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CT Differential Features Anterior Mediastinal Lymphoma and Thymoma

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CT Differential Features Anterior Mediastinal Lymphoma and T...

作者： sagar THAPA 重庆医科大学

学位级别：硕士

Objective: To characterize the CT features of anterior mediastinal thymoma and lymphoma and evaluate CT findings that may help in suggesting specific diagnosis among these *** and Method: A total of fifty eight chest CT studies with pathological diagnosis of thymoma(n = 30),and lymphoma(n =28)were retrospectively reviewed by two radiologists who were blind to the pathological *** CT features such as cyst and calcification within the lesion,contrast enhancement,relation with pleura and adjacent vessels,bone invasion and lymph node enlargement were ***: The presence of associated mediastinal lymphadenopathy was significantly found in lymphoma(67.9%)compared to thymoma.(p 0.05).Conclusion: In conclusion age,lymph nodes involvement,calcification and relationship to adjacent vessels on CT scan will be helpful to give specific diagnosis on anterior mediastinum lymphoma and thymoma.

关键词： Mediastinum Lymphoma Thymoma Computed Tomography

Development of a mixed fruit beverage and pulsed light treatment thereof to obtain a microbially safe and enzymatically stable product

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Food Bioscience 2022年第1期45卷 274-283页

作者： Snehasis Chakraborty sagar Mahale Rishab Dhar Somnath Basak Food Engineering and Technology Department Institute of Chemical Technology Matunga(E)Mumbai400019India

A mixed fruit beverage was formulated according to D-optimal mixture design using apple ber juice(X_(1),45-59%v/v)-an underexplored fruit,carambola juice(X_(2),1-20%v/v),and black table grape juice(X3,35-40%v/v).The crisp overall acceptability(COA)from 16 semi-trained panelists and overall hedonic score(OSH)from consumers were *** best formulation was apple ber:carambola:black table grape juices=59.0:3.5:37.5 v/v with COA and OSH values of 3.23(on a scale of 5)and 7.55(on a scale of 9),***,the efficacy of pulsed light(PL)(18-30 W cm^(-2) for 33-167 s;total fluence 600-5000 J cm^(-2))and thermal treatments(90℃ for 1-5 min)were studied on various attributes of the mixed *** beverages processed at 90℃ for 5 min(thermal treatment)and 5000 J cm^(-2)(PL treatment at 30 W cm^(-2) for 167 s)showed no microbial count with a complete enzyme *** thermally pasteurized sample(90℃/5 min)was more brown(browning index=70.15)than the PL pasteurized beverage(browning index=65.98).Interestingly,the PL pasteurized(5000 J cm^(-2))beverage showed 25%,27%,and 19% more vitamin C,antioxidants,and phenolic compounds,respectively,than the thermally pasteurized(90℃/5 min)*** PL-treated beverage had a greater sensory appeal than the thermally treated ***-treatment can be an efficient non-thermal pasteurization treatment for ensuring complete microbial and enzymatic inactivation with maximal retention of nutritional and sensory attributes of the blended beverage.

关键词： D-optimal mixture design Numerical optimization Non-thermal processing Pasteurization Microbial safety Enzymatic stability

Toll-like receptor-4 antagonism mediates benefits during neuroinflammation

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Neural Regeneration Research 2016年第4期11卷 552-553页

作者： sagar Gaikwad Challagundla Naveen Reena Agrawal-Rajput Laboratory of Immunology School of Biological Sciences and BiotechnologyIndian Institute of Advanced Research

Neuroinflammation following immune activation in the central nervous system（CNS）leads to neuronal loss in specific areas of the CNS resulting in neurodegenerative ***,fine tuning the immune responses within the brai... 详细信息

关键词： neuronal tuning inflammation benefits aberrant microglia inappropriate cytokines bidirectional sepsis

Type 2 reaction associated sensorineural hearing loss in a drug resistant lepromatous leprosy patient: A case report

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Asian Pacific Journal of Tropical Medicine 2023年第9期16卷 425-427,I0001页

作者： Harpreet Singh Pawar Itu Singh Harish Kumar sagar ICMR-National JALMA Institute for Leprosy&Other Mycobacterial Diseases AgraIndia Stanley Browne Research Laboratory the Leprosy Mission(TLM)Community HospitalNew DelhiIndia

Rationale:Leprosy,a chronic granulomatous disease often present clinically as erythema nodosum leprosum,a type 2 *** involvement of cochlear part of audiovestibular system is a *** concerns:A 26-year-old male patient with lepromatous leprosy developed bilateral sensorineural hearing loss(SNHL)during type 2 reactional ***:Recurrent erythema nodosum leprosum in rifampicin-resistant lepromatous ***:Corticosteroids and second-line multidrug ***:The patient improved significantly and was further referred for management of psychosocial impact due to sensorineural hearing ***:The hearing impairment is a rare complication of type 2 *** patient with suspected cranial nerve involvement should essentially be screened by tuning fork tests for early detection of hearing impairment and offer timely intervention as *** high bacteriological index cases should be investigated for antimicrobial resistance in high endemic areas.

