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In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus

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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 595-601页

作者： Mayank Gangwar Vijay C Verma Tryambak D singh sushil K singh RK Goel Gopal Nath Department of Microbiology Institute of Medical Sciences Banaras Hindu University Department of Pharmacology Institute of Medical Sciences Banaras Hindu University Department of Medicinal Chemistry Institute of Medical Sciences Banaras Hindu University Department of Pharmaceutical Engineering Institute of Technology Banaras Hindu University

Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods: The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis ( M. philippinensis ) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus ( E. granulosus ), under in-vitro conditions with reference to the known standard drug Praziquantel . Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.

关键词： Protoscolicidal Echinococcus Hydatidosis Mallotus sp. Anti-helminthic agents Trypan blue

Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef Krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek Katerina Frantálová Michal Krupka Zuzana Kuglerová sushil Kumar singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-Martin Marion Kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander Köhler Marion Harmand Sven Toleikis Katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

Outcome of patients with traumatic cranial nerve palsy admitted to a university hospital in Nepal

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中华神经外科杂志(英文) 2024年第2期10卷 1-7页

作者： Kumari Khusbu Gautam Naveen Parajuli Monika singh Shreejana Pradhananga Amit Sedai Gopal Shilpakar sushil Sharma Mohan Raj Maharajgunj Medical Campus Institute of Medicine Tribhuvan University Maharajgunj Kathmandu Nepal Department of Research Institute of Medicine Maharajgunj Kathmandu Nepal Department of Neurosurgery Tribhuvan University Teaching Hospital Maharajgunj Kathmandu Nepal

Background Cranial nerve palsy (CNP) is a common complication of traumatic brain injury (TBI). Despite a high incidence of TBI in Nepal (382 per 100,000), literature on the specific management and outcome of CNP is lacking. This study aimed to examine the outcomes of TBI patients involving single versus multiple *** A retrospective chart review of 170 consecutive TBI patients admitted to the tertiary neurosurgical center in Nepal between April 2020 and April 2022 was conducted. Demographic, clinical, and etiological characteristics; imaging findings; and management strategies were recorded, compared, and analyzed using descriptive statistics. The Glasgow Outcome Scale Extended (GOSE) was used to measure the outcomes in two groups of patients (single and multiple CNP) at 3 *** Out of 250 eligible patients, 80 were excluded and CNP was noted in 29 (17.1%) of the remaining 170. The median age was 34.9 years, and falls (60.6%) were the most common cause of trauma. TBI severity was categorized based on GCS: mild (82.4%), moderate (15.9%), and severe (1.8%). Cranial nerve involvement was seen in 29 (17.05%) patients: single cranial nerve involvement in 26 (89.65%) and multiple nerve involvement in 3 (10.34%). The most common isolated cranial nerve involved was the oculomotor nerve (37.9%). CT findings revealed a maximum of skull fractures with no significant association between CNP and CT *** CNP is a common consequence of TBI with the most common etiology being falls followed by RTA. Single CNP was more common than multiple CNP with no significant difference in the outcome in the 3-month GOSE score. Further research is needed to determine the burden of traumatic CNP and establish specific management guidelines for different types of CNP.

关键词： Cranial nerve palsy Nepal Outcome Traumatic brain injury

A novel multi-shot target platform for laser-driven laboratory astrophysics experiments

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High Power Laser Science and Engineering 2023年第2期11卷 11-19页

作者： Pablo Perez-Martin Irene Prencipe Manfred Sobiella Fabian Donat Ning Kang Zhiyu He Huiya Liu Lei Ren Zhiyong Xie Jun Xiong Yan Zhang Florian-Emanuel Brack MichalČervenák Pavel Gajdoš Lenka Hronová Kakolee Kaniz Michaela Kozlová Florian Kroll Xiayun Pan Gabriel Schaumann sushil singh MichalŠmíd Francisco Suzuki-Vidal Panzheng Zhang Jinren Sun Jianqiang Zhu Miroslav Krůs Katerina Falk Helmholtz-Zentrum Dresden-Rossendorf Institute of Radiation PhysicsDresdenGermany Technische Universität Dresden DresdenGermany Key Laboratory of High Power Laser and Physics Shanghai Institute of Optics and Fine MechanicsChinese Academy of SciencesShanghaiChina Shanghai Institute of Laser Plasma China Academy of Engineering PhysicsShanghaiChina Institute of Plasma Physics Czech Academy of SciencesPragueCzech Republic Czech Technical University Faculty of Nuclear Sciences and Physical EngineeringPragueCzech Republic Department of Physics Jagannath UniversityDhakaBangladesh ELI-Beamlines Institute of PhysicsCzech Academy of SciencesPragueCzech Republic Institute for Nuclear Physics Technical University of DarmstadtDarmstadtGermany Institute of Physics Czech Academy of SciencesPragueCzech Republic Blackett Laboratory Imperial CollegeLondonUnited Kingdom First Light Fusion Oxford Industrial ParkYarntonOxfordUnited Kingdom

A new approach to target development for laboratory astrophysics experiments at high-power laser facilities is *** the dawn of high-power lasers,laboratory astrophysics has emerged as a field,bringing insight into physical processes in astrophysical objects,such as the formation of *** important factor for success in these experiments is *** date,targets have mainly relied on expensive and challenging microfabrication *** design presented incorporates replaceable machined parts that assemble into a structure that defines the experimental *** can make targets cheaper and faster to manufacture,while maintaining robustness and *** platform is intended for experiments on plasma flows,but it is flexible and may be adapted to the constraints of other experimental *** of targets used in experimental campaigns are shown,including a design for insertion in a high magnetic field *** results are included,demonstrating the performance of the targets.

