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Antihyperglycemic and hepatoprotective properties of miracle fruit(Synsepalum dulcificum) compared to aspartame in alloxan-induced diabetic mice

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Journal of Integrative Medicine 2020年第6期18卷 514-521页

作者： suzan g.haddad Mariam Mohammad Karim Raafat Fatima A.Saleh Department of Medical Laboratory Sciences.Faculty of Health Sciences Beirut Arab UniversityBeirut 115020Lebanon Department of Pharmaceutical Sciences.Faculty of Pharmacy.Beirut Arab University Beirut 115020Lebanon

Objective: This study was undertaken to investigate the antihyperglycemic potential of miracle fruit(MF)as well as its hepatic safety as compared to aspartame in alloxan-induced diabetic ***: MF extracts were prepared and screened for their phytochemical composition using highperformance liquid chromatography(HPLC). Total phenolic, flavonoid and tannin contents and antioxidant potential were also determined. Additionally, MF was evaluated for its sensory attributes. For in vivo work, MF ethanol extract at high(MFH: 500 mg/kg body weight [BW]) and low(MFL: 250 mg/kg BW) doses as well as aspartame were injected intraperitoneally into alloxan-induced diabetic *** glucose levels were determined following acute and subchronic treatment. At the end of the study,animals were sacrificed, serum was collected for biochemical analysis and liver tissues were obtained for histopathological ***: MF ethanol extract contained more flavonoids and tannins, and had higher 1,1-diphenyl-1-picrylhydrazyl radical-scavenging activity(79.61%) compared to MF aqueous extract(P g the major polyphenol. Additionally, sensory analysis of MF showed that its intake is effective in masking undesirable sourness. Subchronic administration of MFH proved amelioration of hyperglycemia in mice as compared to aspartame. Moreover, aspartame treatment significantly elevated(P gy;however, hepatic architecture was restored by low and high doses of ***: MF is an effective antihyperglycemic with hepatoprotective properties that can be used as a healthier alternative sweetening agent in place of aspartame for sour beverages.

关键词： Miracle fruit Synsepalum dulcificum Aspartame Histopathology Phytochemical analysis Sensory evaluation

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Uncovering the dominant contribution of intermediate volatility compounds in secondary organic aerosol formation from biomass-burning emissions

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National Science Review 2024年第3期11卷 150-158页

作者： Kun Li Jun Zhang David M.Bell Tiantian Wang Houssni Lamkaddam Tianqu Cui Lu Qi Mihnea Surdu Dongyu Wang Lin Du Imad El haddad Jay g.Slowik Andre S.H.Prevot Environment Research Institute Shandong University Laboratory of Atmospheric Chemistry Paul Scherrer Institute

Organic vapors from biomass burning are a major source of secondary organic aerosols(SOAs). Previous smog chamber studies found that the SOA contributors in biomass-burning emissions are mainly volatile organic compounds(VOCs). While intermediate volatility organic compounds(IVOCs) are efficient SOA precursors and contribute a considerable fraction of biomass-burning emissions, their contribution to SOA formation has not been directly observed. Here, by deploying a newly-developed oxidation flow reactor to study SOA formation from wood burning, we find that IVOCs can contribute ～70% of the formed SOA, i.e.>2 times more than VOCs. This previously missing SOA fraction is interpreted to be due to the high wall losses of semi-volatile oxidation products of IVOCs in smog chambers. The finding in this study reveals that SOA production from biomass burning is much higher than previously thought, and highlights the urgent need for more research on the IVOCs from biomass burning and potentially other emission sources.

关键词： atmospheric chemistry biomass burning secondary organic aerosol intermediate volatility organic compounds

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Evaluation of sour gas-low salinity waterflooding in carbonate reservoirs-A numerical simulation approach

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Petroleum Research 2023年第2期8卷 131-150页

作者： Lawrence Opoku Boampong Roozbeh Rafati Amin Sharifi haddad School of Engineering University of AberdeenFN371Fraser Noble BuildingSchool of EngineeringUniversity of AberdeenAB243UEUK

