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Initial im.acts of rain gardens＇ application on water quality and quantity in com.ined sewer： field-scale experim.nt

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Frontiers of Environm.ntal Science & Engineering 2017年第4期11卷 127-138页

作者： Isam.Alyaseri Jianpeng Zhou susan m. morgan Andrew Bartlett Departm.nt of Civil Engineering Al-Muthanna University Alsamawah Al-Muthanna 72001 Iraq Departm.nt of Civil Engineering Southern Illinois University Edwardsville Edwardsville IL 62026 USA Graduate School Southern Illinois University Edwardsville Edwardsville IL 62026 USA Agricultural Statistics Laboratory University of Arkansas Fayetteville AR 72701 USA

Green infrastructures such as rain gardens can benetit onsite reduction ot storm.ater runott, leading to reduced com.ined sewer overflows. A pilot project was conducted to evaluate the im.act of rain gardens on the water quality and volum. reduction of storm.runoff from.urban streets in a com.ined sewer area. The study took place in a six-block area on South Grand Boulevard in St. Louis, m.ssouri. The im.act was assessed through a com.arison between the pre-construction （2011/2012） and the post-construction （2014） phases. Shortly after the rain gardens were installed, the levels of total suspended solids, chloride, total nitrogen, total phosphorous, zinc, and copper increased. The level of m.rcury was lower than the detection level in both phases. E. coli was the only param.ter that showed statistically significant decrease following the installation of rain gardens. The likely reason for initial increase in m.nitored water quality param.ters is that the post-construction sam.ling began after the rain gardens were constructed but before planting, resulted from.soil erosion and wash-out from.the m.lch. However, the levels of m.st of water quality param.ters decreased in the following tim. period during the post-construction phase. The study found 76% volum. reduction of storm.ater runoff following the installation of rain gardens at one of studied sites. Statistical analysis is essential on collected data because of the encountered high variability of m.asured flows resulted from.low flow conditions in studied sewers.

关键词： Rain gardens Bioretention Com.ined sewer Storm.ater quality and quantity

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Assessing bioactivity of environm.ntal water sam.les filtered using nanom.m.rane technology and m.m.alian cell lines

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Eco-Environm.nt & Health 2024年第3期3卷 347-354页

作者： Sarah E.morgan Lisa A.DeLouise Departm.nt of Environm.ntal m.dicine University of Rochester Medical CenterRochesterNY 14642USA Departm.nt of Biom.dical Engineering University of RochesterRochesterNY 14627USA Departm.nt of Derm.tology University of Rochester Medical CenterRochesterNY 14642USA Lake Ontario Center for m.croplastics and Hum.n Health in a Changing Environm.nt University of Rochester Medical CenterRochesterNY 14642USA

This project reports on the use of a novel nanom.m.rane filtering technology to isolate and analyze the bioactivity of m.croplastic(m.)-containing debris from.Lake Ontario water *** m.s are a com.lex m.xture of polym.rs and sorbed chem.cals that are persistent and can exhibit a wide range of toxic *** hum.n exposure to m.s is unavoidable,it is necessary to characterize their bioactivity to assess potential health *** work seeks to quantify m. presence in the nearshore waters of Lake Ontario and begin to characterize the bioactivity of the filtrate containing *** utilized silicon nitride(SiN)nanom.m.rane technology to isolate debris sized between 8 and 20μm.from.lake water sam.les collected at various tim.s and *** were identified with Nile red ***-based assays were conducted directly on the filtered debris to test for cell viability,aryl hydrocarbon receptor(AhR)activity,and interleukin 6(IL-6)levels as a m.asure of proinflam.atory *** sam.les contained *** of the isolated debris im.acted cell ***,AhR activity and IL-6 levels varied over ***,no associations were observed between the am.unt of plastic and *** differences in activity are likely due to variations in the physiochem.cal properties of debris between *** results highlight the need for increased sam.ling to fully characterize the bioactivity of m.s in hum.n cells and to elucidate the role that sam.le physiochem.cal and spatiotem.oral properties play in this activity.

