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Triple rule-out computed tomography angiography:Evaluation of acute chest pain in COVID-19 patients in the emergency department

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World Journal of Radiology 2022年第8期14卷 311-318页

作者： suzan bahadir Sonay Aydın Mecit Kantarci Edhem Unver Erdal Karavas Düzgün CanŞenbil Department of Radiology Baskent UniversityAntalya 07000Turkey Department of Radiology Erzincan Binali Yıldırım UniversityErzincan 24100Turkey Department of Radiology Ataturk UniversityErzurum 25100Turkey Department of Chest Disease Erzincan Binali Yildirim UniversityErzincan 24100Turkey

BACKGROUND The aim of this study was to define clinical evidence supporting that triple ruleout computed tomography angiography(TRO CTA)is a comprehensive and feasible diagnostic tool in patients with novel coronavirus disease 2019(COVID-19)who were admitted to the emergency department(ED)for acute chest *** diagnostic imaging strategies in COVID-19 related thromboembolic events,will help for rapid and noninvasive diagnoses and results will be effective for patients and healthcare systems in all *** To define clinical evidence supporting that TRO CTA is a comprehensive and feasible diagnostic tool in COVID-19 patients who were admitted to the ED for acute chest pain,and to assess outcomes of optimizing diagnostic imaging strategies,particularly TRO CTA use,in COVID-19 related thromboembolic *** TRO CTA images were evaluated for the presence of coronary artery disease,pulmonary thromboembolism(PTE),or acute aortic *** analyses were used for evaluation of significant association between the variables.A two tailed P-value<0.05 was considered statistically *** Fifty-three patients were included into the *** 31 patients(65.9%),there was not any pathology,while PTE was diagnosed in 11 *** was no significant relationship between the rates of pathology on CTA and history of *** the other hand,the diabetes mellitus rate was much higher in the acute coronary syndrome group,particularly in the PTE group(8/31=25.8%vs 6/16=37.5%,P=0.001).The rate of dyslipidemia was significantly higher in the group with pathology on CTA while compared to those without pathology apart from imaging findings of the pneumonia group(62.5%vs 38.7%,P<0.001).Smoking history rates were similar in the ***,D-dimer,fibrinogen,C-reactive protein,and erythrocyte sedimentation rate values were higher in COVID-19 cases with additional *** TRO CTA is an effective imaging method in evaluat

关键词： COVID-19 Pulmonary thromboembolism Coronary artery disease Acute aortic syndromes Triple rule-out computed tomography angiography

Lacidipine,thiamine pyrophosphate and their combination on the ocular ischemic syndrome induced by bilateral common carotid artery ligation

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International Journal of Ophthalmology(English edition) 2024年第5期17卷 815-821页

作者： Ibrahim Cicek Ahmet Mehmet Somuncu Durdu Altuner bahadir Suleyman Renad Mammadov Seval Bulut Taha Abdulkadir Coban Tugba Bal Tastan Halis Suleyman Department of Ophthalmology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Pharmacology Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Clinical Biochemistry Faculty of MedicineErzincan Binali Yildirim UniversityErzincan 24100Turkey Department of Histology and Embryology Faculty of MedicineErzincan Binali Yildirim University ErzincanErzincan 24100Turkey

AIM:To investigate the effect of lacidipine,thiamine pyrophosphate(TPP)and the combination of lacidipine and TPP against oxidative and inflammatory eye damage induced by bilateral common carotid artery ligation in ***:Male albino Wistar rats were categorized as those who underwent sham surgery(SG),right and left common carotid cross-clamping and unclamping procedure(CCU),lacidipine+CCU(LCCU),TPP+CCU(TCCU),and combination of lacidipine and TPP(LTC)+CCU(LTCCU).One hour before anesthesia,the LCCU(n=6)received lacidipine(4 mg/kg,orally)and the TCCU(n=6)received TPP(20 mg/kg,intraperitoneally).The SG(n=6)and CCU(n=6)received the same volume of distilled water from the same *** anesthesia(60 mg/kg ketamine,intraperitoneally),the necks of the rats were opened in the *** was created for 10min by placing clips on the right and left common carotid *** in the SG only underwent subcutaneous *** 10min,the clips were removed and reperfusion was achieved for six ***,the animals were euthanized(120 mg/kg ketamine,intraperitoneally)and the levels of oxidant,antioxidant and proinflammatory cytokines in the eye tissues were *** retinal tissue of the eye was also examined ***:Lacidipine,TPP,and LTC significantly prevent the increase in malondialdehyde,tumor necrosis factoralpha,interleukin-1β(IL-1β),and IL-6 levels,decrease in total glutathione levels,superoxide dismutase and catalase activities and histopathological retinal damage in eye tissue induced by bilateral common carotid artery ligation in *** impact of these drugs on protection is determined to be LTC>lacidipine>***:As a result of the study,it is concluded that LTC may be more effective than lacidipine and TPP alone in treating ocular ischemic syndrome.

