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Lifestyle after Cardiac Rehabilitation: Did the Message Come across, and Was It Feasible? An Analysis of Patients’ Narratives

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Health 2014年第19期6卷 2641-2650页

作者： Marie Veje Knudsen sussie laustsen Annemette Krintel Petersen Sanne Angel Department of Physiotherapy and Occupational Therapy Aarhus University Hospital Aarhus Denmark Centre of Research in Rehabilitation (CORIR) Department of Clinical Medicine Aarhus University Hospital and Aarhus University Aarhus Denmark Department of Cardiothoracic and Vascular Surgery Aarhus University Hospital Aarhus Denmark Section of Nursing Department of Public Health Aarhus University Aarhus Denmark

Lifestyle following heart disease is considered important to prevent and reduce cardiovascular risk factors. Thus, cardiac rehabilitation is focused on potential lifestyle changes. Further insight into patients’ perspective on lifestyle after cardiac rehabilitation is needed as changing habits following heart disease is a complex matter. The objective of this study was to explore the characteristics of lifestyle after cardiac rehabilitation. A phenomenological-hermeneutic approach with qualitative interviews was performed in 20 patients six months after completing a hospital-based cardiac rehabilitation programme in 2012 at Aarhus University Hospital, Denmark. The patients were diagnosed with ischemic heart disease, heart failure or left heart valve disease. The interviews were analysed using the interpretation theory by Ricoeur. The variation in reactions to cardiac rehabilitation were: 1) considering prior lifestyle to be appropriate, maybe with minor adjustments;2) acknowledging the need for incorporating lifestyle changes;and 3) reconciling or feeling guilt when being unable to manage changes. Participation in the cardiac rehabilitation programme was a positive experience, but it had minor influence on long-term adherence to recommended lifestyle. The important thing in establishing new routines was whether they aroused interest, and whether the experience of changes was perceived as necessary and manageable. In future cardiac rehabilitation, focusing on patients’ interests and supporting them in incorporating recommendations into their everyday life might be essential following heart disease, also after ending cardiac rehabilitation.

关键词： Cardiac Disease Cardiac Rehabilitation Lifestyle Change Qualitative Study

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Hyperpolarized ^(13)C MRI in hepatocellular carcinoma:Unmet questions during clinical translation

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Chinese Medical Journal 2024年第13期137卷 1516-1518页

作者： Zheng Ye Bin Song Christoffer laustsen Department of Radiology West China HospitalSichuan UniversityChengduSichuan 610041China The MR Research Center Department of Clinical MedicineAarhus UniversityAarhus N 8200Denmark

Hyperpolarized(HP)^(13)C magnetic resonance imaging(MRI)is a powerful molecular imaging *** dissolution dynamic nuclear polarization(d-DNP),it can achieve dramatic signal increase and allows for dynamic and quantitative investigation of real-time metabolism in vivo.[1]The typical HP^(13)C MRI workflow begins with formulating the^(13)C probe,and then placing it in the hyperpolarization equipment to achieve the desired signal amplification level,which typically amounts to an increase in the MRI signal by more than 10,000 *** subsequent data acquisition is supported by a specialized^(13)C coil and^(13)C acquisition sequence,and finally quantitative and visualized metabolic information is obtained through a post-processing *** date,research of HP^(13)C MRI has focused on diabetes,cardiovascular diseases,and cancers,[2]showing great promises in tumor detection and the evaluation of therapeutic efficacy.

关键词： metabolism polarized specialized

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Hyperbaric Oxygen Treatment for Diabetic Retinopathy and Neuropathy in a Streptozotocin Induced Diabetic Rat Model

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Journal of Biomedical Science and Engineering 2021年第12期14卷 391-401页

作者： Jesper G. Madsen Martin N. Skov Kasper Hansen Christoffer laustsen Niels Ejskjær Henning Andersen Michael Pedersen Department of Clinical Medicine Comparative Medicine Lab Aarhus University Aarhus Denmark Zoophysiology Department of Biology Aarhus University Aarhus C Denmark Department of Forensic Medicine Aarhus University Aarhus N Denmark Department of Clinical Medicine The MR Research Centre Aarhus University Aarhus Denmark Department of Clinical Medicine Aalborg University Aalborg Denmark Steno Diabetes Center North Denmark Aalborg University Hospital Aalborg Denmark Department of Neurology Aarhus University Hospital Aarhus Denmark

