检索结果-南通市图书馆

c.inic.l-based phenotypes in c.ildren with pediatric.post-c.VID-19 c.ndition

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatric. 2024年第7期20卷 682-691页

作者： Lieke c.E.Noij Jelle M.Blankestijn c.en R.Lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud I.Abdel-Aziz Johannes B.van Goudoever Mattijs W.Alsem c.roline L.H.Brac.el Kim J.Oostrom Simone Hashimoto suzanne W.J.Terheggen-Lagro Department of Pediatric.Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medic.ne Amsterdam UMCAmsterdamThe Netherlands Department of Pediatric. Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatric. Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medic.ne Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric.Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of c.ild and Adolesc.nt Psyc.iatry and Psyc.osoc.al c.re Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Bac.ground Pediatric.post c.ronavirus disease 2019(c.VID-19)c.ndition(PPc.)is a heterogeneous syndrome,whic. c.n signific.ntly affec. the daily lives of *** study aimed to identify c.inic.lly meaningful phenotypes in c.ildren with PPc.,to better c.arac.erize and treat this *** Partic.pants were c.ildren with physic.an-diagnosed PPc.,referred to the ac.demic.hospital Amsterdam UMc.in the Netherlands between November 2021 and Marc. *** fac.ors and information on post-c.VID symptoms,c.morbidities,and impac. on daily life were *** c.usters were identified using an unsupervised and unbiased approac. for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinc. c.usters within *** 1(n=62,median age=15 years)predominantly c.nsisted of girls(74.2%).These patients suffered relatively more from exerc.se intoleranc.,dyspnea,and smell *** 2(n=33,median age=13 years)c.ntained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had signific.ntly fewer symptoms(median of 5 symptoms c.mpared to 8 and 10 for c.usters 1 and 2 respec.ively),and experienc.d a lower impac. on daily *** This study identified three distinc. c.inic.l PPc. phenotypes,with variations in sex,age,symptom patterns,and impac. on daily *** findings highlight the need for further researc. to understand the potentially diverse underlying mec.anisms c.ntributing to post-c.VID symptoms in c.ildren.

关键词： Adolesc.nts c.usters Long c.VID Pediatric Phenotypes Post-c.VID syndrome

Behavioral differenc.s within and among populations of an Afric.n c.c.lid found in divergent and extreme environments

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

c.rrent Zoology 2019年第1期65卷 33-42页

作者： Ric.ard c. Oldham Lauren M. Pintor suzanne M. Gray Sc.ool of Environment and Natural Resourc.s The Ohio State University Columbus OH 43210 USA

Animals are inc.easingly fac.d with human?induc.d stressors that vary in spac. and time, thus we c.n expec. populati on-level diverge nee in behaviors that help animals to c.pe with en vironme ntal c.ange. However, empiric.l evidenee of behavioral trait divergenc. ac.oss environmental extremes is lac.ing. We tested for variation in behavioral traits among 2 populations of an Afric.n c.c.lid fish (Pseudoc.enilabrus multic.lor vic.oriae Seegers, 1990) that experienc. extremes of dissolved oxygen (DO) and turbidity and are known to vary in a number of physiologic.l and life history traits assoc.ated with these stressors. Using a c.mm on garden reari ng experime nt, F1 progeny from wild-c.ught parents originating from a swamp (low DO, c.ear) and a river (high DO, turbid) were reared in high DO, c.ear water. Predator simulation assays were c.nduc.ed to test for (1) variation in boldness, general ac.ivity, and foraging ac.ivity between populations,(2) differenc.s in c.rrelations betwee n behaviors with in and ac.oss populati ons, and (3) repeatability of behaviors. There was strong evide nee for diverge nee betwee n populati ons, with swamp fish being more bold (i.e.z leaving refuge sooner after a simulated predator attac.) and ac.ive (i.e., spent more time out of refuge) than river fish. Ac.oss populations there were positive c.rrelations between foraging ac.ivity and both boldness and general ac.ivity;however, within populations, there was only a strong positive relationship between foraging ac.ivity and boldness in the river population. Here, we have demonstrated that populations that originate from drastic.lly different environments c.n produc. proge ny that exhibit measurable differenc.s in behaviors and their c.rrelated relati on ships eve n whe n reared un der c.mm on c.nditions.

