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Publication and integration of Gly.odatabase

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Publication and integration of Glycodatabase

宫颈癌放疗后复发用FDG-PET检测——肿瘤的容积和FDG摄取值

2008年全国糖生物学学术会议

作者： Shikanai T. Shimma y. suzuki y. Fujita N. Kamey.ma A. Hirabay.shi J. Kaji H. Togay.chi A. Sato T. Ito H. Tateno H. Narimatsu H. Research Center for Medical Gly.oscience(RCMG) National Institute of Advanced Industrial Science and Technology (AIST).JAPAN

Construction of a human gly.ogene library.and the development of two kinds of sy.tems for analy.ing oligosaccharide sturctures in AIST through NEDO ***,186 human gly.ogenes were expressed and produced human ty.e *** h...

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世界核心医学期刊文摘（妇产科学分册） 2006年第6期2卷 50-51页

作者： Sakurai H. suzuki y. Nonaka T. 翁梨驹 Department of Radiation Oncology Gunma University Graduate School of Medicine 3- 39- 22 Showa- machi Maebashi Gunma 371- 8511 Japan

Purpose. We evaluated the use of positron emission tomography.(PET) with fluorine- 18- labeled fluoro- 2- deoxy. d- glucose (FDG) in follow- up study.after radiation therapy.in patients with uterine cervical carcinoma. Materials and methods. Thirty. two studies in 25 patients were reviewed. Twenty.patients were treated with external beam irradiation and intracavitary.brachy.herapy. and five with irradiation following initial surgery. Time frominitial treatment to FDG- PET was 23.3 (5.2- 88.0) months. Rationale for FDG- PET was the presence of sy.ptoms in 6 patients, abnormal serum tumor marker values in 13, abnormal lesions on other diagnostic imaging modalities in 19, and patient request in 2. On visualization of a lesion, the maximum standardized uptake value (maxSUV) of the lesion was calculated, and values over 2.0 were classified as FDG- positive. Maximum tumor diameter and tumor volume in the corresponding disease were estimated by.computed tomography.(CT) or magnetic resonance imaging (MRI). Results. Sensitivity.and specificity.of FDG- PET in the detection of recurrent disease were 91.5% (43/47) and 57.1% (4/7), respectively. Four false negative findings were seen for small lung metastases having a volume less than 1 cm3. Three false- positive cases were a localized pneumonitis, a benign pubic bone fracture,and a fibrosis after interstitial brachy.herapy. Sensitivity.for extrapelvic ly.ph node metastases was extremely.high (100% ); in contrast, sensitivity.and specificity.for lung and bone lesions were 75.0% (12/16) and 33.3% (1/3), respectively. Regarding tumor volume measurement, good correlation between maxSUV on FDG- PET and tumor volume was obtained (lung metastases, P = 0.03; extrapelvic nodes, P y. all corresponding lesions over 1 cm3 showed a maxSUV value greater than 2.0. Conclusion. FDG- PET is a useful tool for the detection of extrapelvic lesions during the follow- up period after radiation therapy.for cervical cancer. T

关键词： FDG-PET 血清肿瘤标志物标准摄取值疾病复发放疗宫颈癌正电子发射断层成像异常病变容积检测

选择性中性粒细胞和单核细胞吸附血浆分离置换法作为未应用激素治疗的活动性溃疡性结肠炎患者的一线治疗:一项前瞻性无对照研究

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世界核心医学期刊文摘（胃肠病学分册） 2005年第1期1卷 5-6页

作者： suzuki y. y.shimura N. Saniabadi A.R. Saito y. Dr. 陈云茹 SakuraHospital Faculty of Medicine Toho University564-1 Shimoshizu Sakura City Chiba 285-874 Japan

Corticosteroid therapy.of ulcerative colitis (UC) is associated with frequent adverse side effects and poor quality.of ***, adsorptive granulocy.e and monocy.e/macrophage apheresis has shown efficacy.in patients with severe steroid refractory.UC. The objective of this study.was to investigate if, instead of corticosteroids, adsorptive leukocy.apheresis has efficacy.as the first-line therapy.for steroid-naive patients with active UC. Twenty.patients, aged 15-49 y.ars, with a meanclinical activity.index (CAI) of 8.6 were recruited. Adsorptive leukocy.apheresis was done with Adacolumn, which contains cellulose acetate beads as adsorptive carriers for granulocy.es and monocy.es (Fcγ R and complement receptors expressing leukocy.es). Each patient received 6 to 10 leukocy.e apheresis sessions of 60min duration, at 2 sessions/week. Efficacy.was assessed 1 week after the last session. Post treatment, the mean CAI was 3.0 (P=0.001), and 17 of 20 patients (85% ) were in remission. There were significant falls in C-reactive protein (P= 0.0003), total white cell counts (P=0.003), neutrophils (P=0.0029),and monocy.es(P=0.0038), an increase in ly.phocy.es(P= 0.001), and increases in the blood levels of soluble TNF-α receptors I(P=0.0007) and II(P=0.0045) in the column outflow(blood return to the patients). Further, at 8 months, 60% of patients had maintained their remission. No severe side effectswere reported. In conclusion, adsorptive leukocy.apheresis should reduce corticosteroid therapy.in patients with moderate UC; cases with early.stage active disease may.benefit most.

