检索结果-南通市图书馆

Safety and Therapeutic Efficacy of the Lewis Y Carbohydrate Specific Humanized Antibody MB311 in Patients with Malignant Effusion

引用

Journal of Cancer Therapy 2014年第1期5卷 28-37页

作者： Thomas Bauernhofer Helmut Samonigg Peter Regitnik Werner Weitzer Brigitte Lileg Günter Waxenecker susanne wiederkum Manuela Kainer Manfred Schuster Hans Loibner Markus Fido Ralf Kircheis Andreas Nechansky Igeneon Vienna Austria Medical University Graz Graz Austria

Purpose: Investigation of safety and tolerability as well as therapeutic efficacy of the LeY specific humanized mAb MB311 in cancer pts with malignant effusions in a Phase II clinical trial. Experimental Design: An openlabel, single treatment arm, uncontrolled study with MB311 (100 mg per dose, intravenous infusion on day 1 and 7) in pts with malignant effusion (ascites or pleural effusion) was conducted with the primary objective to examine safety and tolerability as well as pharmacokinetics. Secondary objectives were assessment of pharmacodynamics, volumetric measurement of the malignant effusion and obtaining data for several immunological parameters. Results: Five pts (2 pts with gastric cancer and malignant ascites, 3 pts with breast cancer and malignant pleural effusion/ascites) have completed the study. MB311 was well tolerated with only two pts showing the easily manageable side effects nausea, vomiting (up to grade 2) and one episode of skin rash (grade 2) after the first application. Data of 4 pts were available for evaluating immunologic results and efficacy. In all pts significant levels of MB311 could be detected in the systemic blood circulation and the effusion leading to increased infiltration of CD45 positive immune cells (4/5 pts) and resulting in a reduction of tumor cell counts as detected by immunocytochemistry of effusion samples in 3/5 pts). Most interestingly, the pt with the highest LeY positive tumor showed a significant reduction of effusion volume after treatment—this decrease was also evident for Her2/neu positive tumor cells which were dramatically reduced after MB311 treatment in this breast cancer pt. Conclusion: MB311 was well tolerated in patients with malignant effusions, permeated into malignant effusion and attracted immune cells leading to decreased tumor cell counts in the effusion. In the case of strong LeY expression of malignant cells in the effusion a pronounced decrease in LeY, EpCAM and Her2/neu positive tumor cells and a

关键词： Passive Immunotherapy Therapeutic Antibody Circulating Tumor Cells Malignant Effusion Lewis Y Carbohydrate Ascites

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Comparison of carotenoid,chlorophyll concentrations and their biosynthetic transcript levels in different coloured cauliflower

引用

Horticultural Plant Journal 2024年第3期10卷 743-754页

作者： Fatemeh Izadpanah Katja Frede Forouzandeh Soltani susanne Baldermann Food Chemistry and Human Nutrition Leibniz Institute of Vegetable and Ornamental CropsTheodor-Echtermeyer-Weg 114979 GroßbeerenGermany Department of Food Chemistry Institute of Nutritional SciencesUniversity of PotsdamArthur-Scheunert-Allee 114-11614558 NuthetalGermany Department of Horticultural Science University of TehranDaneshkade Ave31587-77871KarajIran Faculty of Life Sciences:Food Nutrition and HealthFood MetabolomeUniversity of BayreuthFritz-Hornschuch-Straße1395326 KulmbachGermany

