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Correlation between tear fluid and serum vitamin D levels

Eye and Vision 2016年第1期3卷 178-182页

作者： swaminathan sethu Rohit Shetty Kalyani Deshpande Natasha Pahuja Nandini Chinnappaiah Aarti Agarwal Anupam Sharma Arkasubhra Ghosh GROW Research Laboratory Narayana Nethralaya Foundation#258/A Hosur RoadNarayana Health CityBommasandra560099 BangaloreIndia Cornea and Refractive Surgery Division Narayana NethralayaBangaloreIndia

Background:Vitamin D deficiency is associated with a range of systemic diseases including ocular *** objective of this study is to measure tear vitamin D levels and investigate the correlation between serum and tear vitamin D ***:A total of 48 healthy volunteers without any systemic and ocular disease were recruited for this observational cohort *** was collected using clot activator coated Vacutainer®Plus *** fluid was collected using Schirmer’s *** and tear total 25-hydroxyvitamin D levels were measured by competitive chemiluminescent ELISA and the correlation between the levels were ***:The measured serum 25-hydroxyvitamin D level ranged between 3.3 and 27.5 ng/ml(Mean±SEM,9.4±0.7 ng/ml;Median 8.4 ng/ml).Significantly(p<0.0001)higher level of 25-hydroxyvitamin D was detected in the tears(Mean±SEM,17.0±1.6 ng/ml;Range 3.2–45.8 ng/ml;Median,16.3 ng/ml)compared to *** average of~2 fold(Mean±SEM,1.9±0.2;Range 0.4–5.8;Median,1.7)higher 25-hydroxyvitamin D was observed in tears compared to serum in the *** addition,a positive correlation was observed between serum and tear 25-hydroxyvitamin D levels(r=0.5595;p<0.0001).Conclusions:A higher level of 25-hydroxyvitamin D was observed in the tear fluid compared to that of the *** would be beneficial to consider tear vitamin D levels to study its role with reference to ocular surface diseases.

关键词： Vitamin D 25-hydroxyvitamin D 1,25-dihydroxyvitamin D Tears Serum

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