关键词：溃疡性结肠炎血浆分离置换法中性粒细胞临床活动白细胞总数淋巴细胞数巨噬细胞生活质量补体受体

脑桥海绵状血管瘤患者出现垂直旋转性眼震和双眼分离性水平凝视麻痹

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 3-4页

作者： Washio N. suzuki y. y.maki T. 陈立军 Department of Ophthalmology Sapporo Medical University School of Medicine S1 W16 Chuou-ku Sapporo 060- 8543 Japan

We report the case of a 16 y.ar old girl with verticaltorsional oscillations. She had a 4 y.ar history.of bilateral horizontal gaze palsy.caused by.a cavernous angioma in the medial part of the dorsal pons. She presented with vertical oscillopsia that had worsened during the past 3 months. Unilateral three dimensional ey.movements and bilateral horizontal ey. movements were recorded using a magnetic search coil method and direct current electro-oculography. respectively. She had vertical-torsional oscillations (avera-ge frequency. 3.0 Hz) leaving vertical saccades and pursuits intact. The average amplitudes of the vertical and torsional components were 2.0° and 0.6° , respectively. Her horizontal rapid ey. movements were severely.impaired; however, her horizontal pursuits and slow phases of vestibulo-ocular reflex were only.partially.impaired (gain y. movements.

关键词：旋转性眼震凝视麻痹分离性海绵状血管瘤海棉状血管瘤眼球运动眼电图前庭眼球反射平均频率运动障碍

宽视角快响应速度的有源矩阵LCD显示模式(英文)

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液晶与显示 1993年第3期 59-64页

作者： T. Miy.shjta,P. Vetter,M. suzuki,y. y.maguchi,T. Uchida Tohoku University Sendai Japan Tohoku University Sendai Japan Tohoku University Sendai Japan Tohoku University Sendai Japan Tohoku University Sendai Japan

在有源矩阵显示中视角是一个很重要的参数。为了解决视角问题,本文利用弯曲排列的液晶盒和光学补偿器提出了一个新的液晶显示模式,并讨论了这种液晶显示的设计原则以及转换速度。

关键词： LCD 液晶显示有源矩阵

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2例双眼先天性视乳头异常患者的不同表现

世界核心医学期刊文摘（眼科学分册） 2006年第8期2卷 44-45页

作者： suzuki y. Kawase E. Nishina S. Azuma N. 王静波 Department of Ophthalmology National Center for Child Health and Development 2- 10- 1 Okura Setagaya-ku Tokyo 157- 8535 Japan

Purpose: Description of two patients, each with different features of congenital optic disc anomalies in the two ey.s. Methods: Case report. Results: Patient 1, a 3- month-old girl, showed retinochoroidal coloboma involving the optic nerve in the right ey. and optic nerve hy.oplasia in the left ey.. Patient 2, a 5- month-old boy. showed retinal fold extending inferiorly.in the right ey. and optic disc coloboma in the left ey.. Conclusions: Since in both cases coloboma was seen in one ey., the optic nerve hy.oplasia or retinal fold in the fellow ey. of these two patients may.have been related to the timing of embry.nic fissure opening or closing.

关键词：视神经发育不全对侧眼男性患儿闭合时间

经正电子发射断层摄像术检查出的一例伴同侧偏盲的多发性硬化病例

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 52-52页

作者： MuraiH. Kiy.sawaM. suzuki y. 肖颖 Dept. of Ophthalmol. and Vis. Sci. Tokyo Medical and Dental University 1- 5- 45 Yushima Bunkyo-ku Tokyo 113- 8591 Japan

Background: To demonstrate the efficacy.of positron emission tomography.(PET) for examining multiple sclerosis (MS) patients with hemianopia. Case: A 20- y.ar-old man visited us with a complaint of left homony.ous hemianopia and headache. Observations: The patient’ s visual acuity.was 1.2 (n.c.) OD and 0.9 (1.0) OS. Magnetic resonance imaging (MRI) showed a mass in the temporoparietal lobe. A pathological diagnosis of MS was made by.brain biopsy. Low glucose metabolism in the lesion and visual cortex was observed by.PET with 18F-fluorodeoxy.glucose. PET with 11C-flumazeny. revealed a reduction of 11C-uptake in the demy.linated optic radiation, and only.a slight reduction of 11C-uptake in the primary.visual cortex. The results of 11C-flumazeny. PET suggested a slight reduction of neuronal density. In 2 y.ars, the visual field recovered to the normal state. Conclusion: PET can be a useful tool for estimating the visual outcome of patients with hemianopia in MS.

