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Butyrate-induced GPR41 Activation Inhibits Histone Acetylation and Cell Growth

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Journal of Genetics and Genomics 2012年第8期39卷 375-384页

作者： Jin Wu Zongli Zhou Yinghe Hu suzhen dong Shanghai Engineering Research Center for Molecular Therapeutics and New Drug Development East China Normal University Shanghai 200062 China Institute of Chemical and Translational Genomics East China Normal University Shanghai 200062 China Shanghai Institute of Brain Functional Genomics MOE & STCSM Key Lab of Brain Functional Genomics East China Normal University Shanghai 200062 China

Butyrate has been recently identified as a natural ligand of the G-protein-coupled receptor 41 （GPR41）. In addition, it is an inhibitor of histone deacetylase （HDAC）. Butyrate treatment results in the hyperacetylation of histones, with resultant multiple biological effects including inhibition of proliferation, induction of cell cycle arrest, and apoptosis, in a variety of cultured mammalian cells. However, it is not clear whether GPR41 is actively involved in the above-mentioned processes. In this study, we generated a stable cell line expressing the hGPR41 receptor in order to investigate the involvement of GPR41 on butyrate-induced biochemical and physiologic processes. We found that GPR41 activation may be a compensatory mechanism to counter the increase in histone H3 acetylation levels induced by butyrate treatment. Moreover, GPR41 had an inhibitory effect on the anti-proliferative, pro-apoptotic effects of butyrate. GPR41 expression induced cell cycle arrest at the Gl-stage, while its activation by butyrate can cause more cells to pass the G1 checkpoint. These results indicated that GPR41 was associated with histone acetylation and might be involved in the acetylation-related regulation of cell processes including proliferation, apoptosis, and the cell cycle.

关键词： GPR41 Butyrate HDAC inhibitor Anti-proliferation Cell cycle arrest

Study on the simulated pickling of 443NT medium chrome ferritic stainless steel

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Baosteel Technical Research 2010年第1期4卷 50-52页

作者： PENG Jianguo LUO suzhen dong Wenbo Stainless Steel Technology Center Research Institute Baoshan Iron ＆ Steel Co. Ltd. Shanghai 200431 China

The oxide scale structure of 443NT hot-rolled strips was analyzed. The pickling of 443NT stainless steel was simulated via the 6σ experimental design. The results indicate that parabolic relations exist between the pickling scores and some of the pickling influencing factors, such as the nitric acid density, the hydrofluoric acid density and the pickling temperature. Effective pickling of 443NT can be achieved by controlling the pickling processing parameters with the HNO3 density ranging from 80 g/L to 180 g/L ,the HF density from 20 g/L to 40 g/L and the pickling temperature from 45 ℃ to60 ℃.

关键词： simulated pickling 443NT ferritic stainless steel

孕20~36周正常胎儿主动脉弓峡部和动脉导管直径的MRI测量

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中华围产医学杂志 2021年第3期24卷 220-225页

作者：刘可董素贞上海交通大学医学院附属上海儿童医学中心放射科 200127

目的探讨孕20~36周正常胎儿主动脉弓峡部直径和动脉导管直径的MRI测量的可行性,并探讨二者与孕周的关系。方法回顾性纳入2018年6月至2020年6月在上海交通大学医学院附属上海儿童医学中心行产前胎儿超声检查不能清楚显示四腔心结构,而行... 详细信息

目的探讨孕20~36周正常胎儿主动脉弓峡部直径和动脉导管直径的MRI测量的可行性,并探讨二者与孕周的关系。方法回顾性纳入2018年6月至2020年6月在上海交通大学医学院附属上海儿童医学中心行产前胎儿超声检查不能清楚显示四腔心结构,而行胎儿MRI检查也未发现心血管结构异常的257例孕妇,胎儿娩出后均经新生儿超声心动图证实心血管结构正常。重新调阅胎儿MRI图像,在稳态自由进动序列主动脉弓横轴位切面测量主动脉弓峡部中央部位直径,即主动脉弓峡部直径,同时在动脉导管近降主动脉处测量动脉导管直径。测量重复3次,取平均值。计算主动脉弓峡部直径和动脉导管直径对于孕周的第5、50、95百分位数和相应的95%CI,计算主动脉弓峡部直径与动脉导管直径比值的平均值和95%CI。采用Pearson相关分析和回归分析判断主动脉弓峡部直径和动脉导管直径与孕周的关系。结果主动脉弓峡部直径与孕周的回归方程为主动脉弓峡部直径(mm)=-2.85+0.22×孕周(周),二者呈线性正相关(R2=0.737,P<0.001)。主动脉弓峡部直径第50百分位数在孕20~28周为1.8~3.5 mm,在孕28~36周为3.5~5.0 mm。动脉导管直径与孕周的回归方程为动脉导管直径(mm)=-2.17+0.19×孕周(周),二者呈线性正相关(R2=0.606,P<0.001)。动脉导管直径第50百分位数在孕20~28周为2.0~3.5 mm,在孕28~36周为3.2~4.8 mm。孕20、22、24、26、28、30、32、34、36周的胎儿主动脉弓峡部直径与动脉导管直径比值的95%CI分别为0.8~1.1、0.8~1.0、0.8~1.0、0.8~1.3、0.8~1.5、0.9~1.5、0.9~1.7、0.9~1.1和1.0~1.3,接近1。结论MRI测量胎儿主动脉弓峡部直径与动脉导管直径可行,在超声检查不满意时,可做为评估手段。主动脉弓峡部直径和动脉导管直径与孕周呈一定的线性相关。

