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Missed opportunities for hepatitis C treatment at a tertiary care hospital in South Australia

World Journal of Hepatology 2022年第8期14卷 1576-1583页

作者： Sreecanth Sibhi Raja suzanne edwards Jeffrey Stewart Dep Huynh Department of Gastroenterology The Queen Elizabeth HospitalWoodville 5011South AustraliaAustralia Department of Statistician School of Public HealthUniversity of AdelaideAdelaide 5000South AustraliaAustralia

BACKGROUND Hepatitis C is a global epidemic and an estimated 230000 Australians were living with chronic hepatitis C in *** effective public health policy and state commitment,Australia has utilised the advent of direct acting antiviral(DAA)therapy to transform the therapeutic landscape for hepatitis C virus(HCV).However,treatment rates are falling and novel public health approaches are required to maintain momentum for HCV *** discourse in cascades of care have focused on expanding testing capabilities but less attention has been given to linking previously diagnosed patients back to *** simple and focused study rests on the premise that hospital admissions are an excellent opportunity to identify and refer previously diagnosed patients for HCV *** To assess whether inpatients with HCV are appropriately referred on for *** We conducted a retrospective single centre cohort study that examined all patients with HCV presenting to The Queen Elizabeth Hospital(QEH)inpatient service between January 1 and December 31,*** is a tertiary care hospital in South *** main inclusion criteria were patients with active HCV infection who were eligible for DAA *** study cohort was identified using a comprehensive list of diagnosis based on international classification of diseases-10 AM codes for chronic viral *** were excluded from the analysis if they had previously received DAA therapy or spontaneously cleared *** presenting with decompensated liver cirrhosis or other systemic medical conditions conferring poor short-term prognosis were also excluded from the *** primary outcome of our study was referral of patients for HCV *** outcomes included assessment of factors predicting treatment *** There were 309 inpatients identified with hepatitis C as a principal or additional diagnosis between January 1 and December 31,*** these patients,

关键词： Hepatitis C Viral hepatitis Treatment cascade Hepatology Public health Missed opportunities

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Standards of liver cirrhosis care in Central Australia

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World Journal of Hepatology 2022年第3期14卷 559-569页

作者： Sreecanth S Raja Robert G Batey suzanne edwards Hein H Aung Department of Gastroenterology Alice Springs HospitalAlice Springs 0870Northern TerritoryAustralia Department of Medicine Alice Springs HospitalAlice Springs 0870Northern TerritoryAustralia Department of Statistician School of Public HealthUniversity of AdelaideAdelaide 5000South AustraliaAustralia

BACKGROUND Liver cirrhosis and hepatocellular carcinoma(HCC)are highly prevalent in Australia’s Northern *** factors include high levels of alcohol consumption,viral hepatitis and metabolic *** Aboriginal residents form a significant proportion of the Central Australian population and present a challenge to traditional models of liver *** surveillance and variceal screening are core components of liver cirrhosis *** To assess participation in HCC and variceal surveillance programmes in a Central Australian liver cirrhosis patient *** Retrospective cohort study of patients with liver cirrhosis presenting to Alice Springs Hospital,Australia between January 1,2012 and December 31,*** data,disease severity,attendance at hepatology clinics,participation in variceal and/or HCC surveillance programmes was *** analyses were conducted to assess factors associated with two independent outcomes:Participation in HCC and variceal *** Of 193 patients were identified.82 patients(42.4%)were female.154 patients(80%)identified as *** Model for End-stage Liver Disease Score at diagnosis was *** was the most common cause of *** patients were younger than non-Aboriginal patients(48.4 years vs 59.9 years,P<0.001).There were similar rates of excess alcohol intake(72.6%vs 66.7%,P=0.468)and obesity(34.5%vs 38.4%,P=0.573 across non-Aboriginal and Aboriginal cohorts.20.1%of patients took part in HCC surveillance and 42.1%of patients completed variceal *** patients were less likely to engage with either HCC surveillance(OR:0.38,95%CI:0.16-0.9,P=0.025)or undergo variceal screening(OR:0.31,95%CI:0.14-0.65,P=0.002).CONCLUSION HCC or variceal surveillance programmes had less uptake amongst Aboriginal *** emphasis needs to be placed on eliminating cultural obstacles to accessing hepatology services.