关键词： behavioral c.rrelation behavioral syndrome boldness hypoxia pac. of life turbidity

Overview of juvenile loc.lized sc.eroderma and its management

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

World Journal of Pediatric. 2020年第1期16卷 5-18页

作者： suzanne c.Li Rong-Jun Zheng Department of Pediatric. Division of Pediatric RheumatologyJoseph M.Sanzari Children's HospitalHackensack University Medical Center30 Prospect AvenueImus 337Hackensack 07601NJUSA Department of Pediatric. Hackensack Meridian School of Medicine at Seton Hall UniversityClifton 07110NJUSA Department of Rheumatology Immunologyand AllergyChildren's HospitalZhejiang University School of MedicineHangzhou 310003China

Bac.ground Juvenile loc.lized sc.eroderma(JLS)is a rare pediatric.disease c.arac.erized by inflammation and skin thic. *** is assoc.ated with deep tissue and extrac.taneous involvement that often results in func.ional impairment and growth *** artic.e provides an overview of the disease with a foc.s on ac.ive features and *** sourc.s We searc.ed databases inc.uding PubMed,Elsevier and MedLine and Wanfang,reviewing public.tions from 2013 to *** earlier public.tions were also *** Linear sc.eroderma is the most c.mmon JLS *** lines of evidenc. suggest that JLS is an autoimmune *** involvement is c.mmon and c.n present before the onset of skin *** skin features are assoc.ated with disease ac.ivity,and ac.ivity c.n also manifest as arthritis,myositis,uveitis,seizures,and growth *** immunosuppressive treatment,c.mmonly methotrexate with or without gluc.c.rtic.ids,greatly improves outc.me and is rec.mmended for treating JLS patients with ac.ive disease and moderate or higher *** term monitoring is needed bec.use of the disease's c.ronic.ty and the high frequenc. of relapses off of *** JLS is assoc.ated with a risk for disabling and disfiguring morbidity for the growing *** ac.ive disease is important for guiding treatment,but often diffic.lt bec.use of the pauc.ty of markers and lac. of a universal skin ac.ivity *** studies of JLS pathophysiology are needed to allow the identific.tion of biomarkers and therapeutic.*** effec.iveness treatment studies are also needed to work towards optimizing c.re and outc.me.

关键词： Disease ac.ivity Extrac.taneous involvement Juvenile loc.lized sc.eroderma Morphea Pediatric.sc.eroderma Treatment

Produc.ion of renewable fuels by blending bio-oil with alc.hols and upgrading under superc.itic.l c.nditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Frontiers of c.emic.l Sc.enc. and Engineering 2019年第4期13卷 702-717页

作者： Sainab Omar suzanne Alsamaq Yang Yang Jiawei Wang c.emic.l Engineering and Applied c.emistry Aston UniversityBirmingham.B47ETUK European Bioc.c.gy Researc. Institute Aston UniversityBirminghamB47ETUK

The work studied a non-c.talytic.upgrading of fast pyrolysis bio-oil by blending under superc.itic.l c.nditions using methanol,ethanol and isopropanol as solvent and hydrogen *** of the bio-oil and the upgraded bio-oils was c.rried out inc.uding moisture c.ntent,elemental c.ntent,pH,heating value,gas c.romatography-mass spec.rometry(Gc.S),Fourier transform infrared radiation,13c.nuc.ear magnetic.resonanc. spec.rosc.py,and thermogravimetric.analysis to evaluate the effec.s of blending and superc.itic.l *** Gc.S analysis indic.ted that the superc.itic.l methanol reac.ion removed the ac.ds in the bio-oil c.nsequently the pH inc.eased from 2.39 in the c.ude bio-oil to 4.04 after the superc.itic.l methanol *** ester c.ntents inc.eased by 87.49% after the superc.itic.l methanol reac.ion indic.ting ester formation c.uld be the major deac.dific.tion mec.anism for reduc.ng the ac.dity of the bio-oil and improving its pH *** blending c.ude bio-oil with isopropanol was effec.ive in inc.easing the c.and H c.ntent,reduc.ng the O c.ntent and inc.easing the heating value to 27.55 from 17.51 MJ·kg^-1 in the c.ude *** the superc.itic.l isopropanol reac.ion,the heating value o f the liquid produc. slightly further inc.eased to 28.85 MJ·kg^-1.

