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Synthesis of a highly recoverable 3D MnO2/rGO hybrid aerogel for efficient adsorptive separation of pharmaceutical residue

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Journal of Environmental Sciences 2022年第8期34卷 194-203页

作者： Billie Yan Zhang Hiew Wan Ting Tee Nicholas Yung Li Loh Kar Chiew Lai svenja Hanson Suyin Gan Suchithra Thangalazhy-Gopakumar Lai Yee Lee Department of Chemical and Environmental Engineering University of Nottingham MalaysiaJalan Broga43500 SemenyihSelangor Darul EhsanMalaysia Department of Chemical and Environmental Engineering University of Nottingham Ningbo ChinaNingbo 315100China

Water contamination by non-steroidal anti-inflammatory drugs,such as acetaminophen,is an emerging ecological *** this study,a newthree-dimensionalmanganese dioxideengrafted reduced graphene oxide(3D MnO_(2)/rGO)hybrid aerogel was developed for acetaminophen *** synthesis involved firstly the self-assembly of GO aerogel,followed by thermal reduction and in-situ MnO_(2) growth by *** aerogel demonstrated interlinked planes with smooth surfaces deposited with MnO_(2) nanospheres and pores of 138.4–235.3μm *** influences of adsorbent dosage,initial pH,acetaminophen concentration,temperature and contact time were *** was determined that the adsorption of acetaminophen occurred on uniform sorption sites in the aerogel,as suggested by the best fit of data to the Langmuir isotherm,yielding a maximum adsorption capacity of 252.87 mg/*** highest adsorption performance of the 3D MnO_(2)/rGO aerogel was attained at a dosage of 0.6 g/L,initial pH of 6.2 and temperature of 40℃.The process kinetics were in-line with the pseudo-first-order and pseudo-second-order kinetics at 10 and 20–500 mg/L concentrations,*** assay showed the spontaneity and endothermicity features of the 3D MnO_(2)/rGO-acetaminophen *** acetaminophen adsorption mechanisms were mainly hydrogen bonding and pore ***,the as-synthesised aerogel was effectively regenerated using acetone and re-utilised in four adsorption-desorption ***,the results highly recommend the implementation of the 3D MnO_(2)/rGO hybrid aerogel for purification of wastewater polluted by acetaminophen residue.

关键词： Acetaminophen Adsorption Adsorption mechanism 3D reduced graphene oxide Manganese oxide nanoparticles Regeneration

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Bcl-2 degradation is an additional pro-apoptotic effect of polo-like kinase inhibition in cholangiocarcinoma cells

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World Journal of Gastroenterology 2017年第22期23卷 4007-4015页

作者： svenja Sydor Sami Jafoui Lena Wingerter Sandra Swoboda Joachim C Mertens Guido Gerken Ali Canbay Andreas Paul Christian D Fingas Department of Gastroenterology and Hepatology University Hospital EssenUniversity Duisburg-Essen Department for General Visceral and Transplantation SurgeryUniversity Hospital EssenUniversity Duisburg-Essen Division of Gastroenterology and Hepatology University Hospital Zurich

To examine the influence on apoptotic mechanisms following inhibition of polo-like kinases as therapeutically approach for cholangiocellular cancer *** most cholangiocarcinomas are chemotherapy-resistant due to mechanisms preventing tumor cell death, we investigated the effect of Cisplatin on cholangiocellular carcinoma (CCA) cell lines KMCH-1 and Mz-Ch-1. Polo-like kinases (PLK) are important regulators of the cell cycle and their inhibition is discussed as a potential therapy while PLK inhibition can regulate apoptotic mediators. Here, cells were treated with PLK inhibitor BI6727 (Volasertib), Cisplatin, and in combination of both compounds. Cell viability was assessed by MTT; apoptosis was measured by DAPI staining and caspase-3/-7 assay. Western blot and qRT-PCR were used to measure expression levels of apoptosis-related molecules Bax and *** cell viability in the CCA cell lines KMCH-1 and Mz-Ch-1 was reduced in all treatment conditions compared to vehicle-treated cells. Co-treatment with BI6727 and cisplatin could even enhance the cytotoxic effect of cisplatin single treatment. Thus, co-treatment of cisplatin with BI6727 could slightly enhance the cytotoxic effect of the cisplatin in both cell lines whereas there was evidence of increased apoptosis induction solely in Mz-Ch-1 as compared to KMCH-1. Moreover, PLK inhibition decreases protein levels of Bcl-2; an effect that can be reversed by the proteasomal degradation inhibitor MG-132. In contrast, protein levels of Bax were not found to be altered by PLK inhibition. These findings indicate that cytotoxic effects of Cisplatin in Mz-Ch-1 cells can be enhanced by cotreatment with *** conclusion, BI6727 treatment can sensitize CCA cells to cisplatin-induced apoptosis with proteasomal Bcl-2 degradation as an additional pro-apoptotic effect.

