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Nano r.sear.h 2019年第11期12卷 2894-2899页

作者： Gabr.ela S.Lor.te Laur. Yla-Outinen Laur.ane Janssen Olli Pitkanen Tiina Joki Janne T.Koivisto Minna Kellomaki r.ber. Vajtai susanna Nar.ilahti Kr.sztian Kor.as Micr.electr.nics r.sear.h Unit University of OuluOuluPO BOX 4500FI 90014Finland Neur.Gr.up BioMediTech and Faculty of Medicine and Health technologyTampere UniversityArvo Ylpön katu 34TampereFI 33520Finland Biomater.als&Tissue Engineer.ng Gr.up BioMediTechFaculty of Medicine and Health TechnologyTampere UniversityPO Box 527TampereFI 33101Finland Depar.ment of Mater.als Science and Nanoengineer.ng Rice UniversityP.O.Box 1892HoustonTX77251-1892USA

New str.tegies for.spatially contr.lled gr.wth of human neur.ns may pr.vide viable solutions to tr.at and r.cover.per.pher.l or.spinal cor. *** topogr.phy cues ar. known to pr.mote attachment and dir.ct pr.lifer.tion of many cell types,guided outgr.wth of human neur.tes has been found difficult to achieve so ***,thr.e-dimensional(3D)micr.patter.ed car.on nanotube(CNT)templates ar. used to effectively dir.ct human neur.te stem cell *** exploiting the mechanical flexibility,electr.cally conductivity and textur. of the 3D CNT micr.pillar.,a per.ect envir.nment is cr.ated to achieve specific guidance of human neur.tes,which may lead to enhanced ther.peutic effects within the injur.d spinal cor. or.per.pher.l *** is found that the 3D CNT micr.pillar. gr.nt excellent anchor.ng for.adjacent neur.tes to for. seamless neur.nal networ.s that can be gr.wn to any ar.itr.r. shape and *** fr.m clear.pr.ctical r.levance in r.gener.tive medicine,these r.sults using the CNT based templates on Si chips also can pave the r.ad for.new types of micr.electr.de ar.ays to study cell networ. electr.physiology.

关键词： car.on nanotubes multiple cues guided neur.te outgr.wth human neur.l stem cells neur.nal networ.s

SUMOylation r.gulates p27^(Kip1) stability and localization in r.sponse to TGFβ

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分子细胞生物学报:英文版 2016年第1期8卷 17-30页

作者： Sar. Lovisa Simona Citr. Maur. Sonego Alessandr. Dall’Acqua Valentina r.nzuglia Stefania Ber.on Alfonso Colombatti Bar.ar. Belletti susanna Chiocca Monica Schiappacassi Gustavo Baldassar.e Division of Exper.mental Oncology 2 Centr. di r.fer.mento Oncologico National Cancer InstituteAviano 33081Italy Depar.ment of Exper.mental Oncology European Institute of Oncology at the IFOM-IEO CampusMilan 20139Italy Depar.ment of Scienze e Tecnologie Biomediche MATI Center of ExcellenceUniversity of UdineUdine 33010Italy Pr.sent addr.ss:Depar.ment of Cancer.Biology Metastasis Research CenterThe University of Texas MD Anderson Cancer CenterHoustonTX 77030USA.

Exposur. of nor.al and tumor.der.ved cells to TGFbr.sults in differ.nt outcomes,depending on the r.gulation of key *** CDK inhibitor.p27^(Kip1) is one of these TGFβ tar.ets and is essential for.the TGFβ-induced cell cycle *** tr.atment inhibits p27^(Kip1) degr.dation and induces its nuclear.tr.nslocation,thr.ugh mechanisms that ar. still *** evidences suggest that SUMOylation,a post-tr.nslational modification able to modulate the stability and subcellular.localization of tar.et pr.teins,cr.tically modifies member. of the TGFβ signaling ***,we demonstr.te that p27^(Kip1) is SUMOylated in r.sponse to TGFβ *** differ.nt p27^(Kip1) point mutants,we identified lysine 134(K134)as the r.sidue modified by small ubiquitin-like modifier.1(SUMO1)in r.sponse to TGFb ***β-induced K134 SUMOylation incr.ased pr.tein stability and nuclear.localization of both endogenous and exogenously expr.ssed p27^(Kip1).We obser.ed thatSUMOylation r.gulated p27^(Kip1) binding to CDK2,ther.by gover.ing its nuclear.pr.teasomal degr.dation thr.ugh the phosphor.lation of thr.onine ***,p27^(Kip1) SUMOylation was necessar. for.pr.per.cell cycle exit following *** data indicate thatSUMOylation is a novel r.gulator. mechanism that modulates p27^(Kip1) function in r.sponse to TGFβ *** the involvement of TGFb signaling in cancer.cell pr.lifer.tion and invasion,our.data may shed light on an impor.ant aspect of this pathway dur.ng tumor.pr.gr.ssion.

