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中西医结合治疗以腹痛为主的流行性出血热20例

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河南中医学院学报 2003年第5期18卷 52-52页

作者：苏同宝魏素云刘朝阳安阳市第五人民医院

我院1999年1月～2002年1月共收治流行性出血热(EHF)54例,其中以'发热、腹痛'为主诉者33例,对其中20例腹痛较重者,采用中西医结合进行治疗,效果较好,现报告如下.

关键词：流行性出血热腹痛病毒唑青霉素山莨菪碱足三里穴

Millimeter-wave radar-based algorithm for multi-person identification

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Millimeter-wave radar-based algorithm for multi-person ident...

Targeting PKM2 signaling cascade with salvianic acid A normalizes tumor blood vessels to facilitate chemotherapeutic drug delivery

第43届中国控制会议

作者： Jingpeng wei Jian Guo Ming Chen Zheyu Wang suyun Sun School of Computer Science Nanjing University of Posts and Telecommunications Jiangsu High Technology Research Key Laboratory for Wireless Sensor Networks Nanjing University of Posts and Telecommunications

Millimeter-wave radar-based identification technology has received extensive academic attention due to its advantages of passivity and nonintrusiveness. However, current research mostly focuses on single-target vital signs identification. And research on multi-person target identification is very few. Moreover, existing algorithms are unable to accurately monitor and separate multiple human targets in a scene, resulting in a low accuracy. To address these problems, this paper proposes a multi-person identification algorithm based on vital signs. The algorithm combines the minimum variance beam forming technique,the cell average constant false alarm rate and the k-means clustering method to extract the single person vital sign signals from the multi-person target signals. Next, the algorithm designs a multiscale fusion network model to extract features from phase one-dimensional waveform signals and two-dimensional short-time Fourier transform spectrograms, and then integrates ***, the purpose of identity recognition is achieved through classification. Simulation experiments show that the proposed algorithm effectively separate multi-person targets and achieve a higher recognition accuracy than that of traditional algorithms.

关键词： Multi-person identification FMCW radar beamforming feature fusion vital signs

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Acta Pharmaceutica Sinica B 2024年第5期14卷 2077-2096页

作者： Cheng Qian Yueke Zhou Teng Zhang Guanglu Dong Mengyao Song Yu Tang Zhonghong wei suyun Yu Qiuhong Shen Wenxing Chen Jaesung P.Choi Juming Yan Chongjin Zhong Li Wan Jia Li Aiyun Wang Yin Lu Yang Zhao Jiangsu Key Laboratory for Pharmacology and Safety Evaluation of Chinese Materia Medica Nanjing University of Chinese MedicineNanjing 210023China School of Medicine&Holistic Integrative Medicine Nanjing University of Chinese MedicineNanjing 210023China Centre for Inflammation Faculty of ScienceCentenary InstituteSchool of Life SciencesUniversity of Technology SydneySydney NSW 2050Australia Jiangsu Key Laboratory of Immunity and Metabolism Department of Pathogenic Biology and ImmunologyNational Experimental Demonstration Center for Basic Medicine EducationXuzhou Laboratory of Infection and ImmunityXuzhou Medical UniversityXuzhou 221004China Department of General Surgery Jiangsu Province Hospital of Chinese MedicineAffiliated Hospital of Nanjing University of Chinese MedicineNanjing 210029China Macquarie Medical School Faculty of MedicineHuman Health SciencesMacquarie UniversitySydney NSW 2109Australia

Aberrant tumor blood vessels are prone to propel the malignant progression of tumors,and targeting abnormal metabolism of tumor endothelial cells emerges as a promising option to achieve vascular normalization and antagonize tumor ***,we demonstrated that salvianic acid A(SAA)played a pivotal role in contributing to vascular normalization in the tumor-bearing mice,thereby improving delivery and effectiveness of the chemotherapeutic *** was capable of inhibiting glycolysis and strengthening endothelial junctions in the human umbilical vein endothelial cells(HUVECs)exposed to ***,SAA was inclined to directly bind to the glycolytic enzyme PKM2,leading to a dramatic decrease in endothelial *** importantly,SAA improved the endothelial integrity via activating theβ-Catenin/Claudin-5 signaling axis in a PKM2-dependent *** findings suggest that SAA may serve as a potent agent for inducing tumor vascular normalization.

