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Adenovirus F40/41 Gastroenteritis-Associated Emphysematous Gastritis:A Case Report

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Infectious Diseases & Immunity 2024年第2期4卷 93-95页

作者： Maulik K.Lathiya Abigail T.La Nou Maria E.Linnaus susan M.Cullinan Emergency Department Mayo Clinic Health SystemEau Claire 54703WIUSA Critical Care Medicine Mayo Clinic Health SystemEau Claire 54703WIUSA General Surgery Department Mayo Clinic Health SystemEau Claire 54703WIUSA

Emphysematous gastritis(EG)is a rare form of gastritis characterized by gastric wall *** is associated with a high mortality *** case report describes a patient with a history of atrial fibrillation treated with apixaban,prior stroke,and schizoaffective disorder who showed epigastric tenderness on ***,no peritonitis signs were recorded,and laboratory values revealed high lactate levels and the presence of adenovirus F40/*** computed tomography scan showed extensive portal venous gas in the left hepatic lobe of the liver,as well as pneumatosis involving the entire stomach,indicating *** diagnosis was histologically confirmed and initially managed medically,which proved inefficacious,necessitating surgical intervention in the form of a laparotomy and esophagojejunostomy with Roux-en-y *** case report suggests a potential association between EG and adenovirus F40/41–induced gastroenteritis,thereby emphasizing the challenging nature of *** underscores the need for comprehensive research to enhance our understanding of its underlying causes and effective treatment strategies.

关键词： Emphysema Gastritis Human adenovirus F40/41 Immunocompromised

Pre-operative visceral adipose tissue radiodensity is a potentially novel prognostic biomarker for early endoscopic post-operative recurrence in Crohn’s disease

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World Journal of Gastrointestinal Surgery 2024年第3期16卷 740-750页

作者： Phillip Gu Shishir Dube Norman Gellada So yung Choi susan Win yoo Jin Lee Shaohong yang Talin Haritunians Gil y Melmed Eric A Vasiliauskas Niru Bonthala Gaurav Syal Andres J yarur David Ziring Shervin Rabizadeh Phillip Fleshner Cindy Kallman Suzanne Devkota Stephan R Targan Dalin Li Dermot PB McGovern Department of Medicine Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Imaging Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Biostatistics Shared Resource Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Internal Medicine Keimyung University School of MedicineDaegu 42601South Korea Department of Medicine University of California at Los AngelesLos AngelesCA 90095United States Department of Medicine University of California at San DiegoSan DiegoCA 92093United States Department of Pediatrics Cedars-Sinai Medical CenterLos AngelesCA 90048United States Department of Surgery Cedars-Sinai Medical CenterLos AngelesCA 90048United States

BACKGROUND Evidence suggests inflammatory mesenteric fat is involved in post-operative recurrence(POR)of Crohn’s disease(CD).However,its prognostic value is INTRODUCTION Crohn’s disease(CD)is a debilitating chronic immune-mediated inflammatory disease(IMID)of the gastrointestinal tract that is increasing in incidence and prevalence globally[1].CD patients often undergo surgery for disease-related complic-ations and/or medically refractory ***,surgery is not curative,and many patients develop post-operative recurrence(POR)of CD with a significant proportion eventually requiring additional *** advances in early detection and therapeutics,the contemporary 10-year risk of surgery has improved from 50%to 26%,but the risk of recurrent surgery has remained unchanged at 30%,suggesting a need to improve post-operative management strategies[2].Presently,there are two accepted strategies to mitigate POR,but each have potential ***,patients start early post-operative pharmacologic prophylaxis within 4-6 wk after *** strategy can potentially overtreat a subset of patient who may not develop long-term disease recurrence off ***,these patients are at risk of medication-related adverse events and the direct and indirect costs associated with therapy with little or no benefit[3].The second strategy is performing early colonoscopy within 6-12 months after surgery and escalating therapy based on FOOTNOTES Author contributions:Gu P is the guarantor of the article and was involved in concept and design,data collection,statistical analysis,drafting of manuscript,and final approval of manuscript;Dube S and Choi Sy were involved in statistical analysis,drafting of the manuscript,and final approval of manuscript;Gellada N,Win S,Lee yJ and yang S were involved in the data collection,drafting of the manuscript,and final approval of manuscript;Haritunians T and Li D were involved in data analysis and interpretation,drafting

