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Evaluation of bone remodeling in regard to the age of scaphoid non-unions

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World Journal of Orthopedics 2016年第7期7卷 418-425页

作者： susanne Rein Uwe Hanisch Hans-Eberhard schaller Hans Zwipp Stefan Rammelt Stefan Weindel Department of Plastic and Hand Surgery Burn UnitTrauma Center Bergmannstrost Center of Orthopaedics and Traumatology University Medicine "Carl Gustav Carus" DresdenTechnicalUniversity Dresden Institute of Pathology "Carl Thiem" Hospital Deptartment of Plastic Hand Reconstructive and Burn SurgeryTrauma Center Tuebingen University Deptartment of Hand Aesthetic and Plastic SurgeryHospital of Linth

AIM: To analyse bone remodeling in regard to the age of scaphoid non-unions(SNU) with ***: Thirty-six patients with symptomatic SNU underwent surgery with resection of the pseudarthrosis. The resected material was evaluated histologically after staining with hematoxylin-eosin(HE), tartrate resistant acid phosphatase(TRAP), CD 68, osteocalcin(OC) and osteopontin(OP). Histological examination was performed in a blinded ***: The number of multinuclear osteoclasts in the TRAP-staining correlated with the age of the SNU and was significantly higher in younger SNU(P = 0.034; r = 0.75). A higher number of OP-immunoreactive osteoblasts significantly correlated with a higher number of OC-immunoreactive osteoblasts(P = 0.001; r = 0.55). Furthermore, a greater number of OP-immunoreactive osteoblasts correlated significantly with a higher number of OP-immunoreactive multinuclear osteoclasts(P = 0.008; r = 0.43). SNU older than 6 mo showed a signifi-cant decrease of the number of fibroblasts(P = 0.04). Smoking and the age of the patients had no influence on bone remodeling in ***: Multinuclear osteoclasts showed a significant decrease in relation to the age of SNU. However, most of the immunhistochemical findings of bone remodeling do not correlate with the age of the SNU. This indicates a permanent imbalance of bone formation and resorption as indicated by a concurrent increase in both osteoblast and osteoclast numbers. A clear histological differentiation into phases of bone remodeling in SNU is not possible.

关键词： Bone remodeling Histology Immunohistological staining Scaphoid non-union Scaphoid Wrist joint

First-line anti-VEGF plus EGFR-TKI in EGFR-mutant NSCLC: adding the ARTEMIS trial to the puzzle of current evidence

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Signal Transduction and Targeted Therapy 2022年第1期7卷 4-6页

作者： susanne Hafner Institute of Pharmacology of Natural Products and Clinical Pharmacology Ulm UniversityD-89081 UlmGermany

In the ARTEMIS-CTONG1509 multicenter phase 3 study recently published in Cancer Cell,Zhou et *** the combination of the EGFR tyrosine kinase inhibitor(TKI)erlotinib and anti-angiogenic bevacizumab in treatmentnaive Chinese patients with advanced EGFR-mutant non-small cell lung cancer(NSCLC).^(1) The primary endpoint of progression-free survival(PFS)was significantly exte nded from 11.2 months with erloti nib mono therapy to 17.9 mon ths with the combination.

关键词： NSCLC TKI EGFR

Four-wheel-drive immune protection

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Signal Transduction and Targeted Therapy 2022年第10期7卷 3637-3638页

作者： Fabian Heinrich susanne Krasemann Institute of Legal Medicine University Medical Center Hamburg Eppendorf20251 HamburgGermany Institute of Neuropathology University Medical Center Hamburg Eppendorf20251 HamburgGermany

In a recent study published in Cell,Zhang and colleagues provide the first longitudinal study comparing four different COVID-19 vaccines head-to-head for binding and neutralizing antibodies,spike-specific CD4+or CD8+T... 详细信息

关键词： antibodies immune vaccines

Cation engineering on lead iodide perovskites for stable and high-performance photovoltaic applications