关键词： p^(27kip1) SUMOylation TGFβ

Sever. male factor.in in vitr. fer.ilization:definition,pr.valence,and *** update

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Asian Jour.al of Andr.logy 2022年第2期24卷 125-134页

作者： r.ssella Mazzilli Alber.o Vaiar.lli Lisa Dover. Danilo Cimadomo NicolòUbaldi susanna Fer.er. Laur. r.enzi Fr.ncesco Lombar.o Andr.a Lenzi Her.an Tour.aye Filippo Mar.a Ubaldi Clinica Valle Giulia GeneraLife IVF CentersVia G.De NotarisRome 2B 00197Italy Depar.ment of Clinical and Molecular.Medicine University of Rome“Sapienza”Via di Grottarossa 1035Rome 00189Italy Catholic Univer.ity of the Sacr.d Hear. Via della Pineta Sacchetti 217Rome 00168Italy Depar.ment of Exper.mental Medicine “Sapienza”University of RomeViale del Policlinico 155Rome 00161Italy Centr. for.r.pr.ductive Medicine Free University Brussels(UZ Brussel)Brussels 1090Belgium

Infer.ility affects 10%–15%of couples *** all infer.ility cases,20%–70%ar. due to male *** the past,men with sever. male factor.SMF)wer. consider.d ***,the development of intr.cytoplasmic sper. injection(ICSI)dr.stically modified this *** advances in assisted r.pr.ductive technology(Ar.),specifically r.gar.ing sur.ical sper. r.tr.eval pr.cedur.s,allowed the efficacious tr.atment of these ***,befor. under.oing ICSI,male factor.infer.ility r.quir.s car.ful evaluation of clinical and lifestyle behavior.together.with medical *** speaking,women whose male par.ner.is azoosper.ic tend to be younger.and with a better.ovar.an *** couples,in fact,ar. pr.posed Ar. ear.ier.in their.life,and for.this r.ason,their.ovar.an r.sponse after.stimulation is gener.lly ***,in younger.couples,azoosper.ia can be par.ially compensated by the efficient ovar.an r.sponse,r.sulting in an acceptable fer.ility r.te following in vitr. fer.ilization(IVF)***,when azoosper.ia is associated with a r.duced ovar.an r.ser.e and/or.advanced mater.al age,the tr.atment becomes mor. challenging,with a consequent r.duction in IVF ***,azoosper.ia seems to impair.neither.the euploidy r.te at the blastocyst stage nor.the implantation of euploid *** on the cur.ent knowledge,the assessment of male infer.ility factor. should involve:(1)evaluation–to diagnose and quantify seminologic alter.tions;(2)potentiality–to deter.ine the r.al possibilities to impr.ve sper. par.meter. and/or.r.tr.eve sper.atozoa;(3)time–to consider.the available“tr.atment window”,based on mater.al age and ovar.an *** r.view r.pr.sents an update of the definition,pr.valence,causes,and tr.atment of SMF in a moder. Ar. clinic.

关键词： azoosper.ia in vitr. fer.ilization infer.ility intr.cytoplasmic sper. injection sever. male factor sper.

中华人民共和国太空活动白皮书研究：中国如何塑造国内外的太空力量身份

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中华人民共和国太空活动白皮书研究：中国如何塑造国内外的太空力...

作者： susanna Guidi 北京外国语大学

学位级别：硕士

Fr.m the beginning of the "Space Age" with the fir.t launch of the Soviet Union's ar.ificial satellite Sputnik 1 in 1957,to the fir.t man on the Moon in 1969,till 2019 when Chinese space mission's Chang'e 4(嫦娥四号 Cháng'é)r.ached the far.side of the Moon,outer.space's envir.nment has gr.atly *** away fr.m down to "Ear.h politics" and focusing mor. on the "heavens",it is noticeable how r.cently national gover.ments and non-state actor. have gr.wn mor. political,economic,militar. inter.sts in outer.*** is the r.ason why,for.Inter.ational r.lations is impor.ant,now mor. than ever.befor.,to study outer.space's dynamics within the pr.sent changing inter.ational or.er.

