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“With This Disease, You Take Whatever Chances There Are”—A Study on Socio-Cultural and Psychological Aspects of Experiments Regarding Huntington’s Disease

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Open Journal of Medical Psychology 2016年第4期5卷 72-87页

作者： susanne Lundin Eva Torkelson Marsanna Petersen Department of Arts and Cultural Sciences Lund University Lund Sweden Stellenbosch Institute for Advanced Studies (STIAS) Wallenberg Research Centre at Stellenbosch University Stellenbosch South Africa Department of Psychology Lund University Lund Sweden

Although relatively rare, Huntington’s disease (HD) has fatal consequences. There is no cure for the disease, which leads to an early death. Worldwide, scientists are trying to develop therapeutic methods that could cure the disease, including new molecular gene therapeutic methods. At Lund University, research on HD is now about to step from animal models to trials with humans. The project is special in its design since it involves both medical studies and socio-cultural and psychological research to explore and meet the many challenges that experimental trials with HD patients give rise to. The aim of the present study was to investigate the viewpoints of individuals affected by HD on the issues of participation and exerting influence if taking part in a medical study on gene therapy that has not previously been tested on humans. A total of 16 participants, recruited through the national association for HD and through the neurological clinic at Lund University in Sweden, took part in a focus group or in a survey study. A thematic analysis, to explore the transcribed text from the focus groups as well as from the written mail responses, was conducted by means of Nvivo, a program for qualitative data analysis. Results showed three main themes expressing reasons for participation: participation as a last resort, as an activity of hope, and as a way to take responsibility for the development of a cure that will benefit future generations. The responses relating to the question about affected individuals’ view of exerting influence resulted in two themes. The first theme was having a voice when researchers design experiments, which may give a sense of receiving respect. The second was that influence is an essential part of the information process before agreeing to take part in an experimental trail.

关键词： Huntington’s Disease Participation in Clinical Trials Influence Focus Groups Coping

A fossil-calibrated relaxed clock for Ephedra indicates an Oligocene age for the divergence of Asian and New World clades and Miocene dispersal into South America

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Journal of Systematics and Evolution 2009年第5期47卷 444-456页

作者： Stefanie M.ICKERT-BOND Catarina RYDIN susanne S.RENNER University of Alaska UA Museum of the North Herbarium and Institute of Arctic Biology Institute of Systematic Botany University of Zurich University of Munich Systematic Botany and Mycology

Ephedra comprises approximately 50 species,which are roughly equally distributed between the Old and New World deserts,but not in the intervening regions(amphitropical range).Great heterogeneity in the substitution rates of Gnetales(Ephedra,Gnetum,and Welwitschia) has made it difficult to infer the ages of the major divergence events in Ephedra,such as the timing of the Beringian disjunction in the genus and the entry into South ***,we use data from as many Gnetales species and genes as available from GenBank and from a recent study to investigate the timing of the major divergence *** of the tradeoff between the amount of missing data and taxon/gene sampling,we reduced the initial matrix of 265 accessions and 12 loci to 95 accessions and 10 loci,and further to 42 species(and 7736 aligned nucleotides) to achieve stationary distributions in the Bayesian molecular clock *** from a relaxed clock with an uncorrelated rates model and fossil-based calibration reveal that New World species are monophyletic and diverged from their mostly Asian sister clade some 30 mya,fitting with many other Beringian *** split between the single North American and the single South American clade occurred approximately 25 mya,well before the closure of the Panamanian ***,the biogeographic history of Ephedra appears dominated by long-distance dispersal,but finer-scale studies are needed to test this hypothesis.

关键词： biogeography Ephedra relaxed molecular clock dating uncorrelated rates model.

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神经重症监护中的预后预测与共同决策

英国医学杂志中文版 2022年第12期25卷 712-720页

作者： Kelsey Goostrey susanne Muehlschlegel 莫云凌(译) Department of neurology University of Massachusetts Chan Medical SchoolWorcesterMAUSA Department of anesthesiology/critical care University of Massachusetts Chan Medical SchoolWorcesterMAUSA Department of surgery University of Massachusetts Chan Medical SchoolWorcesterMAUSA 航空医学研究所附属医院

神经重症监护病房(NICU)中的预后预测至关重要。急性重症脑损伤(SABI)患者由于损伤自身表现或者镇静的需要无法做出自己的决定。代理决策者通常是患者的家属,必须代表患者做出决定。然而,由于SABI的突发性和意外性,很多人对自己作为代... 详细信息

