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A survey of zoonotic diseases in trade cattle slaughtered at Tanga city abattoir:a cause of public health concern

Asian Pacific Journal of Tropical Biomedicine 2012年第1期2卷 55-60页

作者： swai es Schoonman L Veterinary Investigation Centre(VIC) Tanga Dairy Trust(TADAT)

Objective:To estimate the prevalence of hydatidosis,cysticercosis,tuberculosis,leptospirosis,brucellosis and toxoplasmosis in slaughtered bovine stock(aged≥3 years)at Tanga city abattoir,***:Prevalence estimation of the five zoonotic diseases was undertaken through an active abattoir and sero-survey was carried out in Tanga city,during the period of January 2002and March *** samples collected from a sub-sample(n=51)of the slaughter stock were serologically screened for antibodies against brucellosis,leptospirosis and toxoplasmosis using Rose Bengal plate test,microscopic agglutination test(for 5 serovars of Leptospira interrogans)and Eiken latex agglutination test,*** same animals were tested for tuberculosis using the single intradermal tuberculin ***:Post mortem examination of 12 444 slaughter cattle(10 790 short horn zebu and 1 654 graded)over a period of twenty two months,showed a prevalence of 1.56%(194)for hydatidosis,1.49%(185)for cysticercosis and 0.32%(40)for *** all three zoonoses,a statistically significant difference in infection rates was noted between the short horn zebu and graded breeds(Pes of animals with brucellosis,toxoplasmosis and leptospirosis antibodies were found to be 12%,12%and 51%,*** most common leptospiral antibodies detected were those against antigens of serovars Leptospira hardjo(29%),Leptospira tarassovi(18%),Leptospira bataviae(4%)and Leptospira pomona(0%).With regard to tuberculosis,10%(n=5)of the animals tested were classified as non-specific reactors or ***:The study findings suggest that brucellosis,toxoplasmosis and leptospirosis are prevalent in Tanga and provide definitive evidence of slaughtered stock exposure to these zoonotic agents with concurrent public health consequences.

关键词： Abattoir Slaughter stock Zoonoses Risk Tanga Tanzania Brucellosis Toxoplasmosis Leptospirosis Antibody Seroprevalence Zoonotic disease

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Microbial quality and associated health risks of raw milk marketed in the Tanga region of Tanzania

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Asian Pacific Journal of Tropical Biomedicine 2011年第3期1卷 217-222页

作者： swai es Schoonman L Veterinary Investigation Centre(VIC) Tanga Dairy Trust(TADAT)

Objective:To evaluate micmbial quality and associated health risks of raw milk marketed in the Tanga region of ***:A microbial quality assessment of marketed raw milk was undertaken by evaluating 59 samples of milk from selling points(collecting centres =15),bicycle boys(12) and kiosks/restaurants(32) in Tanga city during April-May *** and milkborne hazards were assessed using a combination of tests in order to quantify the occurrence of Brucellosis(milk ring test),escherichia coli(***) O157:H7(culture),the coliforra bacteria as well as standard plate count(SPC).Specific gravity(SG) determination was used as an indicator of ***:The mean coliform plate count(c.f.u/mL) of milk handled by bicycle boys(4.2×10~6) was significantly higher than that handled by collecting centres(3.0×10~6) and kiosk/ restaurants(1.4× 10~6),respectively(P es collected,33(56%) were Brucella milk ring test(MRT)-positive and 78%and 17%of the samples graded satisfactorily based on SG and coliform plate counts as prescribed by East African Community standards for raw *** was no verocytotoxigenic ***(VTEC) O157:H7 in any of the milk samples collected and analysed during the present ***:It can be concluded that raw market milk in the study area is of poor bacteriological quality and hazardous for human consumption. This highlights the need to implement good hygiene practices and effective monitoring from production through the delivery chain to the *** studies are needed for detection of toxins that are produced by ***,other pathogenic spore forming bacteria(Bacillus *** Clostridium spp.) and other harmful microorganisms.