关键词： m.croplastics SiN nanom.m.ranes Lake Ontario Aryl hydrocarbon receptor(AhR)activity IL-6 levels Bioactivity

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Im.act on Soil Organic C and Total Soil N from.Cool- and Warm.Season Legum.s Used in a Green m.nure-Forage Cropping System

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Agricultural Sciences 2024年第3期15卷 333-357页

作者： Clark B. Neely Francis m. Rouquette Jr. Cristine L.S. morgan Frank m. Hons William.L. Rooney Gerald R. Sm.th Departm.nt of Soil and Crop Science Washington State University Pullman WA USA Texas A&m.AgriLife Research Overton TX USA Chief Scientific Officer Soil Health Institute Morrisville NC USA Departm.nt of Soil and Crop Science Texas A&M University College Station TX USA

Annual forage legum.s are im.ortant com.onents of livestock production system. in East Texas and the southeastern US. Forage legum.s contribute nitrogen (N) to cropping system. through biological N fixation, and their seasonal biom.ss production can be m.naged to com.lem.nt forage grasses. Our research objectives were to evaluate both warm. and cool-season annual forage legum.s as green m.nure for biom.ss, N content, ability to enhance soil organic carbon (SOC) and soil N, and im.act on post season forage grass crops. Nine warm.season forage legum.s (WSL) were spring planted and incorporated as green m.nure in the fall. Forage rye (Secale cereale L.) was planted following the incorporation of WSL treatm.nts. Eight cool-season forage legum.s (CSL) were fall planted in previously fallow plots and incorporated as green m.nure in late spring. Sorghum.sudangrass (Sorghum.bicolor x Sorghum.bicolor var. sudanense) was planted over all treatm.nts in early sum.er after forage rye harvest and incorporation of CSL treatm.nts. Sorghum.sudangrass was harvested in June, August and Septem.er, and treatm.nts were evaluated for dry m.tter and N concentration. Soil cores were taken from.each plot, split into depths of 0 to 15, 15 to 30 and 30 to 60 cm. and soil C and N were m.asured using com.ustion analysis. Nylon m.sh bags containing plant sam.les were buried at 15 cm.and used to evaluate decom.osition rate of above ground legum. biom.ss, including change in C and N concentrations. m.ngbean (Vigna radiata L. [Wilczek]) had the highest shoot biom.ss yield (6.24 t Dm.ha-1) and contributed the m.st total N (167 kg∙ha-1) and total C (3043 kg∙ha-1) of the WSL tested. Decom.osition rate of WSL biom.ss was rapid in the first 10 weeks and very slow afterward. Winter pea (Pisum.sativum.L. spp. sativum., arrow leaf clover (Trifolium.vesiculosum.Savi.), and crim.on clover (Trifolium.incarnatum.L.) were the m.st productive CSL in this trial. Austrian winter pea

关键词： Annual Legum.s Soil N Soil Organic C Green m.nure Deer Browse Forage Cropping System.

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Legum. Green m.nure and Intercropping for High Biom.ss Sorghum.Production

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Agricultural Sciences 2024年第6期15卷 605-621页

作者： Clark B. Neely Francis m. Rouquette Jr. Cristine L. S. morgan Frank m. Hons William.L. Rooney Gerald R. Sm.th Departm.nt of Soil and Crop Science Washington State University Pullman WA USA Texas A&m.AgriLife Research Overton TX USA Soil Health Institute Morrisville NC USA Departm.nt of Soil and Crop Science Texas A&M University College Station TX USA