Although significant amount of H_(2)S(sour gas)rich natural gas is estimated globally,but not much attention has been given to the application of H_(2)S in the oil recovery *** studies on the use of H_(2)S in oil recovery processes showed that H_(2)S has the potential of improving the oil recovery,and it can be even more effective than using CO_(2) in some processes.H_(2)S can equally dissolve in the water,react with the reservoir rock to change its surface charge,porosity,and ***,previous in-vestigations on H_(2)S oil recovery attributed the improved oil recoveries to the higher miscibility of H_(2)S in the oil,and the reduction in the oil ***,there is limited understanding on the H_(2)S-oil-brine-rock geochemical interactions,and how they impact the oil recovery *** study aims to investigate the interactions between H_(2)S,oil,and carbonate formations,and to assess how the combi-nation of H_(2)S and low salinity water can impact the wettability and porosity of the reservoirs.A triple layer surface complexation model was used to understand the influence of key parameters(e.g.,pressure,brine salinity,and composition)on the H_(2)S-brine-oil-rock ***,the effects of mineral content of the carbonate rock on H_(2)S interactions were ***,the results of the H_(2)S-oil-brine-rock interactions were compared with a study where CO_(2) was used as the injected *** of the study showed that the seawater and its diluted forms yielded identicalζ-potential values of about 3.31 mV at a pH of *** indicates that at very low pH condition,pH controls the ζ-potential of the oil-brine interface regardless of the brine's ionic *** study further demonstrated that the presence of other minerals in the carbonate rock greatly reduced the calcite *** instance,the calcite dissolution was reduced by 4.5%when anhydrite mineral was present in the carbonate *** from the s

关键词： Low salinity water flooding Zeta potential Wettability alteration Carbonate reservoirs Carbon dioxide storage Sour gas injection

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ON THE IDENTIFICATION OF RESIDUAL IMPACT PROPERTIES OF MATERIALS BY ACOUSTO-ULTRASONICS——A PATTERN RECOgNITION APPROACH

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Acta Mechanica Sinica 1995年第1期11卷 34-43页

作者： g.J.Molina Y.M.haddad Dept.of Mechanical Engineering University of OttawaOttawaCanada K1N 6N5

This paper deals with the application of Acousto-ultrasonics,in con- junction with Pattern Recognition and Classification techniques,to the identification of residual impact properties of a class of polymeric material,namely,Polyvinylchlo- ride(PVC).PVC specimens of different low-energy repeated impact damage states are processed by Acousto-ultrasonics(AU)to retrieve AU signals in the form of dig- italized *** AU signals are grouped as distinct classes,each pertaining to a known level of repeated impact *** features of these AU signals are used to build Pattern Recognition(PR)*** classifiers are used to identify unknown damage states in other PVC specimens by classifying the re- trieved AU signals as belonging to one of the *** obtained results indicate that Acousto-ultrasonics in combination with Pattern Recognition and Classification techniques can be used for the quantitative non-destructive identification of damage states in PVC specimens of unknown low-energy repeated impact conditions.

关键词： pattern recognition acousto-ultrasonics impact damage quantitative non-destructive examination

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A randomized open-label trial of on-demand rabeprazole vs ranitidine for patients with non-erosive reflux disease

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World Journal of gastroenterology 2012年第19期18卷 2390-2395页

作者： Abdallah A Kobeissy Jana g Hashash Faek R Jamali Assaad M Skoury Reham haddad Sarah El-Samad Rami Ladki Rola Aswad Assaad M Soweid Division of gastroenterology Department of Internal MedicineAmerican University of Beirut Medical CenterHamra 1103 2090BeirutLebanon Department of Surgery American University of Beirut Medical CenterHamra 1103 2090BeirutLebanon Department of Pharmacy Practice School of PharmacyLebanese American UniversityPO Box 36ByblosLebanon

AIM:To compare the efficacy of the proton-pump inhibitor,rabeprazole,with that of the H 2-receptor antagonist,ranitidine,as on-demand therapy for relieving symptoms associated with non-erosive reflux disease(NERD).METHODS:This is a single center,prospective,randomized,open-label trial of on-demand therapy with rabeprazole(group A) vs ranitidine(group B) for 4 ***-three patients who presented to the American University of Beirut Medical Center with persistent gastroesophageal reflux disease(gERD) symptoms and a normal upper gastrointestinal endoscopy were eligible for the *** in group A(n = 44) were allowed a maximum rabeprazole dose of 20 mg twice daily,while those in group B(n = 39) were allowed a maximum ranitidine dose of 300 mg twice *** was assessed by patient evaluation of global symptom relief,scores of the SF-36 quality of life(QoL) questionnaires,total number of pills used,and number of medication-free ***:Among the 83 patients who were enrolled in the study,76 patients(40 in the rabeprazole group and 36 in the ranitidine group) completed the 4-wk *** characteristics were comparable between both *** 4 wk,there was no significant difference in the subjective global symptom relief between the rabeprazole and the ranitidine groups(71.4% vs 65.4%,respectively;P = 0.9).There were no statistically significant differences between mean cumulative scores of the SF-36 QoL questionnaire for the two study groups(rabeprazole 22.40 ± 27.53 vs ranitidine 17.28 ± 37.06;P = 0.582).There was no significant difference in the mean number of pills used(rabeprazole 35.70 ± 29.75 vs ranitidine 32.86 ± 26.98;P = 0.66).There was also no statistically significant difference in the mean number of medication-free days between both ***:Rabeprazole has a comparable efficacy compared to ranitidine when given on-demand for the treatment of *** medications were associated with improved quality of life.