神经重症监护病房(NICU)中的预后预测至关重要。急性重症脑损伤(SABI)患者由于损伤自身表现或者镇静的需要无法做出自己的决定。代理决策者通常是患者的家属,必须代表患者做出决定。然而,由于SABI的突发性和意外性,很多人对自己作为代理人的角色毫无准备。这些代理人往往需要依赖NICU的临床医生为其提供疾病的转归(预后),据此做出替代判断,并代表患者决定治疗强度和监护目标。因此,怎样得出预后评估并与家属进行沟通显得极为重要。NICU的预后预测在不同的临床医生和机构之间差异很大,目前缺乏相应的循证指南。共同决策(SDM)是指代理人和临床医生根据患者的价值观、偏好一起做出个性化的决策,它被认为是改善临床医生和患者家属沟通情况的一个机会,能够确保患者得到他们自己愿意选择的治疗决定。本综述根据相关研究和专家意见,概述了NICU中预后预测的重要性及其当前面临的挑战,简要说明了预后预测和SDM是如何相互交叉相互影响的。

关键词：临床医生预后预测神经重症监护病房循证指南重症脑损伤共同决策 NICU 治疗强度

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气候变化传播:历史、挑战、进程和发展方向

东岳论丛 2013年第10期34卷 15-23页

作者： susanne Moser 赖晨希 susanne Moser Research & Consulting Santa Cruz CA U. S. 英国伦敦政治经济学院

20世纪80年代中后期,人为气候变化出现在公共议程中,气候变化传播开始得到广泛关注。本文梳理了有效气候传播的已有认知、假定及尚未厘清的问题,回顾了气候传播的历史,进而讨论了面临的挑战,如不可见的起因、远隔性的影响、缺乏对影响... 详细信息

20世纪80年代中后期,人为气候变化出现在公共议程中,气候变化传播开始得到广泛关注。本文梳理了有效气候传播的已有认知、假定及尚未厘清的问题,回顾了气候传播的历史,进而讨论了面临的挑战,如不可见的起因、远隔性的影响、缺乏对影响的直观感受、缺少采取减缓行动的动力、怀疑人类活动的全球性影响、气候变化的复杂性和不确定性、要做出改变的迹象不够充分、知觉局限及利己主义等。本文重点关注传播进程中的关键要素,如目的、传播范围、受众、框架、信息、传播者、传播模式和渠道、对结果和传播有效性的评估等。这些要素和一些影响传播进程的语境因素息息相关。最后本文对气候传播研究的发展方向提出了建议。

关键词：气候变化传播发展历史挑战关键要素影响因素发展方向

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The Graded Inclusion of Algae (<i>Spirulina platensis</i>) or Insect (<i>Hermetia illucens</i>) Meal as a Soybean Meal Substitute in Meat Type Chicken Diets Impacts on Growth, Nutrient Deposition and Dietary Protein Quality Depending on the Extent of Amino Acid Supplementation

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Open Journal of Animal Sciences 2018年第2期8卷 163-183页

作者： Carmen Neumann susanne Velten Frank Liebert Department of Animal Sciences Division Animal Nutrition PhysiologyGeorg-August-University of GoettingenGoettingenGermany

Three consecutive growth experiments were conducted to evaluate growth performance, whole body analyses and protein quality parameters from chicken diets with 50%, 75% and 100% substitution of soybean meal (SBM) by Spirulina meal (SM) or partly defatted Hermetia meal (HM). Each of the experiments was divided into a starter period (1 - 21 d) and a grower period (22 - 34 d). One-day-old male growing chickens (Ross 308) were randomly allotted to 48 floor pens making use of 6 birds/pen (Exp.1) or 7 birds/pen (Exp. 2, 3), and the experiments included a control diet (n = 12) and four experimental diets (n = 9). Experiment 1 examined a 50 % replacement of SBM by the alternative proteins under study, both on a basic and an advanced level of amino acid (AA) fortification to meet the recommended ideal amino acid ratio (IAAR). In experiment 2, 75% (starter diet) and 50% (grower diet) replacement of SBM was investigated. Experiment 3 investigated the effects of complete SBM substitution by SM or HM in starter and grower diets. In the second and third experiment diets with both of the alternative proteins and the control diet were AA supplemented to meet the current IAAR. In a further step, the calculated first limiting AA (LAA) was reduced to 80% of its requirement recommendation to allow for further evaluation of the individual AA efficiency according to the “Goettingen approach”. Different levels (50%, 75%, or 100%) of replacing SBM by HM or SM in chicken diets depressed dietary protein quality (p 0.001) and zoo-technical parameters (p 0.001) with only a basic level of AA supplementation. This effect was much more pronounced in diets with SM. However, with an extended level of dietary AA supplementation zoo-technical parameters (p 0.001), crude protein deposition (p 0.001) and protein quality parameters (p 0.001) were significantly improved. HM diets with an advanced level of AA tended to provide higher dietary protein quality and growth performance as compared to all SBM rep

关键词： Growing Chickens Amino Acids N Utilization Model Growth Performance Body Analyses Alternative Proteins Feed Protein Quality

Subjective and Objective Results of Native Anterior Vaginal Wall Repair in Local Anesthesia:A 10-Year Follow-Up