关键词： Tumor necrosis factor-related apoptosis-inducing ligand Myeloid cell leukemia-1 Hedgehog pathway Cisplatin Chemotherapy resistance

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Comparative effectiveness of medical treatment *** surgery for histologically proven non-alcoholic steatohepatitis and fibrosis:a matched network meta-analysis

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Hepatobiliary Surgery and Nutrition 2022年第5期11卷 696-708,I0008-I0011页

作者： Adrian T.Billeter Beatrice Reiners svenja E.Seide Pascal Probst Eva Kalkum Christian Rupp Beat P.Müller-Stich Department of General Visceral and Transplant SurgeryUniversity of HeidelbergHeidelbergGermany Institute of Medical Biometry and Informatics University of HeidelbergHeidelbergGermany The Study Center of the German Surgical Society(SDGC) HeidelbergGermany Department of Gastroenterology and Hepatology University of HeidelbergHeidelbergGermany

Background:Non-alcoholic steatohepatitis(NASH)comprises a major healthcare problem affecting up to 30%of patients with obesity and the associated risk for cardiovascular and liver-related *** new drugs for NASH-treatment are currently *** study thus far directly compared surgical and non-surgical therapies for *** network meta-analysis compares for the first time the effectiveness of different therapies for NASH using a novel statistical ***:The study was conducted according to the PRISMA guidelines for network ***,CENTRAL and Web of Science were searched without restriction of time or language using a validated search *** investigating therapies for NASH in adults with liver biopsies at baseline and after at least 12 months were *** with liver cirrhosis were *** of bias was assessed with ROB-2 and ROBINS-I-tools.A novel method for population-adjusted indirect comparison to include and compare single-arm trials was *** outcomes were NASH-resolution and improvement of ***:Out of 7,913 studies,twelve randomized non-surgical studies and twelve non-randomized surgical trials were ***-resolution after non-surgical intervention was 29%[95%confidence interval(CI):23-40%]and 79%(95%CI:72-88%)after *** network meta-analysis showed that surgery had a higher chance of NASH-resolution than medication[odds ratio(OR)=2.68;95%CI:1.44-4.97]while drug treatment was superior to placebo(OR=2.24;95%CI:1.55-3.24).Surgery(OR=2.18;95%CI:1.34-3.56)and medication(OR=1.79;95%CI:1.39-2.31)were equally effective to treat fibrosis compared to placebo without difference between *** results did not change when only new drugs specifically developed for the treatment of NASH were ***:Metabolic surgery has a higher effectiveness for NASH-therapy than medical therapy while both were equally effective regarding improvement of *** d

关键词： Non-alcoholic fatty liver disease(NAFLD) non-alcoholic steatohepatitis(NASH) metabolic surgery fatty liver

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《口语语料库语言学:从单模态到多模态》介绍

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当代语言学 2017年第1期19卷 142-145页

作者： svenja Adolphs Ronald Carter 方清明英国诺丁汉大学华南师范大学国际文化学院

《口语语料库语言学：从单模态到多模态》（Spoken Corpus Linguistics. FromMonomodal to Multimodal）由英国诺丁汉大学svenjaAdolphs和RonaldCarter两位教授合著，2013年4月由Routledge出版。该书为“Routledge语料库语言学新进展”... 详细信息