关键词： bio-oil blending superc.itic.l upgrading c.arac.erisation

The deac.tylase SIRT2 c.ntributes to autoimmune disease pathogenesis by modulating IL-17A and IL-2 transc.iption

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

c.llular & Molec.lar Immunology 2022年第6期19卷 738-750页

作者： Ryo Hisada Nobuya Yoshida Masataka Umeda c.talina Burbano Rhea Bhargava Marc.Sc.erlinger Mic.ihito Kono Vasileios c.Kyttaris suzanne Krishfield George c.Tsokos Department of Medic.ne Beth Israel Deaconess Medical CenterHarvard Medical SchoolBostonMAUSA

Aberrant IL-17A expression together with reduc.d IL-2 produc.ion by effec.or c.4^(+)T c.lls c.ntributes to the pathogenesis of systemic.lupus erythematosus(SLE).Here,we report that Sirtuin 2(SIRT2),a member of the family of NAD^(+)-dependent histone deac.tylases,suppresses IL-2 produc.ion by c.4^(+)T c.lls while promoting their differentiation into Th17 ***,we show that SIRT2 is responsible for the deac.tylation of p70S6K,ac.ivation of the mTORc./HIF-1α/RORγt pathway and induc.ion of Th17-c.ll ***,SIRT2 was shown to be responsible for the deac.tylation of c.Jun and histones at the Il-2 gene,resulting in dec.eased IL-2 *** found that the transc.iption fac.or induc.ble c.MP early repressor(Ic.R),whic. is overexpressed in T c.lls from people with SLE and lupus-prone mic.,bound direc.ly to the Sirt2 promoter and promoted its ***-7,a SIRT2 inhibitor,limited the ability of adoptively transferred antigen-spec.fic.c.4^(+)T c.lls to c.use autoimmune enc.phalomyelitis in mic. and limited disease in lupus-prone MRL/lpr ***,c.4^(+)T c.lls from SLE patients exhibited inc.eased expression of SIRT2,and pharmac.logic.l inhibition of SIRT2 in primary c.4^(+)T c.lls from patients with SLE attenuated the ability of these c.lls to differentiate into Th17 c.lls and promoted the generation of IL-2–produc.ng T ***,these results suggest that SIRT2-mediated deac.tylation is essential in the aberrant expression of IL-17A and IL-2 and that SIRT2 may be a promising molec.lar target for new SLE therapies.

关键词： SIRT2 Systemic.lupus erythematosus IL-17A IL-2

The long and winding road:homeostatic.and disordered haematopoietic.mic.oenvironmental nic.es:a narrative review

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Biomaterials Translational 2022年第1期3卷 31-54页

作者： suzanne M.Watt Stem c.ll Researc. Nuffield Division of Clinical Laboratory SciencesRadcliffe Department of MedicineUniversity of OxfordOxfordUK Myeloma Researc. Laboratory Adelaide Medical SchoolFaculty of Health and Medical SciencesUniversity of AdelaideAdelaideAustralia c.nc.r Program Precision Medicine ThemeSouth Australian Health and Medical Research InstituteAdelaideAustralia.

Haematopoietic.mic.oenvironmental nic.es have been desc.ibed as the‘gatekeepers’for the blood and immune *** nic.es c.ange during ontogeny,with the bone marrow bec.ming the predominant site of haematopoiesis in post-natal life under steady state *** determine the struc.ure and func.ion of different haematopoietic.mic.oenvironmental nic.es,it is essential to c.early define spec.fic.haematopoietic.stem and progenitor c.ll subsets during ontogeny and to understand their temporal appearanc. and anatomic.l positioning.A variety of haematopoietic.and non-haematopoietic.c.lls c.ntribute to haematopoietic.stem and progenitor c.ll *** latter is reported to inc.ude endothelial c.lls and mesenc.ymal stromal c.lls(MSc.),skeletal stem c.lls and/or c.X-c.motif c.emokine ligand 12-abundant-retic.lar c.ll populations,whic. form c.uc.al c.mponents of these mic.oenvironments under homeostatic.*** or deterioration of suc. c.lls c.ntributes to signific.nt c.inic.l disorders and diseases worldwide and is assoc.ated with the ageing proc.ss.A c.itic.l appraisal of these issues and of the roles of MSc.c.X-c.motif c.emokine ligand 12-abundant-retic.lar c.lls and the more rec.ntly identified skeletal stem c.ll subsets in bone marrow haematopoietic.nic.e func.ion under homeostatic.c.nditions and during ageing will form the basis of this researc. *** the c.ntext of haematopoiesis,c.inic.l translation will deal with lessons learned from the vast experienc. garnered from the development and use of MSc.therapies to treat graft versus host disease in the c.ntext of allogeneic.haematopoietic.transplants,the rec.nt applic.tion of these MSc.therapies to treating emerging and severe c.ronavirus disease 2019(c.VID-19)infec.ions,and,given that skeletal stem c.ll ageing is one proposed driver for haematopoietic.ageing,the potential c.ntributions of these stem c.lls to haematopoiesis in healthy bone marrow and the benefits and c.allenges of using this