关键词： Salvianic acid A Tumor vascular normalization PKM2 β-Catenin Claudin-5 Endothelial glycolysis Tight junctions Doxorubicin

药理学呼吸系统药章节线上线下混合教学的设计

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中国中医药现代远程教育 2025年第2期23卷 48-51页

作者：李晓曼吴媛媛余苏云韦忠红王爱云陈文星马宏跃陆茵南京中医药大学药学院江苏省中药药效与安全性评价重点实验室江苏南京210023 南京中医药大学医学院·整合医学学院江苏南京210023 江苏省中医药防治肿瘤协同创新中心江苏南京210023 南京中医药大学药学院江苏南京210023

为了探讨“互联网+”时代如何合理、适当地设计并运用线上教学资源构建新型课堂,使线上线下混合式教学达成既定目标,以南京中医药大学中医学专业2020级本科生为研究对象,以药理学中“呼吸系统药”章节为例,从课前、课中、课后3个阶段探... 详细信息

为了探讨“互联网+”时代如何合理、适当地设计并运用线上教学资源构建新型课堂,使线上线下混合式教学达成既定目标,以南京中医药大学中医学专业2020级本科生为研究对象,以药理学中“呼吸系统药”章节为例,从课前、课中、课后3个阶段探索线上线下混合式教学模式在教学中的应用。结果发现线上与线下课堂的有效融合解决了传统课堂教学形式枯燥单一、学生主体地位易被忽略、师生缺乏互动、教学内容不可重温及单纯线上教学学生自觉性差等问题,提高了教学效率、提升了教学活力,较好地完成了教学目标和教学任务。

关键词：药理学呼吸系统药线上线下混合教学模式

Novel HMGCS2 pathogenic variants in a Chinese family with mitochondrial 3-hydroxy-3-methylglutaryl-CoA synthase deficiency

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Pediatric Investigation 2019年第2期3卷 86-90页

作者： Pengfei Zhang Xuyun Hu Ruolan Guo Jun Guo wei Li suyun Qian Chanjuan Hao Jun Liu Department of Pediatric Intensive Care Unit.BejLiing Children’s Hospital.CapitaI Medical University:National Center for Children’s Health.Beiiing l 00045 China Beiiing Key Laboratory for Genetics of Birth Defects.Beiiing Pediatric Research Institute:MOE Kev Laboratory of Major Diseases in Children Genetics and Birth Defects Control Center.Belling Children’s Hospital.Capital Medical UniversityNational Center for Children’s HealthBeiiingChina Henan Key Laboratory of Pediatric Inherited&Metabolic Diseases.Henan Children’s Hospital.Zhengzhou Hospital of Beij ing Children’s Hospital ZhengzhouChina

Importance:Mitochondrial 3-hydroxy-3-methylglutaryl-CoA (HMG-CoA) synthase deficiency is a rare and underdiagnosed disorder with fewer than 30 patients reported *** application of whole-exome sequencing in patients could improve our understanding of this ***:To identify the genetic causes and evaluate the phenotype of mitochondrial HMG-CoA synthase deficiency in a pediatric patient with uncommon features that included ketosis and elevated lactate and ***:The proband was referred to the pediatric intensive care unit of Beijing Children's Hospital and selected for molecular testing with whole-exome *** parents and sibling also underwent sequencing for segregation ***:We identified two novel mutations (c.1347_1351 delAGCCT/***450Profs*7 and c.1201G>T/ ***401*) in the HMG-CoA synthase-2 gene (HMGCS2,NM_005518.3) in the proband and her *** variants were classified as pathogenic variants according to the American College of Medical Genetics and Genomics/ Association for Molecular Pathology *** acidosis in the proband was corrected with continuous renal replacement therapy and she left hospital after 21 days of ***:Our results extend the genotypic and phenotypic spectrum of HMGCS2 mutation in mitochondrial HMG-CoA synthase deficiency patients and serve as a reminder for physicians to consider mitochondrial HMG-CoA synthase deficiency in newborns and children with coma and hypoketotic hypoglycemia after fasting.

