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Interleukin 6 and Bone Erosions in Rheumatoid Arthritis in an African Hospital

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Open Journal of Rheumatology and Autoimmune Diseases 2024年第1期14卷 13-19页

作者： Paul Eloundou Aly Kamissoko Fernando Kempta Francine Same Bebey William Beko’o Ange Ngeuleu William Nguekouo Estelle Megne suzy Manizou Madeleine Singwe Faculty of Medicine and Pharmaceutical Sciences University of Douala Douala Cameroon Department of Internal Medicine Cité Verte District Hospital Yaounde Cameroon Cameroon CHU Ignace Deen Conakry Guinea Faculty of Medicine University of Dschang Dschang Cameroon Faculty of Medicine and Biomedical Sciences Yaoundé University of Yaoundé I Yaounde Cameroon

Introduction: Rheumatoid arthritis (RA) is a chronic, erosive and deforming inflammatory rheumatic disease. In the era of biotherapies and the arrival of biosimilars in sub-Saharan Africa, the objective of this study was to describe plasma IL-6 variations in RA patients at Cité Verte District Hospital (Cameroon). Material and Methods: Descriptive and analytical cross-sectional study from December 1, 2021 to May 31, 2022. We included patients over 18 years old suffering from RA (ACR/EULAR 2010). Patients with an infection were not included. The data collected were age, sex, smoking status, family history, disease duration, disease activity by DAS28, CRP, rheumatoid factor, and plasma level of IL-6. Bone erosion was sought on radiography and ultrasound. Result: We included 31 patients, 25 of whom were women (80.6%). The mean age was 47.27 ± 17.97 years. Disease activity was predominantly moderate (32.3%) and severe (32.3%). Mean IL-6 level was 15.29 ± 2.36 pg/ml (extremes: 11.26 pg/ml and 20.15 pg/ml). IL-6 levels were higher in patients with a history of smoking. Similarly, IL-6 levels were higher in patients with mildly active RA in remission than in moderately and severely active RA. Mean IL-6 levels were significantly higher in patients with erosive RA (16.3 pg/ml VS 14.6 pg/ml). Conclusion: IL-6 levels were significantly elevated in men, weaned smokers and patients with bone erosions.

关键词： Rheumatoid Arthritis Interleukin 6 Bone Erosion-DAS28 Sub-Saharan Africa

Noninvasive Ventilation Interfaces in the Treatment of Acute Respiratory Insufficiency: A Critical Review

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Open Journal of Emergency Medicine 2024年第3期12卷 95-103页

作者： Andréa Nóbrega Cirino Nogueira Chakira Torres Lima Renata dos Santos Vasconcelos suzy Maria Montenegro Pontes Arnaldo Aires Peixoto Junior Renan Magalhães Montenegro Junior Clinical Research Unit Walter Cantdio University Hospital Federal University of Cear/EBSERH Fortaleza Brazil

Background: Noninvasive ventilation (NIV) is an important therapeutic modality for the treatment of acute respiratory failure (ARF). In this review, we critically analyze randomized controlled trials on the most used NIV interfaces in the treatments of ARF. Methods: The searches were conducted in the Medline, Lilacs, PubMed, Cochrane, and Pedro databases from June to November 2021. The inclusion criteria were Randomized clinical trials (RCTs) published from 2016 to 2021 in Portuguese, Spanish, or English and involving adults (aged ≥ 18 years). The eligibility criteria for article selection were based on the PICO strategy: Population—Adults with ARF;Intervention—NIV Therapy;Comparison—Conventional oxygen therapy, high-flow nasal cannula (HFNC) oxygen therapy, or NIV;Outcome—improvement in ARF. The search for articles and the implementation of the inclusion criteria were independently conducted by two researchers. Results: Seven scientific articles involving 574 adults with ARF due to various causes, such as chest trauma, decompensated heart failure, coronavirus disease 2019 (COVID-19), and postoperative period, among others, were included. The interfaces cited in the studies included an oronasal mask, nasal mask, full-face mask, and helmet. In addition, some favorable outcomes related to NIV were reported in the studies, such as a reduction in the rate of orotracheal intubation and shorter length of stay in the ICU. Conclusions: The most cited interfaces in the treatment of ARF were the oronasal mask and the helmet.

