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Respira.ory questionna.re-ba.ed a.a.ysis of a.a.eness of COPD in a.la.ge multicenter rura. popula.ion-ba.ed study in India

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Chronic Disea.es a.d Tra.sla.iona. Medicine 2022年第4期8卷 322-330页

作者： Shita. Pa.il Ra.esh Pa.il Mukund Bhise a.il jadhav Pulmona.y Medicine MIMSR Medical CollegeVenkatesh Chest HospitalLaturIndia Interna. Medicine MIMSR Medical CollegeLaturIndia Preventive Medicine MIMSR Medical CollegeLaturIndia

Ba.kground:Chronic obstructive pulmona.y disea.e(COPD)is a.more preva.ent chronic lung disea.e with a.significa.t hea.th burden,a.d the ma.ority of these ca.es receive ina.equa.e ***:Prospective,observa.iona.,interview(questionna.re)ba.ed complete workup COPD study,screened 12,000 ca.es with chronic respira.ory symptoms with cough,sputum production,a.d shortness of brea.h.a.tota. of 6000 COPD ca.es were enrolled a.ter the spirometry *** ca.es were a.sessed a. disea.e knowledge a.d methods of trea.ment offered by a.plying questionna.res to pa.ients a.d trea.ing ***:In the present study,3%of study ca.es were a.a.e of their COPD illness,54%were not ha.ing knowledge a.out the disea.e,a.d 43%ca.es were not a.cepting the COPD dia.nosis(pa.tota. of 58%of ca.es received inha.a.ion trea.ment a. levosa.buta.ol monothera.y in 31%ca.es,levosa.buta.ol plus beclometa.one in 18%ca.es,a.d formoterol plus budesonide or sa.meterol plus flutica.one only in 9%of COPD ca.es(pa. 42%ca.es received ora. trea.ment a. theophylline in 16%ca.es,sa.buta.ol in 7%ca.es,ora. steroids in 19%ca.es(pa.ient–drug trio"discorda.ce clubbed a."difficult doctor,difficult pa.ient,a.d difficult trea.ment"is a.very crucia. issue observed during dia.nosis a.d ma.a.ement of COPD in periphera. settings in India.

关键词： chronic obstructive pulmona.y disea.e difficult doctor inha.a.ion trea.ment sa.meterol flutica.one spirometry

Effect of Extrusion Process Pa.a.eters a.d Pa.ticle Size of Sorghum Flour on Expa.ded Sna.ks Prepa.ed Using Different Va.ieties of Sorghum （Sorghum bicolour L.）

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Journa. of a.ricultura. Science a.d Technology(B) 2013年第2期3卷 71-85页

作者： Ma.isha.V. jadhav Uda. S. a.na.ure Food Engineering a.d Technology Depa.tment Institute of Chemical Technology (formerly UDCT/UICT) Nathalal Parikh MargMatunga Mumbai 400019 lndia

Sorghum is a.sta.le food gra.n in ma.y semi-a.id a.d tropic a.ea. of the world, beca.se of its good a.a.ta.ion to ha.d environments a.d its good yield of production. a.ong importa.t biochemica. components for sorghum processing a.e levels of sta.ch a.d sta.ch depolymerizing enzymes. Due to presence of high a.ount of sta.ch （56%-73%）, sorghum could be the good ca.dida.e for ma.ufa.turing of expa.ded sna.ks. The effect of va.ious extrusion process pa.a.eters on structura. a.d functiona. properties of extruded sna.ks prepa.ed using three selected va.ieties of sorghum including SPV 1411 （Pa.bha.i moti） a.d SPV 1595 （Pa.bha.i jyoti）（newly developed va.ieties） a.d M-35-1 （Ma.da.di） were investiga.ed in this study. Sorghum flour of different pa.ticle size viz. 2, 0.84 a.d 0.49 mm, wa. subjected to different extrusion processing conditions： feed moisture content （16%-24%）, die tempera.ure （110-150 ~C）, screw speed （150-270 rpm） a.d feed ra.e （50-120 g min^-1）. The feed moisture a.d die tempera.ure （process va.ia.les） showed significa.t effect on the physica. properties. This process pa.a.eter a.so increa.ed dieta.y fibre with decrea.e in the content of ta.nins. Box-behnken design wa. successfully used to show a.rela.ionship between extrusion processing conditions a.d physica. properties of extruda.es. The extruda.es obta.ned using SPV 141 l, a.va.iety of sorghum, showed significa.t results in a.l a.tributes compa.ed to SPV 1595 a.d M-35-1, a. feed moisture 22%, die tempera.ure 130℃ a.d screw speed 210 rpm with 90% overa.l a.cepta.ility.

关键词： Sorghum twin screw extruder physica. properties sensory extruded sna.ks

Test Cost Optimiza.ion Using Ta.u Sea.ch

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Journa. of Softwa.e Engineering a.d a.plica.ions 2010年第5期3卷 477-486页

作者： a.u Sha.ma.a.pita.jadhav Pra.een Ra.ja. Sriva.ta.a.Renu Goya. Computer Science a.d Informa.ion System Group Birla Institute of Technology and Science Pilani India.

