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Associations of accelerometry-measured and self-reported physical activity and sedentary behavior with skeletal muscle energetics:The study of Muscle,Mobility and Aging(sOMMA)

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Journal of sport and Health science 2024年第5期13卷 621-630页

作者： Yujia(susanna)Qiao Terri L.Blackwell Peggy M.Cawthon Paul M.Coen steven R.Cummings Giovanna Distefano samaneh Farsijani Daniel E.Forman Bret H.Goodpaster stephen B.Kritchevsky Theresa Mau Frederico G.s.Toledo Anne B.Newman Nancy W.Glynn Department of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA san Francisco Coordinating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Department of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Translational Research Institute AdventHealthOrlandoFL 32804USA Department of Medicine(Geriatrics and Cardiology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Department of Internal Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocrinology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Background:skeletal muscle energetics decline with age,and physical activity(PA)has been shown to offset these declines in older ***,many studies reporting these effects were based on self-reported PA or structured exercise ***,we examined the associations of accelerometry-measured and self-reported PA and sedentary behavior(sB)with skeletal muscle energetics and explored the extent to which PA and sedentary behavior would attenuate the associations of age with muscle ***:As part of the study of Muscle,Mobility and Aging,enrolled older adults(n=879),810(age=76.4±5.0 years old,mean±sD;58%women)had maximal muscle oxidative capacity measured ex vivo via high-resolution re spirometry of permeabilized myofibers(maximal oxidative phosphorylation(maxOXPHOs))and in vivo by ^(31)phosphorus magnetic resonance spectroscopy(maximal adenosine triphosphate(ATP_(max))).Accelerometry-measured sedentary behavior,light activity,and moderate-to-vigorous PA(MVPA)were assessed us.ng a wrist-worn ActiGraph GT9X over 7 ***-reported sedentary behavior,MVPA,and all PA were assessed with the Community Healthy Activities Model Program for seniors(CHAMPs)*** regression models with progressive covariate adjustments evaluated the associations of sedentary behavior and PA with muscle energetics,as well as the attenuation of the age/muscle energetics association by MVP A and sedentary *** a sensitivity analysis,we also examined activPAL-measured daily step count and time spent in sedentary behavior and their associations with muscle ***:Every 30 min/day more of ActiGraph-measured MVPA was associated with 0.65 pmol/(s×mg)higher maxOXPHOs and 0.012 mM/s higher ATP_(max)after adjusting for age,site/technician,and sex(ps not associated with maxOXPHOs or ATP_(max).Meanwhile,every 30 min/day spent in ActiGraph-measured sedentary behavior was associated with 0.39 pmol/s×mg lower maxOXPHOs and0.

关键词： Aging Exercise Mitochondria

Identification of Pu and U isotopic composition and its applications in environmental and CBRN research

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Defence Technology（防务技术） 2021年第3期17卷 728-740页

作者： susanna salminen-Paatero Paula Vanninen Jussi Paatero Department of Chemistry RadiochemistryP.O.Box 55FI-00014University of HelsinkiFinland VERIFIN-Finnish Institute for the Verification of the Chemical Weapons Convention Department of ChemistryP.O.Box 55FI-00014University of HelsinkiFinland Finnish Meteorological Institute Observation ServicesP.O.Box 503FI-00101HelsinkiFinland

This paper describes the most common presently used methods for detecting uranium and plutonium isotopes after their introduction to environment. Known isotope ratios of U and Pu in different nuclear events are important tool for characterizing the sources of nuclear material. Detection techniques both in field and in laboratory are presented, as well as different models that can be used for identifying the origin and age of the nuclear material. Identification of the source of nuclear material in environmental samples is needed for estimating the quality and quantity of the nuclear hazard. This information is essential in risk assessment and crisis management, in chemical, biological, radiological and nuclear(CBRN) research after e.g. a terrorist attack, in radioecology and environmental radioactivity research.

关键词： CBRN Nuclear contamination Plutonium isotope ratios Uranium isotope ratios Nuclear fingerprinting Nuclear particle

Insights from human sleep research on neural mechanisms of Alzheimer’s disease

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Neural Regeneration Research 2020年第7期15卷 1251-1252页

作者： susanna Cordone Luigi De Gennaro Department of Psychology University of Rome"Sapienza"RomeItaly IRCCs Fondazione santa Lucia RomeItaly

Alzheimer's disease(AD)is considered as the major cause of dementia and affects about 50 million people in world population,with an expected increase of 27%in the coming decades,as reported by the most recent AD *** fast-growing empirical evidence is highlighting the close relationship between sleep and AD since the preclinical stage of the disease,pointing to an important role of sleep in the occurrence and progression of AD.