Carotenoids and chlorophylls are among the most widely distributed pigments in nature that play essential roles in the photosynthetic apparatus and confer diverse colours in *** all vegetables,cauliflower(Brassica oleracea ***)is rich in phytochemicals and is an important crop grown all over the *** study investigates carotenoid and chlorophyll concentrations in differently pigmented cultivars and elucidates the role of transcriptional regulation of carotenoid accumulation including lutein andβ-***,we characterised changes in pigments by UHPLC-DAD-ToF-MS and changes in transcript levels of carotenoid metabolic genes by qRT-PCR in florets and leaves of orange(‘Jaffa'and‘Sunset'),purple(‘Di Sicilia Violetto'and‘Graffiti'),green(‘Trevi')and white(‘Clapton')*** levels of all carotenoid metabolic genes showed different transcript level patterns in the leaves and *** to the other cultivars,the orange cultivars had the highest levels ofβ-carotene in the florets and lutein in the leaves resulting in changes lutein/β-carotene *** the green cultivar,higher transcript levels were also found,especially for phytoene synthase and phytoene desaturase genes of the core biosynthesis ***,no increased carotenoid concentrations were observed,possibly due to a higher carotenoid turnover induced by the carotenoid cleavage dioxygenase 4 in the green *** the white(‘Clapton')and purple(‘Di Sicilia Violetto'and‘Graffiti')cultivars the phytoene desaturase transcript levels as well as carotenoid concentrations were *** concentrations changed in trend comparable to the carotenoid concentrations and were only significantly lower in the leaves of the orange cultivar‘Jaffa'.Also,the chlorophyll a/b ratio changed in‘Jaffa'.In florets the highest chlorophylls concentrations were observed for the green cultivar(‘Trevi')and the purple cultivar(‘Di Sicilia Violetto').Taken together,the study dem

关键词： Brassica oleracea L.var.botrytis Carotenoid Lutein β-Carotene Biosynthesis qRT-PCR

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Does ash dieback affect the reproductive ecology of Fraxinus excelsior L.?

引用

Journal of Forestry Research 2024年第2期35卷 54-69页

作者： Anna‑Katharina Eisen Lisa Buchner Barbara Fussi susanne Jochner‑Oette Physical Geography/Landscape Ecology and Sustainable Ecosystem Development Catholic University of Eichstätt-Ingolstadt85072 EichstättGermany Bavarian Office for Forest Genetics(AWG) 83317 TeisendorfGermany

Forest tree species reproduction is a key factor in maintaining the genetic diversity of future generations and the stability of forest *** ongoing ash dieback disease could affect the reproductive ecology of Fraxinus excelsior *** have a major impact on the quantity and quality of pollen and *** this study,we investigated pollen production and viability of pollen and seeds of ash trees with different health status from 2018 to *** were collected from 105 trees(pollen production),pollen from 125 trees(pollen viability),and seeds from 53 trees(seed quality)in two seed orchards and in one floodplain forest in southern *** all parameters were examined at every site every *** average pollen production per tree was estimated at 471.2±647.9 billion pollen *** addition,we found that a high number of inflorescences did not equate to high pollen production per *** production of healthy and diseased trees did not differ significantly,although only 47%of severely diseased male trees(vs.72%for healthy trees)produced *** regards to pollen viability,the TTC test showed an average viability of 73%±17%.Overall,there was a slight tendency for diseased trees to have less viable ***,a significant difference could only be calculated for trees in the floodplain *** percentage of germinable seeds in 2018 was 38%in the floodplain forest and 57%in one of the seed *** percentage of viable seeds(TTC test)ranged from 17 to 22%in the orchards in ***-viable seeds were usually heavily infested by *** general,seed quality was not significantly different between healthy and diseased *** results indicate that ash dieback affects flower formation and pollen viability but not pollen production or seed ***,the fact that hardly any flowering was observed,especially for trees that were seriously affected,suggests a negative effect of ash dieback on reproductive per

关键词： Common ash Seed orchard Floodplain forest Pollen production Viability TTC test Seed stratification Phenology

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Experienced Involvement (ExIn) in Social-Psychiatric Care of Germany-Challenges and Chances

引用

Sociology Study 2024年第3期14卷 129-142页

作者： susanne Iris Bauer Fulda University of Applied Sciences FuldaGermany

This study explores the integration of Experienced Involvement(ExIn)in social-psychiatric care in Germany,emphasizing both the challenges and opportunities it *** European Leonardo da Vinci Project(2005-2007)established a curriculum for ExIn,promoting participatory structures in psychiatric *** peer support is well-established in other European countries,Germany’s experience is still *** research uses a mixed methods design,combining quantitative surveys and qualitative interviews,to investigate the professional experiences of ExIn recovery companions and team colleagues in German clinics and support *** findings reveal numerous benefits:for social-psychiatric services,ExIn enhances service quality,inclusivity,and accessibility;for team colleagues,it fosters reflexivity,hope,and trust,and improves self-care;for service users,it provides empowerment,easy access to support,trust,and hope,and offers credible role *** these benefits,challenges such as stigmatization,lack of recognition,and financial constraints remain and require to be *** study highlights the need and provides implications for a dedicated and inclusive approach to effectively implementing ExIn,ultimately enriching psychiatric care through experiential knowledge and reducing prejudice within mental health services.