关键词： Crohn’s disease Surgery Visceral adipose tissue Mesenteric adipose tissue Creeping fat Computed tomography

Total organic halogen(TOX) in human urine: A halogen-specific method for human exposure studies

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Journal of Environmental Sciences 2017年第8期29卷 285-295页

作者： susana y.Kimura Weiwei Zheng Taylor N.Hipp Joshua M.Allen susan D.Richardson Department of Chemistry and Biochemistry University of South Carolina Key Laboratory of Public Health Safety Ministry of Education Department of Environmental Health School of Public Health Fudan University

Disinfection by-products（DBPs） are a complex mixture of compounds unintentionally formed as a result of disinfection processes used to treat drinking water. Effects of long-term exposure to DBPs are mostly unknown and were the subject of recent epidemiological studies. However,most bioanalytical methods focus on a select few DBPs. In this study, a new comprehensive bioanalytical method has been developed that can quantify mixtures of organic halogenated compounds, including DBPs, in human urine as total organic chlorine（TOCl）, total organic bromine（TOBr）, and total organic iodine（TOI）. The optimized method consists of urine dilution, adsorption to activated carbon, pyrolysis of activated carbon, absorption of gases in an aqueous solution, and halide analysis with ion chromatography and inductively coupled plasma-mass spectrometry. Spike recoveries for TOCl, TOBr, and TOI measurements ranged between 78% and 99%. Average TOCl, TOBr, and TOI concentrations in five urine samples from volunteers who consumed tap water were 1850, 82, and 21.0 μg/L as X^-, *** who consumed spring water（control） had TOCl, TOBr, and TOI average concentrations in urine of 1090, 88, and 10.3 μg/L as X^-, respectively. TOCl and TOI in the urine samples from tap water consumers were higher than the control. However, TOBr was slightly lower in tap water urine samples compared to mineral water urine samples, indicating other sources of environmental exposure other than drinking water. A larger sample population that consumes tap water from different cities and mineral water is needed to determine TOCl, TOBr, and TOI exposure from drinking water.

关键词： Adsorbable organic halogen(AOX) Total organic halogen(TOX) Disinfection by-products(DBPs) Total organic chlorine(TOCl) Total organic bromine(TOBr) Total organic iodine(TOI) Urine Drinking water

Optimizing perioperative Crohn's disease management: Role of coordinated medical and surgical care

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World Journal of Gastroenterology 2015年第4期21卷 1182-1188页

作者： Jennifer L Bennett Christina y Ha Jonathan E Efron susan L Gearhart Mark G Lazarev Elizabeth C Wick Department of Surgery The Johns Hopkins University School of MedicineBaltimoreMD 21287United States Division of Gastroenterology the Johns Hopkins University School of MedicineBaltimoreMD 21287United States Division of Digestive Diseases the David Geffen School of Medicine at University of California Los AngelesLos AngelesCA 90095United States

AIM: To investigate rates of re-establishing gastroenterology care, colonoscopy, and/or initiating me-dical therapy after Crohn's disease(CD) surgery at a tertiary care referral ***: CD patients having small bowel or ileocolonic resections with a primary anastomosis between 2009-2012 were identified from a tertiary academic referral center. CD-specific features, medications, and surgical outcomes were abstracted from the medical record. The primary outcome measure was compliance rates with medical follow-up within 4 wk of hospital discharge and surveillance colonoscopy within 12 mo of surgery. RESULTS: Eighty-eight patients met study inclusion criteria with 92%(n = 81) of patients returning for surgical follow-up compared to only 41%(n = 36) of patients with documented gastroenterology follow-up within four-weeks of hospital discharge, P y postoperative medical follow-up included younger age, longer length of hospitalization, postoperative biologic use and academic center patients. In the study cohort, 75.0% of patients resumed medical therapy within 12 mo, whereas only 53.4% of patients underwent a colonoscopy within 12 mo of ***: Our study highlights the need for coordinated CD multidisciplinary clinics and structured handoffs among providers to improve of quality of care in the postoperative setting.

关键词： Coordinated care Crohn’s disease Postoperative pro

Showering in Flint, MI: Is there a DBP problem?

