检索结果-南通市图书馆

Recovery rates of combination antibiotic therapy using in vitro microdialysis simulating in vivo conditions

Journal of Pharmaceutical Analysis 2018年第6期8卷 407-412页

作者： Jayesh A.Dhanani suzanne l.parker Jeffrey lipman Steven C.Wallis Jeremy Cohen John Fraser Adrian Barnett Michelle Chew Jason A.Roberts Burns Trauma and Critical Care Research Centre The University of Queensland UQ Centre for Clinical Research Department of Intensive Care Medicine Royal Brisbane & Women's Hospital Faculty of Health Queensland University of Technology Critical Care Research Group The University of Queensland Institute of Health and Biomedical Innovation & School of Public Health and Social Work Queensland University of Technology Department of Anaesthesiology and Intensive Care and Department of Medical and Health Sciences Link?ping University School of Pharmacy The University of Queensland Department of Pharmacy Royal Brisbane & Women's Hospital

Microdialysis is a technique used to measure the unbound antibiotic concentration in the interstitial spaces, the target site of action. In vitro recovery studies are essential to calibrating the microdialysis system for in vivo studies. The effect of a combination of antibiotics on recovery into microdialysate requires investigation. In vitro microdialysis recovery studies were conducted on a combination of vancomycin and tobramycin, in a simulated in vivo model. Comparison was made between recoveries for three different concentrations and three different perfusate flow rates. The overall relative recovery for vancomycin was lower than that of tobramycin. For tobramycin, a concentration of 20μg/ml and flow rate of 1.0μl/min had the best recovery. A concentration of 5.0μg/ml and flow rate of 1.0μl/min yielded maximal recovery for vancomycin. large molecular size and higher protein binding resulted in lower relative recoveries for vancomycin. Perfusate flow rates and drug concentrations affected the relative recovery when a combination of vancomycin and tobramycin was tested. low perfusate flow rates were associated with higher recovery rates. For combination antibiotic measurement which includes agents that are highly protein bound, in vitro studies performed prior to in vivo studies may ensure the reliable measurement of unbound concentrations.

关键词： Microdialysis Combination antibiotic therapy Relative recovery rate Pharmacokinetics Anti-infectives Protein binding

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Diagnosis of CAH in a Sub Saharan Country: Visible Part of Iceberg

引用

Open Journal of Pediatrics 2024年第2期14卷 227-233页

作者： suzanne Sap Ritha Mbono Hélène Kamo Jocelyn Tony Charlotte Eposse Jeannette Epée Isabelle Mekone Adele Bodieu Gaelle Ntsoli Paul Olivier Koki Mother and Child Center of the Chantal Biya Foundation University of Yaoundé I Yaoundé Cameroon laquintinie Hospital University of Douala Douala Cameroon Genral Hospital of Garoua University of Garoua Garoua Cameroon Human Reproductive Center and Research on Fertility of Yaoundé University of Yaoundé I Yaoundé Cameroon Yaounde General Hospital University of Yaoundé I Yaoundé Cameroon Yaounde Central Hospital Yaoundé Cameroon laquintiinie Hospital Douala Cameroon

Introduction :Congenital adrenal hyperplasia (CAH) is the most common cause of primary adrenal insufficiency. It is a rare monogenic recessive disorder. In African setting in absence of neonatal screening, the diagnosis is still late, based on a clinical approach. During this clinical enquiry, information from past history or pedigree of the patient is of a huge importance and may revealed surprises. Patients and Methods: In this observational study, we retrospectively included all patients with a diagnosis of CAH. The diagnosis of CAH was retained based on a high 17 hydroxyprogesterone level in addition to clinical and morphological findings. From patients’ files, we extracted data on family history of disease, pedigree, clinical findings and genetics when available of 39 patients from two endocrinopeadiatric centers. Results: In 13 (30%) families, we found 20 reported deaths of infant less than 12 months. In these 13 families, half of the patients followed had 21 hydroxylase deficiencies and had 11 hydroxylase deficiencies. Unsurprisingly, we suspected adrenal insufficiency in these patients at verbal autopsy even in families with a patient with 11 hydroxylase deficiency. Other non DSD malformations or genetic disorders with apparently no link with CAH were reported in 3 families. The father of a patient reported to have hypospadias. Conclusion: Each diagnosis of CAH made in our context is visible part of an iceberg. Behind a diagnosis of CAH made in our setting, is a long course of care, a dramatic past history revealing access to appropriate care disparity. Neonatal screening should thus be considered as an emergency.