关键词： peer involvement professionalized peer support social psychiatry inclusion education of social works

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Distortions in focusing laser pulses due to spatio-temporal couplings:an analytic description

引用

High Power Laser Science and Engineering 2024年第3期12卷 20-40页

作者： Klaus Steiniger Fabia Dietrich Daniel Albach Michael Bussmann Arie Irman Markus Loeser Richard Pausch Thomas Püschel Roland Sauerbrey susanne Schöbel Ulrich Schramm Mathias Siebold Karl Zeil Alexander Debus Helmholtz-Zentrum Dresden-Rossendorf DresdenGermany CASUS-Center for Advanced Systems Understanding GörlitzGermany Technische Universität Dresden DresdenGermany

In ultra-short laser pulses,small changes in dispersion properties before the final focusing mirror can lead to severe pulse distortions around the focus and therefore to very different pulse properties at the point of laser±matter interaction,yielding unexpected interaction *** mapping between far-and near-field laser properties intricately depends on the spatial and angular dispersion properties as well as the focal *** a focused Gaussian laser pulse under the influence of angular,spatial and group-delay dispersion,we derive analytical expressions for its pulse-front tilt,duration and width from a fully analytic expression for its electric field in the time±space domain obtained with scalar diffraction *** expression is not only valid in and near the focus but also along the entire propagation distance from the focusing mirror to the *** relating angular,spatial and group-delay dispersion before focusing at an off-axis parabola,where they are well measurable,to the respective values in the pulse’s focus are obtained by a ray tracing ***,these formulas are used to show in example setups that the pulse-front tilts of lasers with small initial dispersion can become several tens of degrees larger in the vicinity of the focus while being small directly in the *** formulas derived here provide the analytical foundation for observations previously made in numerical *** numerically simulating Gaussian pulse propagation and measuring properties of the pulse at distances several Rayleigh lengths off the focus,we verify the analytic expressions.

关键词： group-delay dispersion pulse-front tilt spatio-temporal couplings third-order dispersion ultra-short laser pulses

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Comparison of methods for deriving phenotypes from incomplete observation data with an application to age at puberty in dairy cattle

引用

Journal of Animal Science and Biotechnology 2024年第2期15卷 535-545页

作者： Melissa A.Stephen Chris R.Burke Jennie E.Pryce Nicole M.Steele Peter R.Amer susanne Meier Claire V.C.Phyn Dorian J.Garrick DairyNZ Ltd 605 Ruakura RoadHamilton 3240New Zealand AL Rae Centre for Genetics and Breeding-Massey University RuakuraHamilton 3214New Zealand Agriculture Victoria Research AgriBioCentre for AgriBioscienceBundooraVictoria 3083Australia School of Applied Systems Biology La Trobe UniversityBundooraVictoria 3083Australia AbacusBio DunedinNew Zealand

