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maximizing biomass utilization: An integrated strategy for coproducing multiple chemicals

Journal of Energy Chemistry 2025年第1期100卷 180-191页

作者： Byeongchan Ahn Sua Jo Jonggeol na J.Jay Liu Young-Ju kim Wangyun Won Department of Chemical and Biological Engineering Korea University Department of Chemical Engineering (Integrated process) Kyung Hee University Department of Chemical Engineering and materials Science Ewha Womans University Department of Chemical Engineering Pukyong National University Resources Engineering Plant Research Department Korea Institute of Geoscience and Mineral Resources

Lignocellulosic biomass is one of the viable solutions to alleviate the global warming. However, the limited utilization of biomass majorly focused on cellulose and hemicellulose restricts the economic and environmental feasibilities. To cope with this issue, we proposed an integrated process of co-producing 1,6-hexanediol（1,6-HDO） with tetrahydrofuran and adipic acid from biomass, referred to as Strategy A. To compare the impacts of lignin upgrading and feedstock, Strategy B, which co-produces tetrahydrofuran alone, and Strategy C, which is the traditional route to produce 1,6-HDO from fossil fuels, were used. Heat networks are also designed to reduce operating costs and indirect carbon emissions due to energy consumption, saving 87% and 83% of the heat and cooling requirements, respectively, in Strategy A. The market competitiveness of Strategy A was evaluated by determining the minimum selling price through techno-economic analysis, and sustainability was thoroughly investigated by quantifying the environmental impacts through both midpoint and endpoint life-cycle assessments（LCAs）.Strategy A was found to be the most favorable both economically（USRDSCHARDOLLAR3,402/ton） and environmentally（-26.9 kg CO2eq.）. This indicates that lignin valorization is not only economically but also environmentally preferred. Finally, changes in economic and environmental feasibilities depending on economic, process, and environmental parameters were investigated using sensitivity and uncertainty analyses. The results of these analyses provide valuable insight into bio-based chemical production.

关键词： Biorefinery Carbon mitigation Climate change Global warming Lignin utilization Bioeconomy

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Boosting Oxygen Evolution Reaction Performance on NiFe‑Based Catalysts Through d‑Orbital Hybridization

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nano-micro Letters 2025年第1期17卷 281-292页

作者： Xing Wang Wei Pi Sheng Hu Haifeng Bao na Yao Wei Luo State key Laboratory of New Textile materials and Advanced Processing Technology Key Laboratory of New Textile Materials and Applications of Hubei ProvinceSchool of Materials Science and EngineeringWuhan Textile UniversityWuhan 430200People’s Republic of China College of Chemistry and molecular Sciences Wuhan UniversityWuhan 430072People’s Republic of China

Anion-exchange membrane water electrolyzers(AEmWEs)for green hydrogen production have received intensive attention due to their feasibility of using earth-abundant NiFe-based *** introducing a third metal into NiFe-based catalysts to construct asymmetrical m-NiFe units,the d-orbital and electronic structures can be adjusted,which is an important strategy to achieve sufficient oxygen evolution reaction(OER)performance in ***,the ternary NiFem(m:La,mo)catalysts featured with distinct m-NiFe units and varying d-orbitals are reported in this *** and theoretical calculation results reveal that the doping of La leads to optimized hybridization between d orbital in NiFem and 2p in oxygen,resulting in enhanced adsorption strength of oxygen intermediates,and reduced rate-determining step energy barrier,which is responsible for the enhanced OER *** critically,the obtained NiFeLa catalyst only requires 1.58 V to reach 1 A cm^(−2) in an anion exchange membrane electrolyzer and demonstrates excellent long-term stability of up to 600 h.

关键词： NiFe-based catalysts d-orbital coupling Oxygen evolution reaction Anion exchange membrane electrolyzer

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Fk506 contributes to peripheral nerve regeneration by inhibiting neuroinflammatory responses and promoting neuron survival

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Neural Regeneration Research 2025年第7期20卷 2108-2115页

作者： Yuhui kou Zongxue Jin Yusong Yuan Bo ma Wenyong Xie na Han Department of Trauma and Orthopedics Peking University People’s HospitalBeijingChina national Center for Trauma medicine Peking University People’s HospitalBeijingChina key Laboratory of Trauma and Neural Regeneration(Peking University) Ministry of EducationBeijingChina Trauma medicine Center Peking University People’s HospitalBeijingChina Department of Orthopedics China-Japan Friendship HospitalBeijingChina

