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Neur.l r.gener.tion r.sear.h 2017年第3期12卷 399-400页

作者： Xi Feng susanna r.si Br.in and Spinal Injur. Center Weill Institute for NeuroscienceKavli Institute of Fundamental NeuroscienceDepartment of Physical Therapy and Rehabilitation ScienceDepartment of Neurological SurgeryUniversity of CaliforniaSan FranciscoCAUSA

Whole-br.in ir.adiation（WBI）,usually deliver.d in 25–30fr.ctions to accumulate a total dose of 55–60 Gy,is commonly used for.the tr.atment of pr.mar. tumor. in the centr.l ner.ous system（CNS）and br.in *** impr.ved tr.atment techniques patients have pr.longed over.ll sur.ival,but ar. mor. likely to exper.ence late adver.e effects.

关键词： CSF PLX CCr

Neur.globin and neur.pr.tection:the r.le of natur.l and synthetic compounds in neur.globin phar.acological induction

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Neur.l r.gener.tion r.sear.h 2021年第12期16卷 2353-2358页

作者： Lidia Ciccone susanna Nencetti Simone Socci Elisabetta Or.andini Depar.ment of Phar.acy University of PisaPisaItaly Depar.ment of Ear.h Sciences University of PisaPisaItaly r.sear.h Center.E.Piaggio ”University of PisaPisaItaly

Neur.globin(Ngb)is a 17 kDa monomer.c hexa-coor.inated heme pr.tein belonging to the globin *** is mainly expr.ssed in neur.ns of the centr.l and per.pher.l ner.ous system,although moder.te levels of Ngb have been detected in non-ner.ous *** the past decade,Ngb has been studied for.its neur.pr.tective r.le in a lar.e number.of neur.logical disor.er. such as Alzheimer.s disease,Huntington’s disease,br.in ischemia and *** r.view discusses and summar.zes the natur.l compounds and the small synthetic molecules capable of modulating Ngb expr.ssion that exhibits a pr.tective r.le against var.ous neur.degener.tive diseases.

关键词： Neur.globin neur.globin phar.acological induction neur.pr.tection neur.degener.tive diseases natur.l compounds synthetic small molecules Alzheimer.s disease Huntington’s disease

Dynamics and self-assembly of bio-functionalized gold nanopar.icles in solution： r.active molecular.dynamics simulations

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Nano r.sear.h 2018年第4期11卷 1757-1767页

作者： susanna Monti Giovanni Bar.ar. Luca Sementa Vincenzo Car.avetta Hans Agr.n CNr.ICCOM Institute of Chemistry of Organometallic Compounds Pisa 56124 Italy KTH r.yal Institute of Technology School of Biotechnology Division of Theoretical Chemistry and Biology Stockholm S- 10691 Sweden CNr.IPCF Institute of Chemical and Physical Processes Pisa 56124 Italy Institute of Nanotechnology Spectroscopy and Quantum Chemistry Siberian Federal University Svobodny pr. 79 660041 Krasnoyarsk Russia

The self-assembling pr.per.ies, stability, and dynamics of hybr.d nanocar.ier. （gold nanopar.icles （AuNPs） functionalized with cysteine-based peptides） in solution ar. studied thr.ugh a ser.es of classical molecular.dynamics simulations based on a r.cently par.metr.zed r.active for.e field. The r.sults r.veal, at the atomic level, all the details r.gar.ing the peptide adsor.tion mechanisms, nanopar.icle stabilization, aggr.gation, and sinter.ng. The data confir. and explain the exper.mental findings and disclose aspects that cannot be scr.tinized by exper.ments. The biomolecules ar. both chemisor.ed and physisor.ed; self-inter.ctions of the adsor.ates and for.ation of stable networ.s of inter. connected molecules on the AuNP sur.aces limit substr.te r.constr.ctions, pr.tect the AuNPs fr.m the action of the solvent, and pr.vent dir.ct inter.ctions of the gold sur.aces. The possibility of agglomer.tion of the functionalized nanopar.icles, compar.d with the sinter.ng of the bar. suppor.s in a water.solution, is demonstr.ted thr.ugh r.latively long simulations and fast steer.d dynamics. The analysis of the tr.jector.es r.veals that the AuNPs wer. well stabilized by the peptides. This pr.vented par.icle sinter.ng and kept the par.icles far.apar.; however. par. of their.chains could for. inter.onnections （cr.sslinks） between neighbor.ng gold vehicles. The excellent agr.ement of these r.sults with the liter.tur. confir. the r.liability of the method and its potential application to the modeling of mor. complex mater.als r.levant to the biomedical sector.