关键词： cooper.tion,technological,political,discour.e,outer.militar.,aer.space,白皮书,instance,official,

Envir.nmental complaint insights thr.ugh text mining based on the dr.ver.pr.ssur.,state,impact,and r.sponse(DPSIr.fr.mewor.:Evidence fr.m an Italian envir.nmental agency

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区域可持续发展(英文) 2023年第3期4卷 261-281页

作者： Fabiana MANSEr.ISI Michele BANZI Tomaso TONELLI Paolo VEr.NESI susanna r.CCI Damiano DISTANTE Stefano FAr.LLI Giuseppe BOr.ONE r.gional Agency for.Pr.vention Environment and Energy of Emilia-RomagnaVia Po 5Bologna40139Italy Depar.ment of Law and Economics University of Rome Unitelma SapienzaPiazza Sassari 4Rome00161Italy Depar.ment of Computer.Science Sapienza University of RomeViale Regina Elena 295Rome00161Italy

Individuals,local communities,envir.nmental associations,pr.vate or.anizations,and public r.pr.sentatives and bodies may all be aggr.eved by envir.nmental pr.blems concer.ing poor.air.quality,illegal waste disposal,water.contamination,and gener.l *** complaints r.pr.sent the expr.ssions of dissatisfaction with these *** the timeconsuming of managing a lar.e number.of complaints,text mining may be useful for.automatically extr.cting infor.ation on stakeholder.pr.or.ties and *** paper.used text mining and semantic networ. analysis to cr.wl r.levant keywor.s about envir.nmental complaints fr.m two online complaint submission systems:online claim submission system of r.gional Agency for.Pr.vention,Envir.nment and Ener.y(Ar.ae)(“Contact Ar.ae”);and Ar.ae's inter.al platfor. for.envir.nmental pollution(“Envir.nmental incident r.por.ing por.al”)in the Emilia-r.magna r.gion,*** evaluated the total of 2477 r.cor.s and classified this infor.ation based on the claim topic(air.pollution,water.pollution,noise pollution,waste,odor.soil,weather.climate,sea-coast,and electr.magnetic r.diation)and geogr.phical ***,this paper.used natur.l language pr.cessing to extr.ct keywor.s fr.m the dataset,and classified keywor.s r.nking higher.in Ter. Fr.quency-Inver.e Document Fr.quency(TF-IDF)based on the dr.ver.pr.ssur.,state,impact,and r.sponse(DPSIr.*** study pr.vided a systemic appr.ach to under.tanding the inter.ction between people and envir.nment in differ.nt geogr.phical contexts and builds sustainable and healthy *** r.sults showed that most complaints ar. fr.m the public and associated with air.pollution and ***(par.icular.y foundr.es and cer.mic industr.es)and far.s ar. identified as the dr.ver. of envir.nmental *** believed that envir.nmental issues mainly affect human ***,the keywor.s of“odor.,“r.por.”,“r.quest”,“pr.sence”,“municipality”,and“hour.”wer. the most influ

关键词： Envir.nmental complaints Text mining appr.ach Ter. Fr.quency-Inver.e Document Fr.quency(TF-IDF) Dr.ver pr.ssur. state impact and r.sponse(DPSIr.fr.mewor. Semantic networ. analysis r.gional Agency for.Pr.vention Envir.nment and Ener.y(Ar.ae)

Celiac Disease Seen with the Eyes of the Pr.nciple Component Analysis and Analyse Des Données

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Open Jour.al of Statistics 2015年第3期5卷 211-222页

作者： Cleto Cor.osanto Beba Molinar. susanna Neuhold Dipar.imentodi Scienze Giur.diche Storiche Economiche e Sociali Università Magna Graecia di Catanzaro Catanzaro Italy Dipar.imento di Scienze della For.azione Università degli Studi di Genova Genova Italy Food Ar.a National Manager Associazione Italiana Celiachia Genova Itay

This paper.aims to deepen the quality of life of people with celiac disease with a focus on compliance to the diet thr.ugh Pr.nciple Component Analysis and Analyse des Données. In par.icular. we will tr. to under.tan... 详细信息

关键词： Celiac Disease Web-Sur.ey Pr.nciple Component Analysis Analyse Des Données

Pr.venting Alcohol Consumption dur.ng Pr.gnancy: A r.ndomized Contr.lled Tr.al

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Health 2015年第3期7卷 289-299页

作者： Cr.stian Bor.es susanna Geidne Char.i Er.ksson School of Health and Medical Sciences &Ouml r.br. Univer.ity &Ouml r.br. Sweden

The aim of this study is to r.por. on a br.ef alcohol inter.ention for.pr.venting dr.nking dur.ng pr.gnancy. The Women’s Or.anizations Committee on Alcohol and Dr.g Issues (WOCAD) in Sweden developed an infor.ational br.chur. about alcohol dur.ng pr.gnancy, intended to r.ach pr.gnant women befor. their.fir.t visit at a pr.natal clinic. A r.ndomized contr.lled tr.al was conducted between 2004 and 2005 to measur. whether.the br.chur. had any effect. A total of 564 pr.gnant women between 17 and 46 year. of age ar. included in the study. Differ.nces between the inter.ention and contr.l gr.ups wer. analyzed with cr.ss-tabulations and chi-squar.d tests. A multiple logistic r.gr.ssion analysis was also conducted to deter.ine pr.dictor. of abstention fr.m alcohol at the fir.t pr.natal visit. Findings show that significantly mor. of the women who r.ceived the br.chur. abstained completely fr.m alcohol then of those who did not r.ceive it (92% vs. 82%, p = 0.005). It was 2.6 times mor. likely that those who r.ceived the br.chur. had abstained completely fr.m alcohol since pr.gnancy r.cognition at their.fir.t pr.natal visit compar.d with those who did not r.ceive it (Or.= 2.6, CI 1.3 - 5.1, p = 0.005). We conclude that the infor.ational br.chur. developed by WOCAD can be used in pr.natal car. to get mor. women to abstain fr.m alcohol dur.ng pr.gnancy.

