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International Journal of Ophthalmology(English edition) 2020年第7期13卷 1167-1169页

作者： Satoru Kase Shinki Chin Teruhiko Hamanaka Yasuhiro Shinmei Takeshi Ohguchi susumu Ishida Department of Ophthalmology Faculty of Medicine and Graduate School of MedicineHokkaido UniversitySapporo CityHokkaido 060-8638Japan Department of Ophthalmology Japan Red Cross Medical CenterTokyo 150-8935Japan

Dear Editor,I am *** Kase,from the Department of Ophthalmology,Faculty of Medicine and Graduate School of Medicine,Hokkaido University.I write to present the case of clinicopathological findings in Axenfeld-Rieger syn... 详细信息

关键词： Medicine Rieger congenital

Prognostic factors of minimally invasive surgery for gastric cancer: Does robotic gastrectomy bring oncological benefit?

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World Journal of Gastroenterology 2021年第39期27卷 6659-6672页

作者： Masaya Nakauchi Koichi Suda susumu Shibasaki Kenichi Nakamura Shinichi Kadoya Kenji Kikuchi Kazuki Inaba Ichiro Uyama Department of Gastroenterological Surgery Fujita Health UniversityToyoake 470-1192AichiJapan Department of Gastroenterological Surgery Ishikawa Prefectural Central HospitalKanazawa 920-8535IshikawaJapan

BACKGROUND Gastric cancer is the third leading cause of cancer-related death worldwide and surgical resection remains the sole curative treatment for gastric *** invasive gastrectomy including laparoscopic and robotic approaches has been increasingly used in a few *** far,only a few reports have investigated the oncological outcomes following minimally invasive *** To determine the 5-year survival following minimally invasive gastrectomy for gastric cancer and identify prognostic *** This retrospective cohort study identified 939 patients who underwent gastrectomy for gastric cancer during the study *** excluding 125 patients with non-curative surgery(n=77),other synchronous cancer(n=2),remnant gastric cancer(n=25),insufficient physical function(n=13),and open gastrectomy(n=8),a total of 814 consecutive patients with primary gastric cancer who underwent minimally invasive R0 gastrectomy at our institution between 2009 and 2014 were retrospectively ***,5-year overall and recurrence-free survival were analyzed using the Kaplan–Meier method with the log-rank test and Cox regression analyses,while factors associated with survival were determined using multivariate *** Our analysis showed that age>65 years,American Society of Anesthesiologists(ASA)physical status 3,total or proximal gastrectomy,and pathological T4 and N positive status were independent predictors of both 5-year overall and recurrencefree ***,the included patients had a 5-year overall and recurrence-free survival of 80.3%and 78.2%,*** the 814 patients,157(19.3%)underwent robotic gastrectomy,while 308(37.2%)were diagnosed with pathological stage II or III ***,our findings showed that robotic gastrectomy was an independent positive predictor for recurrence-free survival in patients with pathological stage II/III[hazard ratio:0.56(0.33-0.96),P=0.035].Comparison of recurrence-fre

关键词： Laparoscopy Gastric cancer Minimally invasive surgery Prognostic factor Stomach neoplasms

Positional Changes of the Hyoid Bone after Correction of the Glosso-Larynx—Hyoid Bone Complex (HBC)

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International Journal of Clinical Medicine 2020年第5期11卷 252-256页

作者： susumu Mukai Otorhinolaryngology Mukai Clinic Kanagawa Japan

Human hyoid bone floats in the neck. Downwards of an amount of about half vertebra and 0.3 cm forward following the correction of the glosso-larynx (CGL) was observed by simple XP. Disappearance of symptoms of the ankyloglossia with deviation of the epiglottis and larynx (ADEL) and increased of body temperature were observed after CGL. The results suggest that hyoid bone makes a complex that controls not only respiration and swallowing but also controls metabolism. It might be called hyoid bone complex (HBC). Human hyoid bone floats in the neck. Downwards of an amount of about half vertebra and 0.3 cm forward following the correction of the glosso-larynx (CGL) was observed by simple XP. Disappearance of symptoms of the ankyloglossia with deviation of the epiglottis and larynx (ADEL) and increased of body temperature were observed after CGL. The results suggest that hyoid bone makes a complex that controls not only respiration and swallowing but also controls metabolism. It might be called hyoid bone complex (HBC).