关键词：主动脉,胸动脉导管磁共振成像胎儿妊娠中期

Advances in the pathogenesis of Alzheimer’s disease:a re-evaluation of amyloid cascade hypothesis

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Translational Neurodegeneration 2012年第1期1卷 140-151页

作者： suzhen dong Yale Duan Yinghe Hu Zheng Zhao Shanghai Engineering Research Center for Molecular Therapeutics and New Drug Development East China Normal UniversityShanghai 200062China Institute of Chemical and Translational Genomics East China Normal UniversityShanghai 200062China Key Laboratory of Brain Functional Genomics Ministry of EducationShanghai Key Laboratory of Brain Functional GenomicsEast China Normal University3663 Zhongshan Road(N)Shanghai 200062China

Alzheimer’s disease(AD)is a common neurodegenerative disease characterized clinically by progressive deterioration of memory,and pathologically by histopathological changes including extracellular deposits of amyloid-beta(A-beta)peptides forming senile plaques(SP)and the intracellular neurofibrillary tangles(NFT)of hyperphosphorylated tau in the *** review focused on the new developments of amyloid cascade hypothesis with details on the production,metabolism and clearance of A-beta,and the key roles of some important A-beta-related genes in the pathological processes of *** most recent research advances in genetics,neuropathology and pathogenesis of the disease were also discussed.

关键词： Alzheimer’s disease A-beta APP BACE1 Presenilins ApoE Neprilysin/insulin-degrading enzyme

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MRI定量评估胎儿脑体积

中国医学影像技术 2020年第8期36卷 1121-1126页

作者：任婧雅董素贞上海交通大学医学院附属上海儿童医学中心放射科上海200127

目的观察MRI定量脑体积评估胎儿大脑发育的价值。方法对60例排除胎儿中枢神经系统异常或发育不良、孕周(GA)21~37周的单胎妊娠孕妇行胎儿MR检查,采用单次激发快速自旋回波(SSTSE)序列采集胎儿MRI,经后处理后手动分割大脑,测量胎儿三维... 详细信息

目的观察MRI定量脑体积评估胎儿大脑发育的价值。方法对60例排除胎儿中枢神经系统异常或发育不良、孕周(GA)21~37周的单胎妊娠孕妇行胎儿MR检查,采用单次激发快速自旋回波(SSTSE)序列采集胎儿MRI,经后处理后手动分割大脑,测量胎儿三维脑体积指标颅腔内体积(ICV)、脑总容积(TBV)和脑脊液容积(CFV),计算大脑二维径线指标,包括大脑双顶径(BPD)、骨性双顶径(SBD)、枕额径(SOD)及头围(HC)。分析二维径线指标及三维脑体积指标与GA的相关性,并进行回归分析;观察三维脑体积指标与二维径线指标间的关系。结果TBV(r=0.98)、ICV(r=0.97)、CFV(r=0.89)、BPD(r=0.96)、SBD(r=0.94)、SOD(r=0.96)、HC(r=0.96)均与GA呈高度正相关(P均<0.01)。TBV及ICV与二维径线各指标间均高度正相关(P均<0.01),HC与CFV间亦呈高度相关(P<0.01)。结论MRI三维定量脑体积可较好评估GA 21~37周胎儿颅脑生长发育,有望为产前诊断胎儿脑疾病及研究其发病机制提供新的影像学手段。

关键词：脑体积胎儿磁共振成像

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MRI诊断胎儿重复肾畸形

中国医学影像技术 2018年第7期34卷 1055-1058页

作者：纪慧董素贞上海交通大学医学院附属上海儿童医学中心放射科上海200127

目的探讨产前MRI诊断胎儿重复肾畸形的价值。方法回顾性分析22例经出生后随访证实为重复肾畸形的产前MRI及超声资料,并与随访结果对照。结果 22例患儿中,左侧重复肾脏畸形9例、右侧重复肾脏畸形8例、双侧重复肾脏畸形5例。11例伴肾积水... 详细信息

目的探讨产前MRI诊断胎儿重复肾畸形的价值。方法回顾性分析22例经出生后随访证实为重复肾畸形的产前MRI及超声资料,并与随访结果对照。结果 22例患儿中,左侧重复肾脏畸形9例、右侧重复肾脏畸形8例、双侧重复肾脏畸形5例。11例伴肾积水,其中上半肾积水7例、全肾积水4例;7例伴输尿管异位开口;2例伴输尿管囊肿。15例(15/22,68.18%)产前超声与产前MRI对诊断一致,其中2例诊断均不完全准确;7例(7/22,31.82%)诊断不一致,产前超声误诊2胎、诊断不全5胎。结论对于诊断胎儿重复肾畸形,当超声显示不满意时,MRI可发挥重要补充作用。

