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Standard vs magnifying narrow-band imaging endoscopy for diagnosis of Helicobacter pylori infection and gastric precancerous conditions

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World Journal of Gastroenterology 2021年第18期27卷 2238-2250页

作者： Jun-Hyung Cho Seong Ran Jeon So-Young Jin suyeon park Digestive Disease Center Soonchunhyang University HospitalSeoul 04401South Korea Department of PathologySoonchunhyang University HospitalSeoul 04401South Korea Department of Pathology Soonchunhyang University HospitalSeoul 04401South Korea Department of Medical Biostatistics Soonchunhyang University HospitalSeoul 04401South Korea

BACKGROUND Advances in endoscopic imaging enable the identification of patients at high risk of gastric ***,there are no comparative data on the utility of standard and magnifying narrow-band imaging(M-NBI)endoscopy for diagnosing Helicobacter pylori(***)infection,gastric atrophy,and intestinal *** To compare the diagnostic performance of standard and M-NBI endoscopy for *** gastritis and precancerous *** In 254 patients,standard endoscopy findings were classified into mosaic-like appearance(type A),diffuse homogenous redness(type B),and irregular redness with groove(type C).Gastric mucosal patterns visualized by M-NBI were classified as regular round pits with polygonal sulci(type Z-1),more dilated and linear pits without sulci(type Z-2),and loss of gastric pits with coiled vessels(type Z-3).RESULTS The diagnostic accuracy of standard and M-NBI endoscopy for *** gastritis was 93.3%and 96.1%,*** gastric precancerous conditions,the accuracy of standard and M-NBI endoscopy was 72.0%vs 72.6%for moderate to severe atrophy,and 61.7%vs.61.1%for intestinal metaplasia in the corpus,*** to type A and Z-1,types B+C and Z-2+Z-3 were significantly associated with moderate to severe atrophy[odds ratio(OR)=5.56 and 8.67]and serum pepsinogen I/II ratio of≤3(OR=4.48 and 5.69).CONCLUSION Close observation of the gastric mucosa by standard and M-NBI endoscopy is useful for the diagnosis of *** gastritis and precancerous conditions.

关键词： Endoscopy Magnifying narrow-band imaging Helicobacter pylori Gastric atrophy Intestinal metaplasia Pepsinogen

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Moisture sorption,thermal,and caking characteristics of L-lysine-carbonate granules

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Food Bioscience 2023年第3期53卷 2983-2990页

作者： suyeon An Sungahm Ahn Andres Letona Ji Hyun Shin Seung Hoon Kang Jae Yun Jeong Sang Min park Jun Woo Kim Daeung Yu Hee Chung Donghwa Chung Food Technology Major Graduate School of International Agricultural TechnologySeoul National UniversityPyeongchang25354Republic of Korea CJ BIO Research Institute CJ CheilJedangSuwon16495Republic of Korea Institute of Food Industrialization Institutes of Green Bio Science and TechnologySeoul National UniversityPyeongchang25354Republic of Korea Department of Food and Nutrition Changwon National UniversityChangwon51140Republic of Korea Center for Food and Bioconvergence Seoul National UniversitySeoul08826Republic of Korea

L-Lysine,an essential amino acid,is often produced in the granular form of L-lysine-monohydrochloride(L-lysine-HCl).To address chemical waste and processing cost concerns associated with the production of L-lysine-HCl granules,an alternative process has been recently developed for the production of L-lysine as granules of L-lysine-carbonate(L-lysine-CO_(3)).In the present study,the moisture sorption,thermal,and caking properties of L-lysine-CO_(3) granules were investigated in comparison with commercial L-lysine-HCl granules.L-Lysine-CO_(3) granules showed a popcorn-like surface structure(59.0%crystallinity),while L-lysine-HCl granules exhibited an angular crystalline structure(72.9%crystallinity).L-Lysine-CO_(3) granules had a less compact structure than L-lysine-HCl granules and showed excellent initial flowability comparable to L-lysine-HCl granules.L-Lysine-CO_(3) granules were more hygroscopic than L-lysine-HCl granules,probably due to their lower crystallinity and less compact structure.L-Lysine-CO_(3) granules began to undergo thermal decomposition at 192℃,probably due to CO_(2) release,followed by melting at 234℃ and further decomposition,while L-lysine-HCl granules underwent melting at 251℃,and then began to undergo thermal decomposition at 260℃.No glass transition was observed for either lysine-CO_(3) or L-lysine-HCl *** test under pressurized and accelerated conditions showed that L-lysine-CO_(3) granules were more prone to caking and formed harder agglomerates than L-lysine-HCl *** results showed that L-lysine-CO_(3) granules were more hygroscopic,less thermally stable,and more prone to caking,compared to commercial L-lysine-HCl ***,these properties of L-lysine-CO_(3) granules were at acceptable levels for commercial use,thus L-lysine-CO_(3) granules have high potential for commercial development.

关键词： L-Lysine-carbonate granules Moisture sorption Thermal transition Thermal stability Caking

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