关键词： high magnetic fields laboratory astrophysics laser-plasma interaction magnetized plasmas target design

Alignment of solid targets under extreme tight focus conditions generated by an ellipsoidal plasma mirror

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Matter and Radiation at Extremes 2019年第2期4卷 30-35页

作者： Deepak Kumar Michal Smid sushil singh Alexander Soloviev Hannes Bohlin Konstantin Burdonov Gashaw Fente Alexander Kotov Livia Lancia Vit Leedl Sergey Makarov Michael Morrissey Sergey Perevalov Denis Romanovsky Sergey Pikuz Ryousuke Kodama David Neely Paul McKenna Tomas Lastovicka Mikhail Starodubtsev Stefan Weber Motoaki Nakatsutsumi Julien Fuchs ELI Beamlines Institute of Physics5.kvetna 83525241 Dolni BrezanyCzech Republic Institute of Applied Physics of the Russian Academy of Sciences(IAP RAS) 46 Ulyanov Street603950 Nizhny NovgorodRussia LULI-CNRS Ecole PolytechniqueCEA:Universite Paris-SaclayUPMC Univ Paris 06:Sorbonne UniversitiesF-91128 Palaiseau CedexFrance Research Center Toptec Institute of Plasma PhysicsSobotecka 166051101 TurnovCzech Republic Joint Institute for High Temperatures Russian Academy of Science(JIHT RAS) Moscow 125412Russia Division of Electrical Electronic and Information EngineeringGraduate School of EngineeringOsaka UniversityOsakaJapan Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Department of Physics SUPA University of StrathclydeGlasgow G40NGUnited Kingdom European XFEL GmbH Holzkoppel 422869 SchenefeldGermany

The design of ellipsoidal plasma mirrors(EPMs)for the PEARL laser facility is *** EPMs achieve a magnification of 0.32 in focal spot size,and the corresponding increase in focused intensity is expected to be about *** and implementing such focusing optics for short-pulse(<100 fs)systems paves the way for their use in future high-power facilities,where they can be used to achieve intensities beyond 1023W/cm^(2).A retro-imaging-based target alignment system is also described,which is used to align solid targets at the output of the ellispoidal mirrors(with a numerical aperture of 0.75 in this case).

关键词： beyond mirror extreme

Novel CMS lines in pigeonpea[Cajanus cajan(L.)Millspaugh]derived from cytoplasmic substitutions,and their effective restoration and deployment in hybrid breeding

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The Crop Journal 2017年第1期5卷 89-94页

作者： Abhishek Bohra Rintu Jha Indra Prakash singh Gaurav Pandey Shalini Pareek Partha Sarathi Basu sushil Kumar Chaturvedi Narendra Pratap singh ICAR Indian Institute of Pulses Research(IIPR)Kanpur 208024India

The availability of stable cytoplasmic male sterile(CMS or A) lines coupled with a robust restoration system(R lines) is an essential prerequisite for efficient hybrid ***-enabled hybrid technology holds immense potential to enhance the long-stagnant productivity of pigeonpea. In the present investigation, cytoplasmic substitutions were made in the nuclear backgrounds of early-maturing pigeonpea varieties or lines. Three new CMS lines(ICPL 88039 A, Pusa 992 A, and DPP 3-2A) resulted from genetic crosses involving cytoplasmic donors from A2(GT 288A) and A4(ICPA 2089) categories. In addition to visual inspection of anthers, pollen-staining techniques and scanning electron microscopy(SEM)analysis were used to confirm pollen sterility. Further, given the relevance of the plant mitochondrial genome to CMS manifestation, 25 mitochondrion-specific DNA markers were assayed on these newly developed A lines and isogenic maintainer(B) lines. DNA polymorphism between Pusa 992 A and Pusa 992 B as revealed by the nad7a_del marker confirmed the successful combination of sterilizing cytoplasm(A4) and nonrestoring nuclear background(Pusa 992). Such cytoplasm-specific DNA markers are required for A2-CMS as well. Further, to assess restoration ability, potential restorers were crossed with these CMS lines, and as a consequence, promising A × R combinations exhibiting 100%pollen fertility could be identified. In parallel, we also analyzed the inheritance patterns underlying fertility restoration using ICPL 88039A-derived F2 and BC1F1populations,and established a monogenic dominant model to explain the phenomenon of A2-CMS restoration. In summary, we report the successful development of new CMS lines and describe their effective deployment in hybrid breeding of pigeonpea.