关键词： Congenital Adrenal Hyperplasia

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Clinical-based phenotypes in children with pediatric post-COVID-19 condition

引用

World Journal of Pediatrics 2024年第7期20卷 682-691页

作者： lieke C.E.Noij Jelle M.Blankestijn Coen R.lap Marlies A.van Houten Giske Biesbroek Anke-Hilse Maitland-van der Zee Mahmoud I.Abdel-Aziz Johannes B.van Goudoever Mattijs W.Alsem Caroline l.H.Brackel Kim J.Oostrom Simone Hashimoto suzanne W.J.Terheggen-lagro Department of Pediatric Pulmonology and Allergy Amsterdam UMCLocation AMCEmma Children’s HospitalAmsterdam University Medical CenterRoom G2-222Meibergdreef 91105AZAmsterdamThe Netherlands Department of Pulmonary Medicine Amsterdam UMCAmsterdamThe Netherlands Department of Pediatrics Spaarne GasthuisHoofddorpThe Netherlands Department of Pediatrics Emma Children’s HospitalAmsterdam University Medical CenterAmsterdamThe Netherlands Department of Rehabilitation Medicine Amsterdam Movement SciencesMeibergdreef 9AmsterdamThe Netherlands Department of Paediatric Pulmonology Department of PaediatricsTergooi MCHilversumThe Netherlands Department of Child and Adolescent Psychiatry and Psychosocial Care Amsterdam UMCAmsterdam Reproduction and DevelopmentAmsterdamThe Netherlands

Background Pediatric post coronavirus disease 2019(COVID-19)condition(PPCC)is a heterogeneous syndrome,which can significantly affect the daily lives of *** study aimed to identify clinically meaningful phenotypes in children with PPCC,to better characterize and treat this *** Participants were children with physician-diagnosed PPCC,referred to the academic hospital Amsterdam UMC in the Netherlands between November 2021 and March *** factors and information on post-COVID symptoms,comorbidities,and impact on daily life were *** clusters were identified using an unsupervised and unbiased approach for mixed data *** Analysis of 111 patients(aged 3–18 years)revealed three distinct clusters within *** 1(n=62,median age=15 years)predominantly consisted of girls(74.2%).These patients suffered relatively more from exercise intolerance,dyspnea,and smell *** 2(n=33,median age=13 years)contained patients with an even gender distribution(51.5%girls).They suffered from relatively more sleep problems,memory loss,gastrointestinal symptoms,and *** 3(n=16,median age=11 years)had a higher proportion of boys(75.0%),suffered relatively more from fever,had significantly fewer symptoms(median of 5 symptoms compared to 8 and 10 for clusters 1 and 2 respectively),and experienced a lower impact on daily *** This study identified three distinct clinical PPCC phenotypes,with variations in sex,age,symptom patterns,and impact on daily *** findings highlight the need for further research to understand the potentially diverse underlying mechanisms contributing to post-COVID symptoms in children.

关键词： Adolescents Clusters long COVID Pediatric Phenotypes Post-COVID syndrome

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

JMCB Symposium 2019:The legend of p53 ***

引用

Journal of Molecular Cell Biology 2019年第7期11卷 628-629页

作者： Ping Zhang suzanne P.Christen Gareth l.Bond ludwig Institute for Cancer Research Nuffield Department of MedicineUniversity of OxfordOxford 0X3 7DQUK The Simons Center for Systems Biology Institute for Advanced StudyPrincetonNJ 08540USA

The exciting symposium hosted by Journal of Molecular Cell Biology (JMCB),with the theme 'The legend of p53 ***',took place in Hangzhou,China on May 10-12,*** symposium provided the opportunity for delegates in the fields of p53 biology,epigenetics,and cancer research to share scientific updates and to bridge the gap between basic scienee and translational *** delegates also enjoyed celebrations ofthe 40th anniversary ofthe discovery of p53,as well as the 50th anniversary ofthe discovery of RNA polymerases.

