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Outcome of patients with traumatic cranial nerve palsy admitted to a university hospital in Nepal

中华神经外科杂志(英文) 2024年第2期10卷 1-7页

作者： k.mari khusbu Gautam Naveen Parajuli Monika singh Shreejana Pradhananga Amit Sedai Gopal Shilpakar sushil Sharma Mohan Raj Maharajgunj Medical Campus Institute of Medicine Tribhuvan University Maharajgunj Kathmandu Nepal Department of Research Institute of Medicine Maharajgunj Kathmandu Nepal Department of Neurosurgery Tribhuvan University Teaching Hospital Maharajgunj Kathmandu Nepal

Background Cranial nerve palsy (CNP) is a common complication of traumatic brain injury (TBI). Despite a high incidence of TBI in Nepal (382 per 100,000), literature on the specific management and outcome of CNP is lacking. This study aimed to examine the outcomes of TBI patients involving single versus multiple *** A retrospective chart review of 170 consecutive TBI patients admitted to the tertiary neurosurgical center in Nepal between April 2020 and April 2022 was conducted. Demographic, clinical, and etiological characteristics; imaging findings; and management strategies were recorded, compared, and analyzed using descriptive statistics. The Glasgow Outcome Scale Extended (GOSE) was used to measure the outcomes in two groups of patients (single and multiple CNP) at 3 *** Out of 250 eligible patients, 80 were excluded and CNP was noted in 29 (17.1%) of the remaining 170. The median age was 34.9 years, and falls (60.6%) were the most common cause of trauma. TBI severity was categorized based on GCS: mild (82.4%), moderate (15.9%), and severe (1.8%). Cranial nerve involvement was seen in 29 (17.05%) patients: single cranial nerve involvement in 26 (89.65%) and multiple nerve involvement in 3 (10.34%). The most common isolated cranial nerve involved was the oculomotor nerve (37.9%). CT findings revealed a maximum of skull fractures with no significant association between CNP and CT *** CNP is a common consequence of TBI with the most common etiology being falls followed by RTA. Single CNP was more common than multiple CNP with no significant difference in the outcome in the 3-month GOSE score. Further research is needed to determine the burden of traumatic CNP and establish specific management guidelines for different types of CNP.

关键词： Cranial nerve palsy Nepal Outcome Traumatic brain injury

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Ion emission from warm dense matter produced by irradiation with a soft x-ray free-electron laser

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Matter and Radiation at Extremes 2024年第1期9卷 71-84页

作者： Josef krása Tomás Burian Vera Hájková Jaromír Chalupský Šimon Jelínek katerina Frantálová Michal krupka Zuzana kuglerová sushil k.mar singh Vojtech Vozda Ludek Vysín MichalŠmíd Pablo Perez-martin marion kühlman Juan Pintor Jakub Cikhardt Matthias Dreimann Dennis Eckermann Felix Rosenthal Sam M.Vinko Alessandro Forte Thomas Gawne Thomas Campbell Shenyuan Ren YuanFeng Shi Trevor Hutchinson Oliver Humphries Thomas Preston Mikako Makita Motoaki Nakatsutsumi Xiayun Pan Alexander köhler marion Harmand Sven Toleikis katerina Falk Libor Juha Department of Radiation and Chemical Physics Institute of PhysicsCzech Academy of SciencesNa Slovance 218221 Prague 8Czech Republic Laser Plasma Department Institute of Plasma PhysicsCzech Academy of SciencesZa Slovankou 318200 Prague 8Czech Republic Department of Surface and Plasma Science Faculty of Mathematics and PhysicsCharles University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Department of Physical Electronics Faculty of Nuclear Science and Engineering PhysicsCzech Technical University in PragueV Holesovi ckách 218000 Prague 8Czech Republic Helmholtz-Zentrum Dresden-Rossendorf Bautzner Landstraße 40001328 DresdenGermany DESY Photon Science Notkestraße 85D-22607 HamburgGermany Institut de Minéralogie de Physique des Matériaux et de CosmochimieUMR 7590–UPMC/CNRS/IRD/MNHNSorbonne Université4 place Jussieu75005 ParisFrance Department of Physics Faculty of Electrical EngineeringCzech Technical University in PragueTechnická216627 Prague 6Czech Republic Center for Soft Nanoscience University of MünsterBusso-Peus-Straße 10D-48149 MünsterGermany Department of Physics Clarendon LaboratoryUniversity of OxfordParks RoadOxford OX13PUUnited Kingdom Central Laser Facility STFC Rutherford Appleton LaboratoryDidcot OX110QXUnited Kingdom Lawrence Livermore National Laboratory 7000 East AvenueLivermoreCalifornia 94550USA European XFEL GmbH Holzkoppel 4D-22869 SchenefeldGermany Technische Universität Dresden 01062 DresdenGermany

