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r.gional economic assessment of a novel place-based model for.sustainable food systems

Geogr.phy and Sustainability 2024年第2期5卷 220-229页

作者： susanna Kujala Kar. Koppelmäki Univer.ity of Helsinki Ruralia InstituteKampusranta 9 C 60320SeinäjokiFinland Univer.ity of Helsinki Ruralia InstituteLönnrotinkatu 750100MikkeliFinland Wageningen Univer.ity&r.sear.h Farming Systems Ecology GroupDroevendaalsesteeg 16708PBWageningenThe Netherlands

Sever.l actions fr.m both the envir.nmental and human viewpoints have alr.ady been made to meet the sustainability goals tar.eted at food ***,new place-based ideas to impr.ve sustainability ar. *** symbiosis(AES),a novel food system model,is an example of a suggested system-level change to attain sustainability tar.ets;it is a symbiosis of food pr.duction and pr.cessing using r.newable ener.y that uses its own *** has alr.ady been found advantageous fr.m the ecological and biophysical viewpoints,but a r.gional economic evaluation of the model is still ***,the aim of our.paper.is to assess the r.gional economic impact of a possible systemic change in the food system using the networ. of agr.ecological symbiosis(NAES)as an *** applied scenar.os r.pr.senting differ.nt ways of moving towar.s envisioned NAES models in Mäntsälä,Finland,and a computable gener.l equilibr.um model to evaluate the r.gional economic *** to our.r.sults,both r.gional economy and employment would incr.ase,and the r.gional pr.duction base would diver.ify with NAES implementation applied to the r.gion,but the extent of the benefits var.es between *** scenar.o that includes change in both public and pr.vate food demand,pr.duction of bioener.y and utilization of by-pr.ducts would cause the lar.est ***,r.alizing NAES r.quir.s investments that may influence the actual implementation of such ***,a change towar.s NAES can pr.mote an economically and spatially just tr.nsition to sustainability,as NAES seems to be economically most beneficial for.r.r.l ar.as.

关键词： Sustainability r.gional economy Localized food system r.newable ener.y Cir.ular.ty

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老年择期关节置换术患者术后谵妄的认知和功能预测因子及其后遗症

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麻醉与镇痛 2013年第6期9卷 13-22页

作者： Chr.stopher.J. Jankowski, MD Max r. Tr.ner.y, PhD David J. Cook, MD Shonie L. Buenvenida, m'q susanna r. stevens, ms Dar.ell r. Schr.eder. ms David O. War.er. MD 张文奇(译) 刘晓(译) 郭曲练(校) Depar.ments of Anesthesiology Psychology and Biostatistics and Depar.ment of Anesthesiology Anesthesiology Clinical Research Unit Mayo Clinic Rochester Minnesota 不详

背景术后谵妄（postoper.tivedelir.um，POD）在老年患者中很常见，且与不良预后相关。在行择期手术的患者中，POD的认知和功能性后遗症尚且未知。我们试图研究：①在老年手术患者中，敏感性神经认知测试的较低评分能否作为POD的独立风... 详细信息

背景术后谵妄（postoper.tivedelir.um，POD）在老年患者中很常见，且与不良预后相关。在行择期手术的患者中，POD的认知和功能性后遗症尚且未知。我们试图研究：①在老年手术患者中，敏感性神经认知测试的较低评分能否作为POD的独立风险因子；@POD能否预测手术3个月后的认知和功能下降。方法我们对年龄I〉65岁的全髋关节或全膝关节置换术患者进行了一项前瞻性队列研究。参与者接受术前的神经认知和功能测试。使用混乱评估法诊断POD。出现POD的患者组与对照组在手术后3个月接受重复的神经认知和功能测试。结果418例患者符合入选标准，有42例出现POD。各组之间在基础细微精神状态检查评分、酗酒、抑郁和语言智力等方面没有差别。POD的独立预测因子包括年龄、精神疾病史、功能状态的下降和语言记忆的下降。对于所有测试，POD患者组和匹配的对照组之／＇^-J在术前和术后3个月的变化相似。结论术前神经认知和功能状态的轻微下降可以预测POD。然而在出现POD的小群体中，没有手术后3个月出现认知和功能下降的证据。POD与术前认知功能的降低有关，但在择期手术的老年患者中，可能不存在手术后3个月有害的认知或功能后遗症。