关键词： symposium JMCB polymerases

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

妇幼卫生合作项目中的应用科研

引用

中国妇幼保健 1991年第4期 35-36页

作者： Robert l.parker 刘运国联合国儿童基金会驻华代表处

应用科研是《加强中国基层妇幼卫生·计划生育服务》合作项目中的一个重要组成部分。包括研究在内的项目活动,已为中国政府、联合国儿童基金会、联合国人口基金和世界卫生组织共同认可。对国际组织来说,在同中国的合作中,与执行项目密... 详细信息

应用科研是《加强中国基层妇幼卫生·计划生育服务》合作项目中的一个重要组成部分。包括研究在内的项目活动,已为中国政府、联合国儿童基金会、联合国人口基金和世界卫生组织共同认可。对国际组织来说,在同中国的合作中,与执行项目密切相关的应用科研占有较高的优先地位。在本项目中,应用科研就是探索如何利用现有的医学与保健知识,改善个体与群体的生存与健康状况。联合国儿童基金会执行主任格兰特先生曾指出:“或许和更多的医学新发现同样重要但却紧迫

关键词：妇幼卫生个人卫生中华人民共和国联合国儿童基金会

来源：

同方期刊数据库评论

在线全文

同方期刊数据库

学校读者我要写书评

暂无评论

Strong laws of large Numbers for Double Sums of Banach Space Valued Random Elements

引用

Acta Mathematica Sinica,English Series 2019年第5期35卷 583-596页

作者： Robert parker Andrew ROSAlSKY Department of Biostatistics University of Florida Department of Statistics University of Florida

For a double array {V_(m,n), m ≥ 1, n ≥ 1} of independent, mean 0 random elements in a real separable Rademacher type p(1 ≤ p ≤ 2) Banach space and an increasing double array {b_(m,n), m ≥1, n ≥ 1} of positive constants, the limit law ■ and in l_p as m∨n→∞ is shown to hold if ■ This strong law of large numbers provides a complete characterization of Rademacher type p Banach spaces. Results of this form are also established when 0 laced on the random elements and without any geometric conditions placed on the underlying Banach space.

关键词： Real separable Banach space double array of independent random elements strong law of large numbers almost sure convergence Rademacher type p Banach space convergence in lp

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Zircon U-Pb and Hf isotopes of volcanic rocks from the Batamayineishan Formation in the eastern Junggar Basin

引用

Chinese Science Bulletin 2010年第36期55卷 4150-4161页

作者： SU YuPing ZHENG JianPing GRIFFIN William l TANG HuaYun O'REIllY suzanne Y lIN XiangYang Faculty of Earth Sciences China University of Geosciences Wuhan 430074 China National Key Centre for Geochemical Evolution and Metallogeny of Continents ( GEMOC) Macquarie University Sydney NSW 2109 Australia

内部结构的研究被进行从 Batamayineishan 形成调查 U-Pb 年龄，踪迹元素和玄武岩的锆石的 Hf 同位素。暗岩从练习井圣罐头被获得 1 在 Junggar 盆以内在东方 luliang 上高举。跟踪所有样品是 magmatic 的锆石表演的元素数据，与类似的 ... 详细信息

内部结构的研究被进行从 Batamayineishan 形成调查 U-Pb 年龄，踪迹元素和玄武岩的锆石的 Hf 同位素。暗岩从练习井圣罐头被获得 1 在 Junggar 盆以内在东方 luliang 上高举。跟踪所有样品是 magmatic 的锆石表演的元素数据，与类似的 REE 模式，包括积极 Ce (Ce=5.06134 ) ，而是否定 Eu (Eu=0.06 ? 0.55 ) 在重稀土元素元素的异例和丰富。在 25 谷物之中，一致年龄被细分进三个组；300.4 整潲祺潧整的年龄？

关键词：准噶尔盆地东部岛弧火山岩形成年龄 Hf同位素锆石 Pb 碰撞后构造环境岩石圈地幔

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Chronotype and self-reported sleep,alertness,and mental health in U.S. sailors

引用

Military Medical Research 2022年第2期9卷 259-261页

作者： Elizabeth M.Harrison Alexandra P.Easterling Emily A.Schmied suzanne l.Hurtado Gena l.Glickman Center for Circadian Biology University of California San DiegoSan DiegoUSA leidos Inc.San DiegoUSA Health and Behavioral Sciences Department Naval Health Research CenterSan DiegoUSA School of Public Health San Diego State UniversitySan DiegoUSA Departments of Psychiatry and Neuroscience Uniformed Services University of the Health SciencesBethesdaUSA

