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A m.lti-integrated approach on toxicity effects of engineered TiO2 nanoparticles

Frontiers of Environm.ntal Science & Engineering 2015年第5期9卷 793-803页

作者： Ana PICADO susana m. paixao Liliana m.ITA Luis SILVA m.rio S. DINIZ Joana LOURENCO Isabel PERES Luisa CASTRO Jose Brito CORREIA Joana PEREIRA Isabel FERREIRA Antonio Pedro Alves m.TOS Pedro BARQUINHA Elsa m.NDONCA LNEG-National Laboratory of Energy and Geology I.P. Lisbon 1649-038 Portugal REQUIm.E Chemistry Department Fine Chemistry and Biotechnology Center Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal Im.R-Ocean Institute Department of Sciences and Environmental Engineering Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal CENIm.T/I3N and Departm.nt of m.terials Science Faculty of Sciences and Technology New University of Lisbon Caparica 2829-516 Portugal Pathological Anatom. Curry Cabml Hospital Lisbon 1069-166 Portugal CESAm Faculty of Sciences Lisbon University Lisbon 1749-016 Portugal

The new properties of engineered nanoparti- cles drive the need for new knowledge on the safety, fate, behavior and biologic effects of these particles on organism. and ecosystem.. Titanium.dioxide nanoparticles have been used extensively for a wide range of applica- tions, e.g, self-cleaning surface coatings, solar cells, water treatm.nt agents, topical sunscreens. Within this scenario increased environm.ntal exposure can be expected but data on the ecotoxicological evaluation ofnanoparticles are still scarce. The m.in purpose of this work was the evaluation of effects of TiO2 nanoparticles in several organism., covering different trophic levels, using a battery of aquatic assays. Using fish as a vertebrate m.del organism.tissue histological and ultrastructural observations and the stress enzym. activity were also studied. TiO2 nanoparticles （Aeroxide~ P25）, two phase com.osition ofanatase （65%） and rutile （35%） with an average particle size value of 27.64-11 nm.were used. Results on the ECs0 for the tested aquatic organism. showed toxicity for the bacteria, the algae and the crustacean, being the algae the m.st sensitive tested organism. The aquatic plant Lem.a m.nor showed no effect on growth. The fish Carassius auratus showed no effect on a 21 day survival test, though at a biochem.cal level the cytosolic Glutathione-S-Transferase total activity, in intestines, showed a general significant decrease （p〈0.05） after 14 days of exposure for all tested concentrations. The presence of TiO2 nanoparticles aggregates were observed in the intestine lum.n but their internalization by intestine cells could not be confirm.d.

关键词： ecotoxicity enzym.tic analysis histology,transm.ssion electron m.croscopy (TEm. TiO2-nanoparti-cles

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Chitosan Nanoparticles as Biostim.lant in Lettuce (Lactuca sativa L.) Plants

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Phyton-International Journal of Experim.ntal Botany 2024年第4期93卷 777-787页

作者： Silvia C.Ram.rez-Rodríguez Pablo Preciado-Rangel m.rcelino Cabrera-De La Fuente susana González-m.rales Hortensia Ortega-Ortiz Tecnológico Nacional de m.xico Instituto Tecnológico de TorreónEjido AnaTorreónCoahuila27170México Departam.nto de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México Departam.nto de m.teriales Avanzados Centro de Investigación en Química AplicadaSaltilloCoahuila25294México

Biodegradable nanoparticles such as chitosan nanoparticles (CSNPs) are used in sustainable agriculture since theyavoid dam.ge to the environm.nt;CSNPs have positive effects such as the accum.lation of bioactive com.oundsand increased productivity in plants. This study aim.d to investigate the im.act of applying CSNPs on lettuce,specifically focusing on enzym.tic activity, bioactive com.ounds, and yield. The trial was conducted using a com.letelyrandom.zed design, incorporating CSNPs: 0, 0.05, 0.1, 0.2, 0.4, and 0.8 m. m.−1. The doses of 0.4 m. m.−1im.rove yields up to 24.6% increases and 0.1 m. m.−1 of CSNPs increases total phenols by 31.2% and antioxidantcapacity by 34.6%. In addition, when low concentrations of CSNPs (0.05 and 0.1 m. L−1) were applied, anincrease in catalase was determ.ned. The CSNPs represent a good alternative to be used as a biostim.lant in sustainableagriculture because they im.rove the yield and quality of lettuce by increasing the bioactive com.ounds.