Fk506(Tacrolimus)is a systemic immunosuppressant approved by the *** and Drug ***506 has been shown to promote peripheral nerve regeneration,however,its precise mechanism of action and its pathways remain *** this study,we established a rat model of sciatic nerve injury and found that Fk506 improved the morphology of the injured sciatic nerve,increased the numbers of motor and sensory neurons,reduced inflammatory responses,markedly improved the conduction function of the injured nerve,and promoted motor function *** findings suggest that Fk506 promotes peripheral nerve structure recovery and functional regeneration by reducing the intensity of inflammation after neuronal injury and increasing the number of surviving neurons.

关键词： Fk506 inflammation motor neurons nerve regeneration neuron peripheral nerve injury sensory neurons

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基于粒子群优化算法的农业机器人控制策略研究

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农机化研究 2025年第1期47卷 205-209页

作者：王娜吴延凯许娜河南工业职业技术学院河南南阳473000

介绍了粒子群优化算法的概念,并由数学模型、边界约束和环境约束对农业机器人优化约束模型进行了分析,实现了对农业机器人的动态避障和路径规划。仿真实验表明:针对复杂的作业环境,农业机器人可以进行最优避障路径规划,且算法收敛速度较... 详细信息

介绍了粒子群优化算法的概念,并由数学模型、边界约束和环境约束对农业机器人优化约束模型进行了分析,实现了对农业机器人的动态避障和路径规划。仿真实验表明:针对复杂的作业环境,农业机器人可以进行最优避障路径规划,且算法收敛速度较快,能够满足设计要求,证明系统具有一定的可行性。

关键词：农业机器人粒子群优化约束模型避障路径规划

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multiple haploids, triploids, and tetraploids found in modern-day “living fossil” Ginkgo biloba

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Horticulture Research 2018年第1期5卷 190-201页

作者： PetrŠmarda Lucie Horová Ondřej knápek Heidi Dieck martin Dieck katarína Ražná Pavel Hrubík Laszlo orlóci Laszlo Papp kristýna Veselá Pavel Veselý Petr Bureš Department of Botany and Zoology Masaryk UniversityKoltlářská2CZ-61137BrnoCzech Republic Herrenkamper Gärten Herrenkamp 1DE-27254SiedenburgGermany Department of Genetics and Plant Breeding Slovak University of Agriculture in NitraTr.A.Hlinku 294976NitraSlovakia Slovak University of Agriculture in Nitra Faculty of Horticulture and Landscape EngineeringDunajská1694911NitraSlovakia Botanical Garden of Eötvös University Illés utca 25BudapestHungary

Ginkgo biloba,the last extant representative of a lineage of mesozoic gymnosperms,is one of the few seed plants with an exceptionally long(~300 myr)evolutionary history free of genome-wide duplications(polyploidy).Despite this genome conservatism,we have recently found a viable spontaneous tetraploid Ginkgo sapling during routine screening of several plants,demonstrating that natural polyploidy is possible in *** we provide a much wider flow cytometry survey of ploidy in some European Ginkgo collections,and own seedlings(>2200 individuals and~200 cultivars).We found a surprisingly high level of ploidy variation in modern-day Ginkgo and documented altogether 13 haploid,3 triploid,and 10 tetraploid Ginkgo plants or cultivars,most of them being morphologically distinct from common *** frequently produced polyploid(dihaploid)buds or *** showed some genome size *** surveyed plants provide a unique resource for future Ginkgo research and breeding,and they might be used to accelerate the modern diversification of this nearly extinct plant lineage.

关键词： routine breeding spite

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Effect of a Traffic Speed Based Cruise Control on an Electric Vehicle’s Performance and an Energy Consumption model of an Electric Vehicle

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IEEE/CAA Journal of Automatica Sinica 2020年第2期7卷 386-394页

作者： Anil k.madhusudhanan Xiaoxiang na Department of Engineering University of Cambridge