We report on an experiment performed at the FLASH2 free-electron laser(FEL)aimed at producing warm dense matter via soft x-ray isochoric *** the experiment,we focus on study of the ions emitted during the soft x-ray ablation process using time-of-flight electron multipliers and a shifted Maxwell–Boltzmann velocity distribution *** find that most emitted ions are thermal,but that some impurities chemisorbed on the target surface,such as protons,are accelerated by the electrostatic field created in the plasma by escaped *** morphology of the complex crater structure indicates the presence of several ion groups with varying *** find that the ion sound velocity is controlled by the ion temperature and show how the ion yield depends on the FEL radiation attenuation length in different materials.

关键词： electrostatic emitted chemi

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OTS Scheme Based Secure Architecture for Energy-Efficient IoT in Edge Infrastructure

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Computers, Materials & Continua 2021年第3期66卷 2905-2922页

作者： sushil k.mar singh Yi Pan Jong Hyuk Park Department of Computer Science and Engineering Seoul National University of Science and TechnologySeoul01811South Korea Department of Computer Science Georgia State UniversityAtlantaGA30302-5060USA

For the past few decades,the Internet of Things(IoT)has been one of the main pillars wielding significant impact on various advanced industrial applications,including smart energy,smart manufacturing,and *** applications are related to industrial plants,automation,and e-healthcare *** applications have several issues related to developing,planning,and managing the ***,IoT is transforming into G-IoT(Green Internet of Things),which realizes energy *** provides high power efficiency,enhances communication and ***,this paradigm did not resolve all smart applications’challenges in edge infrastructure,such as communication bandwidth,centralization,security,and *** this paper,we propose the OTS Scheme based Secure Architecture for Energy-Efficient IoT in Edge Infrastructure to resolve these *** OTS-based Blockchain-enabled distributed network is used at the fog layer for security and *** evaluated our proposed architecture’s performance quantitatively as well as security and *** conducted a comparative analysis with existing studies with different measures,including computing cost time and communication *** a result of the evaluation,our proposed architecture showed better performance.

关键词： Blockchain energy-efficient IoT ots scheme edge infrastructure security and privacy

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In-vitro scolicidal activity of Mallotus philippinensis (Lam.) Muell Arg. fruit glandular hair extract against hydatid cyst Echinococcus granulosus

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Asian Pacific Journal of Tropical Medicine 2013年第8期6卷 595-601页

作者： Mayank Gangwar Vijay C Verma Tryambak D singh sushil k singh Rk Goel Gopal Nath Department of Microbiology Institute of Medical Sciences Banaras Hindu University Department of Pharmacology Institute of Medical Sciences Banaras Hindu University Department of Medicinal Chemistry Institute of Medical Sciences Banaras Hindu University Department of Pharmaceutical Engineering Institute of Technology Banaras Hindu University

Objective: To investigate new scolicidal agent from natural resources to cope with the side effects associated with synthetic drugs in Echinococcosis. Methods: The scolicidal potential of methanolic fruit powder extract (10 and 20 mg/mL) of Mallotus philippinensis ( M. philippinensis ) was investigated. Viability of protoscoleces was confirmed by trypan blue exclusion method, where mortality was observed at concentration of 10 and 20 mg/mL in 60 min treatment against Echinococcus granulosus ( E. granulosus ), under in-vitro conditions with reference to the known standard drug Praziquantel . Results: At concentration 10 and 20 mg/mL, the mortality rate was observed 97% and 99% respectively for 60 min treatment; while up to 93% mortality was observed with 20 mg/mL for only 10 min treatment. The concentration above 20 mg/mL for above 2 h showed 100% mortality, irrespective of further incubation. Conclusions: As compared with the standard anti-parasitic drug Praziquantel our extract has significant scolicidal activity with almost no associated side effects.

关键词： Protoscolicidal Echinococcus Hydatidosis Mallotus sp. Anti-helminthic agents Trypan blue

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Chelation in Metal Intoxication XLIV: Efficacy of α-Mercapto β-(5-Substituted, 2-Furyl) Acrylic Acids in Mobilizing Intracellularly Bound Cadmium in Rat

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Biomedical and Environmental Sciences 2000年第3期13卷 205-212页

作者： sushil k. TANDON\+1, SATGUR PRASAD, AND SURENDRA singh Industrial Toxicology Research Centre, Lucknow_226001, India Industrial Toxicology Research Centre M.G. Marg Post Box 80 Lucknow-226001 India