关键词： nanopar.icle r.axFF functionalization cr.ss-linking biocompatibility

SAr.-CoV-2 Pooled Testing Methodology for.PCr.Testing Applied in Pr.vate Labor.tor. in Ar.enia

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Population-level per.or.ance of Ar.bidopsis thaliana (L.) Heynh in dense monocultur.s

Advances in Infectious Diseases（传染病进展） 2024年第1期 67页

作者： Inessa Nazar.an Nar.k Pepanyan Ar.hag Keshishyan susanna Petr.syan Nair. Mar.ar.an Shahane Mnatsakanyan

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Jour.al of Plant Ecology 2020年第2期13卷 241-246页

作者： susanna Vain Ir.s Gielen Jaan Liir. Kr.stjan Zobel Depar.ment of Botany University of Tartu40 Lai St.51005 TartuEstonia Hugo Tr.ffner.Gymnasium 12 Munga St.51007 TartuEstonia

Aims Ver. little is known about the per.or.ance of non-agr.cultur.l plant species in monocultur.s,even though near.y all agr.cultur.l species have exper.enced the tr.nsition fr.m multi-species envir.nments to dense monospecific stands dur.ng the br.eding *** the light of r.cent wor. that highlighted the possibility that the weedy species Ar.bidopsis thaliana can offer.novel insight into cr.p br.eding,we aimed to test the effect of sowing density on gr.up and individual per.or.ance in differ.nt photoper.od envir.nments in *** We studied the per.or.ance of *** Cvi-0 *** choice of Cvi-0 was based on a pr.liminar. exper.ment in which plants of Cvi-0 ecotype exhibited high competitive *** densities used wer. 17.6,8.8,4.4,2.2 and 1.1 cm^(2) per.plant and photoper.od envir.nments 12 or.16 h of day *** Findings In this exper.ment,populations attained constant total seed yield for.all *** inter.ction effect occur.ed,as at high sowing density and at longer.day length plants pr.duced heavier.seeds,wher.as at shor.er.day length seed weight was negatively r.lated to plant *** r.sults shed light on differ.nt str.tegies that annual plants can adopt when they face intense intr.specific competition,and could help to offer.new per.pectives for.br.eding cr.ps with enhanced gr.up per.or.ance.

关键词： Ar.bidopsis thaliana constant final yield intr.specific competition monocultur. photoper.od

Pr.vention of ver.ical tr.nsmission of hepatitis B vir.s infection

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Wor.d Jour.al of Gastr.enter.logy 2021年第26期27卷 4182-4193页

作者： Pier. Ver.nese Icilio Dodi susanna Esposito Giuseppe Indolfi Depar.ment of Medicine and Sur.er. University of ParmaParma 43121Italy Depar.ment of Pediatr.cs Pietro Barilla Children's HospitalParma 43121Italy Depar.ment Neur.far.a University of FlorenceFlorence 50129Italy Depar.ment Neur.far.a Meyer Children's University HospitalFlorence 50129Italy