关键词：重复肾胎儿磁共振成像产前诊断

3-[3-(3-florophenyl-2-propyn-1-ylthio)-1,2,5-thiadiazol-4-yl]-1,2,5,6-tetrahydro-1-methylpyridine oxalate,a novel xanomeline derivative,improves neural cells proliferation and survival in adult mice

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Neural Regeneration Research 2012年第1期7卷 24-30页

作者： Xiaoliang Zhang Qiang Gong Shuang Zhang Lin Wang Yinghe Hu Haiming Shen suzhen dong Key Laboratory of Brain Functional Genomics Ministry of Education East China Normal University Shanghai 200062 China Shanghai Engineering Research Center of Molecular Therapeutics and New Drug Development Institute for Advanced Interdisciplinary Research East China Normal University Shanghai 200062 China Institute of Aviation Medicine Civil Aviation University of China Tianjin 300300 China

The present study analyzed the influence of 3-[3-（3-florophenyl-2-propyn-l-ylthio）-1, 2, 5-thiadiazol-4-yl]-1, 2, 5, 6-tetrahydro-l-methylpyridine oxalate （EUK1001）, a novel xanomeline derivative of the M1/M4 receptor agonist, on hippocampal neurogenesis in adult C57BL6 mice. Results showed that 15-day EUK1001 treatment via intraperitoneal injection promoted neural cell proliferation in the dentate gyrus, although cell differentiation did not change. The majority of bromodeoxyuridine-positive cells co-expressed the immature neuronal marker doublecortin. In addition, the level of neurogenesis in the subventricular zone was not altered. Brain-derived neurotrophic factor mRNA expression was up-regulated following EUK1001 treatment, but no change was observed in expression of camp-responsive element binding protein 1, paired box gene 6, vascular endothelial growth factor alpha, neurogenic differentiation factor 1, and wingless-related mouse mammary tumor virus integration site 3A mRNA. These experimental findings indicated that EUK1001 enhanced proliferation and survival of hippocampal cells, possibly by increasing brain-derived neurotrophic factor expression.

关键词： EUK1001 brain-derived neurotrophic factor MjM4 receptor neural regeneration proliferation survival

产前MRI量化评价先天性心脏病胎儿脑二维径线

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中国医学影像技术 2020年第8期36卷 1135-1139页

作者：任婧雅董素贞上海交通大学医学院附属上海儿童医学中心放射科上海200127

目的观察产前MRI量化评价先天性心脏病胎儿脑二维径线的价值。方法150名孕龄(GA)21~39周孕妇(150胎)接受产前胎儿MR检查,其中50胎先天性心脏病(CHD)胎儿(CHD组),GA平均(28.05±4.50)周,包括27胎0.05);≥28周胎儿中,CHD组BBD、BFOL、SOD... 详细信息

目的观察产前MRI量化评价先天性心脏病胎儿脑二维径线的价值。方法150名孕龄(GA)21~39周孕妇(150胎)接受产前胎儿MR检查,其中50胎先天性心脏病(CHD)胎儿(CHD组),GA平均(28.05±4.50)周,包括27胎0.05);≥28周胎儿中,CHD组BBD、BFOL、SOD和HC均小于对照组(P均<0.05),SBD差异无统计学意义(P=0.10)。结论MRI量化评价胎儿颅脑生物学指标可为宫内评估胎儿大脑生长发育情况提供参考。CHD在宫内即可影响胎儿脑发育;中晚孕期CHD胎儿BBD、BFOL、SOD和HC均相对减小。

关键词：脑心脏缺损,先天性胎儿磁共振成像

影像学诊断以外周性性早熟为首发症状的儿童性腺肿瘤

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中国医学影像技术 2023年第8期39卷 1144-1146页

作者：任婧雅董素贞上海交通大学医学院附属上海儿童医学中心放射科上海200127

性早熟指女童8岁、男童9岁之前出现应于青春期发育的第二性征[1],可分为中枢性性早熟和外周性性早熟(peripheral precocious puberty,PPP)。PPP无完整发育程序性过程,为非促性腺激素释放激素依赖性性早熟[2],常见病因包括肾上腺疾病、... 详细信息

性早熟指女童8岁、男童9岁之前出现应于青春期发育的第二性征[1],可分为中枢性性早熟和外周性性早熟(peripheral precocious puberty,PPP)。PPP无完整发育程序性过程,为非促性腺激素释放激素依赖性性早熟[2],常见病因包括肾上腺疾病、性腺肿瘤和麦丘恩-奥尔布赖特综合征(McCune-Albright syndrome,MAS)等[3]。以PPP为首发症状的儿童卵巢/睾丸肿瘤临床少见,本研究观察影像学诊断此类肿瘤的价值。

关键词：儿童肿瘤性腺组织诊断显像青春期早熟

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