关键词： Contamination Health risks Microbial quality Whole raw milk Tanga Tanzania Microorganism Milk-borne hazard escherichia coli Brucellosis Clostridium Bacteriological quality

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Fecal calprotectin and endoscopic scores: The cornerstones in clinical practice for evaluating mucosal healing in inflammatory bowel disease

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World Journal of Gastroenterology 2024年第24期30卷 3022-3035页

作者： Marcia Henriques de Magalhães Costa Ligia Yukie Sassaki Júlio Maria Fonseca Chebli Department of Clinical Medicine Fluminense Federal UniversityRio de Janeiro 24210-200Brazil Department of Internal Medicine Medical SchoolSão Paulo State University(Unesp)Botucatu 18618-686São PauloBrazil Division of Gastroenterology Department of MedicineUniversity Hospital of The Federal University of Juiz de ForaUniversity of Juiz de Fora School of MedicineJuiz de Fora 36036-247Minas GeraisBrazil

Managing inflammatory bowel disease(IBD)is becoming increasingly complex and personalized,considering the advent of new advanced therapies with distinct mechanisms of *** mucosal healing(MH)is a pivotal therapeutic goal in IBD management and can prevent IBD progression and reduce flares,hospitalization,surgery,intestinal damage,and colorectal *** proactive disease and therapy assessment is essential to achieve better control of intestinal inflammation,even if subclinical,to alter the natural course of *** monitoring of fecal calprotectin(FC)levels and interval endoscopic evaluations are cornerstones for evaluating response/remission to advanced therapies targeting IBD,assessing MH,and detecting subclinical ***,we comment on the article by Ishida et al Moreover,this editorial aimed to review the role of FC and endoscopic scores in predicting MH in patients with ***,we intend to present some evidence on the role of these markers in future targets,such as histological and transmural *** prospective multicenter studies with a stricter MH criterion,standardized endoscopic and histopathological analyses,and virtual chromoscopy,potentially including artificial intelligence and other biomarkers,are desired.

关键词： Fecal calprotectin Endoscopic scores Mucosal healing Histological healing Ulcerative colitis Inflammatory bowel diseases

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担当航运业的实践之声——访BIMCO主席Nikolaus ***ües

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中国船检 2024年第6期 61-64页

作者：薛龙玉 Nikolaus H.Schües 不详 BIMCO

航运业是全球经济运行的重要载体,也是世界经济发展的重要支柱。在全球供应链遭受疫情和地缘政治等因素冲击时,航运业和广大海员负重前行,保障了世界贸易的顺畅流通,为各地人民供应维持生活正常运转的必需品;在全球应对气候变化、共推... 详细信息

航运业是全球经济运行的重要载体,也是世界经济发展的重要支柱。在全球供应链遭受疫情和地缘政治等因素冲击时,航运业和广大海员负重前行,保障了世界贸易的顺畅流通,为各地人民供应维持生活正常运转的必需品;在全球应对气候变化、共推可持续发展的浪潮下,航运也正在积极采取行动,拥抱绿色低碳未来。然而,还有许多人对这一切知之甚少。

关键词：航运业世界经济发展地缘政治绿色低碳全球供应链经济运行负重前行重要载体

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Phenazines:Natural products for microbial growth control

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hLife 2024年第3期2卷 100-112页

作者： Cátia A Sousa Marta Ribeiro Francisca Vale Manuel Simões ISEP/P.PORTO School of EngineeringPolytechnic of PortoPortoPortugal LEPABE-Laboratory for Process Engineering EnvironmentBiotechnology and EnergyFaculty of EngineeringUniversity of PortoPortoPortugal ALiCE-Associate Laboratory in Chemical Engineering Faculty of EngineeringUniversity of PortoPortoPortugal