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Journal of Energy Chemistry 2018年第4期27卷 1017-1039页

作者： Jue Gong Peijun Guo Savannah E.Benjamin P.Gregory Van Patten Richard D.schaller Tao Xu Department of Chemistry and Biochemistry Northern Illinois UniversityDeKalbIL 60115USA Center for Nanoscale Materials Argonne National Laboratory9700 South Cass AvenueLemontIL 60439USA Department of Chemistry Middle Tennessee State UniversityMurfreesboroTN 37132USA

Perovskite solar cells （PSCs） based on methylammonium lead iodide （CH3NH3PbI3） have shown unprecedentedly outstanding performance in the recent years. Nevertheless, due to the weak interaction between polar CH3NH3＋（MA＋） and inorganic PbI3 sublattices, CH3NH3PbI3 dramatically suffers from poor moisture stability, thermal decomposition and device hysteresis. As such, strong electrostatic interactions between cations and anionic frameworks are desired for synergistic improvements of the abovementioned issues. While replacements of I with Br and/or CI evidently widen optical bandgaps of perovskite materials, compositional modifications can solely be applied on cation components in order to preserve the broad absorption of solar spectrum. Herein, we review the current successful practices in achieving efficient, stable and minimally hysteretic PSCs with lead iodide perovskite systems that employ photoactive cesium lead iodide （CsPbI3）, formamidinium lead iodide （HC（NH2）2PbI3, or FAPbI3）, MA1-x y-zFAxCsyRbzPbI3 mixed-cation settings as well as two-dimensional butylammonium （C4H9NH3＋, or BA＋）/MA＋, polymeric ammonium （PEI＋）/MA＋ co-cation layered structures. Fundamental aspects behind the stabilization of perovskite phases α-CsPbi3, α-FAPbI3, mixed-cation MA1-x-y-zFAxCsyRb2PbI3 and crystallographic alignment of （BA）2（MA）3Pb4I13 for effective light absorption and charge transport will be discussed. This review will contribute to the continuous development of photovoltaic technology based on PSCs.

关键词： Solar energy conversion Perovskite solar cells Power conversion efficiency Optical bandgaps Device hysteresis Metastabte phases

Real-world evidence for improved outcomes with histamine antagonists and aspirin in 22,560 COVID-19 patients

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Signal Transduction and Targeted Therapy 2021年第8期6卷 2297-2299页

作者： Cameron Mura Saskia Preissner susanne Nahles Max Heiland Philip E.Bourne Robert Preissner School of Data Science and Deportment of Biomedical Engineering University of VirginiaCharlottesvilleVAUSA Department Oral and Maxillofacial Surgery Charite-Universitatsmedizin Berlincorporate member of Freie Universitat BerlinHumboldt-Universitat zu Berlinand Berlin Institute of HealthBerlinGermany Institute of Physiology and Science-IT Charite-Universitatsmedizin Berlincorporate member of Freie Universitat BerlinHumboldt-Universitat zu Berlinand Berlin Institute of HealthBerlinGermany

Dear Editor,The COVID-19 pandemic has driven great interest in the therapeutic potential of repurposed drugs with well-established benefits and safety profiles(toxicity,bioavailability,etc.),many of which act via sign... 详细信息

关键词： drugs category COV

Recirculating IL-1R2^(+) Tregs fine-tune intrathymic Treg development under inflammatory conditions

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Cellular & Molecular Immunology 2021年第1期18卷 182-193页

作者： Eirini Nikolouli yassin Elfaki susanne Herppich Carsten Schelmbauer Michael Delacher Christine Falk Ilgiz A.Mufazalov Ari Waisman Markus Feuerer Jochen Huehn Department of Experimental Immunology Helmholtz Centre for Infection ResearchBraunschweigGermany Institute for Molecular Medicine University Medical Center of the Johannes Gutenberg-University MainzMainzGermany Regensburg Center for Interventional Immunology(RCI) Chair for ImmunologyUniversity Regensburg and University Hospital RegensburgRegensburgGermany Institute of Transplant Immunology Integrated Research and Treatment Center TransplantationIFB-TxHannover Medical SchoolHannoverGermany Hannover Medical School HannoverGermany