关键词： Noninvasive Ventilation Respiratory Insufficiency Respiration Artificial Continuous Positive Airway Pressure

Electrochemical reactivity of In-Pb solid solution as a negative electrode for rechargeable Mg-ion batteries

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Journal of Energy Chemistry 2021年第4期30卷 124-128页

作者： Lucie Blondeau suzy Surble Eddy Foy Hicham Khodja Magali Gauthier UniversitéParis-Saclay CEACNRSNIMBELEEL91191Gif-sur-YvetteFrance UniversitéParis-Saclay CEACNRSNIMBELAPA-IRAMAT91191Gif-sur-YvetteFrance

A composite In-Pb:carbon was successfully synthetized by a two-step mechanochemical synthesis in order to obtain an adequate particles size and structure to investigate the electrochemical reactivity of the In-Pb solid solution towards Mg.A potential synergetic coupling of electroactive elements In and Pb was examined using electrochemical and ex situ X-ray diffraction *** potential profile of the solid solution indicates the formation of Mg_(2)Pb and Mg ***,the diffraction study suggests a peculiar electrochemically-driven amorphization of Mg In during the magnesiation,in strong contrast to Mg In crystallization in In-based and In Bi-based electrodes reported in the *** In and Pb favors the amorphization of Mg In and a high first magnesiation capacity of about 550 m Ah g^(-1),but is thereafter detrimental to the material’s *** results emphasize the possible influence of electrochemically-driven amorphization and crystallization processes on electrochemical performance of battery materials.

关键词： Magnesium battery Negative electrode Alloy Amorphization

Anti-inflammatory Effects of Sanguisorbae Radix on Contact Dermatitis Induced by Dinitrofluorobenzene in Mice

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Chinese Journal of Integrative Medicine 2020年第9期26卷 688-693页

作者： suzy Jo Junghyun Ryu Hanna Kim Miyoung Kim Mi Heon Ryu Hyungwoo Kim Su-ln Cho School of Korean Medicine Pusan National UniversityPusan(626-870)Republic of Korea School of Dentistry Pusan National UniversityPusan(626-870)Republic of Korea

Objective:To investigate the anti-inflammatory effects of Sanguisorbae Radix on contact dermatitis(CD).Methods:Mice were sensitized by painting 30μL of 1-fluoro-2,4-dinitrofluorobenzene(DNFB)onto each ear for 3 *** days later,mice were challenged by painting with 50μL of DNFB onto the shaved dorsum every 2 *** Radix methanol extract(MESR)was applied onto the shaved dorsum every 2 *** effects of MESR on skin thickness,skin weights,histopathological changes,skin lesions and cytokine production in DNFB-induced CD mice were investigated,as well as its effects on body weights and spleen/body weight ***:Topical application of MESR effectively inhibited enlargement of skin thickness and weight(P<0.05).MESR treatment also inhibited hyperplasia,spongiosis and immune cell infiltration induced by DNFB in inflamed tissues and improved lesions on dorsum skin in CD ***,treatment with MESR suppressed the increase in the levels of tumor necrosis factor α(TNF-α,P<0.01)and interferonγ(IFN-γ,P<0.05),***,MESR had no effect on body weight gain or spleen/body weight ***:These data suggest that MESR acts as an anti-inflammatory agent that decreases the production of TNF-α and IFN-γ,resulting in reductions of skin lesions and histopathological changes in inflamed skin tissues.

关键词： Sanguisorba officinalis skin diseases herbal Chinese materia medica

Australian children living with rare diseases:health service use and barriers to accessing care

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World Journal of Pediatrics 2023年第7期19卷 701-709页

作者： suzy Teutsch Yvonne Zurynski Guy DEslick Marie Deverell John Christodoulou Helen Leonard Troy Dalkeith Sandra LJJohnson Elizabeth JElliott Faculty of Medicine and Health Discipline of Child and Adolescent HealthThe University of SydneySydneyNSWAustraliaAustralian Australian Paediatric Surveillance Unit Kids ResearchSydney Children's Hospitals NetworkWestmeadNSWAustralia Australian Institute of Health Innovation Center for Healthcare Resilience and Implementation Scienceand NHMRC Partnership Centre in Health System SustainabilityMacquarie UniversitySydneyNSWAustraliaFaculty of Medicine and HealthDiscipline of Child and Adolescent HealthThe University of SydneySydneyNSWAustralia Government Department of Health Western Australia PerthWAAustralia Murdoch Children's Research Institute and Victorian Clinical Genetics Services Royal Children's HospitalParkvilleVICAustralia Department of Paediatrics The University of MelbourneParkvilleVICAustralia Telethon Kids Institute The University of Western AustraliaNedlandsWAAustralia Genetic Metabolic Disorders Service Sydney Children's Hospitals NetworkWestmeadNSWAustralia