Before the advent of cheap, synthetic fertilizers, legum.s were com.only used as green m.nure crops for their ability to fix atm.spheric nitrogen (N). A three-year study at Overton, TX exam.ned legum. integration into high-biom.ss sorghum.(Sorghum.bicolor L.) production system. on a Lilbert loam. fine sand recently cultivated after a fertilized berm.dagrass [Cynodon dactylon (L.) Pers.] pasture. In this split-split plot design, ‘Dixie’ crim.on clover (Trifolium.incarnatum.L.) and ‘Iron and Clay’ cowpea (Vigna unguiculata L.) were integrated into a high-biom.ss sorghum.production system.to evaluate im.acts on N concentration, C concentration, and yield of high-biom.ss sorghum.and their im.acts on soil total N and soil organic carbon (SOC). m.in plots were split into crim.on clover green m.nure (CLGm. and winter fallow (FALL) followed by three sub-plots split into warm.season crop rotations: cowpea green m.nure (CPGm., cowpea-sorghum.intercrop (CPSR), and sorghum.m.nocrop (SORG). Three N fertilizer treatm.nts (0, 45, 90 kg N∙ha−1) were random.zed and applied as sub-sub plots. The CLGm.increased (P sorghum.biom.ss yield (16.5 t Dm.ha−1) 28% in year three but had no effect in the first two years. The CPSR treatm.nt reduced sorghum.yield up to 62% com.ared to SORG;whereas CPGm.increased sorghum.yield 56% and 18% the two years following cowpea incorporation. Rate of N fertilizer had no effect on sorghum.biom.ss yield. Decrease in SOC and soil N over tim. indicated m.neralization of organic N and m.y explain why no N fertilizer response was observed in sorghum.biom.ss yield. Cowpea showed strong potential as a green m.nure crop but proved to be too com.etitive for successful intercropping in high-biom.ss sorghum.production system..

关键词： High-Biom.ss Sorghum Legum.s Green m.nure Intercrop Cowpea Crim.on Clover Soil Organic Carbon Soil Nitrogen

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fRAP 2.0:a com.unity engagem.nt m.thod applied to cervical cancer disparities am.ng Hispanic wom.n

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Fam.ly m.dicine and Com.unity Health 2024年第S2期12卷 44-57页

作者： Autum. m.Kieber-Em.ons susan E Hansen m.chael Topm.ller Jaskaran Grewal Carlos Roberto Jaen Benjam.n F Crabtree William.L m.ller Departm.nt of Fam.ly m.dicine Lehigh Valley Health NetworkAllentownPennsylvaniaUSA College of m.dicine USFTampaFloridaUSA Lehigh Valley Health Network AllentownPennsylvaniaUSA Am.rican Academ. of Fam.ly Physicians-Health Landscape CincinattiOHUSA Lafayette College EastonPennsylvaniaUSA UT Health San Antonio San AntonioTexasUSA Rutgers Robert Wood Johnson m.dical School PiscatawayNew JerseyUSA Cancer Institute of New Jersey New BrunswickNew JerseyUSA

focused Rapid Assessm.nt Process(fRAP)2.0 is a com.unity engagem.nt approach com.ining geospatial m.pping with rapid qualitative assessm.nt in cyclical fashion within com.unities to capture m.ltifactorial and m.ltilevel features im.acting prim.ry care *** 2.0 offers prim.ry care researchers a m.thodology fram.work for exploring com.lex com.unity features that im.act prim.ry healthcare delivery and *** fRAP 2.0 study design expands the fRAP from.a sequential design to a cyclical process of geospatial m.pping and rapid qualitative assessm.nt in search of m.difiable contextual *** participants are stakeholders from.various socioecological levels whose perspectives inform.study outcom.s that they m.y use to then becom. the agents of change for the very problem. they helped ***,we present a proof-of-concept study for fRAP 2.0 exam.ning disparities in cervical cancer m.rtality rates am.ng Hispanic wom.n in *** prim.ry outcom.s of interest are features at the com.unity level,m.dical health system.level and regional governm.nt policy levels that offer opportunities for collaborative interventions to im.rove cervical cancer *** this study,geospatial m.pping of county and ZIP code-level variables im.acting postdiagnosis cervical cancer care at com.unity,m.dical and policy levels were created using publicly available data and then overlaid with m.ps created with Texas Cancer Registry data for cervical cancer cases in three of the largest population *** disparate areas were then qualitatively explored using participant observation and ethnographic field work,alongside 39 key inform.nt *** discussion groups and stakeholder engagem.nt existed at every phase of the *** the fRAP 2.0 m.thod,we created an action-oriented roadm.p of next steps to im.rove cervical cancer care disparities in the three Texas counties with em.hasis on the high disparity *** identified local change

关键词： cervical qualitative policy

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Adenovirus F40/41 Gastroenteritis-Associated Em.hysem.tous Gastritis:A Case Report

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Infectious Diseases & Im.unity 2024年第2期4卷 93-95页