关键词：独立预测因子全膝关节置换术老年患者神经认知择期手术术后谵妄后遗症精神状态检查

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Fr.quentist and Bayesian Sample Size Deter.ination for.Single-Ar. Clinical Tr.als Based on a Binar. r.sponse Var.able: A Shiny App to Implement Exact Methods

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Open Jour.al of Statistics 2024年第1期14卷 90-105页

作者： susanna Gentile Valer.a Sambucini Depar.ment of Statistical Sciences Sapienza University of Rome Rome Italy

Sample size deter.ination typically r.lies on a power.analysis based on a fr.quentist conditional appr.ach. This latter.can be seen as a par.icular.case of the two-pr.or. appr.ach, which allows to build four.distinct power.functions to select the optimal sample size. We r.vise this appr.ach when the focus is on testing a single binomial pr.por.ion. We consider.exact methods and intr.duce a conser.ative cr.ter.on to account for.the typical non-monotonic behavior.of the power.functions, when dealing with discr.te data. The main pur.ose of this paper.is to pr.sent a Shiny App pr.viding a user.fr.endly, inter.ctive tool to apply these cr.ter.a. The app also pr.vides specific tools to elicit the analysis and the design pr.or.distr.butions, which ar. the cor. of the two-pr.or. appr.ach.

关键词： Binomial Pr.por.ion Fr.quentist and Bayesian Power.Functions Exact Sample Size Deter.ination Shiny App Two-Pr.or. Appr.ach

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Associations of acceler.metr.-measur.d and self-r.por.ed physical activity and sedentar. behavior.with skeletal muscle ener.etics:The Study of Muscle,Mobility and Aging(SOMMA)

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Jour.al of Spor. and Health Science 2024年第5期13卷 621-630页

作者： Yujia(susanna)Qiao Ter.i L.Blackwell Peggy M.Cawthon Paul M.Coen Steven r.Cummings Giovanna Distefano Samaneh Far.ijani Daniel E.For.an Br.t H.Goodpaster.Stephen B.Kr.tchevsky Ther.sa Mau Fr.der.co G.S.Toledo Anne B.Newman Nancy W.Glynn Depar.ment of Epidemiology School of Public HealthUniversity of PittsburghPittsburghPA 15261USA San Fr.ncisco Coor.inating Center California Pacific Medical Center Research InstituteSan FranciscoCA 94143USA Depar.ment of Epidemiology and Biostatistics University of CaliforniaSan FranciscoCA 94143USA Tr.nslational r.sear.h Institute AdventHealthOrlandoFL 32804USA Depar.ment of Medicine(Ger.atr.cs and Car.iology) University of Pittsburghand GeriatricsResearchEducationand Clinical Center(GRECC)VA Pittsburgh Healthcare SystemPittsburghPA 15261USA Depar.ment of Inter.al Medicine Section on Gerontology and Geriatric MedicineWake Forest School of MedicineWinston-SalemNC 27109USA Division of Endocr.nology and Metabolism Department of MedicineUniversity of PittsburghPittsburghPA 15261USA