关键词：雷尼替丁反流食管试验标签随机糜烂 H2受体拮抗剂

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Investigation on Mechanism for Separation of Alkali, Alkaline Metal and Ammonium Cations in Nonaqueous Capillary Electrophoresis

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色谱 2004年第4期22卷 325-328页

作者：刘红霞宋鹃梅张书胜 MACKA Miroslav haddad Paul R Department of Chemistry Zhengzhou University Zhengzhou 450052 China Department of Chemistry Zhengzhou University Zhengzhou 450052 ChinaAustralian Centre for Research on Separation Science School of Chemistry University of TasmaniaTasmania 7001 Australia Australian Centre for Research on Separation Science School of Chemistry University of TasmaniaTasmania 7001 Australia

Capillary electrophoresis (CE) has rapidly gained great interests among researchers in many different fields. One of these areas is the separation of small ions such as inorganic cations[1-9], anions[10-16], and low Mr organic molecules[17-20]. However, as the separation of ions by CE is depended on the difference in electrophoretic mobilities of the ions, and this difference for some of them are very small. Thus, a background electrolyte (BgE) system must be selected to modify the mobilities of the analyte ions, e.g., the actual mobilities of some alkali, alkaline earth metal and ammonium cations are very similar[21].

关键词：碱金属碱性稀土金属毛细管电泳电色谱法铵根离子非水媒介分离

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A New Schiff Base Derivatives Designed to Bind Metal Ion (Cu, Co): Thermodynamics and Biological Activity Studies

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American Journal of Analytical Chemistry 2016年第5期7卷 446-451页

作者： Hanaa Hameed haddad Chemistry Department College of Scienc Basrah University Basrah Iraq

Schiff base synthesis is usually acid catalyzed and it usually requires refluxing the mixture of aldehydes and amine in ethanolic solution. Synthesis and characterization of Schiff base ligands derived from substituted amine and salicylaldehyde and their complexes (Cu2+, Co2+) are reported. The ligands and ligand-complexes were characterized by melting point, FTIR, CHN-elemental analysis and UV-Visible analysis. The UV-Visible and elemental analysis of complexes established (1:2) mole ratio (M:L). The stability constant and thermodynamic parameters (K, Δg, ΔH, ΔS) were determined at different temperature (30 - 40)°C which established that the metal-complexes were very stable. The review describes the promising biological activities of Schiff base and their metal complexes.

关键词： Schiff Base Derivatives Complexes Thermodynamic Parameters FTIR-Spectra Mole Ratio Method CHN Analysis Biological Activity Studies

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不同温度下AA6061/Al_2O_3纳米复合材料的加工图和组织评价（英文）

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Transactions of Nonferrous Metals Society of China 2017年第6期27卷 1248-1256页

作者： H.R.EZATPOUR S.A.SAJJADI M.haddad SABZEVAR A.CHAICHI g.R.EBRAHIMI Faculty of Engineering Sabzevar University of New Technology Sabzevar *** Iran Department of Materials Science and Metallurgical Engineering Engineering FacultyFerdowsi University of Mashhad Mashhad Iran Department of Mechanical & Industrial Engineering Louisiana State University Baton Rouge Louisiana 70803 USA Department of Materials and Polymer Engineering Hakim Sabzevari University Sabzevar Iran

为确定热加工性能的最佳条件,在温度350~500°C、应变率0.0005~0.5 s^(-1)下研究Al6061/Al_2O_3纳米复合材料的热压缩行为。采用双曲正弦函数得到材料热压缩测试活化能为285 kJ/mol。用动态材料模型和相应的加工图,确定了温度450°C、... 详细信息

为确定热加工性能的最佳条件,在温度350~500°C、应变率0.0005~0.5 s^(-1)下研究Al6061/Al_2O_3纳米复合材料的热压缩行为。采用双曲正弦函数得到材料热压缩测试活化能为285 kJ/mol。用动态材料模型和相应的加工图,确定了温度450°C、应变速率0.0005 s^(-1)和温度500°C、应变速率0.0005~0.5 s^(-1)为Al6061/Al_2O_3材料的热加工性能安全区,最大功率损耗率为38%。由于材料大变形,在温度400°C和应变速率0.5 s^(-1)下得到了被伸长和扭结晶粒。