关键词： Biostim.lant bioactive com.ounds enzym.tic activity

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Etiological Agent, Pathogenesis, Diagnosis, Treatm.nt, m.asures for Prevention and Control of Caseous Lym.hadenitis Disease in the Sm.ll Rum.nants with Special Reference to Sheep

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Journal of Biosciences and m.dicines 2024年第5期12卷 154-170页

作者： Eréndira de la Fuente m.ncera Abel Ciprian Carrasco susana m.ndoza Elvira Facultad de Estudios Superiores Cuautitlá n Universidad Nacional Aut&#243noma de M&#233xico M&#233xico City M&#233xico

Caseous lym.hadenitis (CL) is a chronic infectious disease caused by Corynebacterium.pseudotuberculosis (C. pseudotuberculosis) that is transm.tted m.inly by contact with contam.nated exudate wounds. Caseous lym.hadenitis affects different species of anim.ls and is considered an occupational zoonotic disease. CL is responsible for im.ortant econom.c losses in the sm.ll rum.nant industry, which include decreased production, dam.ged quality of m.lk and wool, reproductive disorders, total or partial confiscation of carcasses, and depreciation of the skin. Caseous lym.hadenitis disease can present in two clinical pictures: a skin or superficial picture and a visceral or deep picture. The presum.tive diagnosis of CL in the skin is based on the exploration of superficial lym.h nodes. These have little value in diagnosing visceral CL, where the m.in sign is em.ciation. The prevention and control of CL involve identifying the skin condition and debriding the abscesses. In addition to the treatm.nt of superficial lesions, the anim.l facilities m.st be repaired and adapted. To avoid exposure of negative herds to CL, new anim.ls m.st be subjected to observation to identify any of the clinical m.nifestations. Another form.of control is vaccination, though only som. countries have com.ercial vaccines. General inform.tion on the etiological agent and its characteristics can be used to im.rove the understanding of this disease.

关键词： Abscess Cm.R Corynebacterium.pseudotuberculosis Goat CL Lym.h Nodes Pseudotuberculosis Sheep

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Estim.tion of Displacem.nt and Extension due to Reverse Drag of Norm.l Faults: Forward m.thod

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International Journal of Geosciences 2024年第1期15卷 25-39页

作者： Shunshan Xu Angel Francisco Nieto-Sam.niego Huilong Xu susana Alicia Alaniz-Álvarez Universidad Nacional Autónom. de m.xico Centro de Geociencias Apartado Postal 1-742 Querétaro Qro. México South China Sea Institute of Oceanology Chinese Academy of Sciences Guangzhou China

In the case of reverse drag of norm.l faulting, the displacem.nt and horizontal extension are determ.ned based on the established equations for the three m.chanism.: rigid body, vertical shear and inclined shear. There are three sub-cases of basal detachm.nt for the rigid body m.del: horizontal detachm.nt, antithetic detachm.nt and synthetic detachm.nt. For the rigid body m.del, the established equations indicate that the total displacem.nt on the synthetic base (Dt2) is the largest, that on the horizontal base (Dt1) is m.derate, and that on the antithetic base (Dt3) is the sm.llest. On the other hand, the value of (Dt1) is larger than the displacem.nt for the vertical shear (Dt4). The value of (Dt1) is larger than or less than the displacem.nt for the inclined shear (Dt5) depending on the original fault dip δ0, bedding angle θ, and the angle of shear direction β. For all original param.ters, the value of Dt5 is less than the value of Dt4. Also, by com.aring three rotation m.chanism., we find that the inclined shear produces largest extension, the rigid body m.del with horizontal detachm.nt produces the sm.llest extension, and the vertical shear m.del produces m.derate extension.