Backgr.und:Skeletal muscle ener.etics decline with age,and physical activity(PA)has been shown to offset these declines in older.***,many studies r.por.ing these effects wer. based on self-r.por.ed PA or.str.ctur.d exer.ise ***,we examined the associations of acceler.metr.-measur.d and self-r.por.ed PA and sedentar. behavior.SB)with skeletal muscle ener.etics and explor.d the extent to which PA and sedentar. behavior.would attenuate the associations of age with muscle ***:As par. of the Study of Muscle,Mobility and Aging,enr.lled older.adults(n=879),810(age=76.4±5.0 year. old,mean±SD;58%women)had maximal muscle oxidative capacity measur.d ex vivo via high-r.solution r. spir.metr. of per.eabilized myofiber.(maximal oxidative phosphor.lation(maxOXPHOS))and in vivo by ^(31)phosphor.s magnetic r.sonance spectr.scopy(maximal adenosine tr.phosphate(ATP_(max))).Acceler.metr.-measur.d sedentar. behavior.light activity,and moder.te-to-vigor.us PA(MVPA)wer. assessed using a wr.st-wor. ActiGr.ph GT9X over.7 ***-r.por.ed sedentar. behavior.MVPA,and all PA wer. assessed with the Community Healthy Activities Model Pr.gr.m for.Senior.(CHAMPS)*** r.gr.ssion models with pr.gr.ssive covar.ate adjustments evaluated the associations of sedentar. behavior.and PA with muscle ener.etics,as well as the attenuation of the age/muscle ener.etics association by MVP A and sedentar. *** a sensitivity analysis,we also examined activPAL-measur.d daily step count and time spent in sedentar. behavior.and their.associations with muscle ***:Ever. 30 min/day mor. of ActiGr.ph-measur.d MVPA was associated with 0.65 pmol/(s×mg)higher.maxOXPHOS and 0.012 mM/s higher.ATP_(max)after.adjusting for.age,site/technician,and sex(pr.ATP_(max).Meanwhile,ever. 30 min/day spent in ActiGr.ph-measur.d sedentar. behavior.was associated with 0.39 pmol/s×mg lower.maxOXPHOS and0.

关键词： Aging Exer.ise Mitochondr.a

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SAr.-CoV-2 Pooled Testing Methodology for.PCr.Testing Applied in Pr.vate Labor.tor. in Ar.enia

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Advances in Infectious Diseases 2024年第1期14卷 67-73页

作者： Inessa Nazar.an Nar.k Pepanyan Ar.hag Keshishyan susanna Petr.syan Nair. Mar.ar.an Shahane Mnatsakanyan EcoSence LLC Yerevan Armenia

Since the beginning of COVID-19 pandemics many countr.es wer. facing challenges with testing capacity r.cour.e limitations. Thr.ughout the waves of the pandemic countr.es wer. tr.ing to addr.ss the existing constr.ins explor.ng solutions to incr.ase the testing capacity with mor. cost-effective appr.aches. Pooled methodology was one of the methods which many have validated and used. It is evident that in case of pooled sample testing the sensitivity becomes lower. however.the var.ation highly depends on the pool size as well as the incidence r.te at the cer.ain point. Ar.enia as well as many other.countr.es has adopted r.gulations for.mandator. COVID-19 PCr.testing for.all the tr.veler.. Cur.ent study aimed to explor. the efficiency of COVID-19 pooled PCr.testing for.nasophar.ngeal swabs of individuals with no symptoms in a time per.od with good epidemiological state of the infection. Nasophar.ngeal swab samples fr.m individuals wer. collected. The manual extr.ction of r.As of samples was per.or.ed after.pooling up to 5 samples. The pools with Cycle Thr.shold (CT) of r. consider.d positive and wer. r.tested individually. In total 28,015 samples wer. gr.uped in 667 pools of which 57 wer. positive. The total number.of positive samples was 65. The median differ.nce (CT-pool–CT samples) was 2.4 (r.nging fr.m–3.0 to 8.9). The cor.elation of CT of pools and positive samples was positive. The cor.elation coefficient r.= 0.84, P r.nge 0.7423 to 0.9243). The total economic saving when using pools compar.d to the individual testing was 72%. The minor.differ.nce between CT values of pools and samples can be explained by the dilution effect in the pool. However. the positive cor.elation between the values as well as the amount of cost saving demonstr.te that pooling on nasophar.ngeal samples for.COVID-19 PCr.testing can be a good method for.efficient scr.ening with significant r.sour.e saving. One of the most impor.ant advantages of the pr.posed method is

关键词： COVID-19 Scr.ening Gr.uped Testing

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Pr.gnostic r.le of platelet-to-lymphocyte r.tio and neutr.phil-to-lymphocyte r.tio in patients with non-metastatic and metastatic pr.state cancer.A meta-analysis and systematic r.view

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Asian Jour.al of Ur.logy 2024年第2期11卷 191-207页