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Journal of Environmental Sciences 2017年第8期29卷 271-284页

作者： Joshua M.Allen Amy A.Cuthbertson Hannah K.Liberatore susana y.Kimura Anurag Mantha Marc A.Edwards susan D.Richardson Department of Chemistry and Biochemistry University of South Carolina the Department of Chemistry University of Calgary Civil and Environmental Engineering Virginia Tech

Lead contamination in the City of Flint, MI has been well documented over the past two years, with lead levels above the EPA Action Level until summer 2016. This resulted from an ill-fated decision to switch from Detroit water（Lake Huron） with corrosion control, to Flint River water without corrosion control. Although lead levels are now closer to normal,reports of skin rashes have sparked questions surrounding tap water in some Flint *** study investigated the presence of contaminants, including disinfection by-products（DBPs）, in the hot tap water used for showering in the homes of residents in Flint. Extensive quantitative analysis of 61 regulated and priority unregulated DBPs was conducted in Flint hot and cold tap water, along with the analysis of 50 volatile organic compounds and a nontarget comprehensive, broadscreen analysis, to identify a possible source for the reported skin rashes. For comparison, chlorinated hot and cold waters from three other cities were also sampled, including Detroit, which also uses Lake Huron as its source *** showed that hot water samples generally contained elevated levels of regulated and priority unregulated DBPs compared to cold water samples, but trihalomethanes were still within regulatory limits. Overall, hot shower water from Flint was similar to waters sampled from the three other cities and did not have unusually high levels of DBPs or other organic chemicals that could be responsible for the skin rashes observed by residents. It is possible that an inorganic chemical or microbial contaminant may be responsible.

关键词： Disinfection by-products Disinfection byproducts DBPs Flint Hot water Showering Bathing Drinking water

Exertional heat illness risk factors and physiological responses of youth football players

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Journal of Sport and Health Science 2021年第1期10卷 91-98页

作者： susan W.yeargin John J.Dickinson Dawn M.Emerson Jessica Koller Toni M.Torres-McGehee Zachary y.Kerr Department of Exercise Science University of South CarolinaColumbiaSC 29208USA Palmetto Health/USC Orthopedic Center Keenan High SchoolColumbiaSC 29203USA Department of Health Sportand Exercise SciencesUniversity of KansasLawrenceKS 66045USA Surgi-Care Inc. BostonMA 02115USA Department of Exercise and Sport Science University of North CarolinaChapel HillNC 27599-8700USA

Objective:To determine which intrinsic and extrinsic exertional heat illness(EHI)risk factors exist in youth American football players and observe perceptual and physiological responses of players during events(games and practices).Methods:Cross-sectional cohort study observing 63 youth football players,varying in *** variables were league(weightrestricted(WR,n=27)and age-restricted(AR,n=36))and event *** variables were anthropometrics,work-to-rest ratio,and wet bulb globe *** variables included preparticipation examination and uniform configuration.A subset of 16 players participated in physiological variables(heart rate and gastrointestinal temperature).Data collection occurred on 7 AR and 8 WR nonconsecutive practices and the first 3 games of the ***:Mean values for anthropometric variables were higher(py greater for games,but ratios were significantly higher for practices(χ^2(1,111)=40.62;py of events(77%)observed were in black and red flag wet bulb globe temperature risk categories.A total of 57%of the players had a preparticipation examination,and up to 82%of events observed were in full *** gastrointestinal temperature and heart rate responses ranged widely and no players reached critical ***:Extrinsic(disproportionate work ratios,environmental conditions)and intrinsic(higher body mass index)EHI risk factors exist in youth *** risk factors may be influenced by event and league *** youth football organizations need to create thorough guidelines that address EHI risk factors for local leagues to adopt.

关键词： Adolescents Anthropometrics Core temperature Heat exchange Pediatric Wet bulb globe temperature

PIN FORMED 2 Modulates the Transport of Arsenite in Arabidopsis thaliana

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Plant Communications 2020年第3期1卷 42-56页