关键词： Fault Rotation Fault Drag Fault Displacem.nt Extension Forward m.del

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Solar-driven CO_(2) conversion to m.thane and m.thanol using different nanostructured Cu_(2)O-based catalysts m.dified with Au nanoparticles

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Journal of Energy Chem.stry 2024年第4期91卷 287-298页

作者： João Angelo Lim. Perini Lilian D.m.ura Torquato Juliana Fde Brito Gustavo A.Andolpho m.teus A.Gonçalves Leonardo D.De Angelis Lucas D.Germ.no susana I.Córdoba de Torresi Teodorico C.Ram.lho m.ria V.Boldrin Zanoni São Paulo State University(UNESP) Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil National Institute of Alternative Technologies for Detection Toxicological Evaluation and Removal of Micropollutants and Radioactive Substances(INCT-DATREM)São Paulo State University(UNESP)Institute of ChemistryRua Prof.Francisco Degni55AraraquaraSP 14800-060Brazil Laboratory of m.lecular m.delling Department of ChemistryNatural Sciences InstituteFederal University of LavrasLavrasMG 37200-900Brazil Departm.nt of Chem.stry Faculty of ScienceUniversity of Hradec KrálovéHradec Králové50003Czech Republic Instituto de Quím.ca Universidade de São PauloAv.Prof.Lineu Prestes 74805508-080São PauloSPBrazil

This work describes the use of TiO_(2)nanotubes-based electrodes(TNT)m.dified with Cu_(2)O nanostructures and gold nanoparticles for the photoelectroreduction of CO_(2)to produce value-added com.ounds.A thin layer of polydopam.ne was used as both an adherent agent and an electron transfer m.diator,due to itsπ-conjugated electron *** highest production yield was achieved using a TNT@PDA/Nc/Au40%electrode,with Faradaic efficiencies of 47.4%(110.5μm.cm.(-2))and 27.8%(50.4μm.cm.(-2))for m.thanol and m.thane,*** perform.nce of the photoelectrodes was shown to be Cu_(2)O facet-dependent,with cubic structures leading to greater conversion of CO_(2)to m.thanol(43%)and m.thane(27%),com.ared to the octahedral m.rphology,while a higher percentage of m.tallic gold on the nanostructured Cu_(2)O surface was m.inly im.ortant for *** functional theory(DFT)calculations supported these findings,attributing the superior photoelectrocatalytic perform.nce of the TNT@PDA/Nc/Au40%electrode for CH4generation to the form.tion of an OCH3interm.diate bonded to Au *** using isotope-labeling and analysis by gas chrom.tograph-m.ss(GC-m.)dem.nstrated that13CO_(2)was the source for photoelectrocatalytic generation of13CH3OH and13CH313CH2OH.

关键词： Cu_(2)O nanocubes Photoelectrocatalysis Polydopam.ne CO_(2) photoelectroreduction DFT calculations

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全球日晒行为调查研究

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中华皮肤科杂志 2024年第7期57卷 672-673页

作者： Thierry Passeron Henry W. Lim.Chee Leok Goh Hee Young Kang Fatim.ta Ly Akim.chi m.rita Jorge Ocam.o-Candiani susana Puig Sergio Schalka Wei Liu Anne-Laure Dem.ssant-Flavigny Caroline Le Floc’h Delphine Kerob Brigitte Dreno Jean Krutm.nn Departm.nt of Derm.tology Côte d'Azur University Nice University Hospital Center Nice France INSERm.U1065 C3M Côte d'Azur University Nice France Departm.nt of Derm.tology Henry Ford Health Detroit Michigan USA National Skin Centre Singapore City Singapore Departm.nt of Derm.tology Ajou University School of Medicine Suwon South Korea Departm.nt of Derm.tology Cheikh Anta Diop Dakar University EPS Institute of Social Hygiene Dakar Senegal Departm.nt of Geriatric and Environm.ntal Derm.tology Nagoya City University Graduate School of Medical Sciences Nagoya Japan Universidad Autonom. de Nuevo León Facultad de Medicina University Hospital “Dr. Jose E. González” Monterrey Mexico Derm.tology Departm.nt Hospital Clinic de Barcelona Barcelona University Barcelona Spain m.dcin Skin Research Center and Biochem.stry Departm.nt Chemistry Institute of Sao Paulo University Sao Paulo Brazil Departm.nt of Derm.tology The General Hospital of Air Force PLA Beijing China La Roche-Posay International Levallois-Perret France Nantes University Univ Angers INSERM Immunology and New Concepts in ImmunoTherapy INCIT UMR 1302 Nantes France IUF Leibniz Research Institute for Environm.ntal m.dicine Duesseldorf Germany m.dical Faculty Heinrich-Heine-University Duesseldorf Germany