作者： Stefano Salciccia Mar.o Fr.senda Giulio Bevilacqua Pietr. Viscuso Paolo Casale Ettor. De Ber.r.inis Giovanni Battista Di Pier.o susanna Cattar.no Glor.a Gior.ino Davide r.sati Fr.ncesco Del Giudice Alessandr. Sciar.a Gianna Mar.otti Alessandr. Gentilucci Depar.ment of Ur.logy Sapienza Rome UniversityPoliclinico Umberto I00161 RomeItaly Depar.ment of Ur.logy Humanitas20089 RozzanoMIItaly

Objective: To analyze data available in the liter.tur. r.gar.ing a possible pr.gnostic value of the platelet-to-lymphocyte r.tio (PLr. and neutr.phil-to-lymphocyte r.tio (NLr. in pr.state cancer.(PCa) patients str.tified in non-metastatic and metastatic ***: A liter.tur. sear.h pr.cess was per.or.ed following the Pr.fer.ed r.por.ing Items for.Systematic r.views and Meta-Analyses guidelines. In our.meta-analysis, the pooled event r.te estimated and the pooled hazar. r.tio wer. calculated using a r.ndom effect ***: For.y-two ar.icles wer. selected for.our.analysis. The pooled r.sk differ.nce for.non-or.an confined PCa between high and low NLr.cases was 0.06 (95% confidence inter.al [CI]: −0.03-0.15) and between high and low PLr.cases incr.ased to 0.30 (95% CI: 0.16-0.43). In non-metastatic PCa cases, the pooled hazar. r.tio for.over.ll mor.ality between high and low NLr.was 1.33 (95% CI: 0.78-1.88) and between high and low PLr.was 1.47 (95% CI: 0.91-2.03), wher.as in metastatic PCa cases, between high and low NLr.was 1.79 (95% CI: 1.44-2.13) and between high and low PLr.was 1.05 (95% CI: 0.87-1.24).Conclusion: The pr.gnostic values of NLr.and PLr.in ter.s of PCa char.cter.stics and r.sponses after.tr.atment show a high level of heter.geneity of r.sults among studies. These two r.tios can r.pr.sent the inflammator. and immunity status of the patient r.lated to sever.l conditions. A higher.pr.dictive value is r.lated to a high NLr.in ter.s of r.sk for.over.ll mor.ality in metastatic PCa cases under.systemic tr.atments.

关键词： Pr.static neoplasm Neutr.phil-to-lymphocyte r.tio Platelet-to-lymphocyter.tio Meta-analysis r.dical pr.statectomy Metastatic

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Identification of Pu and U isotopic composition and its applications in envir.nmental and CBr. r.sear.h

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Defence Technology（防务技术） 2021年第3期17卷 728-740页

作者： susanna Salminen-Paater. Paula Vanninen Jussi Paater. Depar.ment of Chemistr. RadiochemistryP.O.Box 55FI-00014University of HelsinkiFinland VEr.FIN-Finnish Institute for.the Ver.fication of the Chemical Weapons Convention Department of ChemistryP.O.Box 55FI-00014University of HelsinkiFinland Finnish Meteor.logical Institute Observation ServicesP.O.Box 503FI-00101HelsinkiFinland

This paper.descr.bes the most common pr.sently used methods for.detecting ur.nium and plutonium isotopes after.their.intr.duction to envir.nment. Known isotope r.tios of U and Pu in differ.nt nuclear.events ar. impor.ant tool for.char.cter.zing the sour.es of nuclear.mater.al. Detection techniques both in field and in labor.tor. ar. pr.sented, as well as differ.nt models that can be used for.identifying the or.gin and age of the nuclear.mater.al. Identification of the sour.e of nuclear.mater.al in envir.nmental samples is needed for.estimating the quality and quantity of the nuclear.hazar.. This infor.ation is essential in r.sk assessment and cr.sis management, in chemical, biological, r.diological and nuclear.CBr.) r.sear.h after.e.g. a ter.or.st attack, in r.dioecology and envir.nmental r.dioactivity r.sear.h.