This paper proposes a cruise control system(CCS)to improve an electric vehicle's range,which is a significant hurdle in market penetration of electric vehicles.A typical driver or a conventional adaptive cruise control(ACC)controls an electric vehicle(EV)such that it follows a lead vehicle or drives close to the speed *** driving behaviour may cause the EV to cruise significantly above the average traffic *** may later require the EV to slow down due to the traffic ripples,wasting a part of the EV's kinetic *** addition,the EV will also waste higher speed dependent dissipative energies,which are spent to overcome the aerodynamic drag force and rolling *** paper proposes a CCS to address this *** proposed CCS controls an EV's speed such that it prevents the vehicle from speeding significantly above the average traffic *** addition,it maintains a safe inter-vehicular distance from the lead *** design and simulation analysis of the proposed CCS were in a mATLAB simulation *** simulation environment includes an energy consumption model of an EV,which was developed using data collected from an electric bus operation in *** the simulation analysis,the proposed system reduced the EV's energy consumption by approximately 36.6%in urban drive cycles and 15.4%in motorway drive ***,the experimental analysis using a Nissan e-NV200on two urban routes showed approximately 30.8%energy savings.

关键词： Cruise control electric vehicle(EV) energy performance safety traffic

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Inhibitory gamma-aminobutyric acidergic neurons in the anterior cingulate cortex participate in the comorbidity of pain and emotion

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Neural Regeneration Research 2025年第10期20卷 2838-2854页

作者： Lu Guan mengting Qiu na Li Zhengxiang Zhou Ru Ye Liyan Zhong Yashuang Xu Junhui Ren Yi Liang Xiaomei Shao Jianqiao Fang Junfan Fang Junying Du Department of Neurobiology and Acupuncture Research Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina key Laboratory for Research of Acupuncture Treatment and Transformation of Emotional Diseases Third School of Clinical MedicineZhejiang Chinese Medical UniversityHangzhouZhejiang ProvinceChina Fuchun Community Health Service Center of Fuyang District HangzhouZhejiang ProvinceChina

Pain is often comorbid with emotional disorders such as anxiety and *** of the anterior cingulate cortex has been implicated in pain and pain-related negative emotions that arise from impairments in inhibitory gamma-aminobutyric acid *** review primarily aims to outline the main circuitry(including the input and output connectivity)of the anterior cingulate cortex and classification and functions of different gamma-aminobutyric acidergic neurons;it also describes the neurotransmitters/neuromodulators affecting these neurons,their intercommunication with other neurons,and their importance in mental comorbidities associated with chronic pain *** understanding on their role in pain-related mental comorbidities may facilitate the development of more effective treatments for these ***,the mechanisms that regulate gamma-aminobutyric acidergic systems remain *** is also unclear as to whether the mechanisms are presynaptic or *** exploration of the complexities of this system may reveal new pathways for research and drug development.

关键词： anterior cingulate cortex anxiety chronic pain circuit communication comorbidity depression gamma-aminobutyric acidergic neurons parvalbumin neurons synaptic transmission

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Pulp health and calcific healing of a complicated crown–root fracture with additional root fracture in a maxillary incisor: A case report

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World Journal of Clinical Cases 2025年第3期13卷 42-49页

作者： na Li Yue-Yue Ren Ying Tang Qi Yang Tian-Tian meng Song Li Jing Zhang Stomatological Hospital and College Anhui Medical UniversityHefei 230032Anhui ProvinceChina Department of Endodontics The Affiliated Stomatological Hospital of Xuzhou Medical UniversityXuzhou 221000Jiangsu ProvinceChina

BACkGROUND Complicated crown–root fracture (CRF) involves severe injury to the crown, root,and pulp, and may be accompanied by multiple root fractures. The loss of a toothhas lifelong consequences for children and teenagers, but the maintenance of pulphealth and the calcific healing of multiple root fractures are rarely reported in *** SUmmARY This case reports healing of a permanent tooth with complicated crown–root andadditional root fractures, in which pulp health was maintained. A 10-year-old girlfell and fractured the root of her maxillary left central incisor at the cervical *** the coronal fragment was repositioned, the tooth was splinted until thetooth was no longer mobile, 2 years later. Eight years after treatment, the toothhas remained asymptomatic with vital pulp and localized gingival ***-beam computed tomography revealed not only calcified healing of the CRFbut also spontaneous healing in an additional undiagnosed root fracture. Thefracture line on the enamel could not be healed by hard tissue and formed agroove in the cervical crown. It was speculated that the groove was related to thelocalized gingival *** This case provides a clinical perspective of the treatment of a tooth with acomplicated CRF and an additional root fracture.