关键词： ocular ischemic syndrome lacidipine thiamine pyrophosphate oxidative stress

Natural Walls of Anatolia: formation and development of Diş Kayalıkları as a structural landform (Sivas, Türkiye)

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Journal of Mountain Science 2023年第7期20卷 1807-1823页

作者： UZUN Ali AYLAR Faruk ZEYBEK Halil Ibrahim GÜRGÖZE Serkan bahadir Muhammet ALEMDAĞ Selçuk Geography Department Ondokuz Mayis UniversitySamsun 55100Turkey Geological Engineering Department Gümüşhane UniversityGümüşhane 29100Turkey

The Diş Kayalıkları is one of the largest and most striking examples of crests in the world and is located between Eskidere and Boğazören villages of the İmranlı district of the Sivas province in Turkey. The crests, which resemble castle walls when viewed from afar, have a real wall pattern due to the right-angled crack system of the bedrock when viewed closely. This study aims at investigating the geomorphological features of the Diş Kayalıkları and determining how the geological and geomorphological evolution of the Diş Kayalıkları took place and how the current formation mechanism continues. In the region, the mid-latitude continental climate prevails with cold humid winters and warm dry summers. The bedrock consists of Miocene bedded deposits of different resistance, folded by young tectonic movements. Diş Kayalıkları was formed by selective erosion of less resistant terrain around a pack of resistant rock on the steeper southern slope of an asymmetrical anticline. It has a length of 4750 m in the approximately northwest-southeast direction, a maximum height of 30 m, and a width varying between 5 and 8 m. In the present morphological appearance of the Diş Kayalıkları, it can be stated that the structure formed after the tectonic formation process was eroded under the control of the local climate and crest formation was realized. In the following process, the crest experienced a polycyclic process where different landforms were formed. There are smaller landforms such as karren, cave and rock window on Diş Kayalıkları, and macrofossil beds in some places. This highly attractive geomorphosite, unknown to wider public, should be investigated from various scientific aspects and should be brought to regional tourism by making the necessary infrastructure and promotion studies.

关键词： Structural landform Crest Geosite DişKayalıkları Sivas

Validation of the PAGE-B score to predict hepatocellular carcinoma risk in caucasian chronic hepatitis B patients on treatment

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World Journal of Gastroenterology 2022年第6期28卷 665-674页

作者： Pinar Gokcen Fatih Guzelbulut Gupse Adali Ayca Gokce Degirmenci Salturk Oguzhan Ozturk Ozgur bahadir Emine Kanatsiz Mevlut Kiyak Kamil Ozdil Hamdi Levent Doganay Department of Gastroenterology Health Sciences UniversityUmraniye Teaching and Research HospitalIstanbul 34764Turkey Department of Gastroenterology Health Sciences UniversityHaydarpasa Numune Teaching and Research HospitalIstanbul 34668Turkey