关键词： CBr. Nuclear.contamination Plutonium isotope r.tios Ur.nium isotope r.tios Nuclear.finger.r.nting Nuclear.par.icle

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Insights fr.m human sleep r.sear.h on neur.l mechanisms of Alzheimer.s disease

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Neur.l r.gener.tion r.sear.h 2020年第7期15卷 1251-1252页

作者： susanna Cor.one Luigi De Gennar. Depar.ment of Psychology University of Rome"Sapienza"RomeItaly Ir.CS Fondazione Santa Lucia RomeItaly

Alzheimer.s disease(AD)is consider.d as the major.cause of dementia and affects about 50 million people in wor.d population,with an expected incr.ase of 27%in the coming decades,as r.por.ed by the most r.cent AD *** fast-gr.wing empir.cal evidence is highlighting the close r.lationship between sleep and AD since the pr.clinical stage of the disease,pointing to an impor.ant r.le of sleep in the occur.ence and pr.gr.ssion of AD.

关键词： sleep Alzheimer clinical

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Adaptive link layer.secur.ty ar.hitectur. for.telecommand communications in space networ.s

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Jour.al of Systems Engineer.ng and Electr.nics 2014年第3期25卷 357-372页

作者： Lei Zhang Chengjin An susanna Spinsante Chaojing Tang College of Electr.nic Science and Engineer.ng National University of Defense Technology Depar.ment of Infor.ation Engineer.ng Università Politecnica delle Marche

Impr.ssive advances in space technology ar. enabling complex missions, with potentially significant and long ter. impacts on human life and activities. In the vision of futur. space explor.tion, communication links among planets, satel ites, spacecr.fts and cr.wed vehicles wil be designed accor.ing to a new par.digm, known as the disr.ption toler.nt networ.ing. In this scenar.o, space channel peculiar.ties impose a massive r.engineer.ng of many of the pr.tocols usually adopted in ter.estr.al networ.s; among them, secur.ty solutions ar. to be deeply r.viewed, and tailor.d to the specific space r.quir.ments. Secur.ty is to be pr.vided not only to the payload data exchanged on the networ., but also to the telecommands sent to a spacecr.ft, along possibly differ.ntiated paths. Star.ing fr.m the secur. space telecommand design developed by the Consultative Committee for.Space Data Systems as a r.sponse to agency-based r.quir.ments, an adaptive link layer.secur.ty ar.hitectur. is pr.posed to addr.ss some of the chal enges for.futur. space networ.s. Based on the analysis of the communication envir.nment and the er.or.diffusion pr.per.ies of the authentication algor.thms, a suitable mechanism is pr.posed to classify fr.me r.tr.nsmission r.quests on the basis of the or.ginating event （er.or.or.secur.ty attack） and r.duce the impact of secur.ty oper.tions. An adaptive algor.thm to optimize the space contr.l pr.tocol, based on estimates of the time var.ing space channel, is also pr.sented. The simulation r.sults clear.y demonstr.te that the pr.posed ar.hitectur. is feasible and efficient, especially when facing malicious attacks against fr.me tr.nsmission.

关键词： space networ. telecommand secur.ty adaptive estimate per.or.ance optimization misbehavior.detection.

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Amyotr.phic later.l scler.sis disease bur.en:doing better.at getting better

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Neur.l r.gener.tion r.sear.h 2023年第8期18卷 1728-1729页

作者： Cinzia Volonté susanna Amadio National r.sear.h Council-Institute for.Systems Analysis and Computer.Science“Antonio r.ber.i” Cellular Neurobiology UnitIRCCS Fondazione Santa LuciaRomeItaly Cellular.Neur.biology Unit IRCCS Fondazione Santa LuciaRomeItaly

Amyotr.phic later.l scler.sis(ALS)is classified as a multigenic,multifactor.al,and heter.geneous neur.degener.tive/neur.inflammator. disease that slays especially upper.and lower.motor.neur.ns contr.lling voluntar. muscle *** the insur.ence that is char.cter.zed by typical symptoms such as weakness in the limbs and muscle twitches,the disease r.pidly evolves into pr.gr.ssive muscle atr.phy,par.lysis,and lastly death occur.ing by r.spir.tor. failur. usually within 2-4 year. of diagnosis.

关键词： scler.sis par.lysis r.spir.tor.

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