关键词： HMGCS2 mutation Hypoketotic hypoglycemia Mitochondrial HMG-CoA synthase deficiency Pediatric intensive care unit Whole-exome sequencing

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论叠合含油气盆地多勘探“黄金带”及其意义

石油勘探与开发 2015年第1期42卷 1-12页

作者：赵文智胡素云刘伟王铜山姜华中国石油勘探开发研究院

蒂索生烃模式指出了"液态窗"存在的温度和深度范围,成为油气勘探的"黄金带",但勘探实践证实中国叠合盆地发育多个勘探"黄金带"。多勘探"黄金带"的形成有3方面因素:1烃源灶多期、多阶段发育与古老烃源岩"双峰式"生烃;2储集层多阶段发育;... 详细信息

蒂索生烃模式指出了"液态窗"存在的温度和深度范围,成为油气勘探的"黄金带",但勘探实践证实中国叠合盆地发育多个勘探"黄金带"。多勘探"黄金带"的形成有3方面因素:1烃源灶多期、多阶段发育与古老烃源岩"双峰式"生烃;2储集层多阶段发育;3成藏多期性与晚期有效性。常规烃源灶、液态烃裂解气源灶以及多套规模有效储集层控制了"黄金带"的时空分布;勘探"黄金带"具有继承叠置与横向迁延的特点,其中古隆起、古斜坡、古台缘与多期继承性断裂带控制了勘探"黄金带"内油气分布。多勘探"黄金带"的提出是对中国近年来油气发现规律认识的深化,表明中国叠合盆地深层仍有经济资源,油气发现呈多期、多阶段的特点,勘探潜力更大。

关键词：叠合盆地多勘探“黄金带” 常规烃源灶液态烃裂解气源灶规模储集层多期成藏深层中国陆上

Clonal and drug resistance dynamics of methicillin-resistant Staphylococcus aureus in pediatric populations in China

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Pediatric Investigation 2019年第2期3卷 72-80页

作者： Xin Yang Yingchao Liu Lijuan Wang suyun Qian Kaihu Yao Fang Dong Wenqi Song Hong Xu Jinghui Zhen wei Zhou Pediatric Intensive Care Unit Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina MOE Key Laboratory of Major Diseases in Children National Key Discipline of Pediatrics(Capital Medical University)National Clinical Research Center for Respiratory DiseasesBeijing Key Laboratory of Pediatric Respiratory Infection DiseasesBeijing Pediatric Research InstituteBeijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina Bacteriology Laboratory Beijing Children's HospitalCapital Medical UniversityNational Center for Children's HealthBeijingChina

Importance:Regional clonal replacements of methicillin-resistant Staphylococcus aureus (MRSA) are *** is necessary to understand the clonal and drug resistance changes in specific ***:To evaluate the clonal and drug resistance dynamics of MRSA in Chinese children from 2010 to ***:MRSA was isolated from patients in Beijing Children's Hospital from 2010 to 2013 and from 2016 to *** molecular characteristics and antibiotic resistance were determined,Results:In total,211 MRSA isolates were collected,and 104 isolates were classified as community-associated MRSA (CA-MRSA).ST59-SCCmec Ⅳ was the most prevalent type in both CA-MRSA (65.4%) and healthcare-associated-MRSA (HA-MRSA) (46.7%).ST239-SCCmec Ⅲ accounted for 21.5% of all HA-MRSA,which were not detected in 2016,and only three isolates were detected in *** pvl gene carrying rate of CA-MRSA was significantly higher than that of HA-MRSA (42.3% vs.29.0%,P =0.0456).Among CA-MRSA,resistance rate to all tested antibiotics excluding chloramphenicol remained stable over the periods of 2010-2013 and ***-MRSA displayed an overall trend of decreased resistance to oxacillin,gentamicin,tetracycline,ciprofloxacin,and rifampin,and increased resistance to chloramphenicol,consistent with the difference of antibiotic resistance patterns between ST59-SCCmec Ⅳ and ST239-SCCmec Ⅲ *** minimal inhibitory concentration (MIC) creep was found in the study period in all MRSA and ST59-SCCmec Ⅳ ***:ST59-SCCmec Ⅳ has spread to hospitals and replaced the traditional ST239-SCCmec Ⅲ clone,accompanied by changes in drug ***,vancomycin MIC creep indicated that the rational use of antibiotics should be seriously considered.

