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国际眼科杂志 2015年第5期15卷 750-754页

作者： Gowtham Jonna Daniel B. Roth Howard F. Fine H. Matthew Wheatley Jonathan L. Prenner Arvin Kheterpal suzanne cohen William J. Feuer 罗格斯大学Robert Wood Johnson医学院眼科美国新泽西州08901 迈阿密大学Miller医学院、Bascom Palmer眼科研究所美国佛罗里达州

目的:探讨下方玻璃体腔注射比上方注射出现注射后眼内炎的几率是否更高。下方小梁切除术滤过泡眼内炎的发病率高于上方小梁切除术滤过泡,有可能是因为细菌聚集在下方的泪湖。方法:经过广泛实践过的眼内炎病例数据库验证,发现在2a的研究... 详细信息

目的:探讨下方玻璃体腔注射比上方注射出现注射后眼内炎的几率是否更高。下方小梁切除术滤过泡眼内炎的发病率高于上方小梁切除术滤过泡,有可能是因为细菌聚集在下方的泪湖。方法:经过广泛实践过的眼内炎病例数据库验证,发现在2a的研究期间内,有5例眼内炎病例。同时,为了评估注射部位对发病率的影响,对治疗过的909例1 121眼共计8672次注射进行了回顾性调查。结果:5眼出现感染性眼内炎,80%的眼内炎病例均是下方注射,尽管所选病例中84.6%是位于上方注射。与感染有关的下方注射部位的危险比是(OR)22.1(P=0.006)。结论:玻璃体腔注射后感染眼内炎的几率很小,仅为0.025%。避免在偏下象限进行玻璃体腔注射可能会进一步减小眼内炎的发病率。

关键词：玻璃体内注射部位抗血管生长因子疗法眼内炎

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维普期刊数据库

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Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions

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Journal of Pharmaceutical Analysis 2018年第6期8卷 407-412页

作者： Jayesh A.Dhanani suzanne L.Parker Jeffrey Lipman Steven C.Wallis Jeremy cohen John Fraser Adrian Barnett Michelle Chew Jason A.Roberts Burns Trauma and Critical Care Research Centre The University of Queensland UQ Centre for Clinical Research Department of Intensive Care Medicine Royal Brisbane & Women's Hospital Faculty of Health Queensland University of Technology Critical Care Research Group The University of Queensland Institute of Health and Biomedical Innovation & School of Public Health and Social Work Queensland University of Technology Department of Anaesthesiology and Intensive Care and Department of Medical and Health Sciences Link?ping University School of Pharmacy The University of Queensland Department of Pharmacy Royal Brisbane & Women's Hospital

Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into microdialysate requires investigation. In vitro microdialysis recovery studies were conducted on a combination of vancomycin and tobramycin, in a simulated in vivo model. Comparison was made between recoveries for three different concentrations and three different perfusate flow rates. The overall relative recovery for vancomycin was lower than that of tobramycin. For tobramycin, a concentration of 20μg/mL and flow rate of 1.0μL/min had the best recovery. A concentration of 5.0μg/mL and flow rate of 1.0μL/min yielded maximal recovery for vancomycin. Large molecular size and higher protein binding resulted in lower relative recoveries for vancomycin. Perfusate flow rates and drug concentrations affected the relative recovery when a combination of vancomycin and tobramycin was tested. Low perfusate flow rates were associated with higher recovery rates. For combination antibiotic measurement which includes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound concentrations.