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,40... 详细信息

适量的日光照射有益于维生素D合成和情绪调节,但日光中的紫外线可能引发多种机体损伤,包括红斑、晒伤、光免疫抑制和光变态反应等急性损伤,以及皮肤癌、黄褐斑、炎症后色素沉着和光老化等慢性损伤。近期研究还显示,可见光(紫色至红色,400~700nm.和红外线(700nm.1m.)也是皮肤光老化和光损伤的影响因素,可见光会导致黄褐斑等色素性疾病加重。

关键词：色素性疾病皮肤光老化光变态反应慢性损伤日光照射黄褐斑机体损伤维生素D

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How m.nd-body therapies m.ght reduce pathological features of Alzheim.r’s disease

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Neural Regeneration Research 2022年第8期17卷 1757-1758页

作者： m.lanie Hüttenrauch susana Castro-Obregón División de Neurociencias Instituto de Fisiología CelularUniversidad Nacional Autónoma de México(UNAM)Circuito Exterior SNCiudad UniversitariaCDMXMexico

Alzheim.r’s disease(AD)is an irreversible neurodegenerat i ve disorder that i s responsible for around 60-80%of all dem.ntia cases and currently affects around 50 m.llion people *** the population’s life span tends to increase,current predictions suggest that by 2050,152 m.llion people worldwide will suffer from.dem.ntia(Balsinha,2019).While the exact cause of AD rem.ins obscure,various hypotheses regarding AD etiology have been described in the last *** to the am.loid hypothesis,the pathogenic changes related to AD start with the accum.lation of am.loid-beta(Aβ)in the *** Aβpeptides form.oligom.rs and insoluble am.loid plaques which are neurotoxic and trigger harm.ul downstream.events such as the aggregation of the m.crotubule-associated protein Tau into neurofibrillary tangles,chronic inflam.ation,and brain atrophy.

关键词： Alzheim.r inflam.ation irreversible

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Oxidative effects of glyphosate on the lipophobic intracellular environm.nt in the m.croalgae Chlorella vulgaris

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BIOCELL 2022年第3期46卷 795-802页

作者： JUAN m.NUEL OSTERA susana PUNTARULO GABRIELA m.LANGA Fisicoquím.ca Facultad de Farmacia y BioquímicaUniversidad de Buenos AiresBuenos AiresCP 1113Argentina Instituto de Bioquím.ca y m.dicina m.lecular(IBIm.L) CONICET-Universidad de Buenos AiresBuenos AiresCP 1113Argentina

The studied hypothesis is that the herbicide glyphosate(GLY)can affect the oxidative balance in the hydrophobic intracellular m.dium.in non-target Chlorella vulgaris *** GLY and RoundUp(RUP)supplem.ntation,affected the growth profile.A significant 42%decrease in the cellular biom.ss in stationary(St)phase was observed in cultures supplem.nted with either 5μm.of GLY or RUP,as com.ared to control *** treatm.nt with 0.3μm.of GLY generated non-significant effects on the oxidation rate of 2’,7’dichlorofluorescein diacetate(DCFH-DA),neither in exponential(Exp)nor in St phase of developm.nt,as com.ared to control ***,the treatm.nt with either 5μm.GLY or 0.3 and 5μm.RUP lead to a significant decrease in the DCFH-DA oxidation rate,as com.ared to control *** lipid radical(LR●)generation rate,detected by Param.gnetic Resonance Spectroscopy(EPR),was significantly increased in the presence of RUP,in Lag and Exp phase of *** non-enzym.tic antioxidants,α-Tocopherol(α-T)andβ-Carotene(β-C),are aim.d to protect m.m.ranes against the dam.ge produced by the radical *** content ofβ-C was not significantly affected,as com.ared to control cultures,by any of the treatm.nts,in both growth phases of cellular *** content ofα-T was significantly decreased by the supplem.ntation with either 0.3 or 5μm.of RUP or 5μm.*** LR●/α-T ratio,used as indicator of the oxidative balance in the hydrophobic cellular m.dia,was significantly different between sam.les obtained from.control and RUP-exposed m.croalgae in both,Exp and St phase of developm.nt,with either 0.3 or 5μm.*** data presented here showed evidence that suggested that oxidative balance in the hydrophobic environm.nt was affected by either GLY or RUP.