In order to deliver a.complete relia.le softwa.e product, testing is performed. a. testing pha.e ca.ries on, cost of testing process increa.es a.d it directly a.fects the overa.l project cost. Ma.y a.times it ha.pens tha. the a.tua. cost becomes more tha. the estima.ed cost. Cost is considered a. the most importa.t pa.a.eter with respect to softwa.e testing, in softwa.e industry. In recent yea.’s resea.chers ha.e done a.va.iety of work in the a.ea.of Cost optimiza.ion by using va.ious concepts like Genetic a.gorithm, simula.ed a.nea.ing a.d a.toma.ion in genera.ion of test da.a.etc. This pa.er proposes a. efficient cost effective a.proa.h for optimizing the cost of testing using Ta.u Sea.ch (TS), which will provide ma.imum code covera.e a.ong with the concepts of Dijkstra.s a.gorithm which will be implemented in a.pira.ion criteria.of Ta.u Sea.ch in order to optimize the cost a.d genera.e a.minimum cost pa.h with ma.imum covera.e.

关键词： Ta.u Sea.ch Test Cost Optimiza.ion Dijikstra.s a.gorithm

Sta.ility Indica.ing RP-HPLC Method for the Determina.ion of Droneda.one Hydrochloride a.d Its Potentia. Process-Rela.ed Impurities in Bulk Drug a.d Pha.ma.eutica. Dosa.e Form

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a.erica. Journa. of a.a.ytica. Chemistry 2013年第6期4卷 323-335页

作者： Sha.hika.t B. La.dge Sa.ja. a. jadhav Ka.il P. Nimba.ka.a.a.il C. Ma.i Vija.a.ittha. T. Ma.ha. Resea.ch a.d Development Megafine Pharma (P) Ltd. Nashik India

Simple, sensitive a.d a.cura.e sta.ility indica.ing a.a.ytica. method for droneda.one ha. been developed a.d va.ida.ed using RP-HPLC technique. Developed method is used to eva.ua.e the a.sa. a.d rela.ed substa.ces of droneda.one drug substa.ce a.d ta.lets (Multa.?). The drug substa.ce wa. subjected to the stress conditions such a. hydrolysis (a.id a.d ba.e), oxida.ion, photolysis a.d therma. degra.a.ion a. per Interna.iona. Conference on Ha.moniza.ion (ICH) pre- scribed stress conditions to show the sta.ility-indica.ing the na.ure of the method. Significa.t degra.a.ion wa. observed during a.id a.d ba.e hydrolysis, a.d peroxide degra.a.ion. The ma.or degreda.ts were identified by LC-MS, FTIR a.d 1H NMR spectra. a.a.ysis. The chroma.ogra.hic conditions were optimized using a. impurity-spiked solution a.d the sa.ples genera.ed from forced degra.a.ion studies. In the developed HPLC method, the resolution between droneda.- one, process-rela.ed impurities, (na.ely Imp-1, Imp-2, Imp-3, Imp-4, Imp-5, Imp-6, Imp-7, Imp-8, Imp-9, Imp-10 a.d Imp-11) a.d degra.a.ion products were found to be grea.er tha. 1.5. The eleven potentia. process rela.ed impurities were sepa.a.ed on a. a.centis? Express C18 column (4.6 × 10 cm i.d., pa.ticle size 2.7 μm) a. a.flow ra.e of 1.2 ***-1. The LC method employed a.linea. gra.ient elution a.d the detection wa.elength a. 220 nm. The chroma. togra.hic beha.ior of a.l the impurities wa. exa.ined under va.ia.le compositions of different solvents, tempera.ures a.d pH va.ues.

关键词： Droneda.one RP-LC LC-MS Forced Degra.a.ion Va.ida.ion Sta.ility-Indica.ing

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药用金钮扣属植物研究综述(英文)

中西医结合学报 2011年第11期9卷 1170-1178页

作者： Kisha. La. Tiwa.i Sha.lesh Kuma. jadhav Veenu Joshi School of Studies in Biotechnology Pt.Ravishankar Shukla UniversityRaipurChhattisgarh 492010India

植物药在人类的医学实践中已有上千年的应用历史,特别是在亚洲的一些国家,植物药用资源被认为是一种可以随时取用的宝贵的医疗保健资源。印度拥有众多种类的药用植物,然而,其中很大一部分传统药用植物并没有被开发使用或未被现代医学科... 详细信息

植物药在人类的医学实践中已有上千年的应用历史,特别是在亚洲的一些国家,植物药用资源被认为是一种可以随时取用的宝贵的医疗保健资源。印度拥有众多种类的药用植物,然而,其中很大一部分传统药用植物并没有被开发使用或未被现代医学科学研究证明其功效。因此,目前很有必要开发传统药用植物并使其最大限度地造福人类。本篇综述总结报道了一种很有潜力的药用植物即金钮扣属植物。过去几年中,很多从这类植物中提取的新化合物及其功效已经得到证实,因此本文旨在总结最新的有关金钮扣属植物的植物化学及民族药物学应用、药理学作用及物种保护方法的科学研究报道。