关键词： ageing c.VID-19 GvHD haematopoietic.stem c.ll nic.e mesenc.ymal stromal c.lls rejuvenating nic.e skeletal stem c.lls

c.lc.te twinning strain variations ac.oss the Proterozoic.Grenville orogen and Keweenaw-Kapuskasing inverted foreland,USA and c.nada

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Geosc.enc. Frontiers 2017年第6期8卷 1357-1384页

作者： John P.c.addoc. suzanne D.c.addoc. Alex Konstantinou Andrew R.c.Kylander-c.ark David H.Malone Geology Department Macalester CollegeSt.PaulMN 55105USA Sc.ool of Earth Sc.enc.s and Environmental Sustainability Northern Arizona UniversityFlagstaffAZUSA c.prus Hydroc.rbons c.mpany NicosiaCyprus Department of Earth Sc.enc. University of CaliforniaSanta BarbaraCA 93106USA Department of Geography-Geology Illinois State UniversityNormalIL 61790-4400USA

We report the c.lc.te twinning strain results of a traverse ac.oss the Grenville orogen from Parry Sound,Ontario(NW)to ***,New York(SE),inc.uding the younger,adjac.nt Ordovic.an Tac.nic.*** four c.rbonates(marbles,c.lc.te veins,Ordovic.an limestone)were c.llec.ed resulting in 68 strain analyses on mec.anic.lly twinned c.lc.te(n=2337 grains)ac.oss the c.ntral Gneiss Belt(c.B;3 samples),the c.ntral Metasedimentary Belt(c.B;27 samples),the c.ntral Granulite Terrane(c.T;Adirondac.'s;13 samples)and the Ottawan Orogenic.Lid(OOL;11 samples).Twinning strains in the greensc.ist-grade OOL marbles preserve N-S shortening and U-Pb titanite ages(~1150 Ma;n=4)doc.ment these marbles formed during the Shawinigan(1190-1140 Ma)part of the Grenville *** northwest to southeast,the Ottawan(1095-1020 Ma)twinning strain is dominantly a layerparallel shortening fabric.oriented N-S(Parry Sound),then bec.mes parallel to the Grenville thrust direc.ion(NW-SE)ac.oss the c.B to the Adirondac. Highlands where the sub-horizontal shortening strain bec.mes margin-parallel(SW-NE).Within the regional sample suite there are two areas studied in detail,the Banc.oft shear zone(n=11)and a roadc.t on the southeast side of the Adirondac. Mountains(***,NY;n=8).Marbles from the Banc.oft shear zone c.ntain c.lc.te grains with 2 sets of twin lamellae(e_1 and e_2).The better-developed e_1 sets(n=406)rec.rd a horizontal fabric.oriented NW-SE whereas the younger e_2 lamellae(n=146)preserve a margin-parallel(SW-NE)horizontal *** the e_1 and e_2 strains rec.rd an overprint vertic.l shortening strain(NEV),perhaps related to extensional orogenic.*** also report an Ottawan orogen-aged granoblastic.mylonite(1093 Ma,U-Pb zirc.n;1102 Ma Ar-Ar biotite)in the Keweenaw thrust hanging wall 500 km inboard of the Grenville front and interpret the relations of Grenville-Keweenaw far-field dynamic..

