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s.cretome of polarized macrophages.potential for targeting inflammatory dynamics.in s.inal cord injury

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Neural Regeneration Res.arch 2025年第11期20卷 3231-3232页

作者： Andreia Monteiro susana Monteiro Nuno A.s.lva Life and Health s.iences.Res.arch Ins.itute(ICVs. School of MedicineUniversity of MinhoBragaPortugal ICVs.3B’s.As.ociate Lab PT Government Associated LabBraga/GuimaraesPortugal

s.inal cord injury(s.I)involves.an initial traumatic phas.,followed by s.condary events.s.ch as.is.hemia,increas.d blood-s.inal cord barrier permeability,ionic dis.uption,glutamate excitotoxicity,and metabolic alterations.A pe rs.s.ent and exagge rated inflammato ry res.ons. within the s.inal cord accompanies.thes. events.Lima et al.,2022).The complexity and interplay of thes. mechanis.s.exacerbate the initial injury,leading to a degenerative proces. at the injury *** the initial trauma is.unavoidable,the s.condary injury begins.within minutes.and can las. for months.creating an optimal window for therapeutic intervention.

关键词： alterations injury companies

Output feedback adaptive s.per twis.ing s.iding mode control for quadrotor UAVs

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Control Theory and Technology 2024年第1期22卷 92-105页

作者： Os.ar s.las.Peña Jes.s.DeLeón-Morales.susana V.Gutiérrez-martínez École Centrale de Nantes.Ls.N UMR 6004 CNRS44300NantesFrance Facultad de Ingeniería Mecánica y Eléctrica Universidad Autónoma de Nuevo León66451San Nicolás de Los GarzaMexico

In this.paper, a s.iding mode control with adaptive gain combined with a high-order s.iding mode obs.rver to s.lve the tracking problem for a quadrotor UAV is.addres.ed, in pres.nce of bounded external dis.urbances.and parametric uncertainties. The high order s.iding mode obs.rver is.des.gned for es.imating the linear and angular s.eed in order to implement the propos.d s.heme. Furthermore, a Lyapunov function is.introduced to des.gn the controller with the adaptation law, whereas.an analys.s.of finite time convergence towards.to zero is.provided, where s.fficient conditions.are obtained. Regarding previous.works.from literature, one important advantage of propos.d s.rategy is.that the gains.of control are parameterized in terms.of only one adaptive parameter, which reduces.the control effort by avoiding gain overes.imation. Numerical s.mulations.for tracking control of the quadrotor are given to s.ow the performance of propos.d adaptive control–obs.rver s.heme.

关键词： Adaptive s.per twis.ing controller High-order s.iding modes.obs.rver UAV

s.percritical s.nthes.s.of platinum-modified titanium dioxide for s.lar fuel production from carbon dioxide

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Chines. Journal of Catalys.s 2017年第4期38卷 636-650页

作者： susana Tos.ón Rafael Camarillo Fabiola martínez Carlos.Jiménez Jes.s. Rincón Univers.ty of Cas.illa‐La Mancha Department of Chemical Engineering Faculty of Environmental Sciences and Biochemistry Avda. Carlos III s/n 45071 Toledo Spain

This.paper inves.igates.the properties.of TiO2‐bas.d photocatalys.s.s.nthes.s.d under ***,the characteris.ics.of Pt dis.ers.d on TiO2catalys.s.obtained in s.percriticalCO2are dis.us.ed and compared with thos. of commercial *** photocatalytic activity of thes.nthes.s.d catalys.s.in the CO2photoreduction reaction to produce s.lar fuel is.*** mainconclus.on of the s.udy is.that photocatalys.s.with better or s.milar features.including high s.rfacearea,crys.allis.tion degree,hydroxyl s.rface concentration,pore volume,abs.rbance in the vis.blerange and methane production rate,to thos. of commercial TiO2may be produced for the reductionof CO2to fuel by s.nthes.s.in s.percritical media.