Background Many phenotypes in animal breeding are derived from incomplete measures,especially if they are challenging or expensive to measure *** include time-dependent traits such as reproductive status,or *** measures for these traits result in phenotypes that are subject to left-,interval-and rightcensoring,where phenotypes are only known to fall below an upper bound,between a lower and upper bound,or above a lower bound *** we compare three methods for deriving phenotypes from incomplete data using age at first elevation(>1 ng/mL)in blood plasma progesterone(AGEP4),which generally coincides with onset of puberty,as an example *** We produced AGEP4 phenotypes from three blood samples collected at about 30-day intervals from approximately 5,000 Holstein–Friesian or Holstein–Friesian×Jersey cross-bred dairy heifers managed in 54 seasonal-calving,pasture-based herds in New *** used these actual data to simulate 7 different visit scenarios,increasing the extent of censoring by disregarding data from one or two of the three *** methods for deriving phenotypes from these data were explored:1)ordinal categorical variables which were analysed using categorical threshold analysis;2)continuous variables,with a penalty of 31 d assigned to right-censored phenotypes;and 3)continuous variables,sampled from within a lower and upper bound using a data augmentation *** Credibility intervals for heritability estimations overlapped across all methods and visit scenarios,but estimated heritabilities tended to be higher when left censoring was *** sires with at least 5 daughters,the correlations between estimated breeding values(EBVs)from our three-visit scenario and each reduced data scenario varied by method,ranging from 0.65 to *** estimated breed effects also varied by method,but breed differences were smaller as phenotype censoring *** Our results indicate that using

关键词： Cattle Gibbs sampler Markov-chain Monte Carlo(MCMC) Puberty

来源：

维普期刊数据库

同方期刊数据库评论

在线全文

学校读者我要写书评

暂无评论

Understanding intrarenal backflow: Intrarenal pressure during ureteroscopy and beyond

引用

Asian Journal of Urology 2024年第2期11卷 139-142页

作者： Palle J.S.Osther susanne S.Osther Maria P.Hesselholt Sofia Byllov Søren K.Lildal Louise F.Øbro Helene Jung Urological Research Center Department of UrologyVejle Hospital(a part of Lillebaelt Hospital)University Hospital of Southern DenmarkVejleDenmark Department of Regional Health Research University of Southern DenmarkOdenseDenmark

The number of ureterorenoscopic procedures for upper urinary tract stone management has increased dramatically during recent years worldwide[1].Developments in flexible ureteroscope and laser technology have made it possible to successfully address larger and more complex stone scenarios *** the other hand,this means that more and more patients are exposed to the potential adverse effects of ureteroscopy[2].In general,ureteroscopy is considered a safe ***,serious complications and even deaths do occur,and these events are most likely underreported[3,4].

关键词： beyond likely ureter

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Dysfunction of the adhesion G protein-coupled receptor latrophilin 1(ADGRL1/LPHN1)increases the risk of obesity

引用

Signal Transduction and Targeted Therapy 2024年第5期9卷 2298-2311页

作者： Heba ZabriTorsten Schöneberg AndréNguyen Dietzsch Hadi Al-Hasani Joachim Altschmied Katharina Bottermann Jana Brendler Judith Haendeler susanne Horn Isabell Kaczmarek Antje Körner Kerstin Krause Kathrin Landgraf Diana Le Duc Laura Lehmann Stefan Lehr Stephanie Pick Albert Ricken Rene Schnorr Angela Schulz Martina Strnadová Akhil Velluva Heba Zabri Torsten Schöneberg Doreen Thor Simone Prömel Rudolf Schönheimer Institute of Biochemistry Medical FacultyLeipzig UniversityLeipzigGermany Institute for Clinical Biochemistry and Pathobiochemistry Medical FacultyGerman Diabetes CenterLeibniz Center for Diabetes Research at Heinrich Heine University DüsseldorfDüsseldorfGermany German Center for Diabetes Research(DZD e.V.) Munich-NeuherbergGermany Cardiovascular Degeneration Clinical Chemistry and Laboratory DiagnosticsMedical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Cardiovascular Research Institute(CARID) Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Pharmacology Medical FacultyUniversity Hospital and Heinrich Heine University DüsseldorfDüsseldorfGermany Institute of Anatomy Medical FacultyLeipzig UniversityLeipzigGermany Center for Pediatric Research Hospital for Children and AdolescentsMedical FacultyLeipzig UniversityLeipzigGermany Helmholtz Institute for Metabolic Obesity and Vascular Research(HI-MAG)of the Helmholtz Zentrum München at the University of Leipzig and University Hospital LeipzigLeipzigGermany Department of Endocrinology NephrologyRheumatologyLeipzig University Medical CenterLeipzigGermany Institute of Human Genetics Leipzig University Medical CenterLeipzigGermany Institute of Cell Biology Department of BiologyHeinrich Heine University DüsseldorfDüsseldorfGermany School of Medicine University of Global Health EquityKigaliRwanda