Background Children with rare diseases experience challenges at home and school and frequently require multi-disciplinary *** aimed to determine health service utilization by Australian children with rare diseases and barriers to access-ing *** Parents completed an online survey on health professional and emergency department(ED)presentations,hospi-talization,and barriers to accessing *** barriers to service access included residential location(city,regional,remote)and child health-related functioning,determined using a validated,parent-completed measure-of-function *** Parents of 462 children with over 240 rare diseases completed the *** with the general population,these children were more likely to be hospitalized[odds ratio(OR)=17.25,95%confidence interval(CI)=15.50-19.20]and present to the ED(OR=4.15,95%CI=3.68-4.68)or a family physician(OR=4.14,95%CI=3.72-4.60).Child functional impairment was nil/mild(31%),moderate(48%)or severe(22%).Compared to children with nil/mild impair-ment,those with severe impairment were more likely to be hospitalized(OR=13.39,95%CI=7.65-23.44)and present to the ED(OR=11.16,95%CI=6.46-19.27).Most children(75%)lived in major cities,but children from regional(OR=2.78,95%CI=1.72-4.55)and remote areas(OR=9.09,95%CI=3.03-25.00)experienced significantly more barriers to healthcare access than children from major *** included distance to travel,out-of-pocket costs,and lack of specialist medical and other health *** Children with rare diseases,especially those with severe functional impairment have an enormous impact on health services,and better integrated multidisciplinary services with patient-centered care are *** must be improved for children living in rural and remote settings.

关键词： Access Health functioning Health service use Rare diseases

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When I Dream

小学生时代（大嘴英语） 2022年第2期 16-19页

作者： suzy Levinson Annie Won(图) 不详

Stars fill my closet.Shoes light the sky.Clouds stretch below me.Shadows float by.Fish sing in treetops.Birds swim downstream.The cat takes sticks.The dog laps up cream.Nothing is quite what it seems when I dream.

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Family Rain Day

小学生时代（大嘴英语） 2021年第1期 24-27页

作者： suzy Levinson Meredith Crandall Brown(图) 不详

Baking cookies,Pillow forts,Silly dancing,Books(all sorts),Jigsaw puzzles,Model planes…We're so happyWhen it rains!

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地区组织在苏丹内战中的作用——以1983-2005年苏丹内战中的东非地区组织为例

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地区组织在苏丹内战中的作用——以1983-2005年苏丹内战中的东非...

作者： suzy Anyango Mark 吉林大学

学位级别：硕士

在过去的几十年间里,苏丹经历了比世界上任何一个地区都多暴力冲突。在非洲历史上这是继安哥拉之后历时最长、最惨重的地区冲突,伤亡人数达高达百万。其结果不仅对苏丹、对整个地区也造成了极具破坏性的影响。虽然没有一个可靠的官方数...