The efficacy of α mercapto β (2_furyl) acrylic acid (MFA), α mercapto β (5_sodiumsulfonate, 2_furyl) acrylic acid (MSFA) and α mercapto β (5_acetoxymethyl, 2_furyl) acrylic acid (MAFA) to mobilize intracellularly bound cadmium in liver and kidney was investigated in rats pre_exposed to cadmium. MFA was effective in reducing cadmium levels of hepatic and renal supernatant cytosolic fraction (SCF) while MSFA and MAFA were effective in lowering cadmium levels of renal SCF and hepatic SCF respectively. All the chelating agents also enhanced the excretion of cadmium more in feces than in urine. However, substitution on the furan ring lowered cadmium mobilizing efficacy of the parent compound, MFA. The treatment with MFA did not affect the status of endogenous zinc and copper while the treatment with MSFA and MAFA enhanced their excretion. MSFA increased hepatic and renal zinc and renal copper while MAFA increased their copper levels.

关键词： Mercapto Substituted Chelation in Metal Intoxication XLIV Furyl Intracellularly Bound Cadmium in Rat Efficacy of Acrylic Acids in Mobilizing

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Novel CMS lines in pigeonpea[Cajanus cajan(L.)Millspaugh]derived from cytoplasmic substitutions,and their effective restoration and deployment in hybrid breeding

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The Crop Journal 2017年第1期5卷 89-94页

作者： Abhishek Bohra Rintu Jha Indra Prakash singh Gaurav Pandey Shalini Pareek Partha Sarathi Basu sushil k.mar Chaturvedi Narendra Pratap singh ICAR Indian Institute of Pulses Research(IIPR)Kanpur 208024India

The availability of stable cytoplasmic male sterile(CMS or A) lines coupled with a robust restoration system(R lines) is an essential prerequisite for efficient hybrid ***-enabled hybrid technology holds immense potential to enhance the long-stagnant productivity of pigeonpea. In the present investigation, cytoplasmic substitutions were made in the nuclear backgrounds of early-maturing pigeonpea varieties or lines. Three new CMS lines(ICPL 88039 A, Pusa 992 A, and DPP 3-2A) resulted from genetic crosses involving cytoplasmic donors from A2(GT 288A) and A4(ICPA 2089) categories. In addition to visual inspection of anthers, pollen-staining techniques and scanning electron microscopy(SEM)analysis were used to confirm pollen sterility. Further, given the relevance of the plant mitochondrial genome to CMS manifestation, 25 mitochondrion-specific DNA markers were assayed on these newly developed A lines and isogenic maintainer(B) lines. DNA polymorphism between Pusa 992 A and Pusa 992 B as revealed by the nad7a_del marker confirmed the successful combination of sterilizing cytoplasm(A4) and nonrestoring nuclear background(Pusa 992). Such cytoplasm-specific DNA markers are required for A2-CMS as well. Further, to assess restoration ability, potential restorers were crossed with these CMS lines, and as a consequence, promising A × R combinations exhibiting 100%pollen fertility could be identified. In parallel, we also analyzed the inheritance patterns underlying fertility restoration using ICPL 88039A-derived F2 and BC1F1populations,and established a monogenic dominant model to explain the phenomenon of A2-CMS restoration. In summary, we report the successful development of new CMS lines and describe their effective deployment in hybrid breeding of pigeonpea.

关键词： Cytoplasm Hybrid Mitochondria Pigeonpea Restorer Sterility

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Variation in Parameters of Ambient Air Quality in National Capital Territory (NCT) of Delhi (India)

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Atmospheric and Climate Sciences 2015年第1期5卷 13-22页

作者： Anunay A. Gour Santosh k. singh sushil k. Tyagi Anubha Mandal Department of Environmental Engineering Delhi Technological University (Formerly Delhi College of Engineering) Delhi India Central Pollution Control Board (CPCB) Delhi India

Air Pollution is an escalating problem worldwide fuelled by increasing anthropogenic activities, speedy development, rapid industrialization, transportation, superfluous use of fossil fuel consumption, increasing global power needs, etc. Also the diverse meteorological factors influence our environment to a great extent. Population explosion has led to remarkable increase in vehicular population. The use solely depends upon the lifestyle of the citizen. Any change in the lifestyle has a remarkable effect on the air we breathe. A comprehensive database for pollution levels from the year 2006 to 2010 was analyzed for a main traffic intersection and a non-traffic area in Delhi (India). The paper asserts that pollutant concentration levels on weekend are lower than those on weekdays (increase on Sundays with respect to weekdays is CO 2.98 times, PM2.5 1.18 times, NO 1.62 times, NO2 5.76 times, SO2 1.27 times and O3 1.15 times). The pollution levels have been found to attenuate on public holidays and weekends. Pollution can hence be related to the weekly cycle of human activities. Pollutions due to vehicular emissions on roads, rails, air or water all serve as major sources of pollution. Hence, viably possible solutions for pollution control can also be achieved by controlling the magnitude of traffic flow on roads.

