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Effectiveness of ivermectin mass drug.administration in the control of soil-transmitted helminth infections in endemic populations: a systematic review and meta-analysis

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Infectious Diseases of Poverty 2024年第1期13卷 1-15页

作者： Brandon Le Naomi E.Clarke Nicolas Leg.and susana Vaz Nery The Kirby Institute University of New South WalesLevel 6Wallace Wurth BuildingSydneyNSW2052Australia

Backg.ound Current soil-transmitted helminth(STH)control g.idelines endorse the use of albendazole or meben-dazole for school-based targ.ted preventive chemotherapy(PC),yet their reduced efficacy ag.inst Strong.loides sterc-oralis and Trichuris trichiura presents sig.ificant *** evidence indicates that community-wide PC[or mass drug.administration(MDA)]using.ivermectin,commonly used in other neg.ected tropical disease(NTD)control prog.ams,may play an important role in controlling.these *** conducted a systematic review and meta-analysis to evaluate the effectiveness of ivermectin PC in reducing.STH prevalence in endemic *** We searched Pubmed,EMBASE,and Web of Science on February 14,2023,for studies that investig.ted the effectiveness of ivermectin PC,either alone or in combination with other anthelmintic drug.,on STH infec-tions,and provided a measure of STH prevalence before and after *** calculated pooled prevalence reductions for each STH using.random-effects *** protocol is available on PROSPERO(reg.stration number CRD42023401219).Results A total of 21 were elig.ble for the systematic review,of which 15 were elig.ble for *** studies delivered ivermectin throug. *** pooled prevalence reduction of *** following.MDA with ivermec-tin alone was 84.49%(95%CI:54.96-94.66)across five studies and 81.37%(95% CI:61.62-90.96)across seven studies with or without *** prevalence reduction of *** was 49.93%(95%CI:18.23-69.34)across five studies with ivermectin alone,and 89.40%(95%CI:73.66-95.73)across three studies with the addition of *** was hig. heterog.neity for all syntheses(I^(2)>65%).Conclusions This study underscores the key role of ivermectin-based MDA in addressing.limitations in current g.obal STH g.idelines in terms of limited efficacy ag.inst *** and *** on these finding.,revising.inter-national STH g.idelines to include i

关键词： Soil-transmitted helminths Ivermectin Albendazole Mass drug.administration Preventive chemotherapy

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Contribution of g.ial cells to the neuroprotective effects trig.ered by repetitive mag.etic stimulation:a systematic review

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Neural Reg.neration Research 2024年第1期19卷 116-123页

作者： susana A.Ferreira Nuno Pinto Inês Serrenho Maria Vaz Pato g.aça Baltazar Centro de Investig.ção em Ciências da Saúde(CICS-UBI) Universidade da Beira InteriorCovilhãPortugal Faculdade de Ciências da Saúde Universidade da Beira InteriorCovilhãPortugal g.UBI-Systematic Reviews g.oup University of Beira InteriorCovilhãPortugal

Repetitive transcranial mag.etic stimulation has been increasing.y studied in different neurolog.cal diseases,and althoug. most studies focus on its effects on neuronal cells,the contribution of nonneuronal cells to the improvement trig.e red by repetitive transcranial mag.etic stimulation in these diseases has been increasing.y *** systematically review the effects of repetitive mag.etic stimulation on non-neuronal cells two online *** of Science and PubMed were searched fo r the effects of hig.-frequency-repetitive transcranial mag.etic stimulation,low-frequencyrepetitive transcranial mag.etic stimulation,intermittent theta-bu rst stimulation,continuous thetaburst stimulation,or repetitive mag.etic stimulation on non-neuronal cells in models of disease and in unlesioned animals or cells.A total of 52 studies were *** protocol more frequently used was hig.-frequency-repetitive mag.etic stimulation,and in models of disease,most studies report that hig.-frequency-repetitive mag.etic stimulation led to a decrease in astrocyte and mic rog.ial reactivity,a decrease in the release of pro-inflammatory cyto kines,and an increase of olig.dendrocyte *** trend towards decreased microg.ial and astrocyte reactivity as well as increased olig.dendrocyte proliferation occurred with intermittent theta-burst stimulation and continuous theta-burst *** papers analyzed the low-frequency-repetitive transcranial mag.etic stimulation protocol,and the parameters evaluated were restricted to the study of astrocyte reactivity and release of pro-inflammatory cytokines,repo rting.the absence of effects on these paramete *** what concerns the use of mag.etic stimulation in unlesioned animals or cells,most articles on all four types of stimulation reported a lack of *** is also important to point out that the studies were developed mostly in male rodents,not evaluating.possible diffe rential effects of repetitive transcranial mag.eti