Service members are at risk for sleep and psychological conditions affecting their readiness. Chronotype(“morningness”or “eveningness”) is strongly associated with sleep, health and performance. The objective of this study was to examine associations between validated measures of chronotype and sleep quality, daytime functioning, alertness,and symptoms of depression, anxiety, and post-traumatic stress disorder(PTSD) in US service members(n=298).Although predominantly young males(who skew toward eveningness in civilian populations), these Sailors skewed toward morningness(35.6% morning, 51.3% intermediate). Eveningness was associated with symptoms of depression and PTSD(Pless time in bed(Pleep disruption(Plertness(Pless likely to consider sleep important for performance(Ples should be aligned with endogenous rhythms, whenever possible, and evening chronotypes may benefit from targeted interventions. Chronotype should be examined alongside health and readiness in service members.

关键词： Circadian Chronotype Sleep Military Readiness Depression Anxiety Post-traumatic stress disorder

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

A review of direct numerical simulations of astrophysical detonations and their implications

引用

Frontiers of physics 2013年第2期8卷 189-198页

作者： suzanne T. Parete-Koon Christopher R. Smith Thomas l. Papatheodore O. E. Bronson Messer National Center for Computational Sciences Oak Ridge National Laboratory Oak Ridge USA TN 37831-6354 Department of Physics and Astronomy University of Tennessee KnoxvilleUSA TN 37996-1200

Multi-dimensional direct numerical simulations （DNS） of astrophysical detonations in degenerate matter have revealed that the nuclear burning is typically characterized by cellular structure caused by transverse instabilities in the detonation front. Type Ia supernova modelers often use one- dimensional DNS of detonations as inputs or constraints for their whole star simulations. While these one-dimensional studies are useful tools, the true nature of the detonation is multi-dimensional. The multi-dimensional structure of the burning influences the speed, stability, and the composition of the detonation and its burning products, and therefore, could have an impact on the spectra of Type Ia supernovae. Considerable effort has been expended modeling Type Ia supernovae at densities above 1 ~ 107 ***-3 where the complexities of turbulent burning dominate the flame propagation. How- ever, most full star models turn the nuclear burning schemes off when the density falls below 1 ~ 107 ***-3 and distributed burning begins. The deflagration to detonation transition （DDT） is believed to occur at just these densities and consequently they are the densities important for studying the properties of the subsequent detonation. This work will review the status of DNS studies of detona- tions and their possible implications for Type Ia supernova models. It will cover the development of Detonation theory from the first simple Chapman-Jouguet （C J） detonation models to the current models based on the time-dependent, compressible, reactive flow Euler equations of fluid dynamics.

关键词： supernova detonations direct numerical simulations

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Male Burmese pythons follow female scent trails and show sex-specific behaviors

引用

Integrative Zoology 2019年第5期14卷 460-469页

作者： Shannon A.RICHARD Eric A.TIllMAN John S.HUMPHREY Michael l.AVERY M.Rockwell.parker Department of Biology James Madison UniversityHarrisonburgVirginiaUSA National Wildlife Research Center Florida Field StationU.S.Department of AgricultureGainesvilleFloridaUSA

Animals communicate with potential mates using species-specific signals,and pheromones are powerful sexual signals that modify conspecific behavior to facilitate mate *** the vertebrates,snakes are especially adept in mate searching via chemical trailing,which is particularly relevant given that many snake species are invasive outside their native *** signals used in mate choice are,thus,potentially valuable tools for management of invasive snake *** Burmese python(Python bivittatus)is an invasive snake in the Florida Everglades where it is negatively impacting native *** this study,we sought to:(i)determine if males can follow conspecific chemical trails in a Y-maze;and(ii)describe the mate searching behaviors exhibited by males while *** males consistently followed a single female scent trail in the maze,but when only a male scent trail was present they did not discriminate between the male and blank *** of tongue-flicking,a proxy for chemosensory sampling,was also marginally higher when males were following female versus male scent ***,when both female and male scent trails were simultaneously present in the Y-maze,males did not show a preference for the female arm,although the tongue-flick rate was higher in the female-only trial compared to female versus *** of multiple male behaviors individually and using an ethogram revealed that behaviors were more frequent and complex in the female-only trials compared to male-only *** behavioral trials are needed to determine if an effective pheromonal approach to Burmese python management is possible.

关键词： chemical ecology invasive species pheromone snake trailing

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：