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Serum midkine levels for the diagnosis and assessment of response to interventional therapy in patients with hepatocellular carcinoma

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Journal of Interventional Medicine 2021年第1期4卷 39-45页

作者： Lin Zheng Hailiang Li Jinhua Huang Jihoon Shin suxia luo Chenyang Guo Yan Zhao Fangkun Li Department of Minimally Invasive Intervention Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengZhou450008China Division of Medical Imaging and Interventional Radiology Sun Yat-sen University Cancer CenterGuangzhou510060China Department of Radiology and Research Institute of Radiology University of UlsanCollege of MedicineAsan Medical Center86Asanbyeongwon-gilSongpa-guSeoul 138-736Republic of Korea Department of Medical Gastroenterology Henan Cancer HospitalThe Affiliated Cancer Hospital of Zhengzhou UniversityZhengZhou450008China

Objective:To explore the clinical significance of serum midkine(MDK) levels for the diagnosis of hepatocellular carcinoma(HCC) and evaluate the efficacy of interventional ***:Eighty-four patients with HCC were enrolled in this retrospective *** received an interventional treatment.A follow-up was performed every 2 months,using magnetic resonance imaging,to determine whether the treatment should be *** alpha-fetoprotein(AFP) and MDK levels were measured at the first diagnosis and during the follow-ups,and the HCC detection rates based on the cutoff values of these two measurements were *** relationships between AFP and MDK and the clinical tumor characteristics and changes in APK and MDK before and after treatment were also compared using a rank sum test and χ2 test,*** prognostic significance of MDK for HCC was determined through regression analysis.A twosided P <0.05 was considered statistically ***:MDK expression was detected in 95.24% of the *** analysis revealed MDK expression in95.35%,95.12%,85.19%,86.67%,and 83.33% of the AFP-positive,AFP-negative,stage A Barcelona clinic liver cancer(BCLC-A),BCLC-A/AFP-positive,and BCLC-A/AFP-negative cases,*** expression after the interventional treatment(66.7%) was significantly lower than that before the treatment(95.2%).The mean posttreatment MDK level was 0.67 ng/mL in patients with a positive response to therapy as compared with 3.66 ng/mL in those with no positive *** patients were followed up for 18 months,and those positive for MDK expression before the intervention were more likely to relapse than patients without MDK *** analysis revealed the highest recurrence rate for patients who were positive for MDK expression before and after ***:Serum MDK may serve as a powerful complement to AFP in the diagnosis of *** measurement may improve the detection rate of BCLC-A and AFP-negativ

关键词： Hepatocellular carcinoma Midkine Interventional treatment Diagnosis Efficacy evaluation

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Emanuel综合征1例报道

中国优生与遗传杂志 2024年第2期32卷 377-379页

作者：冯杏琳申华董瑞丽罗素霞刘丹葛瑶李彬翟莉莉潘锦秀开封市妇产医院医学遗传科/开封市产前诊断中心/河南省医学遗传学重点学科/开封市优生遗传学重点实验室/河南省医学遗传学重点(培育)实验室/开封市产前诊断重点实验室河南开封475000 开封市妇产医院医学影像科河南开封475000 开封市妇产医院临产室河南开封475000

目的对1孕22周有异常生育史并染色体平衡易位携带者孕妇进行产前诊断。方法采用超声检查、羊水产前诊断(染色体核型+CNV-seq)。结果超声检查提示:胎儿小下颌,胎儿生殖器发育不良、小阴茎。羊水穿刺产前诊断结果:胎儿染色体核型为47,X?,+... 详细信息

目的对1孕22周有异常生育史并染色体平衡易位携带者孕妇进行产前诊断。方法采用超声检查、羊水产前诊断(染色体核型+CNV-seq)。结果超声检查提示:胎儿小下颌,胎儿生殖器发育不良、小阴茎。羊水穿刺产前诊断结果:胎儿染色体核型为47,X?,+der(22)t(11;22)(q23.3;q11.1)mat。人类基因组拷贝数变异(CNV)检测结果:seq[hg19]11q23.3q25(116680000–134960000)×3;22q11.1q11.21(16840000–20320000)×3。结合临床表现和实验室检测结果,胎儿诊断为Emanuel综合征,为罕见病。结论对有异常生育史、染色体异常携带者、超声提示胎儿发育异常者进行产前诊断及家系研究,可明确病因,早发现早诊断早干预,是减少患儿出生的关键。