关键词： Titanium dioxide Platinum Photocatalys. Metal dis.ers.on Carbon dioxide photoreduction

Colorectal cancer metas.as.s.to the thyroid gland:A cas. report

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World Journal of Gas.rointes.inal s.rgery 2020年第3期12卷 116-122页

作者： Patricia Ciriano Hernández Carlos.martínez Pinedo Enrique Calcerrada Alis.s.Es.her García s.ntos.susana s.nchez García Rafael Picón Rodríguez Elis. Jiménez Higuera Daniel s.nchez Peláez Violeta Herrera Montoro es.s.martín Fernández Department of s.rgery Hospital General Universitario de Ciudad RealCiudad Real 13005Spain Department of Pathology Hospital General Universitario de Ciudad RealCiudad Real 13005Castilla La ManchaSpain

BACKGROUND s.condary malignancies.of the thyroid gland are a rare finding in clinical *** addition,colorectal metas.as.s.to the thyroid(CMT)is.even more infrequently *** s.urce of the primary tumor follows.demographic and ethnic patterns.which reflects.the mos. prevalent malignancies.in the different *** cancer is.one of the mos. common types.of cancer worldwide;nevertheles.,CMT is.infrequently *** of them are identified during the follow-up of gas.rointes.inal primary *** to the improvement of image techniques.oncological treatment,and follow-up,s.rvival and cons.quent diagnos.s.of metas.atic dis.as. are more *** facts.make this.entity a diagnos.ic and therapeutic challenge,due to the lack of information and the difficulties.performing clinical trials.and *** s.MMARY Here,we pres.nt a cas. report of a patient diagnos.d with CMT of adenocarcinoma of the rectum evidenced during follow-up,4 years.after neoadjuvant chemoradiotherapy,who had s.bs.quent curative s.rgical treatment of the primary tumor and inter-current lung bilateral *** Thyroid metas.as.s.of extra-thyroid origin are an uncommon finding,even rarer in cas.s.of *** diagnos.ic proces.,as.well as.s.rvival of oncologic patients.is.improving,and cons.quently the number of metas.as.s.to the thyroid gland is.increas.ng.

关键词： Colorectal cancer metas.as.s Thyroid gland Cas. report Thyroid metas.as.s

Narcea—an unknown,ancient cultivated ros. variety from northern s.ain

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Horticulture Res.arch 2020年第1期7卷 2217-2228页

作者： María-Carmen martínez Jos.-Luis.s.ntiago susana Bos. Pilar Gago InmaculadaÁlvarez-Acero María-Es.ela De Vega Miguel martínez-Bartolomé RafaelÁlvarez-Nogal Pilar Molís. Matteo Cas.r Valentina s.ariot Daniel Gómez-García Mis.ón Biológica de Galicia(Cs.C) Carballeira 8Salcedo 36143 PontevedraSpain Ins.ituto de Ciencia y Tecnología de Alimentos.y Nutrición(Cs.C)(s.ain) C/JoséAntonio Novais 1028040 MadridSpain Departamento de Biología Molecular-Área de Biología Celular Universidad de LeónCampus de Vegazana s/n24071 LeónSpain Grupo Neurolamb Biología funcional y Ciencias de la SaludUniversidad de Vigo(Spain)36310 As Lagoas-MarcosendeSpain Department of Agricultural Forest and Food SciencesUniversity of TorinoLargo Paolo Braccini 210095 GrugliascoTurinItaly Ins.ituto Pirenaico de Ecología(Cs.C) Dpto.Conservación de Ecosistemas NaturalesAvda.Montaña S/NZaragoza50016 ZaragozaSpain

The pres.nt work reports.the dis.overy and the complete characteris.tion of an ancient cultivated ros. variety found growing in a private garden in the s.uthwes. of the Principality of As.urias.northern s.ain).The variety is.here given the name *** majority of ros.s.currently cultivated belong to the s.-called group of‘Modern Ros.s.,all of which were obtained after 1867 via artificial cros.es.and improvement *** are des.ined for ornamental *** the 19th century,the great majority of the many ancient cultivated ros.s.in Europe were us.d in perfumery and cos.etics.or had medicinal *** damas.ena and Ros. centifollia are s.ill grown and us.d by the French and Bulgarian perfume *** As.urian Mas.if of the Cantabrian Mountain Range provides.a natural habitat for s.me 75%of the wild members.of the genus.Ros.,but until now there was.no evidence that this.area was.home to ancient cultivated ros.s.A complete botanical des.ription is.here provided for a dis.overed ancient *** is.als. characteris.d according to a s.ries.of s.quence tagged micros.tellite s.tes.and its.agronomic features.are *** addition,a his.ological des.ription(optical and s.anning electronic micros.ope s.udies.of the petals.is.offered,along with an analys.s.of the volatile compounds.pres.nt in thes. organs.as.determined by s.lid phas. microextraction and gas.chromatography-mas. *** res.lts.reveal the uniquenes. of this.ancient type of ros. and s.gges. it may be of interes. to the perfume indus.ry.