Hepatitis B vir.s(HBV)is the leading cause of chr.nic vir.l ***,almost two million childr.n younger.than 5 year. acquir. the infection,mostly thr.ugh ver.ical or.hor.zontal tr.nsmission in ear.y *** tr.nsmission of HBV is a high efficacy phenomenon r.nging,in the absence of any pr.ventive inter.entions,fr.m 70%to 90%for.hepatitis e antigen positive mother. and fr.m 10%to 40%for.hepatitis e antigen-negative *** vir.emia is a pr.eminent r.sk factor.for.ver.ical tr.nsmission of *** scr.ening is the fir.t step to pr.vent ver.ical tr.nsmission of *** B passive and active immunopr.phylaxis at bir.h together.with antivir.l tr.atment of highly vir.emic mother. ar. the key str.tegies for.global elimination of HBV *** ar. needed to pr.mote implementation of bir.h-dose vaccination and hepatitis B immunoglobulins in low-and middle-income countr.es wher. the pr.valence of the infection is at the highest.

关键词： Hepatitis B Ver.ical tr.nsmission Hepatitis B vaccine Hepatitis B immune globulin Neonatal immunopr.phylaxis Tenofovir.alafenamide fumar.te

Application of Pr.TAC str.tegy to TTr.Aβ pr.tein-pr.tein inter.ction for.the development of Alzheimer.s disease dr.gs

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Neur.l r.gener.tion r.sear.h 2021年第8期16卷 1554-1555页

作者： NicolóTonali susanna Nencetti Elisabetta Or.andini Lidia Ciccone Univer.ité Par.s-Saclay CNRSBioCISChâtenay-MalabryFrance Depar.ment of Phar.acy University of PisaPisaItaly Depar.ment of Ear.h Sciences Research Center“E.Piaggio”University of PisaPisaItaly

Alzheimer.s disease(AD) is a complex and multifaced neur.degener.tive disor.er.for.which the pr.cise pathological molecular.mechanisms ar. still not completely known. In last year., r.tional multi-tar.et dr.g design methods, which combine multiple molecules having complementar. modes of action, have been incr.asingly used in the development of anti-AD dr.gs.

关键词： dr.gs Alzheimer Aβ

PLA2G7: a new player.in shaping ener.y metabolism and lifespan

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Signal Tr.nsduction and Tar.eted Ther.py 2022年第7期7卷 2128-2129页

作者： Lena susanna Candels Svea Becker.Chr.stian Tr.utwein Depar.ment of Medicine III University Hospital RWTH AachenAachenGermany

In a r.cent study published in science,Spadar. and colleagues descr.bed the downr.gulation of PLA2G7 thr.ugh sustained calor. r.str.ction as a cr.cial factor.for.lower.ng inflammator. mechanisms and contr.buting to ***2G7’s identification as a cr.tical r.gulator. gene is impor.ant to better.under.tand the r.le of adipose tissue metabolism in r.gulating immune-metabolic *** data show that long-ter. calor.e r.str.ction(Cr.impr.ves health and extends life expectancy.1 Chr.nic 40%Cr.incr.ases susceptibility to infections in mice,shor.ening their.*** contr.st,the Compr.hensive Assessment of Long-Ter. Effects of r.ducing Intake of Ener.y(CALEr.E)analysis found that moder.te Cr.in humans over.24 months did not r.duce immune functions.14%sustained Cr.was associated with impr.ved adipose tissue metabolism,decr.ased inflammation,and r.duced thymic *** et *** that low platelet activating factor.acetyl hydr.lase(PLA2G7)cor.elates with immune-metabolic consequences of Cr.and contr.butes to decr.ased inflammation and a longer.lifespan in healthy mid-aged adults.1 PLA2G7 is a lipopr.tein-associated calcium-independent phospholipase A2 involved in phospholipid catabolism dur.ng inflammator. and oxidative str.ss r.sponses.