Obesity is one of the diseases with severe health consequences and rapidly increasing worldwide *** the complex network of food intake and energy balance regulation is an essential prerequisite for pharmacological intervention with obesity.G protein-coupled receptors(GPCRs)are among the main modulators of metabolism and energy ***,for instance,regulate appetite and satiety in certain hypothalamic neurons,as well as glucose and lipid metabolism and hormone secretion from *** in some GPCRs,such as the melanocortin receptor type 4(MC4R),have been associated with early-onset ***,we identified the adhesion GPCR latrophilin 1(ADGRL1/LPHN1)as a member of the regulating network governing food intake and the maintenance of energy *** of the highly conserved receptor in mice results in increased food consumption and severe obesity,accompanied by dysregulation of glucose ***,we identified a partially inactivating mutation in human ADGRL1/LPHN1 in a patient suffering from ***,we propose that LPHN1 dysfunction is a risk factor for obesity development.

关键词： obesity metabolism intake

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

First-line anti-VEGF plus EGFR-TKI in EGFR-mutant NSCLC: adding the ARTEMIS trial to the puzzle of current evidence

引用

Signal Transduction and Targeted Therapy 2022年第1期7卷 4-6页

作者： susanne Hafner Institute of Pharmacology of Natural Products and Clinical Pharmacology Ulm UniversityD-89081 UlmGermany

In the ARTEMIS-CTONG1509 multicenter phase 3 study recently published in Cancer Cell,Zhou et *** the combination of the EGFR tyrosine kinase inhibitor(TKI)erlotinib and anti-angiogenic bevacizumab in treatmentnaive Chinese patients with advanced EGFR-mutant non-small cell lung cancer(NSCLC).^(1) The primary endpoint of progression-free survival(PFS)was significantly exte nded from 11.2 months with erloti nib mono therapy to 17.9 mon ths with the combination.

关键词： NSCLC TKI EGFR

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

Between fighting and tolerance： reproductive biology of wingless males in the ant Cardiocondyla venustula

引用

Insect Science 2017年第5期24卷 818-828页

作者： susanne Jacobs Jurgen Heinze LS ZoologielEvolutionsbiologie Universitat Regensburg Regensburg Germany

Male reproductive tactics vary widely across the species of the ant genus Cardiocondyla, from obligatory lethal combat among co-occurring males to complete mutual tolerance. The African species C. venustula Wheeler, 1908 has an intermediate phylogenetic position between taxa with fighting males and taxa with tolerant males and also shows an intermediate male behavior. Males from 2 native populations in South Africa and a population introduced to Puerto Rico attacked and killed freshly eclosing rivals but rarely engaged in deadly fights with adult competitors, Instead, several males per colony established small ＂territories＂ in their natal nests and defended them against other males. Males with a stable territory had more contact with female sexuals than nonterritorial males and more frequently engaged in mating attempts. In controlled choice experiments, female sexuals did not show any preference for particular males. We suggest that male territoriality in C. venustula is an adaptation to the seasonal production of large numbers of female sexuals by multiple mothers.

关键词： Cardiocondyla ergatoid males Formicidae male competition sexual selection territoriality

来源：

维普期刊数据库评论

在线全文

维普期刊数据库

学校读者我要写书评

暂无评论

欢迎您,

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案：

请选择收藏分类：

通借通还

欢迎您,

建议与咨询 留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

时间限定

文献类型

馆藏选择

核心期刊

语言

文献类型

帮助

文字说明：

检索规则说明：

检索范例：

分类表

所选分类

限定检索结果

文献类型

馆藏范围

日期分布

学科分类号

主题

机构

作者

语言

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

在线全文

请选择保存的检索档案： 新增检索档案 确定 取消

请选择收藏分类： 新增自定义分类 确定 取消

通借通还

建议与咨询留下您的常用邮箱和电话号码，以便我们向您反馈解决方案和替代方法

请选择保存的检索档案：

请选择收藏分类：