关键词：语料库语言学多模态口语英国诺丁汉大学系列丛书引言

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Opportunities and challenges of clinical trials in cardiology using composite primary endpoints

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World Journal of Cardiology 2015年第1期7卷 1-5页

作者： Geraldine Rauch Bernhard Rauch svenja Schüler Meinhard Kieser Institute of Medical Biometry and Informatics University of HeidelbergD-69120 HeidelbergGermany Institut für Herzinfarktforschung D-67063 LudwigshafenGermany

In clinical trials, the primary efficacy endpoint often corresponds to a so-called "composite endpoint". Composite endpoints combine several events of interest within a single outcome variable. Thereby it is intended to enlarge the expected effect size and thereby increase the power of the study. However, composite endpoints also come along with serious challenges and problems. On the one hand, composite endpoints may lead to difficulties during the planning phase of a trial with respect to the sample size calculation, asthe expected clinical effect of an intervention on the composite endpoint depends on the effects on its single components and their correlations. This may lead to wrong assumptions on the sample size needed. Too optimistic assumptions on the expected effect may lead to an underpowered of the trial, whereas a too conservatively estimated effect results in an unnecessarily high sample size. On the other hand, the interpretation of composite endpoints may be difficult, as the observed effect of the composite does not necessarily reflect the effects of the single components. Therefore the demonstration of the clinical efficacy of a new intervention by exclusively evaluating the composite endpoint may be misleading. The present paper summarizes results and recommendations of the latest research addressing the above mentioned problems in the planning, analysis and interpretation of clinical trials with composite endpoints, thereby providing a practical guidance for users.

关键词： Composite endpoint Competing risks Multiple testing Time-to-event Adaptive designs

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《多语言语篇产出：历时和共时视角》述评

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现代外语 2016年第6期39卷 867-871页

作者：庞双子 svenja Kranich Viktor Becher Steffen H?der Juliane House 天津外国语大学北京外国语大学

1.引言翻译与目标语语言发展研究是当前语料库翻译研究的新话题。语言通过翻译进行接触是语言接触中亟待研究的领域。过去几十年间,关于两种语言通过翻译方式相互接触的研究寥寥,未引起足够关注。随着语料库语言学与描写翻译研究的有效... 详细信息

1.引言翻译与目标语语言发展研究是当前语料库翻译研究的新话题。语言通过翻译进行接触是语言接触中亟待研究的领域。过去几十年间,关于两种语言通过翻译方式相互接触的研究寥寥,未引起足够关注。随着语料库语言学与描写翻译研究的有效结合,翻译文本与原创文本比较的语料库实证研究正在兴起,使书面语言接触的考察成为了可能。

关键词：共时多语翻译文本翻译方式文本类型历史语言学翻译领域语义韵实证性研究心理语言学

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灵活的齿轮测量中心

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现代制造 2015年第21期 36-37页

作者： svenja SCHADEK

为了在生产能力得到提高后，仍能确保切削加工的质量安全可靠，一家齿轮生产厂家投资购置了一台齿轮测量装置。该装置可在一个大型齿轮线上使用。由于该齿轮测量装置采用高强度的材料制成，因此具有使用寿命长和精度高的特点。

关键词：齿轮测量中心测量装置生产能力安全可靠切削加工生产厂家大型齿轮使用寿命

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人工智能学习推动自动驾驶开发

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汽车制造业 2018年第18期 48-49页

作者： svenja Getowicz

Sepp Hochreiter先生是AI（人工智能）领域的一位著名人物，谷歌和Facebook等都采用了他的深度学习研究成果。目前，他在“教”汽车怎样独立自主地行驶。

关键词：智能学习人工智能自动驾驶开发研究成果行驶汽车

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Joint Multi-modal Parcellation of the Human Striatum:Functions and Clinical Relevance

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Neuroscience Bulletin 2020年第10期36卷 1123-1136页