The unprecedented problem of antibiotic resistance has become a major challenge for public health,which has contributed to an increase in infections caused by such *** microbial infections,typically biofilm-related,are alsocoupled to an increase in human mortality and ***,the demand for new antimicrobial agents hasincreased along with the evolution of microbial resistance *** products produced by bacteria,such as phenazines,have been recognized as an important source for the development of new antimicrobial agents,through the exploitation of their capacity to increase oxidative stress in other *** are a large groupof nitrogen-containing heterocyclic compounds and are essential for several cellular processes including iron acquisition,signaling events,enzymatic processes,and biofilm ***-inspired antibiotics(i.e.,2-bromo-1-hydroxyphenazine,2,4-dibromo-1-hydroxyphenazine,bromophenazine-21,phenazine-13,and phenazine-14)are veryactive against a wide range of gram-positive and gram-negative bacteria,including those associated with severe *** this study,mechanisms of phenazine-inspired antibiotics in the cellular processes of planktonic and sessilebacteria are ***,the application of phenazine-inspired antibiotics for the eradication of multidrugresistant planktonic and biofilm bacterial infections is also reviewed.

关键词： antimicrobial agents biofilms multidrug-resistant natural products phenazines

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Clinicopathological Description of a Chronic Lymphocytic Leukemia in a Dog

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Open Journal of Veterinary Medicine 2024年第7期14卷 155-162页

作者： Maria Clara Boni Raffi Giovanna Valverde Magalhães Barbosa Alana Carolina Capais Rodrigues Sheila Canevese Rahal John P. Kastelic Luíz Guilherme Dercore Benevenuto Iolanda Simões Braga Beatriz Poloni Batista Felipe César Da Silva Brasileiro Fernanda Barthelson Carvalho de Moura Priscylla Tatiana Chalfun Guimarães Okamoto Regina Kiomi Takahira Alessandra Melchert Noeme Sousa Rocha Department of Veterinary Clinics School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Independent Veterinary Practitioner Department of Veterinary Surgery and Animal Reproduction School of Veterinary Medicine and Animal Science So Paulo State UniversityUNESP Botucatu SP Brazil Faculty of Veterinary Medicine University of Calgary Calgary Canada

Hematopoietic tumors are associated with diagnostic and therapeutic challenges and a poor prognosis. Furthermore, their pathophysiology in dogs is not well understood. Chronic lymphocytic leukemia has been rarely reported in golden retrievers, perhaps due to difficulties in diagnosis and care. An 8-year-old spayed female golden retriever was referred to our hospital with a 2-month history of fatigue, weakness, and selective appetite. The dog was diagnosed with chronic lymphocytic leukemia based on blood smear evaluation. Despite treatment, the dog deteriorated and the owners opted for euthanasia. Histopathological examination revealed atypical lymphocytes in the spleen, extramedullary hematopoiesis in the spleen and liver, bone marrow depletion, moderate neutrophilic myocarditis, and acute renal tubular necrosis. In an immunohistochemical panel, cells in the spleen and bone marrow were positive for anti-CD20, anti-CD45, anti-CD3, anti-IBA-1, anti-Ki67, anti-MUM-1, and anti-PAX-5. In conclusion, the leukemia diagnosis was confirmed through reactive histiocytosis, marked extramedullary hematopoiesis, and other clinical and laboratory findings. Herein, we report a case of chronic lymphocytic leukemia in a female dog with clinical, laboratory, and necroscopy findings.

关键词： Canine Cancer Neoplasia Therapeutics

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灰盖鬼伞中过表达的碱性真菌漆酶在高盐染料废水中的应用潜力

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微生物学报 2024年第8期64卷 3014-3029页

作者：王先华朱雪玲林嘉钇谷贤富彭齐霞肖亚中 Ursula Kües 方泽民安徽大学生命科学学院安徽合肥230601 安徽省现代生物制造重点实验室安徽合肥230601 安徽省微生物与生物催化工程技术研究中心安徽合肥230601 University of Goettingen Goettingen 237077Germany