BACKGROUND Several risk scores have been developed to predict hepatocellular carcinoma(HCC)risk in chronic hepatitis B(CHB)*** majority of risk scores are based on pretreatment variables that are no longer considered risk factors for HCC development due to the suppression of hepatitis B virus replication early in the course of potent antiviral treatment in most *** PAGE-B score,which is based on platelet levels,age and sex,has been shown to accurately predict HCC risk in CHB patients on antiviral treatment in various *** We aimed to evaluate the PAGE-B score in predicting HCC risk in Turkish CHB patients on antiviral *** In this study,we recruited 742 CHB patients who had been treated with tenofovir disoproxil fumarate or entecavir for≥1 *** groups were determined according to the PAGE-B scores as follows:≤9,low;10-17,moderate and≥18,*** cumulative HCC incidences in each risk group were computed using Kaplan-Meier analysis and were compared using the log-rank *** accuracy of the PAGE-B score in predicting HCC risk was evaluated using a timedependent area under the receiver operating characteristic(AUROC)curve at all study time *** and multivariate logistic regression analyses were used to assess the risk factors for HCC *** The mean follow-up time was 54.7±1.2 *** was diagnosed in 26 patients(3.5%).The cumulative HCC incidences at 1,3,5 and 10 years were 0%,0%,0%and 0.4%in the PAGE-B low-risk group;0%,1.2%,1.5%and 2.1%in the PAGE-B moderate-risk group;and 5%,11.7%,12.5%,and 15%in the PAGE-B high-risk group,respectively(log-rank P<0.001).The AUROCs of the PAGE-B score in the prediction of HCC development at 1,3,5 and 10 years were 0.977,0.903,0.903 and 0.865,*** the multivariable analysis,older age,male sex,lower platelet levels,presence of cirrhosis,and absence of alanine aminotransferase normalization at month 6 were associated with HCC development(all P<0.05).C

关键词： Chronic hepatitis B Hepatocellular carcinoma PAGE-B score Surveillance

Taxonomical and Biogeochemical Investigation of Elements in Holocene Mollusk Shells in the South and Southwestern Marmara Basin,Turkey

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Acta Geologica Sinica(English Edition) 2008年第6期82卷 1160-1167页

作者： Saday Azadoglu ALIYEV Ali SARI bahadir KTEN Ankara University Faculty of EngineeringDepartment of Geological Engineering06100 TandoganAnkaraTurkey

Concentrations of some heavy metals and trace elements such as Cr, Ga, Ni, Zn, Mo, Cu, Pb, Yb, Y, Nb, Ti, Sr, Ba, Mn, Sc, Co, V, Zr, Fe, Al, W, Se, Bi, Sb, As, Cd in recent mollusk shells and factors affecting their distribution and deposits collected from various depths in the southern and southwestern parts of the Marmara Sea are investigated. The distribution of the elements in the shells is categorized into four groups. Of these, concentrations of 12 elements （As, Bi, Cd, Co, Ga, Mo, Nb, Sb, Se, Sc, W and Yb） are below zero [（0.053-0.79）×10^-6]; concentrations of seven elements （Cr, Ni, Pb, V, Y, Zr and Cu） are （1.0-6.0）×10^-6; concentrations of four elements （Ti, Mn, Ba and Zn） are 10- 20×10^-6; and concentrations of five elements （Si, Al, Fe, Mg and Sr） are （47.44-268.11）×10^-6. The taxonomic characteristics of the 29 elements were studied separately in mollusk shells such as Chamalea gallina （Linn6）, Pitar rudis （Poli）, Nassarius reticulatus （Linn6）, Venerupis senescens （Coocconi）, Mytilus galloprovincialis （Lamarck）, Mytilaster lineatus （Gemelin in Linne） and Chlamys glabra. It was found that, in mollusk taxonomy, the elements have unique values. In other words, element concentrations in various mollusk shells depend mainly on the taxonomic characteristics of mollusks. In various bionomic environments different element distributions of the same species are attributed to the different geochemical characters of the each environment. Data obtained in this study indicate that the organisms are the most active and deterministic factors of the environment.

关键词： biogenic biogeochemistry fauna element lattice mollusk taxonomy Turkey

Digoxin intoxication： An old enemy in modern era

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Journal of Geriatric Cardiology 2012年第3期9卷 237-242页

作者： bahadir Kirilmaz Serkan Saygi Hasan Gungor Ugur Onsel Turk Emin Alioglu Serdar Akyuz Fatih Asgun Istemihan Tengiz Ertugrul Ercan Department of Cardiology Canakkale Onsekiz Mart University Medical Faculty Canakkale 17100 Turkey Department of Cardiology Odemis State Hospital Izmir 35750 Turkey Department of Cardiology Central Hospital Izmir 35580 Turkey Department of Cardiology Yunus Emre State Hospital Eskisehir 26190 Turkey Department of Cardiovascular Surgery Canakkale Onsekiz Mart University Medical Faculty Canakkale 17100 Turkey