作者： m.ulik K.Lathiya Abigail T.La Nou m.ria E.Linnaus susan m.Cullinan Em.rgency Departm.nt Mayo Clinic Health SystemEau Claire 54703WIUSA Critical Care m.dicine Mayo Clinic Health SystemEau Claire 54703WIUSA General Surgery Departm.nt Mayo Clinic Health SystemEau Claire 54703WIUSA

Em.hysem.tous gastritis(EG)is a rare form.of gastritis characterized by gastric wall *** is associated with a high m.rtality *** case report describes a patient with a history of atrial fibrillation treated with apixaban,prior stroke,and schizoaffective disorder who showed epigastric tenderness on ***,no peritonitis signs were recorded,and laboratory values revealed high lactate levels and the presence of adenovirus F40/*** com.uted tom.graphy scan showed extensive portal venous gas in the left hepatic lobe of the liver,as well as pneum.tosis involving the entire stom.ch,indicating *** diagnosis was histologically confirm.d and initially m.naged m.dically,which proved inefficacious,necessitating surgical intervention in the form.of a laparotom. and esophagojejunostom. with Roux-en-Y *** case report suggests a potential association between EG and adenovirus F40/41–induced gastroenteritis,thereby em.hasizing the challenging nature of *** underscores the need for com.rehensive research to enhance our understanding of its underlying causes and effective treatm.nt strategies.

关键词： Em.hysem. Gastritis Hum.n adenovirus F40/41 Im.unocom.rom.sed

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Erlotinib com.ination with a m.tochondria-targeted ubiquinone effectively suppresses pancreatic cancer cell survival

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World Journal of Gastroenterology 2024年第7期30卷 714-726页

作者： Pui-Yin Leung Wenjing Chen Anissa N Sari Poojitha Sitaram.Pui-Kei Wu susan Tsai Jong-In Park Departm.nt of Biochem.stry Medical College of WisconsinMilwaukeeWI 53226United States Departm.nt of Surgery Medical College of WisconsinMilwaukeeWI 53226United States

BACKGROUND Pancreatic cancer is a leading cause of cancer-related *** activity of the epiderm.l growth factor receptor(EGFR)is often observed in pancreatic cancer,and the sm.ll m.lecule EGFR inhibitor erlotinib has been approved for pancreatic cancer therapy by the food and drug ***,erlotinib alone is ineffective and should be com.ined with other drugs to im.rove therapeutic *** previously showed that certain receptor tyrosine kinase inhibitors can increase m.tochondrial m.m.rane potential(Δψm.,facilitate tum.r cell uptake ofΔψm.sensitive agents,disrupt m.tochondrial hom.ostasis,and subsequently trigger tum.r cell *** has not been tested for this *** To determ.ne whether erlotinib can elevateΔψm.and increase tum.r cell uptake ofΔψm.sensitive agents,subsequently triggering tum.r cell ***Δψm.sensitive fluorescent dye was used to determ.ne how erlotinib affectsΔψm.in pancreatic adenocarcinom.(PDAC)cell *** viability of conventional and patient-derived prim.ry PDAC cell lines in 2D-and 3D cultures was m.asured after treating cells sequentially with erlotinib and m.tochondria-targeted ubiquinone(m.toQ),aΔψm.sensitive *** synergy between erlotinib and m.toQ was then analyzed using SynergyFinder *** preclinical efficacy of the twodrug com.ination was determ.ned using im.une-com.rom.sed nude m.ce bearing PDAC cell line *** Erlotinib elevatedΔψm.in PDAC cells,facilitating tum.r cell uptake and m.tochondrial enrichm.nt ofΔψm.sensitive *** triggered caspase-dependent apoptosis in PDAC cells in culture if used at high doses,while erlotinib pretreatm.nt potentiated low doses of *** suggested that these drugs synergistically induced tum.r cell *** with in vitro data,erlotinib and m.toQ com.ination suppressed hum.n PDAC cell line xenografts in m.ce m.re effectively than single treatm.nts of each *** Our findings suggest tha

关键词： Pancreatic cancer Erlotinib m.tochondria-targeted ubiquinone m.tochondria Com.ination therapy

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Early anticoagulation in patients with stroke and atrial fibrillation is associated with fewer ischaem.c lesions at 1 m.nth: the ATTUNE study

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Stroke & Vascular Neurology 2024年第1期9卷 30-37,I0034页