在过去的几十年间里,苏丹经历了比世界上任何一个地区都多暴力冲突。在非洲历史上这是继安哥拉之后历时最长、最惨重的地区冲突,伤亡人数达高达百万。其结果不仅对苏丹、对整个地区也造成了极具破坏性的影响。虽然没有一个可靠的官方数据,但估算有130万人在相关冲突中丧生。各种有关冲突的报道以及提到的实际数据地告诉我们,武装冲突在人类而言是一场灾难。除了死亡,战争还需为国内及邻国流离失所的人们负责。通过政府间发展组织主导的和平进程,这场冲突以2005年全面和平协议的签署而告终,这个协议在2011年举行的关于南苏丹独立的公投时得以基本上实施。本文通过对上述举措进行比较分析,探讨政府间发展组织领导的和平进程的独特性,并探讨国际社会在和平进程中的中介作用。本文认可了其积极因素,例如坚持自主权、建立专门途径、建立邻近的中介方,尤其是邻国肯尼亚和政府间发展组织的合作伙伴论坛所发挥的重要作用。苏丹的武装冲突和动荡局势使该地区成为世界上最不稳定的地区之一。苏丹境内的很多地区至今都无法摆脱已困扰该地区数十年的军事冲突、暴力犯罪、群体犯罪、极端主义、政局动荡和失败政权的阴影。然而,本地区很少有国家能有效地管理其偏远、广阔的边境地区,因此,跨边界冲突管理和预防落在了中央政府与地区组织合作的肩膀上。这些地方和地区行动者的适应能力和适应性是决定是否,以及在何种程度上成功管理跨境冲突和不稳定问题的关键因素。本文运用现实主义理论来解释冲突与国际关系,旨在以苏丹为视角评估地区组织在苏丹内战中所扮演的角色,研究关注以下主要内容:苏丹武装冲突概述、东非地区组织和政府间发展组织在苏丹武装冲突演变为内战过程中的作用分析。为完成该研究,作者使用了图书馆与互联网上所收集到的相关资料。在这种情况下,充分利用已发表和未发表的数据,将问题放到背景中去印证研究的合理性。所有这些材料也可以被用于理解世界其他地区的普遍情况。研究结果显示,苏丹冲突的解决和管理对地区组织、国家、地区和国际社会构成了重大挑战。东非地区组织与政府间发展组织成功调停了苏丹与南苏丹的冲突,说明了他们在非洲的后冷战背景下开展了更广泛的区域化合作。发生在苏丹北部的冲突是始料未及的,这些冲突主要集中在南北部边境的游牧民聚居区,近期发生在东道国与难民之间以及社区内部关于自然资源管理的冲突也持续了一段时间。苏丹政府为解决这些冲突已经提出了不少设想,制定和修正了各种政策文件,举行了了若干次调停,但主要问题集中于于如何执行各项决议。国际社会在促进区域和平进程中已取得了重大成就。此外,研究结果显示,苏丹冲突中解决冲突和管理的承认力不足,该地区各国尚未出台明确的政策文件,从各种冲突的根本原因,演变过程以及各方的有关问题出发,尝试采取措施解决这些冲突,并有效解决了该地区的冲突。然而国际社会不关心如何惩罚这些冲突的肇事者。本文提出,在苏丹冲突中,地区机构应该作为一个在安全问题和冲突管理方面的跨州合作平台发挥重要作用。旷日持久的冲突、区域叛乱和跨境犯罪对边境安全和国家反应系统造成了巨大压力,地区组织在此情况下应该在检测、预防和跨境反应机制方面起了关键性作用。通过研究本文推断苏丹在经历了二十一年的战争之后,和平终将来临,最近签署的协议正预示着一个和平的未来。协议中已解决的关于宗教压迫、财富权力分配不均衡、种族歧视这些造成内战的根本原因,必须在苏丹政局平稳的条件下继续保持下去。本文研究结果显示,尽管苏丹冲突的解决和管理机制为区域组织构成了重大挑战,但东非地区组织是一个例外。根据研究发现,2005年签订的全面和平协议是一个构建和平的成功案例,julianwarczinski(2008年)给该协议做了详细的解释。全面和平协议,是东非地区组织所主导,并与其它地区组织和政府间发展组织共同努力的结果,并受到来自国际社会的强力支持,特别是美国、日本、挪威、意大利等国(warczinski,2008)。2005年1月9日在肯尼亚奈瓦沙,苏丹政府与南苏丹反政府武装苏丹人民解放运动签署的全面和平协议有效的终止了第二次内战。全面和平协议以苏丹人民解放运动建立“新苏丹”的要求,终止了战争、制衡了全国大会党坚持在北方保留伊斯兰法律(dewaal,2007)。

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Pegylated interferon α/ribavirin therapy enhances bone mineral density in children with chronic genotype 4 HCV infection

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World Journal of Pediatrics 2017年第4期13卷 346-352页

作者： Ahmed Megahed Nanees Salem Abeer Fathy Tarik Barakat Mona Abd El Latif Alsayed suzy Abd El Mabood Khaled R Zalata Ahmed F Abdalla Pediatric Gastroenterology and Hepatology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Endocrinology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pediatric Hematology&Oncology Unit Mansoura University Children's HospitalFaculty of MedicineMansoura UniversityEgypt Pathology Department Faculty of MedicineMansoura UniversityEgypt

Background:The impact of chronic hepatitis C (CHC) on bone mineral density (BMD) has been well studied in adults with a relative paucity of data in children,especially concerning effect of treatment with pegylated interferon (PEG-IFN) plus ribavirin (RV).In the current work,we assessed prospectively changes in BMD in children with CHC before,during,and after ***:Forty-six consecutive children with noncirrhotic genotype 4 CHC were subjected to dual-energy X-ray absorptiometry at baseline,24 weeks,48 weeks of therapy and 24 weeks after ***,bone mineral content (BMC),and Z score of lumbar spine (L2-L4) were *** pubertal stage,viral load,liver function tests,serum calcium,phosphorus,alkaline phosphatase,parathyroid hormone,and liver histopathology were assessed in all included ***:Thirty (65.2%) patients had normal BMD,10 (21.7%) were at risk for low BMD,and 6 (13.1%) had low BMD for chronological *** with low BMD were significantly older (P=0.001),with higher frequency of delayed puberty than other groups (P=0.002).Baseline densitometric parameters (BMD & BMC) were significantly positively correlated with patients' age,weight,height,body mass index and hemoglobin level;while they were insignificantly correlated with basal viral load,histopathology activity index and fibrosis *** parameters improved significantly on PEG-IFN plus RV treatment,this improvement was found to be sustainable 24 weeks after ***:Low BMD is detectable in a proportion of CHC *** therapy leads to a sustainable increase in BMD.

关键词： bone mineral density chronic hepatitis C pegylated interferon ribavirin