关键词： Leprosy reactions Erythema nodosum leprosum Sensorineural hearing loss Drug resistant leprosy

Ileal-anal pouches: A review of its history, indications, and complications

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World Journal of Gastroenterology 2019年第31期25卷 4320-4342页

作者： Kheng-Seong Ng Simon Joseph Gonsalves Peter Michael sagar John Goligher Colorectal Unit St.James’s University HospitalLeeds LS9 7TFUnited Kingdom Institute of Academic Surgery University of SydneyCamperdownNew South Wales 2050Australia Department of Colorectal Surgery Huddersfield Royal InfirmaryCalderdale and Huddersfield NHS Foundation TrustHuddersfield HD3 3EAUnited Kingdom

The ileal pouch anal anastomosis(IPAA)has revolutionised the surgical management of ulcerative colitis(UC)and familial adenomatous polyposis(FAP).Despite refinement in surgical technique(s)and patient selection,IPAA can be associated with significant *** the IPAA celebrated its 40th anniversary in 2018,this review provides a timely outline of its history,indications,and *** has undergone significant modification since *** both UC and FAP,IPAA surgery aims to definitively cure disease and prevent malignant degeneration,while providing adequate continence and avoiding a permanent *** majority of patients experience long-term success,but“early”and“late”complications are *** sepsis is a common early complication with far-reaching consequences of long-term pouch dysfunction,but prompt intervention(either radiological or surgical)reduces the risk of pouch *** in the absence of sepsis,pouch dysfunction is a longterm complication that may have a myriad of *** is a common cause that remains incompletely understood and difficult to manage at times.10%of patients succumb to the diagnosis of pouch failure,which is traditionally associated with the need for pouch *** review provides a timely outline of the history,indications,and complications associated with *** selection remains key,and contraindications exist for this surgery.A structured management plan is vital to the successful management of complications following pouch surgery.

关键词： Ileal pouch Restorative proctocolectomy Ulcerative colitis Crohn’s disease Familial adenomatous polyposis

Acoustic Scene Classification via Classifiers Voting

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Acoustic Scene Classification via Classifiers Voting

作者： Shawn Sudheer sagar 华南理工大学

学位级别：硕士

Acoustic Scene Classification（ASC）is the recognition and categorization of audio data that identifies the environment which it has been *** is quite a challenging application of machine listening due to the noisy nature of the audio *** analyze several state-of-the-art models for ASC on two different *** datasets belong to the IEEE challenge on the Detection and Classification of Acoustic Scenes and Events（DCASE）2017 and *** two datasets are publicly available for research purpose,and consist of 10 and 15 classes of acoustic scenes *** total,57 hours of stereo recordings are available which includes common indoor and outdoor environmental scenes,such as beach,city center,library,forest path train,car,*** propose a method of ASC via fusing the voting of deep neural *** the proposed method,two different acoustic features are first extracted from each audio recording *** cepstral coefficients（MFCC）and Logarithmic filter-bank（LFB）.These features are then fed into three different classifiers（deep neural networks）: Visual Geometry Group（VGG）,Residual Network（Res Net）and Long Short-Term Memory（LSTM）.The motivation for choosing these variety of neural networks is that they have complementary advantages for *** training each network and acquiring the results,fusion of classifiers voting is used to determine a final *** fusion of all the results through voting technique is one of the methods under ensemble *** final Classification Accuracies（CA）that are obtained after the fusion of the classifiers are 73.27% and 76.99% on DCASE 2017 and 2019 datasets *** proposed fusion of classifiers voting obtains the CA improvements by 12.71% and 13.79% on DCASE 2017 and 2019 datasets respectively,compared to the individual baseline classifiers.

