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Patterns of Gustatory Recovery in Patients Affected by the COVID-19 Outbreak

Virologica Sinica 2020年第6期35卷 833-837页

作者： Carlos M.Chiesa-Estomba Jerome R.Lechien Maria R.Barillari sven saussez COVID-19 Task Force of the Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies(YO-IFOS) ParisFrance Department of Otorhinolaryngology-Head and Neck Surgery OsakidetzaHospital Universitario DonostiaSan Sebastian 20014Spain Biodonostia Health Research Institute San Sebastian 20014Spain Department of Human Anatomy and Experimental Oncology Faculty of MedicineUMONS Research Institute for Health Sciences and TechnologyUniversity of Mons(UMons)7000 MonsBelgium Department of Otolaryngology-Head and Neck Surgery Foch HospitalSchool of MedicineUFR Simone VeilUniversite´Versailles Saint-Quentin-en-Yvelines(Paris Saclay University)Paris 92150France Department of Otorhinolaryngology and Head and Neck Surgery CHU de BruxellesCHU Saint-PierreSchool of MedicineUniversite´Libre de BruxellesBrussels 1000Belgium Department of Mental and Physical Health and Preventive Medicine "L.Vanvitelli"University80138 NaplesItaly Department of Head and Neck Surgery EpiCURA HospitalHornu 7331Belgium

Dear Editor,Coronavirus disease 2019(COVID-19)is a viral infection caused by severe acute respiratory syndrome coronavirus 2(SARS-Co V-2).From March 2020,several studies indicate that many subjects affected by mild-to-moderate COVID-19 presented olfactory/gustatory dysfunction(OD/GD)that appeared strongly correlated between them but not with the other symptoms suggestive of upper airway infection(Lechien et al.2020a,b;Hopkins et al.2020;Paderno et al.2020).

关键词： Hopkins Pattern

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Treatment of laryngopharyngeal reflux disease: A systematic review

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World Journal of Clinical Cases 2019年第19期7卷 2995-3011页

作者： Jerome R Lechien Francois Mouawad Maria R Barillari Andrea Nacci Seyyedeh Maryam Khoddami Necati Enver Sampath Kumar Raghunandhan Christian Calvo-Henriquez Young-Gyu Eun sven saussez Laboratory of Anatomy and Cell Biology Faculty of MedicineUMONS Research Institute for Health Sciences and TechnologyUniversity of MonsMons 7000Belgium Laryngopharyngeal Reflux Study Group of Young-Otolaryngologists of the International Federations of Oto-rhino-laryngological Societies Paris 75000France Department of Otolaryngology-Head and Neck Surgery CHU de LilleLille 59000France Division of Phoniatrics and Audiology Department of Mental and Physical Health and Preventive MedicineUniversity of L.VanvitelliNaples 80100Italy ENT Audiology and Phoniatric Unit University of PisaPisa 56100Italy Larynx Function and Acoustic Voice Laboratory Department of Speech TherapySchool of RehabilitationTehran 11369Iran Department of Otolaryngology Marmara University Pendik Training and Research HospitalIstanbul 34722Turkey Department of Otology Neurotology and Skullbase SurgeryMadras ENT Research FoundationTamil Nadu 60028India Department of Otorhinolaryngology and Head and Neck Surgery Hospital Complex of Santiago de CompostelaSantiago de Compostela 15700Spain Department of Otorhinolaryngology and Head and Neck Surgery Kyung Hee University Medical CenterSeoul 130702Korea

BACKGROUNG For a long time,laryngopharyngeal reflux disease(LPRD)has been treated by proton pump inhibitors(PPIs)with an uncertain success *** To shed light the current therapeutic strategies used for LPRD in order to analysis the rationale in the LPRD *** Three authors conducted a PubMed search to identify papers published between January 1990 and February 2019 about the treatment of *** prospective or retrospective studies had to explore the impact of medical treatment(s)on the clinical presentation of suspected or confirmed *** criteria for considering studies for the review were based on the population,intervention,comparison,and outcome *** The search identified 1355 relevant papers,of which 76 studies met the inclusion criteria,accounting for 6457 patients.A total of 64 studies consisted of empirical therapeutic trials and 12 were studies where authors formally identified LPRD with pH-monitoring or multichannel intraluminal impedance-pH monitoring(MII-pH).The main therapeutic scheme consisted of once or twice daily PPIs for a duration ranged from 4 to 24 *** most used PPIs were omeprazole,esomeprazole,rabeprazole,lansoprazole and pantoprazole with a success rate ranging from 18%to 87%.Other composite treatments have been prescribed including PPIs,alginate,prokinetics,and H2 Receptor *** Regarding the development of MII-pH and the identification of LPRD subtypes(acid,nonacid,mixed),future studies are needed to improve the LPRD treatment considering all subtypes of reflux.

关键词： Laryngopharyngeal Reflux Laryngitis Treatment Proton pump inhibitors

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