作者： Xiaojin Liu Simon B.Eickhoff Felix Hoffstaedter Sarah Genon svenja Caspers Kathrin Reetz Imis Dogan Claudia R.Eickhoff Ji Chen Julian Caspers Niels Reuter Christian Mathys Andre Aleman Renaud Jardri Valentin Riedl Iris E.Sommer Kaustubh R.Patil Institute of Neuroscience and Medicine(INM-7 Brain and Behaviour)Research Centre JiilichJiilichGermany Institute of Systems Neuroscience Heinrich Heine University DusseldorfDusseldorfGermany Institute of Neuroscience and Medicine(INM-1) Research Centre Jiilich52428 JiilichGermany Institute for Anatomy I Medical FacultyHeinrich Heine University Dusseldorf40225 DusseldorfGermany Jiilich Aachen Research Alliance-BRAIN(JARA)Institute of Molecular Neuroscience and Neuroimaging Forschungszentrum JiilichRheinisch Westfallische Technische Hochschule(RWTH)Aachen University52074 AachenGermany Department of Neurology Rheinisch Westfallische Technische Hochschule(RWTH)Aachen University52074 AachenGermany Institute of Clinical Neuroscience and Medical Psychology Medical FacultyUniversity of Dusseldorf40225 DusseldorfGermany Department of Diagnostic and Interventional Radiology Medical FacultyUniversity of Dusseldorf40225 DusseldorfGermany Institute of Radiology and Neuroradiology Evangelisches KrankenhausUniversity of Oldenburg26129 OldenburgGermany Department of Neuroscience University Medical Center GroningenUniversity of Groningen9713 AV GroningenThe Netherlands SCALab(CNRS UMR9193)&CHU de LiUe Hopital FontanPole de Psychiatrie(CURE)Universite de Lille59037 LilleFrance Departments of Neuroradiology Nuclear Medicine and Neuroimaging CenterTechnische Universitat Miinchen80333 MunichGermany

The human striatum is essential for both lowand high-level functions and has been implicated in the pathophysiology of various prevalent disorders,including Parkinson's disease(PD)and schizophrenia(SCZ).It is known to consist of structurally and functionally divergent ***,previous parcellations are based on a single neuroimaging modality,leaving the extent of the multi-modal organization of the striatum ***,we investigated the organization of the striatum across three modalities—resting-state functional connectivity,probabilistic diffusion tractography,and structural covariance—to provide a holistic convergent view of its structure and *** found convergent clusters in the dorsal,dorsolateral,rostral,ventral,and caudal *** characterization revealed the anterior striatum to be mainly associated with cognitive and emotional functions,while the caudal striatum was related to action ***,significant structural atrophy in the rostral and ventral striatum was common to both PD and SCZ,but atrophy in the dorsolateral striatum was specifically attributable to *** study revealed a cross-modal convergent organization of the striatum,representing a fundamental topographical model that can be useful for investigating structural and functional variability in aging and in clinical conditions.

关键词： Striatum Multi-modal Connectivity-based parcellation Convergent clusters Voxel-based morphometry Parkinson's disease Schizophrenia

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奥地利费尔德基希市文化中心 Montforthaus in Feldkirch

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设计 2015年第20期28卷 36-37页

作者： Jacob svenja Bockhop

这是坐落在奥地利费尔德基希市的文化中心。这座多功能文化中心服务于费尔德基希及周边地区的市民。它包括举办会议、舞厅、展销会、古典音乐会、流行音乐会和戏剧表演。该建筑和谐地融入费尔德基希这座中世纪古城历史遗址之中。建筑的... 详细信息

这是坐落在奥地利费尔德基希市的文化中心。这座多功能文化中心服务于费尔德基希及周边地区的市民。它包括举办会议、舞厅、展销会、古典音乐会、流行音乐会和戏剧表演。该建筑和谐地融入费尔德基希这座中世纪古城历史遗址之中。建筑的正式表达方式是现代的,其材质则使用了地区传统的大理石,两者之间相互编织融入到城市现状肌理中。

关键词：费尔德文化中心基希建筑外观城市现状历史遗址戏剧表演城市空间地区传统雕塑感

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