关键词： sleep Alzheimer clinical

Neuroglobin and neuroprotection:the role of natural and synthetic compounds in neuroglobin pharmacological induction

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Neural Regeneration Research 2021年第12期16卷 2353-2358页

作者： Lidia Ciccone susanna Nencetti simone socci Elisabetta Orlandini Department of Pharmacy University of PisaPisaItaly Department of Earth sciences University of PisaPisaItaly Research Center“E.Piaggio ”University of PisaPisaItaly

Neuroglobin(ngb)is a 17 kDa monomeric hexa-coordinated heme protein belonging to the globin *** is mainly expressed in neurons of the central and peripheral nervous system,although moderate levels of ngb have been detected in non-nervous *** the past decade,ngb has been studied for its neuroprotective role in a large number of neurological disorders such as Alzheimer’s disease,Huntington’s disease,brain ischemia and *** review discusses and summarizes the natural compounds and the small synthetic molecules capable of modulating ngb expression that exhibits a protective role against various neurodegenerative diseases.

关键词： Neuroglobin neuroglobin pharmacological induction neuroprotection neurodegenerative diseases natural compounds synthetic small molecules Alzheimer’s disease Huntington’s disease

PI3K/mTOR mediate mitogen-dependent HDAC1 phosphorylation in breast cancer:a novel regulation of estrogen receptor expression

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分子细胞生物学报:英文版 2015年第2期7卷 132-142页

作者： simona Citro Claudia Miccolo Laura Meloni susanna Chiocca Department of Experimental Oncology European Institute of OncologyIFOM-IEO Campusvia Adamello 1620139 MilanItaly Department for Molecular Biomedical Research Technologiepark Zwijnaarde927 VIB west9052 GhentBelgium

Histone deacetylase 1(HDAC1)is an important epigenetic controller involvedin transcriptional regulation throughmodification of chromatin *** and epigenetic changes and deregulation of signal transduction pathways have been implicated in the development of breast *** of estrogen receptor a(ERa)expression is one of the mechanisms behind the acquisition of endocrine *** and increased hormone and growth factor receptor signaling in breast cancer cells contribute to resistance to endocrine *** HDACs and the PI3K/mTOR signaling pathway are becoming promis.ng targets in breast cancer,revers.ng also acquired hormone *** we show how mitogens,activating the PI3K/mTOR pathway,trigger the phosphorylation of HDAC1 in breast cancer cells,which is completely dependent on the activity of the p70 s6 kinase(s6K1).Our findings show that s6K1,overexpressed in many breast cancers,controls HDAC1-dependent transcriptional regulation of ERa levels upon mitogenic stimuli,controlling HDAC1 recruitment to the ERa ***,cell treatment with both mTOR and HDACs inhibitors shows an additive effect in inhibiting breast cancer *** confirms the novel cross-talk between the HDAC1 and PI3K pathways with clinical implications towards the treatment of this malignant disease.

关键词： breast cancer estrogen receptor HDAC1/mTOR/PI3K/s6K1

Dynamics and self-assembly of bio-functionalized gold nanoparticles in solution： Reactive molecular dynamics simulations

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Nano Research 2018年第4期11卷 1757-1767页

作者： susanna Monti Giovanni Barcaro Luca sementa Vincenzo Carravetta Hans Agren CNR-ICCOM Institute of Chemistry of Organometallic Compounds Pisa 56124 Italy KTH Royal Institute of Technology School of Biotechnology Division of Theoretical Chemistry and Biology Stockholm S- 10691 Sweden CNR-IPCF Institute of Chemical and Physical Processes Pisa 56124 Italy Institute of Nanotechnology Spectroscopy and Quantum Chemistry Siberian Federal University Svobodny pr. 79 660041 Krasnoyarsk Russia