关键词： Ambient Air Quality Emission Seasonal Variation Weekend Effect Delhi

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Surveying the genomic landscape of silage-quality traits in maize(Zea mays L.)

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The Crop Journal 2023年第6期11卷 1893-1901页

作者： Jatin Sharma Shubham Sharma krishna Sai karnatam Om Prakash Raigar Chayanika Lahkar Dinesh k.mar Saini sushil k.mar Alla singh Abhijit k.mar Das Priti Sharma Ramesh k.mar Department of Plant Breeding and Genetics Punjab Agricultural UniversityLudhianaPunjab 141004India School of Agricultural Biotechnology Punjab Agricultural UniversityLudhianaPunjab 141004India ICAR-Indian Institute of Maize Research LudhianaPunjab 141004India Department of Plant and Soil Science Texas Tech UniversityLubbockTX 79409-2122USA

Despite the longstanding importance of silage as a critical feed source for ruminants,its quality improvement has been largely *** numerous quantitative trait loci(QTL)and genes affecting silage quality in maize have been reported,only a few have been effectively incorporated into breeding *** this gap,the present study undertook a comprehensive meta-QTL(MQTL)analysis involving 523 QTL associated with silage-quality traits collected from 14 published *** the 523 QTL,405 were projected onto a consensus map comprising 62,424 genetic markers,resulting in the identification of 60 MQTL and eight *** average confidence interval(CI)of the MQTL was 3.9-fold smaller than that of the source *** of the 60 identified MQTL were classified as breeder’s MQTL owing to their small CIs,involvement of more QTL,and large contribution to phenotypic ***-third of the MQTL co-localized with DNA marker-trait associations identified in previous genomewide association mapping studies.A set of 78 high-confidence candidate genes influencing silage quality were identified in the MQTL *** genes and associated markers may advance marker-assisted breeding for maize silage quality.

关键词： Meta-QTL Silage quality Maize GWAS Candidate genes

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Buttress plating for a rare case of comminuted medial condylar Hoffa fracture associated with patellar fracture

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Chinese Journal of Traumatology 2012年第4期15卷 238-240页

作者： Ashwani Soni Ramesh k Sen Uttam Chand Saini Dajjit singh sushil Chaudhary Department of Orthopedics Postgraduate Institute of Medical Education and ResearchChandigarh 160012In-dia

Hoffa fracture is an uncommon injury. In the literature, lateral condylar Hoffa fracture is mentioned as a more common injury pattern than medial condylar Hoffa fracture. The mechanism of injury and method of treatment is not very well described in the literature. We are present- ing a rare case of comrninuted medial condylar Hoffa frac- ture with ipsilateral patellar fracture. The mechanism of in-jury has not been described in the literature. Lag screw fixation, which is the most acceptable method of treatment, is not possible due to comminution. We explain the pos- sible mechanism of injury and fix the fracture with L-but- tress plate.

关键词： Fractures, bone kneejoint Femur Pa- tella

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Bilirubin in coronary artery disease:Cytotoxic or protective?

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World Journal of Gastrointestinal Pharmacology and Therapeutics 2016年第4期7卷 469-476页

作者： Nancy Gupta Tavankit singh Rahul Chaudhary sushil k Garg Gurprataap singh Sandhu Varun Mittal Rahul Gupta Roxana Bodin Sachin Sule Department of Medicine Westchester Medical CenterNew York Medical College Department of Medicine Cleveland Clinic Department of Medicine Sinai Hospital of BaltimoreJohns Hopkins University Department of Medicine University of Minnesota Department of Medicine University of Pittsburgh Einstein Healthcare Network Government Medical College Division of Gastroenterology and Hepatobiliary Disease New York Medical College

Bilirubin has traditionally been considered a cytotoxic waste ***,recent studies have shown bilirubin to have anti-oxidant,anti-inflammatory,vasodilatory,anti-apoptotic and anti-proliferative *** properties potentially confer bilirubin a new role of protection especially in coronary artery disease(CAD),which is a low grade inflammatory process exacerbated by oxidative *** fact,recent literature reports an inverse relationship between serum concentration of bilirubin and the presence of *** this article,we review the current literature exploring the association between levels of bilirubin and risk of *** conclude that current evidence is inconclusive regarding the protective effect of bilirubin on CAD.A causal relationship between low serum bilirubin level and increased risk of CAD is not currently established.

关键词： Bilirubin Cytotoxic Protective Anti-oxidant Anti-inflammatory Anti coronary artery disease Lipid peroxidation Gilbert

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