The vast majority of Foxp3^(+)regulatory T cells(Tregs)are generated in the thymus,and several factors,such as cytokines and unique thymic antigen-presenting cells,are known to contribute to the development of these thymus-derived Tregs(tTregs).Here,we report the existence of a specific subset of Foxp3^(+)Tregs within the thymus that is characterized by the expression of IL-1R2,which is a decoy receptor for the inflammatory cytokine *** flow cytometric analysis of the thymocytes from Foxp3^(hCD2)xRAG1^(GFP) reporter mice revealed that the IL-1R2^(+)Tregs are mainly RAG1^(GFP-)and CCR6^(+)CCR7^(-),demonstrating that these Tregs are recirculating cells entering the thymus from the periphery and that they have an activated *** the spleen,the majority of IL-1R2^(+)Tregs express neuropilin-1(Nrp-1)and Helios,suggesting a thymic origin for these ***,among all tissues studied,the highest frequency of IL-1R2^(+)Tregs was observed in the thymus,indicating preferential recruitment of this Treg subset by the *** fetal thymic organ cultures(FTOCs),we demonstrated that increased concentrations of exogenous IL-1β blocked intrathymic Treg development resulting in a decreased frequency of CD25^(+)Foxp3^(+)tTregs and an accumulation of CD25^(+)Foxp3^(-)Treg ***,the addition of IL-1R2^(+)Tregs,but not IL-1R2^(+)Tregs,to reaggregated thymic organ cultures(RTOCs)abrogated the IL-1β-mediated blockade,demonstrating that these recirculating IL-1R2^(+)Tregs can quench IL-1 signaling in the thymus and thereby maintain thymic Treg development even under inflammatory conditions.

关键词： Thymus Treg development Inflammation IL-1 system

The WAK-like protein RFO1 acts as a sensor of the pectin methylation status in Arabidopsis cell walls to modulate root growth and defense

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Molecular Plant 2023年第5期16卷 865-881页

作者： Apolonio I.Huerta Gloria Sancho-Andre´s Juan Carlos Montesinos Javier Silva-Navas Sole`ne Bassard Corinne Pau-Roblot Christopher Kesten Rudolf Schlechter susanne Dora Temurkhan Ayupov Je´rome Pelloux^ Julia Santiago Clara Sa´nchez-Rodrı´guez ETH Zurich Institute of Molecular Plant Biology(D-BIOL)ZurichSwitzerland University of Lausanne Department of Plant Molecular BiologyLausanneSwitzerland UMRT INRAE 1158 BioEcoAgro–BIOPI Biologie des Plantes et Innovation Universite´de Picardie33 Rue St Leu80039 AmiensFrance Present address:Lonza AG VispVisSwitzerland Present address:Institute of Microbiology Freie Universitat BerlinBerlinGermany Present address:Institute of Molecular and Clinical Ophthalmology-Basel BaselSwitzerland Present address:Centro de Biotecnologı´a y Geno´mica de Plantas Universidad Polite´cnica de Madrid(UPM)–Instituto Nacional de Investigacio´n y Tecnologı´a Agraria y Alimentaria(INIA/CSIC)Campus de Montegancedo UPM28223 Pozuelo de Alarco´nSpain

Most organisms adjust their development according to the environmental *** the majority,this implies the sensing of alterations to cell walls caused by different *** the relevance of this process,few molecular players involved in cell wall sensing are known and ***,we show that the wall-associated kinase-like protein RESISTANCE TO FUSARIUM OXySPORUM 1(RFO1)is required for plant growth and early defense against Fusarium oxysporum and functions by sensing changes in the pectin methylation levels in the cell *** RFO1 dwell time at the plasma membrane is affected by the pectin methylation status at the cell wall,regulating MITOGEN-ACTIVATED PROTEIN KINASE and gene *** show that the extracellular domain of RFO1 binds de-methylated pectin in vitro,whose distribution in the cell wall is altered during *** *** analyses also indicate that RFO1 is required for the BR-dependent plant growth alteration in response to inhibition of pectin de-methyl-esterase activity at the cell ***,our work demonstrates that RFO1 is a sensor of the pectin methylation status that plays a unique dual role in plant growth and defense against vascular pathogens.