关键词：伊曼纽尔综合征染色体病染色体平衡易位携带者

Relationship between the expression of ERCC-1,survivin and both efficiency and prognosis of cisplatin contained first-line chemotherapy in advanced lung adenocarcinoma

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The Chinese-German Journal of Clinical Oncology 2009年第5期8卷 265-268页

作者： Xiaobing Chen suxia luo Ning Li Yongping Song Junjie Zen The First Affiliated Hospital of Zhengzhou University He＇nan Province Tumor Hospital Zhengzhou 450008 China Medicine Department He＇nan Province Tumor Hospital Zhengzhou 450008 China

Objective:We analyzed the relationship between the expression of ERCC-1(excisition repair cross complement-1), survivin and sensitivity and prognosis of cisplatin contained regimens first-line chemotherapy in advanced lung ***:Immunohistochemical(IHC) method was used to evaluate the expression of ERCC-1 and survivin in 80 pathologically confirmed advanced lung adenocarcinoma patients given cisplatin-contained regimens first-line *** response rate and survival time were analyzed according to the expression of ERCC-1 and ***:Only 77 patients could be reviewed by IHC *** expression rates of ERCC-1 and survivin were 33.77% and 53.25 % *** worse response rate and shorter TTP/ PFS could be identified in ERCC-1 positive *** with positive expression of survivin had worse survival ***:Expression of ERCC-1 may be a molecular marker of cisplatincontained regimens first-line chemotherapy resistance and poor prognosis in advanced lung adenocarcinoma *** expression of survivin predicates poor prognosis for patients with advanced lung adenocarcinoma.

关键词： lung adenocarcinoma ERCC-1 survivin cisplatin

Study On Application Of Bone-Setting Manipulation Of Traditional Chinese Medicine To Treatprolapse Of Intervertebral Disc

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Study On Application Of Bone-Setting Manipulation Of Traditi...

GT-4A电脑疼痛治疗仪分娩镇痛与椎管内麻醉分娩镇痛的临床效果比较

全国骨伤专业研究生教材统定稿会议

作者： Research and Training Department of luo Youming’s Bone-setting Manipulation,Beijing Chaoyang luo Youming’s Orthopedic and Traumatic Hospital of Traditional Chinese Medicine,Beijing luo Jindian luo suxia luo Yong luo Wei luo Sulan

In this paper,the treatment of prolapse of intervertebral disc with bone-setting manipulation of traditional Chinese medicine was discussed in *** clinical practice,the prolapse of intervertebral disc is a common disease with displacement of nucleus of inter-vertebral disc,rapture of fibrous ring,compression to nerve roots,neuralgia radi- ated to lower limbs and disturbance of neural functions,caused by external *** recent 40 years,more than 10 thousand of patients of prolapse of lumbar intervertebral disc have been treated in this hospital with varied therapies ac- cording to the stage and pattern of the disease and a higher cure rate has been *** analysis of clinical data of 1157 cases showed a total cure rate of 87.64% and a total effective rate of 98.18%.In this paper,the experiences of our clinical practice were summarized,analyzed and discussed in 6 respects:general clinical data,criteria of diagnosis, differential diagnosis,clinical bone-setting manipulation,criteria of therapeutic effect,and *** clinical ap- plication of bone-setting manipulation was particularly mentioned and discussed,including lateral over-bending, pressing with hand or elbow,rotating,and extending and flexing maneuver in a sitting posture together with herbal drugs and other supplemental *** maneuvers should be steadily,accurately and gently applied to produce a prompt therapeutic *** merits are easy to practice,cheap in financial expense,less of side-effects,higher in thera- peutic effect,so believed and welcome by vast patients.