关键词： Viral hepatitis Cirrhosis Hepatocellular carcinoma Alcoholic liver disease Central australia

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The afterlives of rape in medieval English literature

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作者： (1975-)edwards suzanne M.

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Long term outcomes of cardiac transplant for immunoglobulin light chain amyloidosis:The Mayo Clinic experience

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World Journal of Transplantation 2016年第2期6卷 380-388页

作者： Martha Grogan Morie Gertz Arleigh McCurdy Lindsey Roeker Robert Kyle Sudhir Kushwaha Richard Daly Joseph Dearani Richard Rodeheffer Robert Frantz Martha Lacy suzanne Hayman Christopher McGregor Brooks edwards Angela Dispenzieri Department of Cardiovascular Diseases Mayo Clinic Division of Hematology Mayo Clinic Department of Hematology the Ottawa HospitalUniversity of Ottawa Department of Medicine Brigham and Women’s Hospital Division of Cardiovascular Surgery Mayo Clinic Department of Cardiothoracic Surgery University College

AIM: To determine the outcome of orthotopic heart transplantation(OHT) in immunoglobulin light chain(AL) ***: The medical records of patients with AL who underwent orthotopic heart transplantation at the Mayo Clinic in Rochester Minnesota from 1992 to 2011 were reviewed. Patients met at least one of the following at: New York Heart Association class Ⅳ heart failure, ventricular thickness > 15 mm, ejection fraction < 40%. Selection guidelines for heart transplant included age < 60 years, absence of multiple myeloma and significant extra-cardiac organ involvement. Baseline characteristics including age, gender, organinvolvement, and New York Heart Association functional class were recorded. Laboratory data, waiting time until heart transplant, and type of treatment of the underlying plasma cell disorder were recorded. Survival from the time of OHT was calculated using KaplanMeier survival curves. Survival of patients undergoing OHT for AL was compared to that of non-amyloid patients undergoing OHT during the same time ***: Twenty-three patients(median age 53 years) with AL received OHT. There were no deaths in the immediate perioperative period. Twenty patients have died post OHT. For the entire cohort, the median overall survival was 3.5 years(95%CI: 1.2, 8.2 years). The 1-year survival post OHT was 77%, the 2-year survival 65%, and the 5-year survival 43%. The 5-year survival for non-amyloid patients undergoing OHT during the same era was 85%. Progressive amyloidosis contributed to death in twelve patients. Of those without evidence of progressive amyloidosis, the cause of death included complications of autologous hematopoietic stem cell transplantation for 3 patients, post-transplant lymphoproliferative disorder for 2 patients; and for the remaining one death was related to each of the following causes: acute rejection; cardiac vasculopathy; metastatic melanoma; myelodysplastic syndrome; and unknown. Eight patients had rejection at a med

关键词： Heart transplantation Autologous stem cell transplantation Amyloidosis Chemotherapy Heart failure

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英国医学杂志中文版 2003年第2期6卷 127-127页

作者： Carolyn DiGuiseppi Ian Roberts Angie Wade Mark Sculpher Phil edwards Catherine Godward Huiqi Pan suzanne Slater 沈锡宾

研究目的:评估在一个多种族城市群体中,免费分发烟雾报警器后火灾的发生率和与之相关的伤害事件发生率的情况。设计:群体随机对照试验。研究地点:英国伦敦城内2个市镇的40个病房。参与者:原住户,包括老人或小孩,和从市镇委员会租房... 详细信息

研究目的:评估在一个多种族城市群体中,免费分发烟雾报警器后火灾的发生率和与之相关的伤害事件发生率的情况。设计:群体随机对照试验。研究地点:英国伦敦城内2个市镇的40个病房。参与者:原住户,包括老人或小孩,和从市镇委员会租房的住户。干预措施:免费发放20050个烟雾报警器。

关键词：烟雾报警器火灾伤害事件群体随机对照试验发生率英国伦敦

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