关键词： Cytoplasm Hybrid Mitochondria Pigeonpea Restorer Sterility

Chelation in Metal Intoxication XLIV: Efficacy of α-Mercapto β-(5-Substituted, 2-Furyl) Acrylic Acids in Mobilizing Intracellularly Bound Cadmium in Rat

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Biomedical and Environmental Sciences 2000年第3期13卷 205-212页

作者： sushil K. TANDON\+1, SATGUR PRASAD, AND SURENDRA singh Industrial Toxicology Research Centre, Lucknow_226001, India Industrial Toxicology Research Centre M.G. Marg Post Box 80 Lucknow-226001 India

The efficacy of α mercapto β (2_furyl) acrylic acid (MFA), α mercapto β (5_sodiumsulfonate, 2_furyl) acrylic acid (MSFA) and α mercapto β (5_acetoxymethyl, 2_furyl) acrylic acid (MAFA) to mobilize intracellularly bound cadmium in liver and kidney was investigated in rats pre_exposed to cadmium. MFA was effective in reducing cadmium levels of hepatic and renal supernatant cytosolic fraction (SCF) while MSFA and MAFA were effective in lowering cadmium levels of renal SCF and hepatic SCF respectively. All the chelating agents also enhanced the excretion of cadmium more in feces than in urine. However, substitution on the furan ring lowered cadmium mobilizing efficacy of the parent compound, MFA. The treatment with MFA did not affect the status of endogenous zinc and copper while the treatment with MSFA and MAFA enhanced their excretion. MSFA increased hepatic and renal zinc and renal copper while MAFA increased their copper levels.

关键词： Mercapto Substituted Chelation in Metal Intoxication XLIV Furyl Intracellularly Bound Cadmium in Rat Efficacy of Acrylic Acids in Mobilizing

Surveying the genomic landscape of silage-quality traits in maize(Zea mays L.)

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The Crop Journal 2023年第6期11卷 1893-1901页

作者： Jatin Sharma Shubham Sharma Krishna Sai Karnatam Om Prakash Raigar Chayanika Lahkar Dinesh Kumar Saini sushil Kumar Alla singh Abhijit Kumar Das Priti Sharma Ramesh Kumar Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhianaPunjab 141004India School of Agricultural Biotechnology Punjab Agricultural UniversityLudhianaPunjab 141004India ICAR-Indian Institute of Maize Research LudhianaPunjab 141004India Department of Plant and Soil Science Texas Tech UniversityLubbockTX 79409-2122USA

Despite the longstanding importance of silage as a critical feed source for ruminants,its quality improvement has been largely *** numerous quantitative trait loci(QTL)and genes affecting silage quality in maize have been reported,only a few have been effectively incorporated into breeding *** this gap,the present study undertook a comprehensive meta-QTL(MQTL)analysis involving 523 QTL associated with silage-quality traits collected from 14 published *** the 523 QTL,405 were projected onto a consensus map comprising 62,424 genetic markers,resulting in the identification of 60 MQTL and eight *** average confidence interval(CI)of the MQTL was 3.9-fold smaller than that of the source *** of the 60 identified MQTL were classified as breeder’s MQTL owing to their small CIs,involvement of more QTL,and large contribution to phenotypic ***-third of the MQTL co-localized with DNA marker-trait associations identified in previous genomewide association mapping studies.A set of 78 high-confidence candidate genes influencing silage quality were identified in the MQTL *** genes and associated markers may advance marker-assisted breeding for maize silage quality.

关键词： Meta-QTL Silage quality Maize GWAS Candidate genes

Handwritten Character Recognition Using Multiresolution Technique and Euclidean Distance Metric

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Journal of Signal and Information Processing 2012年第2期3卷 208-214页

作者： Dileep Kumar Patel Tanmoy Som sushil Kumar Yadav Manoj Kumar singh Department of Applied Mathematics Institute of Technology Banaras Hindu U Department of Applied Mathematics Institute of Technology Banaras Hindu University Varanasi India Department of Statistics Faculty of Science Banaras Hindu University Varanasi India DST Centre for Interdisciplinary Mathematical Sciences Faculty of Science Banaras Hindu University Varanasi India

In the present paper, the problem of handwritten character recognition has been tackled with multiresolution technique using discrete wavelet transform (DWT) and Euclidean distance metric (EDM). The technique has been tested and found to be more accurate and faster. Characters is classified into 26 pattern classes based on appropriate properties. Features of the handwritten character images are extracted by DWT used with appropriate level of multiresolution technique, and then each pattern class is characterized by a mean vector. Distances from input pattern vector to all the mean vectors are computed by EDM. Minimum distance determines the class membership of input pattern vector. The proposed method provides good recognition accuracy of 90% for handwritten characters even with fewer samples.

关键词： Discrete Wavelet Transform Euclidean Distance Metric Feature Extraction Handwritten Character Recognition Bounding Box Mean Vector