关键词： Methicillin-resistant Staphylococcus aureus (MRSA) Clonal lineage Drug resistance Pediatric China

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爬行焊接机器人在球罐自动焊接中的应用

清华大学学报（自然科学版） 2021年第10期61卷 1132-1143页

作者：冯消冰潘际銮高力生田伟魏然潘百蛙陈永陈苏云清华大学机械工程系北京100084 北京博清科技有限公司北京100176

为了实现大型钢结构件的自动化焊接,尤其解决球罐三维曲面的自动化全位置焊接难题,需要设计一种可在球形表面上稳定行走的机构及适用于多种复杂工况的焊接跟踪控制系统。爬壁机器人将履带与轮式结合,解决了爬壁机构运行的灵活性与负载... 详细信息

为了实现大型钢结构件的自动化焊接,尤其解决球罐三维曲面的自动化全位置焊接难题,需要设计一种可在球形表面上稳定行走的机构及适用于多种复杂工况的焊接跟踪控制系统。爬壁机器人将履带与轮式结合,解决了爬壁机构运行的灵活性与负载能力之间的矛盾,通过视觉跟踪系统自动识别焊缝位置,智能判断焊缝路径轨迹,实现机器人沿焊缝的自主运动和焊缝跟踪。无轨道、无导向的爬行机本体适应球罐的大曲率变化,可以实现在球罐表面的自由行走,满足球罐焊接高效化和智能化的自动焊接需求。

关键词：爬壁焊接机器人大型结构件球罐自动焊接视觉跟踪系统

再论中国陆上深层海相碳酸盐岩油气地质特征与勘探前景

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天然气工业 2014年第4期34卷 1-9页

作者：赵文智胡素云刘伟王铜山李永新中国石油勘探开发研究院

深层碳酸盐岩是我国陆上油气勘探发展的重要接替领域,加强对深层碳酸盐岩的油气地质研究与探索,对于实现我国油气工业持续、稳定、健康发展具有十分重要的现实意义。通过对深层碳酸盐岩基本地质条件的深入分析,发现中国陆上深层碳酸盐... 详细信息

深层碳酸盐岩是我国陆上油气勘探发展的重要接替领域,加强对深层碳酸盐岩的油气地质研究与探索,对于实现我国油气工业持续、稳定、健康发展具有十分重要的现实意义。通过对深层碳酸盐岩基本地质条件的深入分析,发现中国陆上深层碳酸盐岩资源潜力可能超过预期,具备发现大油气田的良好前景。具体表现在4个方面:①发育常规烃源岩和源岩内滞留液态烃裂解两类烃源灶,都可以规模供烃;②受顺层、层间两类岩溶作用和埋藏、热液两类白云石化作用的控制,深—超深层碳酸盐岩仍可以发育规模有效储层;③在递进埋藏和退火受热耦合作用下,部分海相烃源岩可以跨构造期成藏,晚期仍有大量液态烃生成,深层碳酸盐岩油、气均富;④多期构造运动作用形成的大型隆起背景、3种类型成藏模式(隆起斜坡区岩溶储层似层状大面积成藏、古潜山风化壳岩溶储层倒灌式大面积成藏、礁滩储层大范围成藏),以及古隆起围斜区及台缘带广泛发育的地层、岩性圈闭群呈集群式大面积分布。结论认为:中国陆上深层碳酸盐岩具备大面积、规模成藏的有利条件,可以形成大油气田。

关键词：中国陆上海相碳酸盐岩深层烃源灶规模储集层资源潜力勘探前景