关键词： luo bone-setting intervertebral disc clinical researchIn

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临床医学工程 2019年第1期26卷 27-28页

作者：骆苏霞阳春市中医院广东阳江529600

目的探讨椎管内麻醉分娩镇痛和GT-4A电脑疼痛治疗仪分娩镇痛的临床效果。方法选取2017年5月至2018年5月我院接收的孕足月初产妇80例,产程进入活跃期后根据自愿原则分为导乐仪组(采用GT-4A电脑疼痛治疗仪镇痛, n=62)和椎管组(采用椎管内... 详细信息

目的探讨椎管内麻醉分娩镇痛和GT-4A电脑疼痛治疗仪分娩镇痛的临床效果。方法选取2017年5月至2018年5月我院接收的孕足月初产妇80例,产程进入活跃期后根据自愿原则分为导乐仪组(采用GT-4A电脑疼痛治疗仪镇痛, n=62)和椎管组(采用椎管内阻滞麻醉, n=18)。两组产妇均在宫口开大2～3 cm,产程进入活跃期开始采取分娩镇痛,观察其镇痛效果及相关指标。结果椎管组的镇痛有效率为100.0%,明显高于导乐仪组的80.6%(P 0.05)。导乐仪组的阴道助产率明显低于椎管组(P 0.05)。两组的新生儿Apgar评分及产妇产后2 h出血量比较无统计学差异(P>0.05)。结论椎管内阻滞麻醉和GT-4A电脑疼痛治疗仪的镇痛效果均较好,对母婴的健康均无影响,应在产妇知情的情况下根据其意愿选择镇痛方法,综合分析具体应用。

关键词： GT-4A电脑疼痛治疗仪分娩镇痛椎管内麻醉

Relationship between Expression of CEA,E-cadherin and Liver Metastasis in Colorectal Cancer

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Chinese Journal of Clinical Oncology 2008年第6期5卷 429-432页

作者： Ning Li Xiaobing Chen Xiangbin Wan suxia luo Lili Han Mengqiang Zhou Dengwen Yin Li Zhang Department of Oncologic Medicine Henan Tumor Hospital Zhengzhou 450003 Henan Province China Zhengzhou University Cancer Center Zhengzhou 450000 Henan Province China Department of Surgery Henan Tumor Hospital Zhengzhou 450003 Henan ProvinCe China Department of Oncologic Medicine Sun YatSen University Cancer Center Guangzhou 510000 Guangdong Province China

OBJECTIVE To investigate the expression of E-cadherin andCEA in serum in colorectal carcinoma and their relationship withliver *** CEA level was measured post-operativelyby radioimmunoassay of 60 patients with colorectal *** analysis was used to evaluate theexpression of *** In liver metastasis group,24 patients (24/26,92.3%)were high level of CEA,but only 9 patients in non-liver *** difference is significant (P=0.004).Expression ofE-cadherin significantly correlated with differentiation,but wasnot associated with Tstage or N *** metastatic rate innegative expression was higher than that in positive *** the survival analysis showed that time of liver metastasis wassignificant different in two groups (P<0.05).CONCLUSION The expression of CEA in serum can be usedto predict liver mestatasis of colorectal cancer after operation.E-cadherin,associated with tumor differentiation,is also a hopefulindicator for the prediction of liver metastasis in patients withcolorectal cancer.

关键词： colorectal cancer liver metastasis E-cadherin CEA.

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原发性食管小细胞癌的诊疗进展

中国肿瘤临床 2014年第20期41卷 1337-1341页

作者：申威邓文英李宁罗素霞郑州大学附属肿瘤医院河南省肿瘤医院消化内科郑州市450000

食管小细胞癌(primary esophageal small cell carcinoma,PESCC)是一种恶性程度高、易远处转移、预后极差的罕见疾病,近年来,国内外食管小细胞癌的发病率呈明显上升趋势。食管小细胞癌是一种最常见的消化道小细胞癌,但其生物学行为、治... 详细信息