【目的】本研究利用双孢菇(Agaricus bisporus)gpdII启动子,实现了碱性真菌漆酶PIE5(CcPIE5)在灰盖鬼伞(Coprinopsis cinerea)FA2222中的同源过表达。【方法】在mKjalke液体培养基中37℃培养7 d,漆酶活力达到(24.2±1.1)U/mL。纯化的CcPIE5在pH 8.0和60℃下表现出最佳催化活性。【结果】与已经研究报道的真菌漆酶不同,CcPIE5能耐受高浓度NaCl,当NaCl浓度从0升至1.5 mol/L时,CcPIE5的k_(cat)和K_(m)均呈下降趋势,表示CcPIE5在纺织印染废水脱色中有潜在应用价值。进一步在染料废水脱色应用中,以丁香酸作为介体,CcPIE5在pH 8.5和60℃条件下可高效降解(92.9±2.3)%的靛蓝胭脂红。通过LC-MS分析确认,Isatin 5-sulfonic acid(ISA)是靛蓝胭脂红降解的主要副产物。【结论】CcPIE5在高温、碱性和含盐条件下高效脱色染料,是处理环境和工业特定应用的理想选择。

关键词：真菌漆酶过表达灰盖鬼伞高盐靛蓝胭脂红

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Analysis of a passive ankle exoskeleton for reduction of metabolic costs during walking

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Defence Technology（防务技术） 2024年第7期37卷 62-68页

作者： Luís Quinto Pedro Pinheiro Sergio B.Goncalves Ivo Roupa Paula Simoes Miguel Tavares da Silva CINAMIL Academia MilitarInstituto Universitario MilitarLisbonPortugal IDMEC Instituto Superior TecnicoUniversidade de LisboaLisbonPortugal

Modern conflicts demand substantial physical and psychological exertion,often resulting in fatigue and diminished combat or operational *** exoskeletons have been developed recently to address these challenges,presenting various limitations that affect their operational or everyday *** article evaluates the performance of a dual-purpose passive ankle exoskeleton developed for the reduction of metabolic costs during walking,seeking to identify a force element that could be applied to the target *** on the 6-min walk test,twenty-nine subjects participated in the study using three different force *** results indicate that it is possible to reduce metabolic expenditure while using the developed ***,the comfort and range of motion results verify the exoskeleton's suitability for use in uneven terrain and during extended ***,the choice of the force element should be tailored to each user,and the control system should be adjustable to optimise the exoskeleton's performance.

关键词： Ankle passive exoskeleton Metabolic cost reduction Dual-use exoskeleton Gait Biomechanics

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Urea breath test for Helicobacter pylori infection in adult dyspeptic patients: A meta-analysis of diagnostic test accuracy

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World Journal of Gastroenterology 2024年第6期30卷 579-598页

作者： Fabian Fellipe Bueno Lemos Caroline Tianeze de Castro Marcel Silva Luz Gabriel Reis Rocha Gabriel Lima Correa Santos Luís Guilherme de Oliveira Silva Mariana Santos Calmon Cláudio Lima Souza Ana Carla Zarpelon-Schutz Kádima Nayara Teixeira Dulciene Maria de Magalhães Queiroz Fabrício Freire de Melo Instituto Multidisciplinar em Saúde Universidade Federal da BahiaVitória da Conquista 45029-094BahiaBrazil Instituto de Saúde Coletiva Universidade Federal da BahiaSalvador 40110040BahiaBrazil Campus Toledo Universidade Federal do ParanáToledo 85919-899ParanáBrazil Laboratory of Research in Bacteriology UFMGBelo Horizonte 30130-100Minas GeraisBrazil