新治疗形式的 ObjectivesAlthough 开发限制了异羟基洋地黄毒苷用法，异羟基洋地黄毒苷沉醉仍然是能容易被俯看的一个重要问题。在这份报告，当在现代 *** 的异羟基洋地黄毒苷沉醉分析了就医，异羟基洋地黄毒苷沉醉由历史证实了的 71 ... 详细信息

新治疗形式的 ObjectivesAlthough 开发限制了异羟基洋地黄毒苷用法，异羟基洋地黄毒苷沉醉仍然是能容易被俯看的一个重要问题。在这份报告，当在现代 *** 的异羟基洋地黄毒苷沉醉分析了就医，异羟基洋地黄毒苷沉醉由历史证实了的 71 个病人，我们分析了决定性地诊断的一个案例系列，抱怨，临床并且心动电流描记器(ECG ) 调查结果，和浆液异羟基洋地黄毒苷铺平 >；2.0 ng/mL，在五个年时期期间。人口统计、临床的数据，为异羟基洋地黄毒苷使用的指示，异羟基洋地黄毒苷剂量，并发的药，实验室数据，监视的医院，和 ECG 调查结果从所有 *** 被获得 -- 71 个病人(53.5%) 中的八个在承认期间有心失败的症状或以后。百分之 64 个病人比 75 年旧。女性的百分比是 67% 。Atrial 纤维性颤动，高血压和胃肠的抱怨在女性是更经常的(64% 在女性， 30% 在男性， P = 0.007；81% 在女性， 52% 在男性， P = 0.01；50% 在女性， 17.3% 在男性， P = 0.008，分别地) 。死亡率在医院功课期间是表明的 7%.ConclusionsThis 报告在有在学习时期上的异羟基洋地黄毒苷沉醉的病人的减少的死亡率。胃肠的抱怨是在这张人口的最普通的症状。

关键词：地高辛中毒实验室数据胃肠道心电图死亡率女性 ECG

An Improved Genetic Algorithm for Crew Pairing Optimization

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Journal of Intelligent Learning Systems and Applications 2012年第1期4卷 70-80页

作者： bahadir Zeren Ibrahim Ozkol Faculty of Aeronautics and Astronautics Istanbul Technical UniversityIstanbulTurkey.

Crew pairing is a sequence of flights beginning and ending at the same crewbase. Crew pairing planning is one of the primary processes in airline crew scheduling;it is also the primary cost-determining phase in airline crew scheduling. Optimizing crew pairings in an airline timetable helps minimize operational crew costs and maximize crew utilization. There are numerous restrictions that must be considered and just as many regulations that must be satisfied in crew pairing generation. The most important regulations—and the ones that make crew pairing planning a highly constrained optimization problem—are the the limits of the flight and the duty periods. Keeping these restrictions and regulations in mind, the main goal of the optimization is the generation of low cost sets of valid crew pairings which cover all flights in the airline’s timetable. For this research study, We examined studies about crew pairing optimization and used these previously existing methods of crew pairing to develop a new solution of the crew pairing problem using genetic algorithms. As part of the study we created a new genetic operator—called perturbation *** traditional genetic algorithm implementations, this new perturbation operator provides much more stable results, an obvious increase in the convergence rate, and takes into account the existence of multiple crewbases.

关键词： Optimization Genetic Algorithms Crew Planning Crew Pairing Crew Pairing Optimization Airline Crew Planning Airline Crew Pairing Airline Crew Pairing Optimization

Gene expression and histopathological evaluation of thiamine pyrophosphate on optic neuropathy induced with ethambutol in rats

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International Journal of Ophthalmology(English edition) 2016年第10期9卷 1390-1395页

作者： Emine Cinici Nihal Cetin bahadir Suleyman Durdu Altuner Oguzhan Yarali Hilal Balta Ilknur Calik Levent Tumkaya Halis Suleyman Department of Ophthalmology Erzurum Region Education and Research Hospital Department of Pharmacology Faculty of MedicineErzincan University Department of Medical Genetics Goztepe Training and Research HospitalIstanbul Medeniyet University Department of Pathology Erzurum Region Education and Research Hospital Department of Histology and Embryology Faculty of MedicineRecep Tayyip Erdogan University