食管小细胞癌(primary esophageal small cell carcinoma,PESCC)是一种恶性程度高、易远处转移、预后极差的罕见疾病,近年来,国内外食管小细胞癌的发病率呈明显上升趋势。食管小细胞癌是一种最常见的消化道小细胞癌,但其生物学行为、治疗模式及预后均不同于食管鳞癌,国内外尚无关于PESCC的前瞻性随机对照研究。目前临床中对于其组织来源、诊断方式、治疗模式及预后因素尚未形成共识。为加深对PESCC的理解和更好地解决临床问题,本文就近年来食管小细胞癌的相关诊疗进展及不同见解作一综述。

关键词：小细胞癌食管癌手术放疗化疗靶向治疗预后

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肝硬化合并上消化道出血临床诊疗探讨

数理医药学杂志 2016年第7期29卷 980-981页

作者：罗素霞重庆市长寿区中医院重庆401220

目的：探讨肝硬化合并上消化道出血的临床诊查与治疗。方法：回顾性分析某院2013年2月~2015年11月收治的98例肝硬化合并上消化道出血患者的病因及治疗方法。建立Microsoft Excel数据库,对本次研究数据采取SPSS1.30软件进行统计处理。对... 详细信息

目的：探讨肝硬化合并上消化道出血的临床诊查与治疗。方法：回顾性分析某院2013年2月~2015年11月收治的98例肝硬化合并上消化道出血患者的病因及治疗方法。建立Microsoft Excel数据库,对本次研究数据采取SPSS1.30软件进行统计处理。对常规止血、抑酸、补充血容量治疗（对照组n=49）与加用治疗（观察组n=49）效果差异加以分析。结果：对肝硬化合并上消化道出血的患者采取纤维胃镜检查,导致患者出血的原因主要有肝硬化门脉高压导致的胃出血54例,占比55.1%;食管静脉曲张破裂16例,占比16.3%;重症胃粘膜疾病12例,占比12.2%;消化道溃疡11例,占比11.3%;消化道肿瘤5例,占比5.1%。两组不同方法治疗有效率比较,观察组优于对照组,差异显著,存在统计学意义（P〈0.05）。结论：在临床诊治中纤维胃镜为常用手段,应对出血程度、部位及原因作出准确及时的判断并对此进行针对性的治疗手段及细致的监护。

关键词：肝硬化合并上消化道出血诊疗

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不同化疗方案对小细胞食管癌预后的影响

中华肿瘤杂志 2015年第10期37卷 780-783页

作者：申威邓文英李宁魏辰罗素霞郑州大学附属肿瘤医院河南省肿瘤医院消化内科 450000

目的：探讨不同化疗方案对小细胞食管癌（ SCEC）预后的影响。方法回顾性分析62例行化疗为基础的治疗方案的SCEC患者的临床资料，按美国退伍军人医院和国际肺癌研究会制订的标准分为局限期（39例）和广泛期（23例）。采用Cox多因素分析... 详细信息

目的：探讨不同化疗方案对小细胞食管癌（ SCEC）预后的影响。方法回顾性分析62例行化疗为基础的治疗方案的SCEC患者的临床资料，按美国退伍军人医院和国际肺癌研究会制订的标准分为局限期（39例）和广泛期（23例）。采用Cox多因素分析生存状况的影响因素， Kaplan？Meier法和Log rank检验进行生存分析。结果62例患者的中位生存时间为18．0个月，1、2、3年生存率分别为68．8％、38．6％和20．9％。综合治疗组（化疗＋放疗或手术）患者的中位生存时间（20．8个月）高于单纯化疗组（7．6个月，P＜0．05）。不论局限期还是广泛期患者，EP方案（依托泊甙＋顺铂）或CP方案（环磷酰胺＋顺铂）组患者的生存时间与其他方案组比较，差异均无统计学意义（均P＞0．05）。Cox多因素分析显示，肿瘤分期、化疗周期数和治疗模式为影响患者预后的独立因素（均P＜0．05）。结论化疗联合放疗或手术治疗的综合治疗是治疗SCEC最为推荐的治疗模式，适当增加化疗周期数（≥4个周期）可能给患者带来生存获益。 EP或CP方案与其他化疗方案相比，无明显优越性。

关键词：癌,小细胞食管肿瘤抗肿瘤联合化疗方案预后顺铂卡铂