关键词： Microdialysis Combination antibiotic therapy Relative recovery rate Pharmacokinetics Anti-infectives Protein binding

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Perinatal consequences of disproportionate fetal trunk growth

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Open Journal of Obstetrics and Gynecology 2012年第2期2卷 131-135页

作者： Ralph L. Cavalieri suzanne Laroche Wayne R. cohen Department of Obstetrics & Gynecology and Women’s Health Albert Einstein College of Medicine New York USA Departments of Obstetrics and Gynecology Jamaica Hospital Medical Center Weill Cornell Medical College New York USA

Objective: To identify the impact of an abnormally large neonatal chest circumference relative to head circumference on labor and neonatal morbidity. Methods: We used a retrospective cohort design to study 54 obstetric cases in which the neonatal thoracic circumference was ≥2.5 cm greater than that of the head. For each case we sought controls with a smaller thorax-head circumference difference. Ninety-seven controls were matched with their respective cases for birth weight, parity, maternal body mass index (BMI), and maternal ethnicity. Results: Cases had significantly smaller heads and larger trunks than controls (P < 0.0001). Cases were twice as likely (39% vs 19%, P = 0.007) to require admission to the neonatal intensive care unit. There was no significant difference between cases and controls in the frequency of shoulder dystocia, long second stage, or long deceleration phase of labor. However, compound presentations occurred more frequently in the cases than in controls (5.5% vs 0%, P = 0.044). Conclusion: Babies with disproportionately large trunk growth were at risk for requiring neonatal intensive care and for compound presentation.

关键词： Neonatal Morbidity Fetal Dysmorphism Somatic Asymmetry Labor Abnormality Deceleration Phase Shoulder Dystocia Compound Presentation Trunk Circumference Head Circumference

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Takotsubo cardiomyopathy in orthotopic liver transplant recipients: A cohort study using multi-center pooled electronic health record data

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World Journal of Hepatology 2022年第2期14卷 400-410页

作者： Mohammad Zmaili Jafar Alzubi Motasem Alkhayyat Joshua cohen Saqer Alkharabsheh Mariam Rana Paulino A Alvarez Emad Mansoor Bo Xu Robert and suzanne Tomsich Department of Cardiovascular Medicine Sydell and Arnold Miller Family HeartVascular and Thoracic InstituteCleveland Clinic FoundationClevelandOH 44195United States Department of Medicine Division of CardiologyEinstein Medical CenterPhiladelphiaPA 19141United States Department of Gastroenterology Hepatology and NutritionDigestive Disease and Surgery InstituteCleveland Clinic FoundationClevelandOH 44195United States Department of Medicine University Hospitals Cleveland Medical CenterCase Western Reserve UniversityClevelandOH 44106United States Department of Gastroenterology University Hospitals Cleveland Medical CenterCase Western Reserve UniversityClevelandOH 44106United States

BACKGROUND Takotsubo cardiomyopathy(TCM),or stress-induced cardiomyopathy,is associated with adverse *** data suggest that TCM occurring in orthotopic liver transplant(OLT)recipients is associated with elevated perioperative *** To characterize the predictors of TCM in OLT recipients,using a large,multicenter pooled electronic health *** A multi-institutional database(Explorys Inc,Cleveland,OH,USA),an aggregate of de-identified electronic health record data from 26 United States healthcare systems was surveyed.A cohort of patients with a Systematized Nomenclature of Medicine-Clinical Terms of“liver transplant”between 09/2015 and 09/2020 was ***,individuals who developed a new diagnosis of TCM following OLT were ***,the risk associations with TCM among this patient population were characterized using linear *** Between 09/2015 and 09/2020,of 37718540 patients in the database,38740(0.10%)had a history of OLT(60.6%had an age between 18-65 years,58.1%female).A new diagnosis of TCM was identified in 0.3%of OLT recipients(45.5%had an age between 18-65 years,72.7%female),compared to 0.04%in non-OLT patients[odds ratio(OR):7.98,95%confidence intervals:6.62-9.63,(P<0.0001)].OLT recipients who developed TCM,compared to those who did not,were more likely to be greater than 65 years of age,Caucasian,and female(P<0.05).There was also a significant association with cardiac arrhythmias,especially ventricular arrhythmias(P<0.0001).CONCLUSION TCM was significantly more likely to occur in LT recipients vs *** age,Caucasian ethnicity,female gender,and presence of arrhythmias were significantly associated with TCM in LT recipients.

关键词： Takotsubo cardiomyopathy Orthotopic liver transplant Stress-induced cardiomyopathy Clinical outcomes

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