作者： Mohammad Arif Ashraf Kana Umetsu Olena Ponomarenko Michiko Saito Mohammad Aslam Olga Antipova Natalia Dolgova Cheyenne D.Kiani susan Nehzati Keitaro Tanoi Katsuyuki Minegishi Kotaro Nagatsu Takehiro Kamiya Toru Fujiwara Christian Luschnig Karen Tanino Ingrid pickering Graham N.George Abidur Rahman United Graduate School of Agricultural Sciences Iwate UniversityMoriokaIwateJapan Department of Plant Bio Sciences Faculty of AgricultureIwate UniversityMoriokaIwateJapan Molecular and Environmental Science Research Group Department of Geological SciencesUniversity of SaskatchewanSaskatoonSKCanada Argonne National Lab Advanced Photon SourceXSD-MICLemontILUSA Isotope Facility for Agricultural Education and Research Graduate School of Agricultural and Life SciencesThe University of TokyoBunkyo-kuTokyoJapan Department of Radiopharmaceuticals Development National Institute of Radiological SciencesNational Institutes for Quantum and Radiological Science and TechnologyInageChibaJapan Department of Applied Biological Chemistry Graduate School of Agricultural and Life SciencesThe University of TokyoBunkyo-kuTokyoJapan Department of Applied Genetics and Cell Biology University of Natural Resources and Life SciencesVienna(BOKU)Muthgasse 181180 WienAustria Department of Plant Sciences College of Agriculture and BioresourcesUniversity of SaskatchewanSaskatoonSKCanada Agri-Innovation Center Iwate UniversityMoriokaIwateJapan

Arsenic contamination is a major environmental issue,as it may lead to serious health *** reduced trivalent formof inorganic arsenic,arsenite,is in generalmore toxic to plants comparedwith the fully oxidized pentavalent *** arsenite inplants hasbeenshown tobemediatedthrough a large subfamily of plant aquaglyceroporins,nodulin 26-like intrinsic proteins(NIPs).However,the efflux mechanisms,as well as themechanismof arsenite-induced root growth inhibition,remain poorly *** physiology,synchrotron imaging,and root transport assay approaches,we show that the cellular transport of trivalent arsenicals inArabidopsis thalianais stronglymodulatedbyPINFORMED2(PIN2)auxin efflux *** transport assay using radioactive arsenite,X-ray fluorescence imaging(XFI)coupled with X-ray absorption spectroscopy(XAS),and inductively coupled plasma mass spectrometry analysis revealed that pin2 plants accumulate higher concentrations of arsenite in roots comparedwith the *** the cellular level,arsenite specifically targets intracellular sorting of PIN2 and thereby alters the cellular auxin ***,loss of PIN2 function results in arsenite hypersensitivity in *** coupled with XAS further revealed that loss of PIN2 function results in specific accumulation of arsenical species,but not the other metals such as iron,zinc,or calcium in the root ***,these results suggest that PIN2 likely functions as an arsenite efflux transporter for the distribution of arsenical species in planta.

关键词： auxin arsenite PIN2 trafficking transport

ARBs improve stroke outcome through an AT2-dependent, BDNF-induced proangiogenic and prorecovery response

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Neural Regeneration Research 2016年第6期11卷 912-913页

作者： Ahmed Alhusban Abdelrahman y.Fouda susan C.Fagan Jordan University of Science and Technology College of PharmacyIrbidJordan Charlie Norwood VA Medical Center and Center for Pharmacy and Experimental TherapeuticsUniversity of Georgia College of Pharmacyand Georgia Regents UniversityAugustaGAUSA

Preclinical stroke research has introduced a number of potential interventions that can be utilized to enhance recovery after stroke（Lo and Rosenberg,2009）.

关键词： targeted majority utilized Rosenberg failed stimulation inhibit involvement angiogenesis signaling

Implementing General Education in Hong Kong:Government Policies,Institutional Responses,Opportunities and Challenges

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Frontiers of Education in China 2012年第2期7卷 253-269页

作者： Xiaoyan WANG susan GANO-PHILLIPS Office of Research&Innovation Seneca College of Applied Arts&TechnologyMarkhamON CAL3R 5Y1Canada Department of Psychology University of Michigan-FlintFlintMI 48502USA

In this paper,the authors explore the implementation of the government mandate in Hong Kong to move from three-year to four-year undergraduate degree programs which include studies in general education(GE),through an analysis of policies and activities related to the curriculum *** the authors are interested in the substance of these reforms,the primary objective is to explore the relationships between policy initiatives and implementation approaches at different *** Scott’s(2001)new institutional theory as a framework,the authors discuss the policy implementation at the governmental,institutional norms,and cultural *** focusing on the complex interrelationships among influences at different levels within the institution,this paper identifies challenges in the implementation of the new four-year curriculum,and using a case study of one institution,offers suggestions for facilitating that implementation.

关键词： general education(GE) curriculum reform academic structure change higher education Hong Kong