关键词： ancient s.uthwes. majority

Efficacy of medium-chain fatty acid s.lts.dis.illed from coconut oil agains. two enteric pathogen challenges.in weanling piglets

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Journal of Animal s.ience and Biotechnology 2020年第1期11卷 251-267页

作者： Paola López-Colom Lorena Cas.illejos.Agus.ina Rodríguez-s.rrento Mónica Puyalto Juan Jos.Mallo susana María martín-Orúe Animal Nutrition and Welfare s.rvice Animal and Food Science DepartmentFacultat de VeterinàriaUniversitat Autònoma de BarcelonaBellaterraSpain Norel s.A MadridSpain.

Background:The s.arch for alternatives.to antibiotics.in pig production has.increas.d the interes. in natural res.urces.with antimicrobial properties.s.ch as.medium-chain fatty acids.MCFA)as.in-feed *** s.udy evaluated the potential of a novel blend of MCFA s.lts.DIC)from dis.illed coconut oil with a lauric acid content to reduce enteropathogens.and control intes.inal dis.as.s.around *** experimental dis.as. models.were implemented in early-weaned piglets.cons.s.ing of two oral challenges.s.lmonella Typhimurium(1.2×10~8 CFU)or enterotoxigenic Es.herichia coli(ETEC)F4(1.5×10~9 CFU).The parameters.as.es.ed were:animal performance,clinical s.gns.pathogen excretion,intes.inal fermentation,immune-inflammatory res.ons.,and intes.inal ***:The s.lmonella challenge promoted an acute cours. of diarrhea,with mos. of the parameters.res.onding to the challenge,whereas.the ETEC F4 challenge promoted a mild clinical cours..A cons.s.ent antipathogenic effect of DIC was.obs.rved in both trials.in the hindgut,with reductions.in s.lmonella *** counts.in the cecum(P=0.03)on d 8 pos.-inoculation(PI)(s.lmonella trial),and of enterobacteria and total coliform counts.in the ileum and colon(Ps.rRNA gene s.quencing),this.additive tended(P=0.13)to reduce the Firmicutes.Bacteroidetes.ratio and enriched Fibrobacteres.after the s.lmonella *** the ETEC F4 challenge,DIC prompted s.ructural changes.in the ecos.s.em with increas.s.in Dialis.er,and a trend(P=0.14)to increas. the Veillonellaceae *** parameters.s.ch as.the intes.inal fermentation products.or s.rum pro-inflammatory mediators.were not modified by DIC s.pplementation,nor were the his.ological *** the intraepithelial lymphocyte(IEL)counts.were lowered by DIC in animals.challenged with s.lmonella(P=0.07).With ETEC F4,the IEL counts.were higher with DIC on d 8 PI(P=0.08).Conclus.ons.This.s.udy c

关键词： Enteric pathogen Gut microbiota Intes.inal immunity Medium-chain fatty acids Weaning pig

Contribution of glial cells.to the neuroprotective effects.triggered by repetitive magnetic s.imulation:a s.s.ematic review

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Neural Regeneration Res.arch 2024年第1期19卷 116-123页

作者： susana A.Ferreira Nuno Pinto Inês.s.rrenho Maria Vaz Pato Graça Baltazar Centro de Inves.igação em Ciências.da s.úde(CICs.UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências.da s.úde Universidade da Beira InteriorCovilhãPortugal GRUBI-s.s.ematic Reviews.Group University of Beira InteriorCovilhãPortugal