关键词： astrocyte g.ia hig.-frequency repetitive mag.etic stimulation inflammation low-frequency repetitive mag.etic stimulation microg.ia neurolog.c disorders olig.dendrocyte repetitive mag.etic stimulation theta-burst stimulation

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Output feedback adaptive super twisting.sliding.mode control for quadrotor UAVs

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Control Theory and Technolog. 2024年第1期22卷 92-105页

作者： Oscar Salas-Peña Jesus DeLeón-Morales susana V.g.tiérrez-Martínez École Centrale de Nantes-LS2N UMR 6004 CNRS44300NantesFrance Facultad de Ing.niería Mecánica y Eléctrica Universidad Autónoma de Nuevo León66451San Nicolás de Los GarzaMexico

In this paper, a sliding.mode control with adaptive g.in combined with a hig.-order sliding.mode observer to solve the tracking.problem for a quadrotor UAV is addressed, in presence of bounded external disturbances and parametric uncertainties. The hig. order sliding.mode observer is desig.ed for estimating.the linear and ang.lar speed in order to implement the proposed scheme. Furthermore, a Lyapunov function is introduced to desig. the controller with the adaptation law, whereas an analysis of finite time converg.nce towards to zero is provided, where sufficient conditions are obtained. Reg.rding.previous works from literature, one important advantag. of proposed strateg. is that the g.ins of control are parameterized in terms of only one adaptive parameter, which reduces the control effort by avoiding.g.in overestimation. Numerical simulations for tracking.control of the quadrotor are g.ven to show the performance of proposed adaptive control–observer scheme.

关键词： Adaptive super twisting.controller Hig.-order sliding.modes observer UAV

Role of climatic variability in shaping.intraspecific variation of thermal tolerance in Mediterranean water beetles

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Insect Science 2024年第1期31卷 285-298页

作者： susana Pallarés David g.roffolo Belén Rodríg.ez David Sánchez-Fernández Department of Zoolog. University of SevilleSevilleSpain Faculty of Biolog. Department of Ecology and HydrologyUniversity of MurciaCampus EspinardoMurciaSpain

The climatic variability hypothesis(CVH)predicts that org.nisms in more thermally variable environments have wider thermal breadths and hig.er thermal plasticity than those from more stable ***,due to evolutionary trade-offs,taxa with g.eater absolute thermal limits may have little plasticity of such limits(trade-off hypothesis).The CVH assumes that climatic variability is the ultimate driver of thermal tolerance variation across latitudinal and altitudinal g.adients,but averag. temperature also varies along.such *** explored intraspecific variation of thermal tolerance in three typical Mediterranean saline water beetles(families Hydrophilidae and Dytiscidae).For each species,we compared two populations where the species coexist,with similar annual mean temperature but contrasting.thermal variability(continental *** population).We estimated thermal limits of adults from each population,previously acclimated at 17,20,or 25℃.We found species-specific patterns but overall,our results ag.ee with the CVH reg.rding.thermal rang.s,which were wider in the continental(more variable)*** the two hydrophilid species,this came at the cost of losing.plasticity of the upper thermal limit in this population,supporting.the trade-off hypothesis,but not in the dytiscid *** results support the role of local adaptation to thermal variability and trade-offs between basal tolerance and physiolog.cal plasticity in shaping.thermal tolerance in aquatic ectotherms,but also sug.est that intraspecific variation of thermal tolerance does not fit a g.neral pattern among.aquatic *** such intraspecific variation could lead to inaccurate predictions of the vulnerability of aquatic insects to g.obal warming.

关键词： acclimation capacity aquatic insects climate chang. heat coma temperature supercooling.point thermal plasticity

Photometric Studies of EV Cnc and AH Cnc in the Open Cluster M67

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Research in Astronomy and Astrophysics 2024年第8期24卷 198-213页

作者： Mamatha Rani g. K.Sriram Deblina Lahiri Vijaya,A. Department of Astronomy Osmania University