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Open Journal of Obstetrics and Gynecology 2015年第13期5卷 762-767页

作者： Cecilie Hestbech Lundorff Marianne Glavind-Kristensen susanne Maigaard Axelsen Karl Moller Bek susanne Greisen Aarhus University Hospital AarhusDenmark Department of Obstetrics and Gynecology Pelvic Floor UnitAarhus University HospitalAarhusDenmark

Introduction and Hypothesis: This follow-up study evaluates long-term subjective and objective outcome of native tissue anterior vaginal wall repair using local anesthesia. Methods: 72 women were operated. At 10-year follow-up anatomical results were evaluated by clinical examination. Furthermore, the women filled in a validated symptom and quality of life questionnaire. Results: Forty women (56%) completed the 10-year follow-up. Eighteen women (25%) had died within the ten-year follow-up period and fourteen women (19%) were lost to follow-up. Six (15%) of the women who came for follow-up had been reoperated for anterior vaginal wall prolapse within the 10-year follow-up period and were analysed as a separate group. Of the 40 women who came for the 10-year clinical examination none had stage 0 pelvic organ prolapse. Twenty (50%) women had stage 1, whereas, 13 (32%) had stage 2 and 1 (3%) had stage 3 pelvic organ prolapse. Ten years after surgery, 28 women (70%) had no bulge symptoms. Six (15%) of the women experienced bulge symptoms at the time of follow-up. Ten years postoperatively, 30 (75%) of the women in an overall quality of life assessment considered their condition improved after surgery. Conclusion: At 10-year follow-up 70% of women were relieved from their bulge symptoms and 75% still considered themselves better or much better than before the operation. However, 15% of women had been reoperated and 15% still experienced bulge symptoms.

关键词： Colporrhaphy Cystocele Long-Term Follow-Up Reoperation Rate Vaginal Wall Prolapse

Selecting incision-dominant cases for robotic liver resection:towards outpatient hepatectomy with rapid recovery

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Hepatobiliary Surgery and Nutrition 2018年第2期7卷 77-84页

作者： Laleh G.Melstrom susanne G.Warner Yanghee Woo Virginia Sun Byrne Lee Gagandeep Singh Yuman Fong Department of Surgery City of Hope Medical CenterDuarteCAUSA

Background:The premise of minimally invasive surgery(MIS)is to minimize facial and muscle injury in order to enhance recovery from *** MIS surgery for resection of tumors in solid organs is gaining traction,though clear superiority of this approach is lacking and robotic surgery is more *** philosophy in robotically-assisted hepatectomy has been to employ this approach for cases where location of tumors make difficult a classical laparoscopic approach(superior/posterior tumors),and cases where the incision for an open operation dominates the course of ***:This is a retrospective review of a prospectively collected ***:In this study we report 97 cases of liver resection subjected to the robotic approach,of which 90%were resected *** mean operative time was 186±9 min;mean blood loss was 111±15 mL,and complications occurred in 9%.Two thirds of the patients remained in hospital 3 days or less,including three patients subjected to hemihepatectomy(2 left and 1 right).Fourteen individuals were discharged on the same *** strongest predictors of long hospital stay(>3 days)were major hepatectomy(P=0.007),complications(P=0.008),and operative time>210 min(P=0.001).Conclusions:With thoughtful case selection,this is a first demonstration that hepatectomy can be conducted as an out-patient or short-stay procedure.

关键词： Adoption of minimally invasive surgery(MIS) enhanced recovery after surgery(ERAS) robotic MIS hepatectomy surgical outcome

Right and Wrong in Information Retrieval： Information Literacy and Ethics

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通讯和计算机（中英文版） 2010年第6期7卷 54-62页

作者： Olli Makinen Marja Mikola susanne Holmlund Turku University of Applied Sciences Joukahaisenkatu 3 A Turku FI-20520 Finland Vaasa City Library Vaasa FI-65101 Finland The Tritonia Academic Library Vaasa FI-65101 Finland

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风险管理纳入可持续旅游研究

旅游学刊 2014年第3期29卷 4-6页

作者： susanne Becken 陈洁 Griffith Institute for Tourism Griffith University

引言可持续旅游研究通常关注旅游业对环境、经济、社会和文化等方面的影响。它涉及的学科范围很广泛，包括地理学、生态学、人类学、社会学、经济学、政治科学和商业管理研究。目前，在英文学术期刊和其他语种学术期刊，包括中文期刊... 详细信息

引言可持续旅游研究通常关注旅游业对环境、经济、社会和文化等方面的影响。它涉及的学科范围很广泛，包括地理学、生态学、人类学、社会学、经济学、政治科学和商业管理研究。目前，在英文学术期刊和其他语种学术期刊，包括中文期刊（《旅游学刊》）都刊登了大量可持续旅游研究方面的学术论文。

关键词：旅游研究风险管理英文学术期刊《旅游学刊》管理研究政治科学学术论文中文期刊

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