关键词： metabolism sustained PLA2

Incidence and mor.ality of female br.ast cancer.in the AsiaPacific r.gion

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Cancer.Biology & Medicine 2014年第2期11卷 101-115页

作者： Danny r.Youlden susanna M.Cr.mb Cheng Har.Yip Peter.D.Baade Cancer.Council Queensland School of Mathematical Sciences Queensland University of Technology Faculty of Medicine University of Malaya Gr.ffith Health Institute Griffith University School of Public Health and Social Wor. Queensland University of Technology

Objective: To pr.vide an over.iew of the incidence and mor.ality of female br.ast cancer.for.countr.es in the Asia-Pacific ***: Statistical infor.ation about br.ast cancer.was obtained fr.m publicly available cancer.r.gistr. and mor.ality databases(such as GLOBOCAN), and supplemented with data r.quested fr.m individual cancer.r.gistr.es. r.tes wer. dir.ctly age-standar.ised to the Segi Wor.d Standar. population and tr.nds wer. analysed using joinpoint ***: Br.ast cancer.was the most common type of cancer.among females in the r.gion, accounting for.18% of all cases in 2012, and was the four.h most common cause of cancer.r.lated deaths(9%). Although incidence r.tes r.main much higher.in New Zealand and Austr.lia, r.pid r.ses in r.cent year. wer. obser.ed in sever.l Asian countr.es. Lar.e incr.ases in br.ast cancer.mor.ality r.tes also occur.ed in many ar.as, par.icular.y Malaysia and Thailand, in contr.st to stabilising tr.nds in Hong Kong and Singapor., while decr.ases have been r.cor.ed in Austr.lia and New Zealand. Mor.ality tr.nds tended to be mor. favour.ble for.women aged under.50 compar.d to those who wer. 50 year. or.older. Conclusion: It is anticipated that incidence r.tes of br.ast cancer.in developing countr.es thr.ughout the Asia-Pacific r.gion will continue to incr.ase. Ear.y detection and access to optimal tr.atment ar. the keys to r.ducing br.ast cancer.elated mor.ality, but cultur.l and economic obstacles per.ist. Consequently, the challenge is to customise br.ast cancer.contr.l initiatives to the par.icular.needs of each countr. to ensur. the best possible outcomes.

关键词： Asia-Pacific r.gion female br.ast cancer.epidemiology incidence mor.ality

Filling the Disaster.Data Gap:Lessons fr.m Cataloging Singapor.’s Past Disaster.

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Inter.ational Jour.al of Disaster.r.sk Science 2021年第2期12卷 188-204页

作者： Yolanda C.Lin Fer.z Khan susanna F.Jenkins David Lallemant Depar.ment of Geogr.phy and Envir.nmental Studies University of New MexicoAlbuquerqueNM87131USA Asian School of the Envir.nment Nanyang Technological UniversitySingapore639798Singapore Ear.h Obser.ator. of Singapor. Singapore639798Singapore Disaster.r.silience Leader.hip Academy Tulane UniversityNew OrleansLA70112USA

Inter.ational disaster.databases and catalogs pr.vide a baseline for.r.sear.her.,gover.ments,communities,and or.anizations to under.tand the r.sk of a par.icular.place,analyze br.ader.tr.nds in disaster.r.sk,and justify investments in *** because Singapor. is r.utinely identified as one of the safest countr.es in the wor.d,Singapor.’s past disaster. have not been studied extensively with few events captur.d in major.global databases such as *** this ar.icle,we fill the disaster.data gap for.postwar.Singapor.(1950–2020)using specified metr.cs thr.ugh an ar.hival sear.h,r.view of liter.tur.,and analysis of secondar. *** pr.sent four.key lessons fr.m cataloging these ***,we expand Singapor.’s disaster.catalog to 39 events in this time per.od and quantify the extent of this data ***,we identify the mitigating actions that have followed past events that contr.bute to Singapor.’s pr.sent-day ***,we discuss how these past events uncover.continuities among vulner.bility bear.r. in ***,we identify limitations of a disaster.catalog when consider.ng futur. *** expanding the disaster.catalog,this case study of Singapor. suppor.s the need for.compr.hensive under.tanding of past disaster. in or.er.to examine cur.ent and futur. disaster.r.silience.

关键词： Catalog Database Data gap Disaster. r.silience Singapor.