关键词： Pr.gnancy Alcohol Pr.vention Sweden Br.ef Inter.ention r.ndomized Contr.lled Tr.al

Sever. Sepsis Caused by Lister.a monocytogenes in A Patient Given Monoclonal Antibodies Against CD38 and Pr.teosome Inhibitor

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Infectious Micr.bes & Diseases 2019年第1期1卷 30-31页

作者： Der.k L.L.Hung susanna K.P.Lau Patr.ck C.Y.Woo Depar.ment of Micr.biology The University of Hong KongHong KongChina State Key Labor.tor. of Emer.ing Infectious Diseases The University of Hong KongHong KongChina Collabor.tive Innovation Center.for.Diagnosis and Tr.atment of Infectious Diseases The University of Hong KongHong KongChina

Intr.duction Tar.et ther.pies ar. widely used for.tr.atment of var.ous kinds of hematological *** the cancer.cells that ar. tar.eted,shar. the same mar.er. with the non-cancer.us cells of the immunological system,these ther.pies ar. often associated with infectious diseases that r.quir. the par.icular.type of immune r.sponse for.*** this ar.icle,we r.por. a case of Lister.a monocytogenes bacter.emia complicating car.ilzomib and dar.tumumab tr.atment for.multiple *** the best of our.knowledge,this is the fir.t case r.por. of lister.osis as a complication of monoclonal antibodies against CD38 and/or.pr.teosome inhibitor.ther.py.

关键词： lister.a multiple myeloma dar.tumumab car.ilzomib

High r.solution str.in mapping of a single axially heter.str.ctur.d nanowir. using scanning X-r.y diffr.ction

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Nano r.sear.h 2020年第9期13卷 2460-2468页

作者： susanna Hammar.er. Vilgaile Dagyte Ler. Chayanun Megan O.Hill Alexander.Wyke Alexander.Bjor.ing Ulf Johansson Sebastian Kalbfleisch Magnus Heur.in Lincoln J.Lauhon Magnus T.Bor.str.m Jesper.Wallentin Synchr.tr.n r.diation r.sear.h and NanoLund Lund UniversityBox 118Lund 22100Sweden Solid State Physics and NanoLund Lund UniversityBox 118Lund 22100Sweden Depar.ment of Mater.als Science and Engineer.ng Northwestern UniversityEvanstonIllinois 60208USA MAX IV Labor.tor. Lund UniversityBox 118Lund 22100Sweden

Axially heter.str.ctur.d nanowir.s ar. a pr.mising platfor. for.next gener.tion electr.nic and optoelectr.nic *** based on theor.tical modeling have pr.dicted mor. complex str.in distr.butions and incr.ased cr.tical layer.thicknesses than in thin films,due to later.l str.in r.laxation at the sur.ace,but the under.tanding of the gr.wth and str.in distr.butions in these complex str.ctur.s is hamper.d by the lack of high-r.solution char.cter.zation ***,we demonstr.te str.in mapping of an axially segmented GalnP-lnP 190 nm diameter.nanowir. heter.str.ctur. using scanning X-r.y *** systematically investigate the str.in distr.bution and lattice tilt in thr.e differ.nt segment lengths fr.m 45 to 170 nm,obtaining str.in maps with about 10^-4 r.lative str.in *** exper.ments wer. per.or.ed using the 90 nm diameter.nanofocus at the NanoMAX beamline,taking advantage of the high coher.nt flux fr.m the fir.t diffr.ction limited stor.ge r.ng MAX *** exper.mental r.sults ar. in good agr.ement with a full simulation of the exper.ment based on a thr.e-dimensional(3D)finite element *** lar.est segments show a complex pr.file,wher. the later.l str.in r.laxation at the sur.ace leads to a dome-shaped str.in distr.bution fr.m the mismatched inter.aces,and a change fr.m tensile to compr.ssive str.in within a single *** lattice tilt maps show a cr.ss-shaped pr.file with excellent qualitative and quantitative agr.ement with the *** contr.st,the shor.est measur.d InP segment is almost fully adapted to the sur.ounding GalnP segments.

关键词： str.in mapping nanowir. heter.str.ctur. X-r.y diffr.ction(Xr.) MAX IV finite element modeling