关键词： alterations walls pectin

Enhanced room-temperature Na^(+) ionic conductivity in Na_(4.92)y_(0.92)Zr_(0.08)Si_(4)O_(12)

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eScience 2023年第6期3卷 935-945页

作者： Aikai yang Kai yao Mareen schaller Enkhtsetseg Dashjav Hang Li Shuo Zhao Qiu Zhang Martin Etter Xingchen Shen Huimin Song Qiongqiong Lu Ruijie ye Igor Moudrakovski Quanquan Pang Sylvio Indris Xingchao Wang Qianli Ma Frank Tietz Jun Chen Olivier Guillon Forschungszentrum Jülich GmbH Institute of Energy and Climate ResearchMaterials Synthesis and Processing(IEK-1)52425 JülichGermany Institute of Mineral Engineering(GHI) RWTH Aachen UniversityForckenbeckstraße 3352074 AachenGermany Institute for Applied Materials-Energy Storage Systems(IAM-ESS) Karlsruhe Institute of Technology(KIT)76344 Eggenstein-LeopoldshafenGermany Renewable Energy Conversion and Storage Center(RECAST) Haihe Laboratory of Sustainable Chemical TransformationsKey Laboratory of Advanced Energy Materials Chemistry(Ministry of Education)College of ChemistryNankai UniversityTianjin 300071China Deutsches Elektronen-Synchrotron(DESy) Notkestrasse 8522607 HamburgGermany Laboratoire de Cristallographie et Sciences des Materiaux(CRISMAT) CNRSENSICAEN14000 CaenFrance Beijing Key Laboratory of Theory and Technology for Advanced Batteries Materials School of Materials Science and EngineeringPeking UniversityBeijing 100871China Institute of Materials Henan Academy of SciencesHenan Key Laboratory of Advanced Conductor MaterialsZhengzhou 450046China Max Planck Institute for Solid State Research Heisenbergstraße 170569 StuttgartGermany State Key Laboratory of Chemistry and Utilization of Carbon Based Energy Resources Key Laboratory of Advanced Functional MaterialsAutonomous RegionInstitute of Applied ChemistryCollege of ChemistryXinjiang UniversityUrumqiXinjiang 830046China Forschungszentrum Jülich GmbH Helmholtz Institute Münster(IEK-12)52425 JülichGermany Jülich Aachen Research Alliance JARA-Energy52425 JülichGermany

Developing cost-effective and reliable solid-state sodium batteries with superior performance is crucial for stationary energy storage.A key component in facilitating their application is a solid-state electrolyte with high conductivity and ***,we employed aliovalent cation substitution to enhance ionic conductivity while preserving the crystal *** substitution of y^(3+)with Zr^(4+)in Na_(5)ySi_(4)O_(12) introduced Naþion vacancies,resulting in high bulk and total conductivities of up to 6.5 and 3.3 mS cm^(-1),respectively,at room temperature with the composition Na_(4.92)y_(0.92)Zr_(0.08)Si_(4)O_(12)(NyZS).NyZS shows exceptional electrochemical stability(up to 10 V ***þ/Na),favorable interfacial compatibility with Na,and an excellent critical current density of 2.4 mA cm^(-2).The enhanced conductivity of Naþions in NyZS was elucidated using solid-state nuclear magnetic resonance techniques and theoretical simulations,revealing two migration routes facilitated by the synergistic effect of increased Naþion vacancies and improved chemical environment due to Zr^(4+)*** extends the list of suitable solid-state electrolytes and enables the facile synthesis of stable,low-cost Naþion silicate electrolytes.