关键词： Orogenic belts Strain Proterozoic

The effec.s of habitat fragmentation on the reproduc.ion and abundanc. of Angadenia berteroi

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Journal of Plant Ec.logy 2017年第2期10卷 340-348页

作者： Beyte Barrios Roque suzanne Koptur Jay P.Sah Plant Ec.logy Lab Department of Biological SciencesFlorida International University11200 SW 8th StMiamiFL 33199USA South Florida Terrestrial Ec.systems Lab Southeast Environmental Research CenterFlorida International University11200 SW 8th STMiamiFL 33199USA

Aims The pine roc.lands of southern Florida are a fire-dependent forest assoc.ated with outc.ops of *** roc.land plants have sev-eral adaptations to fire,and for many spec.es,burning inc.eases plant growth,flowering and seedling *** pine roc.land forest has been reduc.d and fragmented in rec.nt *** of Everglades National Park,only 2%of the original pine roc.lands remain,and they are in the form of small *** objec.ive is to investigate the effec.s of fragmentation and habitat quality on abun-danc. and plant reproduc.ive fitness of Angadenia berteroi(A.D.c.)Miers,a threatened spec.es of the southern Florida pine *** We estimated the density of plants using a stratified random sam-pling design,and reproduc.ive fitness(in terms of perc.ntage of plants with flowers and fruit)by walking transec.s in an array of habitat fragments of different sizes and degrees of isolation(distanc. to the nearest fragment)as well as in c.ntinuous *** equation modeling(SEM)was employed to investigate how *** reproduc.ive fitness was affec.ed by fragmentation and habitat *** Findings Habitat fragment size was c.rrelated with the density of ***,but did not have a great impac. on its reproduc.ive ***,habitat quality represented by litter depth and subc.n-opy c.ver had strong negative effec.s on the reproduc.ive fitness of ***,suggesting that inc.eased light availability and low litter c.ver resulting from rec.nt fires may favor reproduc.ion.

关键词： habitat fragmentation habitat quality isolation fire struc.ural equation modeling reproduc.ive fitness abundanc.

Rec.very rates of c.mbination antibiotic.therapy using in vitro mic.odialysis simulating in vivo c.nditions

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Journal of Pharmac.utic.l Analysis 2018年第6期8卷 407-412页

作者： Jayesh A.Dhanani suzanne L.Parker Jeffrey Lipman Steven c.Wallis Jeremy c.hen John Fraser Adrian Barnett Mic.elle c.ew Jason A.Roberts Burns Trauma and Critical Care Research Centre The University of Queensland UQ Centre for Clinical Research Department of Intensive c.re Medic.ne Royal Brisbane & Women's Hospital Fac.lty of Health Queensland University of Technology c.itic.l c.re Researc. Group The University of Queensland Institute of Health and Biomedic.l Innovation & Sc.ool of Public.Health and Soc.al Work Queensland University of Technology Department of Anaesthesiology and Intensive c.re and Department of Medical and Health Sciences Link?ping University Sc.ool of Pharmac. The University of Queensland Department of Pharmac. Royal Brisbane & Women's Hospital

Mic.odialysis is a tec.nique used to measure the unbound antibiotic.c.nc.ntration in the interstitial spac.s, the target site of ac.ion. In vitro rec.very studies are essential to c.librating the mic.odialysis system for in vivo studies. The effec. of a c.mbination of antibiotic. on rec.very into mic.odialysate requires investigation. In vitro mic.odialysis rec.very studies were c.nduc.ed on a c.mbination of vanc.myc.n and tobramyc.n, in a simulated in vivo model. c.mparison was made between rec.veries for three different c.nc.ntrations and three different perfusate flow rates. The overall relative rec.very for vanc.myc.n was lower than that of tobramyc.n. For tobramyc.n, a c.nc.ntration of 20μg/mL and flow rate of 1.0μL/min had the best rec.very. A c.nc.ntration of 5.0μg/mL and flow rate of 1.0μL/min yielded maximal rec.very for vanc.myc.n. Large molec.lar size and higher protein binding resulted in lower relative rec.veries for vanc.myc.n. Perfusate flow rates and drug c.nc.ntrations affec.ed the relative rec.very when a c.mbination of vanc.myc.n and tobramyc.n was tested. Low perfusate flow rates were assoc.ated with higher rec.very rates. For c.mbination antibiotic.measurement whic. inc.udes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound c.nc.ntrations.

关键词： Mic.odialysis c.mbination antibiotic therapy Relative rec.very rate Pharmac.kinetic. Anti-infec.ives Protein binding