The self-assembling properties, stability, and dynamics of hybrid nanocarriers （gold nanoparticles （AuNPs） functionalized with cysteine-based peptides） in solution are studied through a series of classical molecular dynamics simulations based on a recently parametrized reactive force field. The results reveal, at the atomic level, all the details regarding the peptide adsorption mechanisms, nanoparticle stabilization, aggregation, and sintering. The data confirm and explain the experimental findings and disclose aspects that cannot be scrutinized by experiments. The biomolecules are both chemisorbed and physisorbed; self-interactions of the adsorbates and formation of stable networks of inter- connected molecules on the AuNP surfaces limit substrate reconstructions, protect the AuNPs from the action of the solvent, and prevent direct interactions of the gold surfaces. The possibility of agglomeration of the functionalized nanoparticles, compared with the sintering of the bare supports in a water solution, is demonstrated through relatively long simulations and fast steered dynamics. The analysis of the trajectories reveals that the AuNPs were well stabilized by the peptides. This prevented particle sintering and kept the particles far apart; however, part of their chains could form interconnections （crosslinks） between neighboring gold vehicles. The excellent agreement of these results with the literature confirm the reliability of the method and its potential application to the modeling of more complex materials relevant to the biomedical sector.

关键词： nanoparticle ReaxFF functionalization cross-linking biocompatibility

Prevention of vertical transmission of hepatitis B virus infection

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World Journal of Gastroenterology 2021年第26期27卷 4182-4193页

作者： Piero Veronese Icilio Dodi susanna Esposito Giuseppe Indolfi Department of Medicine and surgery University of ParmaParma 43121Italy Department of Pediatrics Pietro Barilla Children's HospitalParma 43121Italy Department Neurofarba University of FlorenceFlorence 50129Italy Department Neurofarba Meyer Children's University HospitalFlorence 50129Italy

Hepatitis B virus(HBV)is the leading cause of chronic viral ***,almost two million children younger than 5 years acquire the infection,mostly through vertical or horizontal transmission in early *** transmission of HBV is a high efficacy phenomenon ranging,in the absence of any preventive interventions,from 70%to 90%for hepatitis e antigen positive mothers and from 10%to 40%for hepatitis e antigen-negative *** viraemia is a preeminent risk factor for vertical transmission of *** screening is the first step to prevent vertical transmission of *** B passive and active immunoprophylaxis at birth together with antiviral treatment of highly viraemic mothers are the key strategies for global elimination of HBV *** are needed to promote implementation of birth-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countries where the prevalence of the infection is at the highest.

关键词： Hepatitis B Vertical transmission Hepatitis B vaccine Hepatitis B immune globulin Neonatal immunoprophylaxis Tenofovir alafenamide fumarate

Application of PROTAC strategy to TTR-Aβ protein-protein interaction for the development of Alzheimer's disease drugs

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Neural Regeneration Research 2021年第8期16卷 1554-1555页

作者： NicolóTonali susanna Nencetti Elisabetta Orlandini Lidia Ciccone Université Paris-saclay CNRSBioCISChâtenay-MalabryFrance Department of Pharmacy University of PisaPisaItaly Department of Earth sciences Research Center“E.Piaggio”University of PisaPisaItaly

Alzheimer's disease(AD) is a complex and multifaced neurodegenerative disorder for which the precise pathological molecular mechanisms are still not completely known. In last years, rational multi-target drug design methods, which combine multiple molecules having complementary modes of action, have been increas.ngly used in the development of anti-AD drugs.

关键词： drugs Alzheimer Aβ

PLA2G7: a new player in shaping energy metabolism and lifespan

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signal Transduction and Targeted Therapy 2022年第7期7卷 2128-2129页

作者： Lena susanna Candels svea Becker Christian Trautwein Department of Medicine III University Hospital RWTH AachenAachenGermany

In a recent study published in science,spadaro and colleagues described the downregulation of PLA2G7 through sustained calory restriction as a crucial factor for lowering inflammatory mechanisms and contributing to ***2G7’s identification as a critical regulatory gene is important to better understand the role of adipose tissue metabolism in regulating immune-metabolic *** data show that long-term calorie restriction(CR)improves health and extends life expectancy.1 Chronic 40%CR increases susceptibility to infections in mice,shortening their *** contrast,the Comprehensive Assessment of Long-Term Effects of Reducing Intake of Energy(CALERIE)analysis found that moderate CR in humans over 24 months did not reduce immune functions.14%sustained CR was associated with improved adipose tissue metabolism,decreased inflammation,and reduced thymic *** et *** that low platelet activating factor acetyl hydrolase(PLA2G7)correlates with immune-metabolic consequences of CR and contributes to decreased inflammation and a longer lifespan in healthy mid-aged adults.1 PLA2G7 is a lipoprotein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism during inflammatory and oxidative stress responses.

关键词： metabolism sustained PLA2