Aim: Diabetes Mellitus is a global public health challenge with major and potentially devastating complications, and concomitant complications include retinopathy and neuropathy due to hypoxia and microvascular dysfunction. In this study, we investigated the effect of hyperbaric oxygen therapy as a method to transiently improve tissue oxygenation on diabetic retinopathy and neuropathy in a streptozotocin induced type-1 diabetic rat model (Wistar). Methods: Streptozotocin induced type-1 diabetic rats received 10 sessions of 2-h hyperbaric oxygen exposures (pO2 = 309 kPa) over 2 weeks. Animals were exposed to light stimuli to produce light evoked potentials to estimate the effect of oxygen treatment on diabetic retinopathy. Sciatic nerves were exposed and stimulated to produce muscle evoked potential, which were recorded in the muscles of the foot and subsequently used to evaluate the effect of oxygen treatment on diabetic neuropathy. Results: We found significantly shorter light evoked potential latency and increased amplitude in hyperbaric oxygen treated animals. No change was found in nerve conduction. Conclusions: This study showed that hyperbaric oxygen therapy is a potentially effective treatment for diabetic retinopathy, improving both latency and amplitude of light evoked potentials.

关键词： Diabetic Neuropathy Diabetic Retinopathy Hyperbaric Oxygen Therapy

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丹麦钢铁公司板坯连铸机自动化改造

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中国冶金 2000年第3期10卷 40-44页

作者： B.Lodin T.K.laustsen A.Kjaer J.Weiss H.Preissl P.Juza 丹麦钢铁公司奥钢联工程技术公司

1999年9月。奥钢联工程技术公司(VAI)自动化部成功完成丹麦钢铁公司板坯连铸机自动化系统改造工程,目标是以更先进的喷淋冷却模型取代老式的喷水控制系统,同时提高板坯质量和铸机产量以及实行更为合理的生产和质量管理。整个改造工程历... 详细信息

1999年9月。奥钢联工程技术公司(VAI)自动化部成功完成丹麦钢铁公司板坯连铸机自动化系统改造工程,目标是以更先进的喷淋冷却模型取代老式的喷水控制系统,同时提高板坯质量和铸机产量以及实行更为合理的生产和质量管理。整个改造工程历时仅6个月,其中包括制定技术规范、项目实施、系统调试和试运行。改造后,板坯质量、特别是内部裂纹和宏观偏析方面有极大改善。

关键词：自动化改造板坯连铸机

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治疗成人1型和2型糖尿病的新药Symlin

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国际护理学杂志 2007年第7期26卷 777-777页

作者： laustsen G 周燕（摘）程显山（校）

symlin即Pramlintide是美国FDA批准的一种新的抗高血糖药，用于正用胰岛素治疗的成人患者。该药是在病理生理学和糖尿病治疗的18年研究之后研制成功。主要作用是纠正用胰岛素治疗糖尿病的餐后血糖控制。该病可使病人厌食，导致热量吸收... 详细信息

symlin即Pramlintide是美国FDA批准的一种新的抗高血糖药，用于正用胰岛素治疗的成人患者。该药是在病理生理学和糖尿病治疗的18年研究之后研制成功。主要作用是纠正用胰岛素治疗糖尿病的餐后血糖控制。该病可使病人厌食，导致热量吸收减少，体重下降。

关键词：胰岛素治疗 2型糖尿病成人患者 Pramlintide 新药抗高血糖药 FDA批准糖尿病治疗

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超极化磁共振波谱的原理和应用

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磁共振成像 2015年第12期6卷 881-887页

作者：齐海云张晓璐徐雅芳文建国许予明程敬亮 Albert P.Chen Lotte Bonde Bertelsen Steffen Ringgaard Christoffer laustsen Hans Stodkilde-Jorgensen MR研究中心临床医学系奥胡斯大学郑州大学第一附属医院郑州450052 GE Healthcare

通过动态核极化(dynamic nuclear polarization,DNP)的方法使原子核自旋极化达到热平衡之上来增强分子磁共振10,000倍以上的信号,这一过程称为超极化(hyperpolarization,HP)。溶解性DNP允许超极化分子以液体形式转移至生物体内,可实时... 详细信息

通过动态核极化(dynamic nuclear polarization,DNP)的方法使原子核自旋极化达到热平衡之上来增强分子磁共振10,000倍以上的信号,这一过程称为超极化(hyperpolarization,HP)。溶解性DNP允许超极化分子以液体形式转移至生物体内,可实时观测体内的生物灌注、代谢产物的运输和代谢反应。该技术的发明克服了传统磁共振信号低,不能实时监测体内代谢过程的缺点。本文旨在介绍动态核极化的定义和技术、常用的超极化生物探针、超极化磁共振波谱图像的结果分析以及初步的动物实验和临床试验结果。

关键词：超极化动态核极化生物探针生物反应器磁共振波谱磁共振成像

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Hyperbaric Oxygen Treatment for Diabetic Retinopathy and Neuropathy in a Streptozotocin Induced Diabetic Rat Model

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Journal of Biomedical Science and Engineering（生物医学工程） 2021年第12期

作者： Jesper G. Madsen Martin N. Skov Kasper Hansen Christoffer laustsen Niels Ejskjær Henning Andersen Michael Pedersen

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