关键词： Complicated crown-root fracture multiple root fracture Spontaneous healing Cone-beam computed tomography Long-term follow-up Case report

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脂肪间充质干细胞治疗急性肝损伤的分子机制

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中国组织工程研究 2025年第23期29卷 5041-5050页

作者：杨娜刘杨郝慧琴山西中医药大学中西医结合基础实验室山西省晋中市030619

背景:急性肝损伤是由多种病因诱发的肝脏损害,如未及时治疗则会发展成急性肝衰竭,严重影响患者的生命安全。由于肝脏是人体最大的免疫器官和代谢器官,目前治疗急性肝损伤尚无最优方案。脂肪间充质干细胞因具有多向分化潜能和免疫调节活... 详细信息

背景:急性肝损伤是由多种病因诱发的肝脏损害,如未及时治疗则会发展成急性肝衰竭,严重影响患者的生命安全。由于肝脏是人体最大的免疫器官和代谢器官,目前治疗急性肝损伤尚无最优方案。脂肪间充质干细胞因具有多向分化潜能和免疫调节活性已逐渐成为治疗急性肝损伤的有效工具。目的:综述目前脂肪间充质干细胞及其经不同方式修饰后治疗急性肝损伤的进展和分子机制。方法:从Pubmed、Web of Science与中国知网数据库中检索2000-2023年发表的相关文献,以“Acute liver injury,liver injury,Adipose tissue-derived mesenchymal stem cell,liver Injury Repair,stem cell transplantation,stem cell repair,Cell surface engineering,stem cell modification”为英文检索词,以“急性肝损伤,肝损伤,脂肪间充质干细胞,肝损伤修复,干细胞移植,干细胞修复,干细胞修饰”为中文检索词,最终检索筛选出该领域最新研究进展的62篇文献进行归纳分析。结果与结论:(1)脂肪间充质干细胞作为一种具有多向分化潜能的干细胞治疗急性肝损伤具有生物学优势,较其他两种主要间充质干细胞类型——骨髓间充质干细胞和脐带间充质干细胞具有来源丰富、获取便捷、医学伦理问题少的特点,且较骨髓间充质干细胞的自我更新能力强。(2)脂肪间充质干细胞可以通过降低免疫反应、分化为肝细胞、分泌生长因子和外泌体等多种途径,降低血清炎症因子表达,减少肝脏组织炎性细胞浸润,抑制细胞焦亡和自噬,发挥抗凋亡作用,促进肝窦内皮细胞和肝细胞再生等分子机制改善肝损伤;目前尚无研究表明何种机制为脂肪间充质干细胞治疗急性肝损伤的最佳机制,多数观点认为这些分子机制之间相互影响相互作用协同发挥治疗作用。(3)生物材料修饰和药物预处理等方式可以提升脂肪间充质干细胞治疗急性肝损伤的疗效:一方面,生物材料和药物修饰可以提升脂肪间充质干细胞自身的功能,如提高增殖迁移能力,上调其分泌的生长因子水平,增强抗炎能力等,从而促进脂肪间充质干细胞在损伤部位存活;另一方面,生物材料和药物修饰可以抑制损伤部位炎性细胞活化,促进血管生长,改善损伤部位环境从而提高移植成功率。(4)总之,脂肪间充质干细胞可以通过分泌生长因子和外泌体、发挥免疫调节作用及促进肝脏再生等途径在治疗急性肝损伤中发挥重要作用。随着科学技术的发展,生物材料与药物修饰可以提升脂肪间充质干细胞的自我更新能力,改善急性肝损伤的局部微环境,为进一步促进脂肪间充质干细胞治疗急性肝损伤的临床应用提供新的思路。

关键词：急性肝损伤脂肪间充质干细胞肝脏脂肪组织细胞移植细胞修饰细胞工程损伤修复

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Chung＇s Law of the Iterated Logarithm for Subfractional Brownian motion

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Acta mathematica Sinica,English Series 2017年第6期33卷 839-850页

作者： na na LUAN School of Insurance and Economics University of International Business and Economics Beijing 100029 P. R. China

Let XH = {xH（t）,t ∈ R＋} be a subfractional Brownian motion in Rd. We provide asufficient condition for a self-similar Gaussian process to be strongly locally nondeterministic and show that XH has the property of strong local nondeterminism. Applying this property and a stochastic integral representation of XH, we establish Chung＇s law of the iterated logarithm for XH.

关键词： Subfractional Brownian motion self-similar Gaussian processes small ball probability,Chung's law of the iterated logarithm

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