AIM： To compare the effects of thiamine pyrophosphate（TPP） and thiamine（TM） in oxidative optic neuropathy in rats induced by ***： The animals were divided into four groups：a control group（CG）,an ethambutol control（ETC） group,TM plus ethambutol group（TMG）,and TPP plus ethambutol group（TPPG）.One hour after intraperitoneal administration of TM 20 mg/kg to the TMG group and TPP 20 mg/kg to TPPG group,30 mg/kg ethambutol was given via gavage to all the groups but the *** procedure was repeated once daily for 90 *** that period,all rats were exposed to high levels of anaesthesia in order to investigate the gene expression of malondialdehyde and glutathione in removed optic nerve tissue and histopathologically to examine these tissues. RESULTS： Malondialdehyde gene expression significantly increased,whereas glutathione gene expression significantly decreased in the ETC group compared to the *** could not prevent the increase of malondialdehyde gene expression and the decrease of glutathione,while TPP significantly could ***,significant vacuolization in the opticnerve,single-cell necrosis in the glial cells,and a decrease in oligodendrocytes were observed in the ETC *** in the optic nerve,a decrease in oligodendrocytes and single-cell necrosis were found in the TMG group,while no pathological finding was observed in the TPPG group except for mild ***： TPP protects the optic nerve against the ethambutol-induced toxicity but TM does *** can be beneficial in prophilaxis of optic neuropathy in ethambutol therapy.

关键词： ethambutol gene expression optic neuropathy rat thiamine pyrophosphate

Protective effects of Rutin against methanol induced acute toxic optic neuropathy：an experimental study

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International Journal of Ophthalmology(English edition) 2018年第5期11卷 780-785页

作者： Nurdan Gamze Tasli Ferda Keskin Cimen Yücel Karakurt Turgay Ucak Renad Mammadov bahadir Suleyman Nezahat Kurt Halis Suleyman Department of Ophthalmology Erzincan University HospitalCollege of Medicine Erzincan 24100 Turkey Department of Pathology Erzincan University HospitalCollege of Medicine Erzincan 24100 Turkey Department of Pharmacology Erzincan University HospitalCollege of Medicine Erzincan 24100 Turkey Department of Biochemistry Ataturk University HospitalCollege of Medicine Erzurum 25100 Turkey

AIM：To determine the effects of Rutin on methanol induced optic neuropathy and compare the results with the effects of ***：Totally 30 rats were divided into 5 groups,with 6 rats in each group as follows：healthy controls（C）,methotrexate（MTX）,methotrexate＋methanol（MTM）,methotrexate＋methanol＋ethanol（MTME） and methotrexate＋ methanol＋Rutin（MTMR）.In all rabbits except those of the control group,MTX,diluted in sterile serum physiologic,0.3 mg/kg per oral was applied for 7 d by the aid of a *** this procedure to the rats of MTM,MTME and MTMR groups,20% methanol with a dose of 3 g/kg per oral was given by the aid of a *** MTME group,4 h after the application of methanol,20% ethanol was applied by the same way with a dose of 0.5 g/*** the other hand,in MTMR group 4 h after the application of methanol,Rutin,which was dissolved in distilled water,was applied by the same way with a dose of 50 mg/***：There were statistically significant differences in tissue 8-hydroxy-2 deoxyguanine（8-OHdG）,interleukin-1β（IL-1β）,tumor necrosis factor-alpha（TNF-α）,malondialdehyde（MDA）,myeloperoxidase（MPO）.glutathione peroxidase（t GSH） and superoxide dismutase（SOD） levels between groups（P〈0.001）.In MTMR group tissue 8-OHdG,IL-1β,MDA,and MPO levels were similar with the healthy controls but significantly different than the other *** histopathological evaluations,in MTX group there was moderate focal destruction,hemorrhage and decrease innumber of astrocytes and oligodendrocytes;in MTM group there was severe destruction and edema with decrease in number of astrocytes and oligodendrocytes;in MTME group there was mild hemorrhage,mild edema,mildly dilated blood vessels with congestion while in MTMR group,optic nerve tissue was resembling the healthy ***：Rutin may prevent methanol-induced optic neuropathy via anti-inflammatory effects and decreasing the oxidative *** treatment options are warranted in this disease to avoid loss of vision in pat

关键词： methanol optic neuropathy mtin astrocyte rat