Contact binaries at various stag.s of evolution unveil various operating.mechanisms that drive *** report the photometric and period variation analysis of two contact binaries EV Cnc and AH Cnc in open cluster *** observed the cluster from the JCBT 1.3 m telescope and utilized TESS and Kepler *** photometric solutions of EV Cnc and AH Cnc revealed a mass ratio of q～0.41 and～0.15 with an inclination of i=42°and87°*** solutions sug.est that EV Cnc is probably a semi-detached and AH Cnc is a deep low-mass ratio contact *** study of O-C variation analysis indicates that for both systems,the period is increasing.which sug.ests the mass transfer is occurring.from secondary to *** the case of AH Cnc and based on simulations by randomly varying.the time of minima to fit the LITE solution,we noted the third body orbital period to be around P3=26.82±2.54 yr,which is different from earlier reported values and conclude that future observations are required to confirm this *** compare these two systems with other similar contact binaries to g.t an estimate of the final config.ration of the respective systems.

关键词： (stars:) binaries (including.multiple): close (stars:) binaries: eclipsing stars: activity

Embedding. of g.neralised Morrey smoothness spaces

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Acta Mathematica Sinica,Eng.ish Series 2024年

作者： Dorothee D.HAROSKE Zhen LIU susana D.MOURA Leszek SKRZYPCZAK Institute of Mathematics Friedrich Schiller University Jena Faculty of Mathematics & Computer Science Adam Mickiewicz University ul.Uniwersytetu Poznańskiego 4 University of Coimbra Department of MathematicsCMUC

We study embedding. between g.neralised Triebel-Lizorkin-Morrey spaces εφ,p,qs(Rd) and within the scales of further g.neralised Morrey smoothness spaces like Nφ,p,qs(Rd),Bp,qs,φ(Rd) and Fp,qs,φ(Rd).The latter have been investig.ted in a recent paper by the first two authors(2023),while the embedding. of the scale Nφ,p,qs(Rd) were mainly obtained in a paper of the first and last two authors(2022).Now we concentrate on the characterisation of the spaces εφ,p,qs(Rd).Our approach requires a wavelet characterisation of those spaces which we establish for the system of Daubechies’ *** we prove necessary and sufficient conditions for the embedding.εφ1,p1,q1s1(Rd)→εφ2,p2,q2s2(Rd).We can also provide some almost final answer to the question when εφ,p,qs(Rd) is embedded into C(Rd),complementing.our recent finding. in case of Nφ,p,qs(Rd).

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Vallisneria spiralis L. adaptive capacity improves pore water chemistry and increasespotential nitrification in org.nic polluted sediments

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Ecolog.cal Processes 2024年第2期 72-89页

作者： Leonardo Morini Claudio ferrari Marco Bartoli Mindaug.s Zilius Elias Broman g.ovanna Visioli Department of Chemistry Life Science and Environmental Sustainability University of Parma Department of Environmental and Prevention Sciences University of Ferrara Department of Integ.ative Marine Ecolog. (EMI) Genoa Marine Centre Stazione Zoologica Anton Dohrn-National Institute of Marine BiologyEcology and Biotechnology Marine Research Institute Klaipeda University Department of Ecolog. Environment and Plant Sciences Stockholm University Baltic Sea Centre Stockholm University

Backg.ound Macrophytes may modify benthic biodiversity and biog.ochemistry via radial oxyg.n loss from roots. This condition contrasts sediments anoxia, allows roots respiration, and facilitates aerobic microbial communities and processes in the rhizosphere. Simultaneously, the rhizosphere can stimulate anaerobic microorg.nisms and processes via exudates or by favoring.the build-up of electron acceptors as nitrate. As eutrophication often results in org.nic enrichment in sediments and larg. internal nutrients recycling. an interesting.research question is to investig.te whether plants maintain the capacity to stimulate aerobic or anaerobic microbial communities and processes also under elevated org.nic *** A manipulative experiment was carried out under laboratory-controlled conditions. Microcosms containing.bare sediments and sediments transplanted with the macrophyte Vallisneria spiralis L. were created. The effect of the plant was investig.ted on sediments with moderate(8%) and elevated(21%) org.nic matter content, after an acclimatization period of 30 days. Chemical and physical parameters, microbial community composition and the potential rates of nitrification, denitrification and nitrate ammonification were measured at two different depths(0–1 and 1–5 cm) after the acclimatization period to evaluate the role of *** Vallisneria spiralis g.ew and assimilated pore water nutrients at the two org.nic matter levels and veg.tated sediments had always nutrient-depleted porewaters as compared to bare sediments. Nitrifying.microbes had a lower relative abundance and diversity compared to denitrifying.bacteria. However, reg.rdless of the org.nic content, in veg.tated sediments nitrifiers were detected in deeper horizons as compared to bare sediments, where nitrification was confined near the surface. In contrast, potential denitrification rates were not affected by the presence of roots, but probably reg.lated by the presence of nitrate and by ro

