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作者： Rudianto sutarman（杨建孝）重庆医科大学

学位级别：硕士

Background: Basal Cell Carcinoma (BCC) is the most common skin cancers in the white skin population. Recent studies showed the wide variation of histological subtypes in the classification of BCC around the world. Histological subtypes may imply a different clinical behavior and in recent study also been considered to have different etiology. The differences of clinical behaviors could lead to a low rate of clinical diagnosis accuracy of BCC in a country where the incidence rate of BCC relatively low.Objectives: The aim of this study is to analyze the characteristic of BCC clinically and the clinical diagnosis accuracy for BCC at a hospital-based retrospective study for period 7 years.Methods: All biopsied patients who histopathologically confirmed as BCC and/or all patients who clinically diagnosed as BCC at Dermatology and Venereology Department of First Affiliated Hospital of Chong Qing University of Medical Science from January, 2001 to December, 2007 were included in the study. A retrospective analysis was performed on 83 cases histopathologically confirmed BCC. Result were analyze with SAS 8.2 statistics software by using Pearson Chi-Square Test and Cochran-Armitage Trend Test for hypothesis testing. Result were considered to be statistically significant for p value <0.05.Results: From 83 cases histopathology confirmed as BCC, male: female ratio was 1:0.93. The mean age was 61.72 years (SD±12.99). The youngest age was 21 years, the oldest was 89 years. The highest numbers of BCC were seen in seventh decade age groups which occupied 26.51%. According to histological subtype, 65.06% were nodular, 12.95% superficial, 10.84% pigmented, 8.43% fibroepithelioma of Pinkus (FEP) and 3.61% morpheaform. Except for superficial type which mostly occurred on trunk (66.67%), others type of BCC predominantly occurred on the head and neck region (90.74% of nodular, 60% of pigmented, 100% of morpheaform, 85.71% of FEP). Nodular and morpheaform type were mostly biops

关键词： BCC Histological Subtype Anatomical distribution Misdiagnosis and Miss Diagnosis

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念珠状发1例

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临床皮肤科杂志 2008年第3期37卷 191-191页

作者： Rudianto sutarman 李惠重庆医科大学附属第一医院皮肤科

患儿男，7岁。因枕部和头皮前半部丘疹伴脱发6年余，于2007年2月6日来我科就诊。患儿出生时毛发正常，数月后头发逐渐稀少，枕部和头皮前半部出现毛囊性角化性红色丘疹。头发一般在近头皮1cm处折断，头发最长不超过3cm。眉毛、睫毛及身... 详细信息

患儿男，7岁。因枕部和头皮前半部丘疹伴脱发6年余，于2007年2月6日来我科就诊。患儿出生时毛发正常，数月后头发逐渐稀少，枕部和头皮前半部出现毛囊性角化性红色丘疹。头发一般在近头皮1cm处折断，头发最长不超过3cm。眉毛、睫毛及身体毳毛均正常。其父幼时亦有类似疾病，年龄增大后自行减轻。目前其父枕部头皮仍可见轻度毛囊性角化性丘疹。体格检查：发育正常，智力正常，各系统检查未见异常。

关键词：发念珠状

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Curcumin alters motor coordination but not total number of Purkinje cells in the cerebellum of adolescent male Wistar rats

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Journal of Integrative Medicine 2013年第1期11卷 32-38页

作者： Ginus Partadiredja sutarman Taufik Nur Yahya Christiana Tri Nuryana Rina Susilowati Department of Physiology Faculty of Medicine Universitas Gadjah MadaYogyakarta 55281 Indonesia Department of Anatomy Embryology and Anthropology Faculty of Medicine Universitas Gadjah MadaYogyakarta 55281 Indonesia Department of Histology and Cell Biology Faculty of Medicine Universitas Gadjah MadaYogyakarta 55281 Indonesia

OBJECTIVE： The present study aimed at coordination and the estimate of the total investigating the effects of curcumin on the motor number of cerebellar Purkinje cells of adolescent Wistar rats exposed to ethanol. METHODS： The total of 21 male Wistar rats aged 37 d old were divided into three groups, namely ethanol, ethanol-curcumin, and control groups. The ethanol group received 1.5 g/kg ethanol injected intraperitoneally and water given per oral; the ethanol-curcumin group received 1.5 g/kg ethanol injected intraperitoneally and curcumin extract given per oral; the control group received saline injection and oral water. The treatment was carried out daily for one month, after which the motor coordination performance of the rats was examined using revolving drum apparatus at test days 1, 8, and 15. The rats were finally sacrificed and the cerebellum of the rats was further processed for stereological analysis. The estimate of the total number of Purkinje cells was calculated using physical fractionator method. RESULTS： The ethanol-curcumin group performed better than both ethanol and control groups in the motor coordination ability at day 8 of testing （P〈 0.01）. No Purkinje cell loss was observed as a result of one month intraperitoneal injection of ethanol. CONCLUSION： Curcumin may exert beneficial effects on the motor coordination of adolescent rats exposed to ethanol via undetermined hormetic mechanisms.

关键词： curcumin Purkinje cells antioxidants rats, Wistar

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