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Rolling of Al-SiC_p Composites

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厦门大学学报（自然科学版） 2002年第S1期41卷 103-105页

作者： Rajesh Purohit Anil Kumar Das Rakesh sagar Mechanical Engineering Department Mechanical Engineering DepartmentMechanical Engineering Department IIT Delhi-16IIT Delhi-16IIT Delhi-16

Aluminum based metal matrix composites are offering o utstanding properties in a number of automotive and aircraft components and body structures. The major advantages of these composite materials are their high st rength to weight ratio, high stiffness, high hardness, wear resistance, low coef ficient of thermal expansion, superior dimensional stability and versatility to designer. In addition to these their isotropic properties, good forming characte ristics, easy availability of cheaper reinforcements along with the availability of comparatively low cost, high volume production methods have made them a prom ising material for future growth. Weight reduction is a major goal of automotive innovations. Lighter vehicles/ ai rcraft means less fuel consumption, reduced emissions, and improved performance. Components made from highly loaded aluminium matrix composites are attractive r elative to iron based materials because of their low density, high stiffness (eq uivalent to nodular iron) and better heat transfer characteristics. The basic co st of materials is higher with these advanced composites; however, manufacturing the part to near net shape may offset basic material costs. A good aluminium based material design can improves safety. The aluminium-based composites can give cars better acceleration and braking, improved handling, ex cellent durability, and ease of repair. Tha aluminum-based composite performs a s well or better in crash than conventional steel-structured cars because of th eir larger volume, which can absorb more crash energy. Another excellent advanta ge of Al-SiC p composite in auto design is better stability and response, and reduced noise, vibration/harshness (NHV). These advantages stem from reduced veh icle weight combined with high structural stiffness and also lead to improved st ability and turning response. In the present work Al-SiC p composite plates of 10 to 12 mm thickness w ere cast using sand casting as well as die casting process.

关键词： SiC Rolling of Al-SiC_p Composites Al

Carcinogenesis on the background of liver fibrosis: Implications for the management of hepatocellular cancer

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World Journal of Gastroenterology 2018年第39期24卷 4436-4447页

作者： Joanne Marie O'Rourke Vandana Mridhu sagar Tahir Shah Shishir Shetty Centre for Liver Research Institute of Biomedical ResearchBirmingham B15 2TTUnited Kingdom NIHR Birmingham Biomedical Research Centre University of Birmingham and University Hospitals Birmingham NHS Foundation Trust

Hepatocellular carcinoma(HCC) is now the second leading cause of cancer-related deaths globally and many patients have incurable disease. HCC predominantly occurs in the setting of liver cirrhosis and is a paradigm for inflammation-induced cancer. The causes of chronic liver disease promote the development of transformed or premalignant hepatocytes and predisposes to the development of HCC. For HCC to grow and progress it is now clear that it requires an immunosuppressive niche within the fibrogenic microenvironment of cirrhosis. The rationale for targeting this immunosuppression is supported by responses seen in recent trials with checkpoint inhibitors. With the impact of immunotherapy, HCC progression may be delayed and long term durable responses may be seen. This makes the management of the underlying liver cirrhosis in HCC even more crucial as studies demonstrate that measures of liver function are a major prognostic factor in HCC. In this review, we discuss the development of cancer in the setting of liver inflammation and fibrosis, reviewing the microenvironment that leads to this tumourigenic climate and the implications this has for patient management.

关键词： Hepatocellular cancer Carcinogenesis Inflammation Fibrosis Immunotherapy

Economic Contribution of Forestry Sector to National Economy in Nepal

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Journal of Resources and Ecology 2021年第5期12卷 620-627页

作者： Bharat Prashad BHATT sagar GODAR CHHETRI Thakur SILWAL Megharaj POUDEL Ministry of Forests and Environment Singha DurbarKathmandu 44600Nepal Wamell School of Forestry and Natural Resources University of GeorgiaAthensGA 30605USA Institute of Forestry Tribhuwan UniversityPokhara 22000Nepal

Forests are major sources of energy,timber and non-timber forest products,medicinal and aromatic plants,hydrological functions,biodiversity conservation,and also fundamental sources of revenue collection to the *** indicate that forests could significantly enhance economic growth and create employment opportunities for local communities under intensive *** paper aims to predict the contribution of the forest sector to the national *** economic facets of forestry considered in this paper are revenue generated from timber,non-timber forest products(NTFPs)and medicinal and aromatic plants(MAPs),and protected *** ARIMA model was used to forecast the economic contribution of the forestry *** study found that the total revenue generated from the selling of timber and fuelwood(USD 50.19 million)was higher than the total revenue collected from protected areas(USD 37.58 million)and NTFPs/MAPs(USD 6.9 million)in the past 15 *** model projected that the mean revenue for the timber and fuelwood sale will USD 3.5 million for the next ten ***,the mean revenue will be generated about USD 0.5 million and USD 6.2 million from NTFPs/MAPs and protected areas,respectively,for the next ten *** study limits to take account the in-kind use of forest products such as timber,fodder,fuelwood,etc.,as used by community people within a forest users’***,practicing sustainable forest management,enabling policy documents,establishing forest-based industries,establishing forestry nurseries,conducting agroforestry practices,and tenure security could enhance the forestry sector’s economic aspects.

关键词： economy revenue timber non-timber forest products