关键词： Respiration Swallowing Metabolism Homo Neanderthalensis

Salivary duct carcinoma of the submandibular gland presenting a diagnostic challenge: A case report

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World Journal of Clinical Cases 2021年第12期9卷 2908-2915页

作者： Toshihiro Uchihashi Shingo Kodama Akinari Sugauchi Shinichiro Hiraoka Katsutoshi Hirose Yu Usami susumu Tanaka Mikihiko Kogo First Department of Oral and Maxillofacial Surgery Osaka University Graduate School of DentistrySuita 565-0871OsakaJapan Department of Oral Pathology Osaka University Graduate School of DentistrySuita 565-0871OsakaJapan First Department of Oral and Maxillofacial Surgery Graduate School of DentistryOsaka UniversitySuita 565-0871OsakaJapan

BACKGROUND Salivary duct carcinoma(SDC)is a rare,extremely aggressive malignancy that arises in the submandibular *** can metastasize locally early and therefore is an important differential diagnosis of metastatic disease in cervical lymph nodes or specific lymphadenitis such as tuberculous cervical *** SUMMARY We report a case of SDC in the submandibular gland that presented diagnostic *** lesion was coincidentally discovered through examination of the radiolucent area of the *** failed to confirm the possibility of specific inflammation,leading us to execute an open biopsy to verify the *** surgical specimen showed that the submandibular gland was primarily replaced with a calcified *** histological analysis and confirmation,we performed surgical resection,radiotherapy,and various *** Radiographic imaging characteristics of lymph node metastases of salivary gland cancer,especially of SDC,may resemble other cervical lymphadenitis;calcification at the submandibular gland is the landmark of SDC occurring at the submandibular gland.

关键词： Salivary duct carcinoma Tuberculous cervical lymphadenitis Submandibular gland Calcification Salivary cancers Chemotherapy Case report

Human Nose Might Be Involved in Cooling of the Brain

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International Journal of Clinical Medicine 2015年第7期6卷 482-486页

作者： susumu Mukai Otorhinolaryngology Cervico-Facial Surgery Mukai Clinic Yamato Kanagawa Japan

I have reached the conclusion that the human nose might be involved in cooling of the brain. In this report, I first describe the clinical observations about ankyloglossia with deviation of the epiglottis and larynx (ADEL) with regard to sleep that I have made during my 30 years of otorhino-laryngological experience. Then I describe the physiology of the nose. Next I quote from reports on paradoxical sleep, or REM sleep, from Kitamura K (2009) and Jouvet M (1992). Finally, I present the conclusion that nasal respiration is indispensable to a deep and sound sleep that refreshes humans and promotes vitality.

关键词： Nose Sleep Paradoxical Sleep REM ADEL CGL EVO

Specific Gravity of the Tonsil and the Adenoid

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International Journal of Clinical Medicine 2014年第4期5卷 143-144页

作者： susumu Mukai Otorhinolaryngology Mukai Clinic Kanagawa Japan

Purpose: When considering about adeno-tonsillar hypertrophies it is important to know their weights as well as their specific gravities. Subjects and methods: Specific gravities of 344 tonsils and 117 adenoids were measured. Results: Average specific gravities of tonsils and adenoids were 1.08 (SD: 0.0411), 1.12 (SD: 0.574) respectively. Significant difference was observed between two (p 0.002). Discussion: The palatine tonsils and pharyngeal tonsil or adenoid are in a Waldeyer’s ring. They are thought that they work for lymphatic immune systems. However, there are several differences between tonsil and adenoid. The former has capsule, and increases their weight by growth;on the contrary the latter has no capsule, shrinks by growth. Tonsils are relatively hard mass but adenoids are very soft and easily bleed by touching with cotton swabs via nose. Conclusion: At this study, specific gravity of the adenoid was heavier than that of tonsils. These results suggest that tonsil and adenoid are physiologically different.

关键词： Specific Gravity Adenoid Tonsil Adenotonsilectomy Respiration

Dilatation of the nasal valve by expansion of the vestibular oris (EVO)

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Health 2013年第8期5卷 21-25页

作者： susumu Mukai Otorhinolarynglogy/Maxillofacial Surgery Mukai Clinic Yamato Japan

Introduction: The main signs and symptoms of ankyloglossia with deviation of the epiglottis and larynx (ADEL) are sleep disorders caused by respiratory restraint. The author contrived the surgical procedure of correction of the glosso-larynx (CGL) and expansion of the vestibular oris (EVO) for the cure of ADEL. CGL increases vital capacity (VC) and forced expiratory volume in 1 second (1% FEV). EVO reduces nasal airflow resistance. The most important component of nasal airflow resistance is the nasal valve. Purpose: Our purpose was to measure how wide the nares were dilated after EVO. Method: The width of the nares, height of the nose, length of the philtrum and width of the lip were measured in patients who had signs and symptoms of ADEL, before and after EVO. Result: Significant increases were observed in the width of the nares, height of the nose and length of the lip after EVO. Conclusion: This study confirmed that the nares dilate after EVO. Not only the amelioration of nasal respiration by EVO increases immunity, but also aesthetic effects are obtained after EVO.