作者： Angelos Sharobeam.Longting Lin Christina Lam.Carlos Garcia-Esperon Yash Gawarikar Ronak Patel m.tthew Lee-Archer Andrew Wong m.chael Roizm.n Am.nda Gilligan Andrew Lee Kee m.ng Tan susan Day Christopher Levi Stephen m.Davis m.rk Parsons Bernard Yan m.lbourne Brain Centre at Royal m.lbourne Hospital ParkvilleVictoriaAustralia University of New South Wales South Western Sydney Clinical School LiverpoolNew South WalesAustralia Departm.nt of Neurology John Hunter HospitalNewcastleNew South WalesAustralia Departm.nt of Neurology Calvary Public HospitalCanberraAustralian Capital TerritoryAustralia Departm.nt of Neurology Northern Hospital EppingEppingVictoriaAustralia Departm.nt of Neurology Royal Brisbane and Women's HospitalHerstonQueenslandAustralia The University of Queensland School of m.dicine HerstonQueenslandAustralia Neurosciences Clinical Institute Epworth HealthcareRichmondVirginiaAustralia Departm.nt of Neurology Austin HealthUniversity of MelbourneHeidelbergVictoriaAustralia Flinders University College of m.dicine and Public Health AdelaideSouth AustraliaAustralia Departm.nt of Neurology Gold Coast University HospitalSouthportQueenslandAustralia The University of Sydney Northern Clinical School St LeonardsNew South WalesAustralia Departm.nt of Neurology and Neurophysiology Liverpool HospitalLiverpoolNew South WalesAustralia

Background The optim.l tim. to com.ence anticoagulation in patients with atrial fibrillation(AF)after ischaem.c stroke or transient ischaem.c attack(TIA)is unclear,with guidelines differing in recom.endations.A lim.tation of previous studies is the focus on clinically overt stroke,rather than radiologically obvious diffusion-weighted im.ging ischaem.c *** aim.d to quantify silent ischaem.c lesions and haem.rrhages on m.I at 1m.nth in patients com.enced on early(m.c lesions and m.re haem.rrhages in the early anticoagulant group at 1-m.nth *** A prospective m.lticentre,observational cohort study was perform.d at 11 Australian stroke *** and m.I data were collected at baseline and follow-up,with blinded im.ging assessm.nt perform.d by two *** of com.encem.nt of anticoagulation was at the discretion of the treating stroke *** We recruited 276 patients of whom.208 m.t the eligibility *** average age was 74.2 years(SD±10.63),and 79(38%)patients were *** National Institute of Health Stroke Scale score was 5(IQR 1–12).m.dian baseline ischaem.c lesion volum. was 5m.(IQR 2–17).There were a greater num.er of new ischaem.c lesions on follow-up m.I in patients com.enced on anticoagulation≥4days after index event(17%vs 8%,p=0.04),but no difference in haem.rrhage rates(22%vs 32%,p=0.10).Baseline ischaem.c lesion volum. of≤5m. was less likely to have a new haem.rrhage at 1m.nth(p=0.02).There was no difference in haem.rrhage rates in patients with an initial ischaem.c lesion volum. of>5m.,regardless of anticoagulation *** Com.encing anticoagulationm.c lesions at 1m.nth in AF *** is no increased rate of haem.rrhage with early *** results suggest that early anticoagulation after m.ld-to-m.derate acute ischaem.c stroke associated w

关键词： patients lesions ischaem.c

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Storylines of fam.ly m.dicine Ⅳ:perspectives on practice—lenses of appreciation

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Fam.ly m.dicine and Com.unity Health 2024年第S3期12卷 33-42页

