Department of Metallurgical and Materials Engineering National Institute of Technology

The chemical,physical,thermal and texture properties of iron ores from different regions of Odisha and Chhattisgarh regions,India,have been investigated to understand the compositional variations of Fe,Al2O3,SiO2,S and *** were analyzed for its susceptibility to meet the industrial requirements,for various iron manufacture *** analysis indicated that the majority of the iron ores is rich in hematite(>90wt%),poor in gangue(<4.09wt%SiO2and<3.8wt%Al2O3)and deleterious elements(P<0.065wt%and S<0.016wt%)in all these iron ores found to be *** peaks reviled that the gangue is in the form of kaolinite and quartz,and same was observed in Fourier transform infrared(FTIR)spectroscopy in the range of914to1034cm–*** iron ores were found to have excellent physical properties exemplify with tumbler index(82wt%–91wt%),abrasion index(1.27wt%–4.87wt%)and shatter index(0.87wt%–1.64wt%).FTIR and thermal analysis were performed to assimilate the analysis *** was found that these iron ores exhibit three endothermic reactions,which are dehydration below447K with mass loss of0.13wt%to1.7wt%,dehydroxylation at525–609K with mass loss of1.09wt%–4.49wt%and decomposition of aluminosilicates at597–850K with mass loss of0.13wt%–1.15wt%.From this study,we can conclude that due to its excellent physico-chemical characteristics,these iron ores are suitable for BF and DRI operations.

关键词： iron ore chemical analysis mineralogy analysis thermal analysis textural analysis

Transient MHD Couette Flow in a Rotating Environment Permeated by an Inclined Magnetic Field by Means of a Traveling Magnetic Field Subject to a Forced Oscillation

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World Journal of Mechanics 2018年第9期8卷 362-377页

作者： swapan kumar Ghosh Department of Mathematics Narajole Raj College Narajole West Bengal India

The present investigation reveals to a magnetohydrodynamic (MHD) start up flow of a rotating environment permeated by a traveling magnetic field with reference to a periodic driving force to explore the behaviour of a magnetic field at the resonant level. In a time varying electromagnetic field of sinusoidal in nature subject to ∇⋅J≠0, an oscillating current flow emerges the backbone of a radio emission in which the emission of hot electron gyrates in a magnetic field in the presence of a radiofrequency accelerator. The expedition of a radiofrequency field determines X-emission to expedite radiofrequency voltage under the influence of A.C circuit subject to ∇⋅J≠0. An oscillating current flow deals with an excitation frequency in such a way that phase angle rotates with angular frequency, the magnetic field grows towards the resonant level when the phase angle ωτ=π/2 is compatible with ω>0. In turn, plasma induced laser radiation is influenced by an oscillator with a decisive importance to an excitation frequency in the presence of a magnetic mirror so that maximum reflection occurs as the magnetic field increase in strength abruptly to exhibit resonance fluorescence. A synchronized laser photon light in transmitted from the Sun subject to ωτ=π/2.

关键词： MHD Start Up Flow Forced Oscillation Stagnation Radio Emission X-Emission Resonance Fluorescence Laser Radiation