BACKGROUND Helicobacter pylori(***)infection has been well-established as a significant risk factor for several gastrointestinal *** urea breath test(UBT)has emerged as a leading non-invasive method for detecting *** numerous studies confirming its substantial accuracy,the reliability of UBT results is often compromised by inherent *** findings underscore the need for a rigorous statistical synthesis to clarify and reconcile the diagnostic accuracy of the UBT for the diagnosis of *** *** To determine and compare the diagnostic accuracy of 13C-UBT and 14C-UBT for *** infection in adult patients with *** We conducted an independent search of the PubMed/MEDLINE,EMBASE,and Cochrane Central databases until April *** search included diagnostic accuracy studies that evaluated at least one of the index tests(^(13)C-UBT or ^(14)C-UBT)against a reference *** used the QUADAS-2 tool to assess the methodo-logical quality of the *** utilized the bivariate random-effects model to calculate sensitivity,specificity,positive and negative test likelihood ratios(LR+and LR-),as well as the diagnostic odds ratio(DOR),and their 95%confidence *** conducted subgroup analyses based on urea dosing,time after urea administration,and assessment *** investigate a possible threshold effect,we conducted Spearman correlation analysis,and we generated summary receiver operating characteristic(SROC)curves to assess ***,we visually inspected a funnel plot and used Egger’s test to evaluate publication *** both as reliable diagnostic tools in clinical *** In summary,our study has demonstrated that ^(13)C-UBT has been found to outperform the ^(14)C-UBT,making it the preferred diagnostic ***,our results emphasize the significance of carefully considering urea dosage,assessment timing,and measurement techniques for both tests to enh

关键词： Helicobacter pylori Urea breath test Diagnosis Diagnostic test accuracy Meta-analysis

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Clinical profile and outcomes in very elderly patients with atrial fibrillation anticoagulated with rivaroxaban: data from the EMIR study

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Journal of Geriatric Cardiology 2024年第7期21卷 723-732页

作者： Francisco Marín Manuel Anguita Sánchez Iñaki Lekuona Marcelo Sanmartín Fernán-dez Vivencio Barrios Carlos Perez Muñoz Juan Cosín-Sales Alejandro IPérez Cabeza Vanesa Roldán Schilling Carles Rafols Priu esteban Orenes-Piñero María Asunción es-teve-Pastor Department of Cardiology Hospital Clínico Universitario Virgen de la ArrixacaIMIB-ArrixacaUniversity of MurciaCIBERCVMurciaSpain Department of Cardiology Hospital Reina Sofía CórdobaIMIBICUniversity of CordobaCIBERCVCórdobaSpain Hospital Galdakao-Usansolo BizkaiaSpain Department of Cardiology Hospital Uni-versitario Ramony CajalCIBERCVMadridSpain Department of Cardiology University Hospital Ramóny CajalAl-caláUniversityMadridSpain Medical Center La Capillita Sanlúcar de Barrameda.Private cardiology clinicJerez de la FronteraSpain Department of Cardiology Hospital Arnau de VilanovaValenciaSpain Department of Car-diology Virgen de la Victoria University HospitalCIBERCV.MalagaSpain Department of Haematology Hospital Clínico Universitario Virgen de la ArrixacaUniversity of MurciaMurciaSpain Department of Medical Affairs Bayer HispaniaBarcelonaSpain Department of Biochemistry and Molecular Biology-A University of MurciaMurciaSpain

Objectives To analyze the clinical profile,adequacy of treatment with rivaroxaban and outcomes in octogenarians with atrial(AF),taking rivaroxaban in clinical *** Out of 1433 patients,453(31.6%)were octogenarians at *** to younger patients,octogenarians had more comorbidities,higher CHA2DS2-VASc(4.5±1.3vs.3.0±1.4;Pes(2.0±1.0vs.1.4±1.0;Pescribed in 83.4%of patients,but more frequently in the younger population(71.1%vs.89.1%;P=0.039).After a mean follow-up of 2.2±0.6 years,annual rates of stroke+systemic embolism+transient ische-mic attack,MACE,cardiovascular death and major bleeding were 1.03%,1.24%,1.03%and 1.75%,respectively,in octogenarian *** for progressive heart failure death and major bleeding,rates of outcomes in octogenarians were similar com-pared to younger *** octogenarians,the concomitant use of antiplatelet agents and non-severe dementia were independ-ently associated with the development of ischemic stroke,whereas previous coronary revascularization and heart failure with and higher HAS-BLED score with major ***,Conclusions In clinical practice,around one third of patients taking rivaroxaban are *** patients have many comorbidities and a high thromboembolic *** that,rates of adverse events remain *** is adequately pre-scribed in the majority of octogenarians.

关键词： patients atrial bleeding

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