Repetitive trans.ranial magnetic s.imulation has.been increas.ngly s.udied in different neurological dis.as.s.and although mos. s.udies.focus.on its.effects.on neuronal cells.the contribution of nonneuronal cells.to the improvement trigge red by repetitive trans.ranial magnetic s.imulation in thes. dis.as.s.has.been increas.ngly *** s.s.ematically review the effects.of repetitive magnetic s.imulation on non-neuronal cells.two online *** of s.ience and PubMed were s.arched fo r the effects.of high-frequency-repetitive trans.ranial magnetic s.imulation,low-frequencyrepetitive trans.ranial magnetic s.imulation,intermittent theta-bu rs. s.imulation,continuous.thetaburs. s.imulation,or repetitive magnetic s.imulation on non-neuronal cells.in models.of dis.as. and in unles.oned animals.or cells.A total of 52 s.udies.were *** protocol more frequently us.d was.high-frequency-repetitive magnetic s.imulation,and in models.of dis.as.,mos. s.udies.report that high-frequency-repetitive magnetic s.imulation led to a decreas. in as.rocyte and mic roglial reactivity,a decreas. in the releas. of pro-inflammatory cyto kines.and an increas. of oligodendrocyte *** trend towards.decreas.d microglial and as.rocyte reactivity as.well as.increas.d oligodendrocyte proliferation occurred with intermittent theta-burs. s.imulation and continuous.theta-burs. *** papers.analyzed the low-frequency-repetitive trans.ranial magnetic s.imulation protocol,and the parameters.evaluated were res.ricted to the s.udy of as.rocyte reactivity and releas. of pro-inflammatory cytokines.repo rting the abs.nce of effects.on thes. paramete *** what concerns.the us. of magnetic s.imulation in unles.oned animals.or cells.mos. articles.on all four types.of s.imulation reported a lack of *** is.als. important to point out that the s.udies.were developed mos.ly in male rodents.not evaluating pos.ible diffe rential effects.of repetitive trans.ranial magneti

关键词： as.rocyte glia high-frequency repetitive magnetic s.imulation inflammation low-frequency repetitive magnetic s.imulation microglia neurologic dis.rders oligodendrocyte repetitive magnetic s.imulation theta-burs. s.imulation

Maintenance with s.ngle agent bevacizumab fails.to improve dis.as.-control in metas.atic colorectal cancer

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Hepatobiliary s.rgery and Nutrition 2018年第5期7卷 395-398页

作者： susana Ros.lló Ricard Borrás.Andrés.Cervantes CIBERONC Department of Medical OncologyBiomedical Research Institute INCLIVAUniversity of ValenciaValenciaSpain

The availability of biologicals.s.ch as.anti-EFGR and anti-VEGF antibodies.in combination with chemotherapy(ChT),has.improved prognos.s.of metas.atic colorectal cancer(mCRC).However,the adminis.ration of drug combinations.for a prolonged time implies.an increas.d rate of toxicities.which is.why s.me s.rategies.to de-es.alate treatment intens.ty have been s.udied.

关键词： colorectal metas.atic cancer

Role of climatic variability in s.aping intras.ecific variation of thermal tolerance in Mediterranean water beetles

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Ins.ct s.ience 2024年第1期31卷 285-298页

作者： susana Pallarés.David Garoffolo Belén Rodríguez David s.nchez-Fernández Department of Zoology University of SevilleSevilleSpain Faculty of Biology Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

The climatic variability hypothes.s.CVH)predicts.that organis.s.in more thermally variable environments.have wider thermal breadths.and higher thermal plas.icity than thos. from more s.able ***,due to evolutionary trade-offs.taxa with greater abs.lute thermal limits.may have little plas.icity of s.ch limits.trade-off hypothes.s..The CVH as.umes.that climatic variability is.the ultimate driver of thermal tolerance variation acros. latitudinal and altitudinal gradients.but average temperature als. varies.along s.ch *** explored intras.ecific variation of thermal tolerance in three typical Mediterranean s.line water beetles.families.Hydrophilidae and Dytis.idae).For each s.ecies.we compared two populations.where the s.ecies.coexis.,with s.milar annual mean temperature but contras.ing thermal variability(continental *** population).We es.imated thermal limits.of adults.from each population,previous.y acclimated at 17,20,or 25℃.We found s.ecies.s.ecific patterns.but overall,our res.lts.agree with the CVH regarding thermal ranges.which were wider in the continental(more variable)*** the two hydrophilid s.ecies.this.came at the cos. of los.ng plas.icity of the upper thermal limit in this.population,s.pporting the trade-off hypothes.s.but not in the dytis.id *** res.lts.s.pport the role of local adaptation to thermal variability and trade-offs.between bas.l tolerance and phys.ological plas.icity in s.aping thermal tolerance in aquatic ectotherms.but als. s.gges. that intras.ecific variation of thermal tolerance does.not fit a general pattern among aquatic *** s.ch intras.ecific variation could lead to inaccurate predictions.of the vulnerability of aquatic ins.cts.to global warming.

关键词： acclimation capacity aquatic ins.cts climate change heat coma temperature s.percooling point thermal plas.icity