关键词：多发性硬化病同侧偏盲正电子发射初级视皮质脱髓鞘脱氧葡萄糖反射区损伤区糖代谢检测提示

一项对224例日本眼眶肿瘤患者21年的回顾:起源和部位

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世界核心医学期刊文摘（眼科学分册） 2005年第6期1卷 56-56页

作者： Ohtsuka K. Hashimoto M. suzuki y. 韩静 Departmentof Ophthalmology Sapporo Medical UniversitySchool of Medicine S- 1 W- 16 Chuo-ku Sapporo 060- 8543 Japan

Purpose: To review 244 cases of orbital tumors to determine the distribution of patient age, pathology. and tumor origin and location. Methods: We reviewed cases of histopathologically.or radiologically.verified orbital tumors at our institution from 1981 through 2002, and studied the distribution of patient age, pathology. origin of tumors, and tumor location in the orbit in 244 consecutive patients (aged from 0 to 90 y.ars, mean, 48.7 y.ars; 114 men, 130 women). Results: Among the 244 cases, 213 (89% ) were primary.orbital tumors, 23 (9% ) were secondary.tumors originating in contiguous spaces, and 8 ( 2% )weremetastatic tumors. Regarding the location in the orbit, 122 tumors (50% ) were extraconal, 36 (15% ) were intraconal, and 86 (35% ) were in the lacrimal gland area. The common tumors were reactive ly.phoid hy.erplasia (22% ) and malignant ly.phoma (20% ) in the extraconal area; cavernous hemangioma (25% ), optic nerve glioma (14% ), and optic nerve sheath meningioma (14% ) in the intraconal area; and malignant ly.-phoma (40% ) and pleomorphic adenoma (24% ) in the lacrimal gland area. The age distribution of the 244 patients exhibited two peaks, at 0 to 9 y.ars and 60 to 69 y.ars. In the 0- to 9- y.ar-old patients, the most common tumors were dermoid cy.t (26% ), optic nerve glioma (11% ), capillary.hemangioma (11% ), and hemorrhagic ly.phangioma (11% ). On the other hand, in patients over 40 y.ars of age, the common tumors were malignant ly.phoma (31% ), orbital pseudotumor (24% )- , pleomorphic adenoma (10% ), and cavernous hemangioma (9% ). Conclusions: The pathologic profiles of orbital tumors were characterized according to patient age and the location of the tumor in the orbit. The age of onset, tumor location, and radiological findings provide us with important information for the diagnosis of a tumor prior to biopsy.or tumor resection and for the determination of the treatment strategy.

关键词：眼眶肿瘤恶性淋巴瘤泪腺区海绵状血管瘤毛细血管瘤多形性腺瘤视神经胶质瘤皮样囊肿视神经鞘脑膜瘤年龄分布

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眼眶恶性淋巴瘤在日本患者中的高发病率

世界核心医学期刊文摘（眼科学分册） 2005年第3期1卷 28-28页

作者： Ohtsuka K. Hashimoto M. suzuki y. 张自峰

To review 244 cases of orbital tumors to determine pathologic findings in Japa nese patients. Observational case series. We studied the pathology.and origin of tumors in the orbit in 244 consecutive Japanese patients with orbital tumors at our institution from 1981 through 2002 (age 0 to 90 y.ars, mean, 48.7 y.ars; 11 4 men, 130 women). The most common tumors were ly.phoproliferative diseases (n=1 14, 42.5%), including malignant ly.phoma (n=59, 24.1%) and reactive ly.phoid h y.erplasia (n=45, 18.4%), pleomorphic adenoma (n=21, 8.6%), and cavernous hema ngioma (n=18, 7.4%). The incidence of ly.phoproliferative diseases, especially.malignant ly.phoma, was very.high in Japanese patients.

关键词：恶性淋巴瘤肿瘤病理学多形性腺瘤海绵状血管瘤增生性疾病肿瘤病例病例研究观察性