关键词： Solid-state electrolytes Sodium superionic conductors Na_(4.92)y_(0.92)Zr_(0.08)Si_(4)O_(12) High conductivity Ultra-wide electrochemical window

A review of potential conservation and fisheries benefits of breaching four dams in the Lower Snake River(Washington,USA)

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Water Biology and Security 2022年第2期1卷 10-22页

作者： Adam J.Storch Howard A.schaller Charles E.Petrosky Robert L.Vadas Jr. Benjamin J.Clemens Gary Sprague Norman Mercado-Silva Brett Roper Michael J.Parsley Edward Bowles Robert M.Hughes Jay A.Hesse Oregon Department of Fish and Wildlife Ocean Salmon and Columbia River Program17330 Southeast Evelyn StreetClackamasOR 97015USA U.S.Fish and Wildlife Service 911 Northeast 11th AvenuePortlandOR 97232USA Idaho Department of Fish and Game 600 South Walnut StreetBoiseID 83707USA Unaffiliated OlympiaWAUSA Oregon Department of Fish and Wildlife Corvallis Research Lab28655 Hwy 34CorvallisOR 97333USA National Marine Fisheries Service 650 Capitol MallSacramentoCA 95814USA Centro de Investigacion en Biodiversidad y Conservacion Universidad Autonoma del Estado de MorelosAv.Universidad 1001Col.ChamilpaC.P.62209CuernavacaMorelosMexico National Stream and Aquatic Ecology Center U.S.Forest Service860 North 1200 EastLoganUT 84321USA Independent Fisheries Consultant 191 Sooter RoadUnderwoodWA 98651USA Oregon Department of Fish and Wildlife 4034 Fairview Industrial Drive SoutheastSalemOR 97302USA Amnis Opes Institute 2895 Southeast Glenn StreetCorvallisOR 97333USA Department of Fisheries Wildlife&Conservation Sciences104 Nash HallCorvallisOR 97331USA Nez Perce Tribe Department of Fisheries Resources Management 120 Beaver GradeLapwaiID 83540USA

Abundances of important and imperiled fishes of the Snake River Basin continue to *** assessed the rationale for breaching the four lower Snake River Basin dams to prevent complete loss of these fishes,and to maximize their likelihood of *** summarize the science surrounding Sockeye Salmon(Oncorhynchus nerka),Chinook Salmon(***),steelhead(***),Bull Trout(Salvelinus confluentus),White Sturgeon(Acipenser transmontanus),and Pacific Lamprey(Entosphenus tridentatus).From this,we drew ten conclusions:(1)development of the Columbia River System(including the Snake River Basin)has converted mainstem rivers into reservoirs,altering fish behavior and survival;(2)most populations currently record their lowest abundance;(3)the Columbia River System dams reduce productivity of diadromous fishes in the highest-quality spawning grounds that could buffer against future climate dynamics;(4)past actions have done little to reduce impacts or precipitate recovery;(5)the Columbia River System constrains survival and productivity of salmon,steelhead and Bull Trout;(6)Snake River Basin salmon and steelhead remain at high extinction risk;(7)eliminating migration impediments and improving mainstem habitats are essential for maintaining genetic diversity and improving Bull Trout persistence;(8)the lower Snake River Basin dams preclude passage of adult White Sturgeon,constraining gene flow and recruitment;(9)the lower Snake River Basin dams impede dramatically passage of adult and juvenile Pacific Lamprey,and(10)Snake River Basin Pacific Lamprey is at high risk of *** the four lower Snake River Basin dams is an action likely to prevent extirpation and extinction of these *** from the Columbia River System can inform conservation in other impounded rivers.

关键词： Bull trout Impoundment Pacific lamprey Salmon Steelhead White sturgeon