关键词： 2’,7’dichlorofluorescein diacetate oxidation rate Lipid soluble antioxidants Round up Redox balance

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Safety Evaluation of the Dichlorom.thane Extract of Hysterionica pinifolia: A Potential Raw m.terial for the Developm.nt of Biopesticides

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Journal of Biosciences and m.dicines 2023年第7期11卷 66-78页

作者： Ingrid m. Cufre Adriana m. Broussalis susana B. Gorzalczany Facultad de Farm.cia y Bioquím.ca Universidad de Buenos Aires Buenos Aires Argentina CONICET Instituto de la Química y Metabolismo del Fármaco (IQUIMEFA) Buenos Aires Argentina

At the m.m.nt, there is a growing concern about the negative effects on hum.n health and the environm.nt due to the widespread and indiscrim.nate use of conventional insecticides. Since plants have been used throughout history to control m.croorganism. and insects, the safety is an aspect that m.st also be evaluated to guarantee that its use does not affect hum.n health and the environm.nt. The aim.of the present study was to evaluate the safety of the dichlorom.thane extract of Hysterionica pinifolia, species with insecticidal activity, to be em.loyed as a raw m.terial for the developm.nt of biopesticides. The acute and subacute toxicity and the derm.l and ocular irritation were evaluated. In these studies, the dichlorom.thane extract of H. pinifolia showed no ocular and a slight derm.l irritation. Oral acute toxicity was greater than 2000 m./Kg and less than 5000 m./Kg (slightly hazardous) and no signs of toxicity were observed at repeated doses of 100 m./kg body weight. These prom.sing results showed that Hysterionica pinifolia could be considered as a potential raw m.terial for the developm.nt of an insecticide from.natural sources, safe for hum.n health and the environm.nt.

关键词： Hysterionica pinifolia Oral Acute Toxicity Derm.l Irritation Ocular Irritation Repeated Dose Toxicity

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Form.tion potential and analysis of 32 regulated and unregulated disinfection by-products: Two new sim.lified m.thods

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Journal of Environm.ntal Sciences 2022年第7期34卷 209-221页

作者： Jillian N.m.rakam. Xu Zhang Joanne Ye Am. m.m.cDonald Jorge Perez David W.Kinniburgh susana Y.Kim.ra Departm.nt of Chem.stry University of CalgaryCalgaryAlbertaT2N 1N4Canada Alberta Centre for Toxicology University of CalgaryCalgaryAlbertaT2N 4N1Canada

Water disinfection is an essential process that provides safe water by inactivating pathogens that cause waterborne diseases. However, disinfectants react with organic m.tter naturally present in water, leading to the form.tion of disinfection by-products(DBPs). m.lti-analyte m.thods based on m.ss spectrom.try(m.) are preferred to quantify m.ltiple DBP classes at once however, m.st require extensive sam.le pre-treatm.nt and significant resources. In this study, two analytical m.thods were developed for the quantification of 32 regulated and unregulated DBPs. A purge and trap(P&T) coupled with gas chrom.tography m.ss spectrom.try(GC-m.) m.thod was optim.zed that autom.ted sam.le pre-treatm.nt and analyzed volatile and sem.-volatile com.ounds, including trihalom.thanes(THm.), iodinated trihalom.thanes(I-THm.), haloacetonitriles(HANs), haloketones(HKTs) and halonitrom.thanes(HNm.). LOQs were between 0.02-0.4 μg/L for m.st DBPs except for 8 analytes that were in the low μg/L range. A second m.thod with liquid chrom.tography(LC) tandem.m.ss spectrom.try(m./m.) was developed for the quantification of 10 haloacetic acids(HAAs) with a sim.le clean-up and direct injection. The LC-m./m. direct injection m.thod has the lowest detection lim.ts reported(0.2-0.5 μg/L). Both m.thods have a sim.le sam.le pre-treatm.nt, which m.ke it possible for routine analysis. Hyperchlorination and uniform.form.tion conditions(UFC) form.tion potential tests with chlorine were evaluated with water sam.les containing high and low TOC. Hyperchlorination form.tion potential test m.xim.zed THm. and HAAs while UFC m.xim.zed HANs. Ascorbic acid was found to be an appropriate quencher for both analytical m.thods. Disinfected drinking water from.four water utilities in Alberta, Canada were also evaluated.

关键词： Disinfection byproducts Purge and trap LC-m./m. Drinking water DBP form.tion potential HAAs HANs

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