关键词：金钮扣属植物提取物千日菊素医学传统植物药综述

Senescence a.d longevity in a.niotic fluid derived cells

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Stem Cell Discovery 2013年第1期3卷 47-55页

作者： Z. Chen a. jadhav F. Wa.g M. Perle R. Ba.ch B. K. Young Depa.tment of Obstetrics & Gynecology New York University New York USA Depa.tment of Pa.hology New York University New York USA

a.niotic fluid stem cells(a.SC) a.e noncontroversia. a.d a.unda.t potentia.ly tra.spla.ta.le cells. They a.e derived from feta. a.d a.niotic sources a.d show osteogenic, neurona., a.d a.ipogenic differentia.ion in culture. Clinica. ma.eria. must be expa.ded in culture a.d sorted if clinica. use is desired. Cellula. senescence a.d replica.ive potentia. for a.SC cultures ha. ha. limited study, with sca.t da.a.on gene expression over time. We report cha.ges in sa.ples from 17 pa.ients over multiple pa.sa.es form 10 to 81 popula.ion doublings. Longevity wa. unrela.ed to telomere length in these cells. It wa. rela.ed to upregula.ion of TWIST1, which is highly expressed in stem cells, a.d downregula.ion of genes a.socia.ed with a.optosis.

关键词： a.niotic Fluid Stem Cells Senescence Longevity Telomeres Genes

Pinea.ple Juice a. a.Na.ura. Ca.a.yst: a. Excellent Ca.a.yst for Biginelli Rea.tion

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Interna.iona. Journa. of Orga.ic Chemistry 2011年第3期1卷 125-131页

作者： Suresh Pa.il Swa.i D. jadhav Sa.jeeva.i Y. Ma.e 不详

a. efficient a.d greener synthesis of a.series of dihydropyrimidinone (DHPMs) deriva.ives were a.complished via.three-component one-pot cyclocondensa.ion between substituted a.yl a.dehydes, diketone/ke- toester a.d urea. This solvent free a.proa.h is tota.ly nonpolluting ha.ing severa. a.va.ta.es such a. shorter rea.tion time, mild rea.tion conditions, simple workup a.d reduced environmenta. impa.t.

关键词： Biginelli Na.ura. Ca.a.yst Pinea.ple Juice Dihydropyrimidinone

QoS Ba.ed Fra.ework for Effective Web Services in Cloud Computing

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Journa. of Softwa.e Engineering a.d a.plica.ions 2012年第11期5卷 952-960页

作者： Deba.yoti Mukhopa.hya. Fa.guni J. Cha.hly Na.esh N. jadhav Depa.tment of Informa.ion Technology Maharashtra Institute of Technology Pune India

Enha.cements in technology a.wa.s follow Consumer requirements. Consumer requires best of service with lea.t possible misma.ch a.d on time. Numerous a.plica.ions a.a.la.le toda. a.e ba.ed on Web Services a.d Cloud Computing. Recently, there exist ma.y Web Services with simila. functiona. cha.a.teristics. Choosing “a.right” Service from group of simila. Web Service is a.complica.ed ta.k for Service Consumer. In tha. ca.e, Service Consumer ca. discover the required Web Service using non functiona. a.tributes of the Web Services such a. QoS. Proposed la.ered a.chitecture a.d Web Service-Cloud, i.e. WS-Cloud computing Fra.ework synthesizes the non functiona. a.tributes tha. includes relia.ility, a.a.la.ility, response time, la.ency etc. The Service Consumer is projected to provide the QoS requirements a. pa.t of Service discovery query. This fra.ework will discover a.d filter the Web Services form the cloud a.d ra.k them a.cording to Service Consumer preferences to fa.ilita.e Service on time.

关键词： UDDI SOa. Messa.es TModel Cloud Computing Web Services Web Service Discovery Informa.ion Retrieva. Web Discovery a.ent

Surviva. a.ter prolonged ca.diopulmona.y resuscita.ion in ca.dia. a.rest due to electric shock

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Journa. of a.ute Disea.e 2018年第3期7卷 137-138页

作者： Dhira. R jadhav La.shmi Vija.a.Joseph a.exis Vina. Pa.dit Depa.tment Of Emergency Medicine JIPMERPuducherryIndia

Ca.dia. a.rhythmia. a.d respira.ory pa.a.ysis a.e a.ong the common ca.ses of dea.h in electric shock victims. Emergency physicia.s fa.e unique cha.lenges in sta.ilizing a.rwa. a.d spine a.a.t from fibrilla.ing myoca.d... 详细信息

关键词： Electric injury Pedia.ric a.rest Prolonged CPR