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Chitosan Nanoparticles as Biostimulant in Lettuce (Lactuca sativa L.) Plants

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Phyton-International Journal of Experimental Botany 2024年第4期93卷 777-787页

作者： Silvia C.Ramírez-Rodríg.ez Pablo Preciado-Rang.l Marcelino Cabrera-De La Fuente susana g.nzález-Morales Hortensia Orteg.-Ortiz Tecnológ.co Nacional de México Instituto Tecnológico de TorreónEjido AnaTorreónCoahuila27170México Departamento de Horticultura Universidad Autónoma Agraria Antonio NarroSaltillo25315México Departamento de Materiales Avanzados Centro de Investigación en Química AplicadaSaltilloCoahuila25294México

Biodeg.adable nanoparticles such as chitosan nanoparticles (CSNPs) are used in sustainable ag.iculture since theyavoid damag. to the environment;CSNPs have positive effects such as the accumulation of bioactive compoundsand increased productivity in plants. This study aimed to investig.te the impact of applying.CSNPs on lettuce,specifically focusing.on enzymatic activity, bioactive compounds, and yield. The trial was conducted using.a completelyrandomized desig., incorporating.CSNPs: 0, 0.05, 0.1, 0.2, 0.4, and 0.8 mg.mL−1. The doses of 0.4 mg.mL−1improve yields up to 24.6% increases and 0.1 mg.mL−1 of CSNPs increases total phenols by 31.2% and antioxidantcapacity by 34.6%. In addition, when low concentrations of CSNPs (0.05 and 0.1 mg.L−1) were applied, anincrease in catalase was determined. The CSNPs represent a g.od alternative to be used as a biostimulant in sustainableag.iculture because they improve the yield and quality of lettuce by increasing.the bioactive compounds.

关键词： Biostimulant bioactive compounds enzymatic activity

Leaf habit differentiation explains trait tradeoffs across savanna woody plants

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Forest Ecosystems 2024年第3期11卷 287-295页

作者： Yang.iding.Wang.Da Yang.g.rman Varg.s g. g.ang.ou Hao Jennifer S.Powers Yan Ke Qin Wang.Yunbing.Zhang.Jiaolin Zhang CAS Key Laboratory of Tropical Forest Ecolog. Xishuangbanna Tropical Botanical GardenChinese Academy of SciencesMenglaYunnan 666303China University of Chinese Academy of Sciences Beijing 100049China School of Biolog.cal Sciences University of UtahSalt Lake CityUT 84112USA CAS Key Laboratory of Forest Ecolog. and Manag.ment Institute of Applied EcologyChinese Academy of SciencesShenyang 110016China Department of Ecolog. Evolution and BehaviorUniversity of MinnesotaSt PaulMN 55108USA

Identifying.how leaf habit subdivisions link to the fast–slow and avoidance–tolerance trait tradeoffs can provide new insig.t into diverg.nce in ecophysiolog.cal strateg.es among.plant functional g.oups. Here, we tested a hypothesis that the differentiation across deciduous, semi-deciduous and everg.een woody species contributes to physiolog.cal trait tradeoffs in a dry-hot valley savanna. We investig.ted 11 photosynthetic, morpholog.cal and hydraulic traits of 24 species including.8 deciduous, 10 semi-deciduous and 6 everg.een species. Deciduous species were g.ouped in the fast and avoidance side associated with hig. values of maximum photosynthetic rates,stomatal conductance and leaf size, while everg.een species were g.ouped in the slow and tolerance side associated with hig. photosynthetic water use efficiency, leaf mass per area, sapwood density, Huber value, leaf water potential at turg.r loss point and water potential causing.50% loss of stem hydraulic conductance. Semideciduous species g.nerally had intermediate trait values and represented different physiolog.cal characteristics when compared to deciduous and everg.een species. The physiolog.cal trait tradeoffs showed a close linkag. to the differentiation of these three leaf habits. Our finding. clearly reveal trait tradeoffs related to fast–slow and avoidance–tolerance strateg.es among.diverse savanna plants, sug.esting.a syndrome in multiple ecophysiolog. strateg.es across different leaf habits.

关键词： Dry-hot habitat g.s exchang. Hydraulics Phenolog. Tolerance Valley savanna

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