关键词：纳米复合材料热压缩测试加工图动态再结晶流变失稳

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CDYL1 fosters double-strand break-induced transcription silencing and promotes homology-directed repair

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Journal of Molecular Cell Biology 2018年第4期10卷 341-357页

作者： Enas R. Abu-Zhayia Samah W. Awwad Bella M. Ben-Oz Hanan Khoury-haddad Nabieh Ayoub Department of Biology Technion-Israel Institute of Technology Haifa 3200003 Israel

Cells have evolved DNA damage response (DDR) to repair DNA lesions and thus preserving genomic stability and impeding carcinogenesis. DNA damage induction is accompanied by transient transcription repression. Here, we describe a previously unrecognized role of chromodomain Y-like (CDYL1) protein in fortifying double-strand break (DSB)-induced transcription repression and repair. We showed that CDYL1 is rapidly recruited to damaged euchromatic regions in a poly (ADP-ribose) polymerase 1 (PARP1)-dependent, but ataxia telangiectasia mutated (ATM)-independent, manner. While the C-terminal region, containing the enoyl-CoA hydratase like (ECH) domain, of CDYL1 binds to poly (ADP-ribose) (PAR) moieties and mediates CDYL1 accumulation at DNA damage sites, the chromodomain and histone H3 trimethylated on lysine 9 (H3K9me3) mark are dispensable for its recruitment. Furthermore, CDYL1 promotes the recruitment of enhancer of zeste homolog 2 (EZH2), stimulates local increase of the repressive methyl mark H3K27me3, and promotes transcription silencing at DSB sites. In addition, following DNA damage induction, CDYL1 depletion causes persistent g2/M arrest and alters H2AX and replication protein A (RPA2) phosphorylation. Remarkably, the ‘traffic-light reporter’ system revealed that CDYL1 mainly promotes homology-directed repair (HDR) of DSBsin vivo. Consequently, CDYL1-knockout cells display synthetic lethality with the chemotherapeutic agent, cisplatin. Altogether, our findings identify CDYL1 as a new component of the DDR and suggest that the HDR-defective ‘BRCAness’ phenotype of CDYL1-deficient cells could be exploited for eradicating cancer cells harboring CDYL1 mutations.

关键词：修理裂缝海滨自动数据处理 poly DNA 终端区域 vivo

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Studying host genetic background effects on multimorbidity of intestinal cancer development,type 2 diabetes and obesity in response to oral bacterial infection and high-fat diet using the collaborative cross(CC)lines

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Animal Models and Experimental Medicine 2021年第1期4卷 27-39页

作者： Asal Milhem Hanifa J.Abu Toamih-Atamni Luna Karkar Yael Houri-haddad Fuad A.Iraqi Department of Clinical Microbiology and Immunology Sackler Faculty of MedicineTel-Aviv UniversityTel AvivIsrael Department of Prosthodontics Dental SchoolThe Hebrew UniversityHadassah JerusalemIsrael

Background:Multimorbidity of intestinal cancer(IC),type 2 diabetes(T2D)and obesity is a complex set of diseases,affected by environmental and genetic risk ***-fat diet(HFD)and oral bacterial infection play important roles in the etiology of these diseases through inflammation and various biological ***:To study the complexity of this multimorbidity,we used the collaborative cross(CC)mouse genetics reference *** aimed to study the multimorbidity of IC,T2D,and obesity using CC lines,measuring their responses to HFD and oral bacterial *** study used 63 mice of both sexes generated from two CC lines(IL557 and IL711).For 12 weeks,experimental mice were maintained on specific dietary regimes combined with co-infection with oral bacteria Porphyromonas gingivalis and Fusobacterium nucleatum,while control groups were not *** weight(BW)and results of a intraperitoneal glucose tolerance test(IPgTT)were recorded at the end of 12 weeks,after which length and size of the intestines were assessed for polyp ***:Polyp counts ranged between 2 and 10 per CC *** combination of HFD and infection significantly reduced(Pgain,IL557 males on HFD gained 18 g,while the females gained 10 g under the same conditions and showed the highest area under curve(AUC)values of 40000-45000(min mg/dL)in the ***:The results show that mice from different genetic backgrounds respond differently to a high fat diet and oral infection in terms of polyp development and glucose tolerance,and this effect is gender related.

关键词： high-fat diet(42%fat) intestinal cancer multimorbidity obesity oral bacterial infection type 2 diabetes(T2D)

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