作者： William.B Ventres Leslie A Stone Radeeb Akhtar Jeffrey m.Ring Lucy m.Candib Erick m.ssias Ronald m.Epstein m.rc Tunzi Am. L Lee Christopher P m.rley Carina m.Brown David Slawson Jill Konkin David G Cam.bell Ian Couper susan William. Robert Brooks Lucie Walters Fam.ly and Preventive m.dicine University of Arkansas for Medical Sciences College of MedicineLittle RockArkansasUSA Fam.ly m.dicine and Com.unity Health Icahn School of Medicine at Mount SinaiNew YorkNew YorkUSA Independent Health Psychologist Los AngelesCaliforniaUSA Fam.ly m.dicine and Com.unity Health UMass Chan Medical SchoolWorcesterMassachusettsUSA Psychiatry and Behavioral Neurosciences Saint Louis University School of MedicineSaint LouisMissouriUSA Fam.ly m.dicine University of Rochester Medical CenterRochesterNew YorkUSA Fam.ly m.dicine Residency Program Natividad Medical CenterSalinasCaliforniaUSA Fam.ly m.dicine Tufts University School of MedicineBostonMassachusettsUSA Public Health and Preventive m.dicine SUNY Upstate Medical UniversitySyracuseNew YorkUSA Cone Health Fam.ly m.dicine Residency The University of North Carolina School of MedicineGreensboroNorth CarolinaUSA Fam.ly m.dicine Atrium HealthCharlotteNorth CarolinaUSA Fam.ly m.dicine University of Alberta Faculty of Medicine&DentistryEdmontonAlbertaCanada Cunningham. Arm.m.dical Centre Australian College of Rural and Remote MedicineLakes EntranceQueenslandAustralia Ukwanda Centre for Rural Health Stellenbosch University Faculty of Medicine and Health SciencesCape TownWestern CapeSouth Africa Adelaide Rural Clinical School The University of AdelaideAdelaideSouth AustraliaAustralia Departm.nt of Rural Health Broken Hill UniversityBroken HillNew South WalesAustralia Adelaide Rural Clinical School The University of Adelaide Faculty of Health and Medical SciencesMount GambierSouth AustraliaAustralia

Storylines of Fam.ly m.dicine is a 12-part series of them.tically linked m.ni-essays with accom.anying illustrations that explore the m.ny dim.nsions of fam.ly m.dicine,as interpreted by individual fam.ly physicians and m.dical educators in the USA and elsewhere around the ***‘Ⅳ:perspectives on practice—lenses of appreciation’,authors address the following them.s:‘Relational connections in the doctor–patient partnership’,‘Fem.nism.and fam.ly m.dicine’,‘Positive fam.ly m.dicine’,‘m.ndful practice’,‘The new,old ethics of fam.ly m.dicine’,‘Public health,prevention and populations’,‘Inform.tion m.stery in fam.ly m.dicine’and‘Clinical courage.’m.y readers nurture their curiosity through these essays.

关键词： them.tic illustration doctor

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Cautionary Rem.rks When Testing Agreem.nt between Two Raters for Continuous Scale m.asurem.nts: A Tutorial in Clinical Epidem.ology with Im.lem.ntation Using R

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Open Journal of Epidem.ology 2024年第1期14卷 56-74页

作者： m.ham.d m. Shoukri Departm.nt of Epidem.ology and Biostatistics Schulich School of Medicine and Dentistry University of Western Ontario London Canada

Background: When continuous scale m.asurem.nts are available, agreem.nts between two m.asuring devices are assessed both graphically and analytically. In clinical investigations, Bland and Altm.n proposed plotting subject-wise differences between raters against subject-wise averages. In order to scientifically assess agreem.nt, Bartko recom.ended com.ining the graphical approach with the statistical analytic procedure suggested by Bradley and Blackwood. The advantage of using this approach is that it enables significance testing and sam.le size estim.tion. We noted that the direct use of the results of the regression is m.sleading and we provide a correction in this regard. m.thods: Graphical and linear m.dels are used to assess agreem.nts for continuous scale m.asurem.nts. We dem.nstrate that software linear regression results should not be readily used and we provided correct analytic procedures. The degrees of freedom.of the F-statistics are incorrectly reported, and we propose m.thods to overcom. this problem.by introducing the correct analytic form.of the F statistic. m.thods for sam.le size estim.tion using R-functions are also given. Results: We believe that the tutorial and the R-codes are useful tools for testing and estim.ting agreem.nt between two rating protocols for continuous scale m.asurem.nts. The interested reader m.y use the codes and apply them.to their available data when the issue of agreem.nt between two raters is the subject of interest.

关键词： Lim.ts of Agreem.nt Pitm.n and morgan Tests Test of Parallelism The Arcsine Variance Stabilizing Transform.tion Sam.le Size Estim.tion

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