关键词： Respiration Sleep Ankyloglossia with Deviation of the Epiglottis and Larynx (ADEL) Nasal Valve Depressor Septi Nasi Muscle

Effects of Bare-Ground Revegetation Techniques Using Imperata cylindrica on Changes in the Plant Cover and Species Richness during Early Succession

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Open Journal of Ecology 2016年第8期6卷 471-483页

作者： susumu Yamada Masayuki Nemoto Institute for Agroecosystem Services Graduate School of Agricultural and Life Sciences University of Tokyo Tokyo Japan

Riverdikes are habitats that must be revegetated quickly in order to prevent soil erosion. With increasing pressure to improve the cost efficiency of management, new revegetation techniques suitable under reduced mowing frequencies are required. Imperata cylindrica (L.) P. Beauv. is an important component of grasslands in several Asian countries. Its vigorous rhizome elongation should be useful for quickly covering bare ground. We tested the effects of sowing (at two densities), transplanting, and sodding of I. cylindrica on plant cover and species richness of established vegetation over 3 years. The sodding and high-density sowing treatments achieved the most rapid increase in cover, followed by low-density sowing, transplanting, and the control. By year 2, however, the cover in the low- and high-density sowing treatments was similar. The sodding treatment had significantly fewer species than the other treatments in year 1. Between years 1 and 2 and years 2 and 3, the total number of species increased in the transplanting treatment, whereas it decreased in the sodding and two sowing treatments. Accordingly, if stabilization and erosion control are the priority, introduction of I. cylindrica using sod and high-density sowing is the most suitable method. If immediate green-up is not imperative, low-density sowing is likely to provide available resources for new seedlings of diverse species to become established, allowing the introduction of representative species in semi-natural grasslands. More research will be needed on the effects of introducing diverse species (e.g., sowing seed mixtures) that include I. cylindrica on the resulting floristic composition.

关键词： Restoration Riverdike Sod Sowing Transplanting

A case of mucin producing liver metastases with intrabiliary extension

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World Journal of Gastroenterology 2006年第30期12卷 4918-4921页

作者： Hirotaka Tokai Yujo Kawashita susumu Eguchi Yukio Kamohara Mitsuhisa Takatsuki Sadayuki Okudaira Yoshitsugu Tajima Tomayoshi Hayashi Takashi Kanematsu Department of Transplantation and Digestive Surgery Nagasaki University Graduate School of Biomedical Sciences Nagasaki Japan Department of Pathology Nagasaki University Hospital. Nagasaki Japan

A 75-year-old man was admitted to our hospital with a diagnosis of liver metastases from colon cancer. He underwent right hemicolectomy for cecal cancer eight years ago, and had a metastatic liver tumor in segment 8 （S8）, which was surgically resected about 4 years after the initial operation. Histopathological examination of the resected specimens from both operations revealed a well-differentiated adenocarcinoma with mucinous carcinoma. Four months after the second operation, computed tomography demonstrated a low-density lesion at the cut surface of the remnant liver. Although it was considered to be a postoperative collection of inflammatory fluid, it formed a cystic configuration and increased in size to approximately 5 cm in diameter. With a tentative diagnosis of a recurrence of metastatic cancer, partial hepatectomy of S8 was performed. Histological examination of the resected specimens also revealed mucinous adenocarci- noma, which had invaded into the biliary ducts, replacing and extending along its epithelium. Immunohistochemi-cally, the tumor cells were positive for cytokeratin （CK） 20, but negative for CK7. Therefore, the tumor was diagnosed as a metastatic adenocarcinoma from colonic cancer. Liver metastases of colorectal adenocarcinoma sometimes invade the Glisson＇s triad and grow along the biliary ducts.

关键词： Liver metastases Mucin Intrabiliary extension Cytokeratin 7, Cytokeratin 20

Intestinal Behcet's disease with esophageal ulcers and colonic longitudinal ulcers

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World Journal of Gastroenterology 2006年第16期12卷 2622-2624页

作者： Soichiro Fujiwara Ichiro Shimizu Momoko Ishikawa Kohzo Uehara Hirofumi Yamamoto Michiyo Okazaki Takahiro Horie Arata luchi susumu Ito Department of Internal Medicine Miyoshi Prefectural HospitalTokushimaJapan Department of Digestive and Cardiovascular Medicine Tokushima University Graduate School of MedicineTokushimaJapan

Intestinal Behcet＇s disease in a 38-year-old woman was diagnosed because of the history of recurrent oral aphthous ulcers, erythema nodosum-like eruptions, genital ulcer, and endoscopic findings of esophageal and Ueocolonic punched-out ulcers with colonic longitudinal ulcers. Esophageal lesions and colonic longitudinal ulcers are rarely seen in intestinal Behcet＇s disease. The ulcers of esophagus and ileocolon healed with 3 wk of treatment with prednisolone and mesalazine without any adverse effect. Mesalazine may decrease the total dose of prednisolone required to treat the disease.

关键词： Colonic longitudinal ulcer Esophageal ulcer Intestinal Behcet's disease Mmesalazine